Computed tomography and magnetic resonance imaging features of lipid-rich neuroendocrine tumors of the pancreas

作     者：Yoshihiko Fukukura Toshikazu Shindo Michiyo Higashi Koji Takumi Tomokazu Umanodan Tomohide Yoneyama Takashi Yoshiura 

作者机构：De-partment of RadiologyKagoshima University Graduate School of Medical and Dental Sciences Department of Human PathologyKagoshima University Graduate School of Medical and Dental Sciences 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2015年第21卷第34期

页      面：10008-10017页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100214[医学-肿瘤学] 100106[医学-放射医学] 10[医学] 

基　　金：Japan Society for the Promotion of Science  JSPS  (15K08349) 

主　　题：Neoplasms Chemical shift magnetic resonance imagin 

摘      要：AIM:To clarify the computed tomography(CT) and magnetic resonance imaging(MRI) characteristics of lipid-rich pancreatic neuroendocrine tumors(Pan NETs).METHODS:Enhanced CT and MRI performed before pancreatectomy in 29 patients with 34 histologicallyconfirmed Pan NETs was retrospectively reviewed. Tumor attenuation on CT and signal intensities on conventional(T1- and T2-weighted) and chemical shift MRI were qualitatively analyzed and compared alongside adipose differentiation-related protein(ADRP) immunostaining(ADRP-positive:lipid-rich; ADRP-negative:non-lipid-rich) results using Fisher s exact test or the Mann-Whitney U test. Signal intensity index on chemical shift MRI was quantitatively ***:There were 15 lipid-rich Pan NETs(44.1%) in 12 patients(41.4%). Tumor attenuation during the early,portal venous,and delayed phases of enhanced CT(P = 0.888,0.443,and 0.359,respectively) and signal intensities on conventional MRI(P = 0.698 and 0.798,respectively) were not significantly differentbetween lipid-rich and non-lipid-rich Pan NETs. Four of the 15 lipid-rich Pan NETs exhibited high signal intensity on subtraction chemical shift MRI,and the association of high signal intensity on subtraction imaging with lipid-rich Pan NETs was significant(4 of 15 lipid-rich Pan NETs,26.73%,vs 0 of 19 non-lipid-rich Pan NETs,0%,P = 0.029). Lipid-rich Pan NETs showed a significantly higher signal intensity index than non-lipidrich Pan NETs(0.6% ± 14.1% vs-10.4% ± 14.4%,P = 0.004). Eight of 15 lipid-rich Pan NETs,vs 0 of 19 nonlipid-rich Pan NETs,had positive signal intensity index values in concordance with lipid contents.C O N C L U S I O N :C T c o n t ra s t e n h a n c e m e n t a n d conventional MR signal intensities are similar in lipidrich and non-lipid-rich Pan NETs. Chemical shift MRI can demonstrate cytoplasmic lipids in Pan NETs.