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Computed tomography and magnetic resonance imaging features of lipid-rich neuroendocrine tumors of the pancreas

World Journal of Gastroenterology 2015年第34期21卷 10008-10017页

作者： Yoshihiko Fukukura Toshikazu Shindo Michiyo Higashi Koji Takumi Tomokazu Umanodan Tomohide Yoneyama takashi yoshiura De-partment of Radiology Kagoshima University Graduate School of Medical and Dental Sciences Department of Human Pathology Kagoshima University Graduate School of Medical and Dental Sciences

AIM:To clarify the computed tomography(CT) and magnetic resonance imaging(MRI) characteristics of lipid-rich pancreatic neuroendocrine tumors(Pan NETs).METHODS:Enhanced CT and MRI performed before pancreatectomy in 29 patients with 34 histologicallyconfirmed Pan NETs was retrospectively reviewed. Tumor attenuation on CT and signal intensities on conventional(T1- and T2-weighted) and chemical shift MRI were qualitatively analyzed and compared alongside adipose differentiation-related protein(ADRP) immunostaining(ADRP-positive:lipid-rich; ADRP-negative:non-lipid-rich) results using Fisher's exact test or the Mann-Whitney U test. Signal intensity index on chemical shift MRI was quantitatively ***:There were 15 lipid-rich Pan NETs(44.1%) in 12 patients(41.4%). Tumor attenuation during the early,portal venous,and delayed phases of enhanced CT(P = 0.888,0.443,and 0.359,respectively) and signal intensities on conventional MRI(P = 0.698 and 0.798,respectively) were not significantly differentbetween lipid-rich and non-lipid-rich Pan NETs. Four of the 15 lipid-rich Pan NETs exhibited high signal intensity on subtraction chemical shift MRI,and the association of high signal intensity on subtraction imaging with lipid-rich Pan NETs was significant(4 of 15 lipid-rich Pan NETs,26.73%,vs 0 of 19 non-lipid-rich Pan NETs,0%,P = 0.029). Lipid-rich Pan NETs showed a significantly higher signal intensity index than non-lipidrich Pan NETs(0.6% ± 14.1% vs-10.4% ± 14.4%,P = 0.004). Eight of 15 lipid-rich Pan NETs,vs 0 of 19 nonlipid-rich Pan NETs,had positive signal intensity index values in concordance with lipid contents.C O N C L U S I O N :C T c o n t ra s t e n h a n c e m e n t a n d conventional MR signal intensities are similar in lipidrich and non-lipid-rich Pan NETs. Chemical shift MRI can demonstrate cytoplasmic lipids in Pan NETs.

关键词： Neoplasms Chemical shift magnetic resonance imagin

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Balloon test occlusion of internal carotid artery: Angiographic findings predictive of results

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World Journal of Radiology 2014年第8期6卷 619-624页

作者： Kazufumi Kikuchi takashi yoshiura Akio Hiwatashi Osamu Togao Koji Yamashita Hiroshi Honda Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University

AIM: To reveal angiographic findings to predict the re-sult of balloon test occlusion(BTO).METHODS: The cerebral angiograms of 42 consecu-tive patients who underwent cerebral angiography in-cluding both the Matas and Allcock maneuvers and BTO were retrospectively analyzed. Visualization of the an-terior cerebral artery(ACA) and the middle cerebral ar-tery(MCA) by the cross flow on the tested side during the Matas or Allcock maneuver was graded on a 5-point scale. Circle of Willis(COW) anatomy with respect to the presence/absence of a collateral path to reach the tested internal carotid artery(ICA) was classified intofour categories. A univariate logistic analysis was used to analyze the associations between each angiographic finding and the BTO result. Sensitivity, specificity, accu-racy, positive predictive value, and negative predictive value for each finding were calculated. RESULTS: Five patients(12%) were BTO-positive and the remaining 37 patients(88%) were BTO-negative. Visualizations of the ACA and MCA as well as the COW anatomy were significantly associated with the BTO re-sult(P = 0.0051 for ACA, P = 0.0002 for MCA, and P < 0.0001 for COW anatomy). In particular, good MCA vi-sualization and the presence of an anterior connection(collateral path to the tested ICA from the contralateral ICA via the anterior communicating artery) in the COW were highly predictive for negative BTO(negative pre-dictive value = 100% for both).

关键词： Balloon test occlusion Cross flow Circle of Willis Anterior circulation Posterior circulation

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Resolution of epidural hematoma related to osteoporotic fracture after percutaneous vertebroplasty

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World Journal of Radiology 2013年第8期5卷 325-327页

作者： Hidenari Hirata Akio Hiwatashi takashi yoshiura Osamu Togao Koji Yamashita Hironori Kamano Kazufumi Kikuchi Hiroshi Honda Department of Clinical Radiology Graduate School of Medical SciencesKyushu University

We are the first to report a case that showed spontaneous resolution of epidural hematoma which was related to a steroid-induced osteoporotic compression *** patient had a painful fracture with an intravertebral cleft at L1 accompanying an epidural hematoma *** pain relief was achieved after percutaneous *** resolution of hematoma was noted three months after *** theorized that intravertebral stability after treatment might have played a role in this patient.

关键词： Vertebroplasty Osteoporosis Epidural hematoma Spinal canal compromise Intravertebral cleft

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Computer-aided differential diagnosis system for Alzheimer’s disease based on machine learning with functional and morphological image features in magnetic resonance imaging

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Journal of Biomedical Science and Engineering 2013年第11期6卷 1090-1098页

作者： Yasuo Yamashita Hidetaka Arimura takashi yoshiura Chiaki Tokunaga Ohara Tomoyuki Koji Kobayashi Yasuhiko Nakamura Nobuyoshi Ohya Hiroshi Honda Fukai Toyofuku Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University Fukuoka Japan Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University Fukuoka Japan Division of Radiology Department of Medical Technology Kyusyu University Hospital Fukuoka Japan Faculty of Medical Science Kyushu University Fukuoka Japan Graduate School of Medical Science Kyushu University Fukuoka Japan Division of Radiology Department of Medical Technology Kyusyu University Hospital Fukuoka Japan

Alzheimer’s disease (AD) is a dementing disorder and one of the major public health problems in countries with greater longevity. The cerebral cortical thickness and cerebral blood flow (CBF), which are considered as morphological and functional image features, respectively, could be decreased in specific cerebral regions of patients with dementia of Alzheimer type. Therefore, the aim of this study was to develop a computer-aided classification system for AD patients based on machine learning with the morphological and functional image features derived from a magnetic resonance (MR) imaging system. The cortical thicknesses in ten cerebral regions were derived as morphological features by using gradient vector trajectories in fuzzy membership images. Functional CBF maps were measured with an arterial spin labeling technique, and ten regional CBF values were obtained by registration between the CBF map and Talairach atlas using an affine transformation and a free form deformation. We applied two systems based on an arterial neural network (ANN) and a support vector machine (SVM), which were trained with 4 morphological and 6 functional image features, to 15 AD patients and 15 clinically normal (CN) subjects for classification of AD. The area under the receiver operating characteristic curve (AUC) values for the two systems based on the ANN and SVM with both image?features were 0.901 and 0.915, respectively. The AUC values for the ANN-and SVM-based systems with the morphological features were 0.710 and 0.660, respectively, and those with the functional features were 0.878 and 0.903, respectively. Our preliminary results suggest that the proposed method may have potential for assisting radiologists in the differential diagnosis of AD patients by using morphological and functional image features.

关键词： Computer-aided Classification (CAD) Alzheimer’s Disease Magnetic Resonance Imaging (MRI) Arterial Spin Labeling (ASL) Fuzzy Membership Image Cortical Thickness Cerebral Blood Flow (CBF)

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Automated measurement of three-dimensional cerebral cortical thickness in Alzheimer’s patients using localized gradient vector trajectory in fuzzy membership maps

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Journal of Biomedical Science and Engineering 2013年第3期6卷 327-336页

作者： Chiaki Tokunaga Hidetaka Arimura takashi yoshiura Tomoyuki Ohara Yasuo Yamashita Kouji Kobayashi Taiki Magome Yasuhiko Nakamura Hiroshi Honda Hideki Hirata Masafumi Ohki Fukai Toyofuku Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University Fukuoka Japan Department of Health Sciences Faculty of Medical Sciences Kyushu University Fukuoka Japan Department of Health Sciences Graduate School of Medical Sciences Kyushu University Fukuoka Japan Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University Fukuoka Japan Division of Radiology Department of Medical Technology Kyushu University Hospital Fukuoka Japan

Our purpose in this study was to develop an automated method for measuring three-dimensional (3D) cerebral cortical thicknesses in patients with Alzheimer’s disease (AD) using magnetic resonance (MR) images. Our proposed method consists of mainly three steps. First, a brain parenchymal region was segmented based on brain model matching. Second, a 3D fuzzy membership map for a cerebral cortical region was created by applying a fuzzy c-means (FCM) clustering algorithm to T1-weighted MR images. Third, cerebral cortical thickness was three- dimensionally measured on each cortical surface voxel by using a localized gradient vector trajectory in a fuzzy membership map. Spherical models with 3 mm artificial cortical regions, which were produced using three noise levels of 2%, 5%, and 10%, were employed to evaluate the proposed method. We also applied the proposed method to T1-weighted images obtained from 20 cases, i.e., 10 clinically diagnosed AD cases and 10 clinically normal (CN) subjects. The thicknesses of the 3 mm artificial cortical regions for spherical models with noise levels of 2%, 5%, and 10% were measured by the proposed method as 2.953 ± 0.342, 2.953 ± 0.342 and 2.952 ± 0.343 mm, respectively. Thus the mean thicknesses for the entire cerebral lobar region were 3.1 ± 0.4 mm for AD patients and 3.3 ± 0.4 mm for CN subjects, respectively (p < 0.05). The proposed method could be feasible for measuring the 3D cerebral cortical thickness on individual cortical surface voxels as an atrophy feature in AD.

关键词： Alzheimer’s Disease (AD) Fuzzy C-Means Clustering (FCM) Three-Dimensional Cerebral Cortical Thickness Localized Gradient Vector

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In vivo direct neuronal conversion as a therapeutic strategy for ischemic stroke

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Neural Regeneration Research 2025年第8期20卷 2309-2310页

作者： takashi Irie Taito Matsuda Department of Stem Cell Biology and Medicine Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Neurology Neurological InstituteGraduate School of Medical SciencesKyushu UniversityFukuokaJapan

Stroke causes neuronal loss,which ultimately results in persistent neurological ***,stroke was the third-leading cause of death and disability combined in all ages in 2019,after neonatal disorders and ischemic heart *** that year,there were 12.2 million incident strokes,101 million prevalent strokes,and 143 million disability-adjusted life-years due to stroke.

关键词： neonatal death therapeutic

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Potential of non-Western medicines in chemoradiotherapy for cervical cancer

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World Journal of Clinical Cases 2025年第2期13卷 21-23页

作者： takashi Ono Masashi Koto Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan

This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical *** radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’***,most treatments are supportive,with no specific treatment options available in Western ***-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical *** these potential benefits,challenges such as limited evidence and restricted application areas *** non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.

关键词： Cervical cancer Radiotherapy Non-Western medicine Kampo Herbal medicine

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Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

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The stay coefficient: a novel quantification of the relationship between stay time and travel time for urban shopping behavior analysis

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Geo-Spatial Information Science 2023年第1期26卷 44-57页

作者： takashi Yamada Department of Human Factors Engineering and Environmental Design Faculty of Biology-Oriented Science and TechnologyKindai UniversityWakayamaJapan

Shoppers typically want to spend an amount of time at a destination that is proportional to the travel time required to arrive there;thus,the travel time can be considered the cost of their *** is likely to be the case across regions with different urban structures and *** purpose of this study was therefore to analyze the shopping behaviors contained in travel survey data from three metropolitan areas in Japan to identify common patterns and indicators based on travel time and stay time,thereby obtaining an understanding to inform future trade area *** the travel time and stay time associated with shopping behavior were found to be log-normally distributed regardless of metropolitan area,and four shopping behavior patterns common among the metropolitan areas were ***“stay coeffi-cient”was then defined to express the elasticity of stay time according to travel time,and its values were similar according to shopping behavior pattern regardless of metropolitan *** stay coefficient proposed in this study can therefore be applied to identify shopping behavior patterns in any urban area based on the relationship between travel time and stay time,realizing a novel approach to the analysis of and marketing for trade areas when planning the construction or renovation of commercial *** approach can help inform the decisions of urban policy makers,marketing advisors,and commercial facility operators,and should be of interest to researchers and practitioners working with geospatial,shopping,and other human behavioral characteristics.

关键词： Travel survey shopping behavior travel time stay time stay coefficient trade area analysis

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The Emergent Constructive Approach to Evolinguistics:Considering Hierarchy and Intention Sharing in Linguistic Communication

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Journal of Systems Science and Systems Engineering 2020年第6期29卷 675-696页

作者： takashi Hashimoto School of Knowledge Science Japan Advanced Institute of Science and Technology(JAIST)Nomi 923-1292Japan

Evolinguistics is an attempt to clarify the origins and evolution of language and communication,thereby deepening our understanding of humans from an evolutionary *** origins of language is characterized by the biological evolution of abilities related to language and communication,and the evolution of language by the structuralization and complexification of language knowledge as well as communication systems through cultural *** Evolinguistics,two idiosyncrasies of human linguistic communication are the primary focus,namely,using hierarchically organized symbol sequences in language and sharing intentions in *** believe that the integration of these two characteristics made humans co-creative and smart,and in particular gave us knowledge co-creation *** emergent constructive approach plays an important role in this research,which is a methodology to analyze complex systems by constructing and operating the evolutionary and emergent process of complex *** studies taking this approach are introduced in this *** is a language evolution experiment in a laboratory to consider the process,mechanisms,and neural basis of symbolic communication *** other is an evolutionary simulation of recursive combination,which is thought of as the essential ability to form hierarchical structures.A hypothesis integrating intention sharing and recursive combination is discussed as an abductive reasoning mechanism for understanding others intentions.

关键词： Evolinguistics origins and evolution of language hierarchy intention sharing symbolic communication recursive combination abduction

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