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TlCl及TlBr中的激子发光——电场调制的激发光谱

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发光学报 1975年第6期 21-22页

作者： Kyōsuke shimizu,takao Koda 东京大学应用物理系东京大学应用物理系

铊的卤化物中激子的辐射衰减过程被认为是与这些卤族元素的特征带结构有关的。TlCl及TlBr发光的激发光谱和间接带半导体的特别相似,由此,曾经设想:这些卤化

关键词：激子电场调制准粒子 TlBr TlCl 激发光谱

Distinctive magnetic resonance imaging findings of hepatocellular carcinoma after hepatitis C virus eradication with direct-acting antivirals

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Hepatoma Research 2020年第3期6卷 41-49页

作者： takao shimizu Kaoru Tsuchiya Masayuki Kurosaki Yutaka Yasui Sakura Kirino Keiya Watakabe Leona Osawa Mao Okada Wan Wang Mayu Higuchi Kenta Takaura Shun Kaneko Nobuharu Tamaki Hiroyuki Nakanishi Jun ltakura Yuka Takahashi Tadakazu Hisamatsu Namiki lzumi Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyo 180-8610Japan Department of Gastroenterology and Hepatology Kyorin University HospitalTokyo 180-8610Japan

Aim:The aim of the present study was to evaluate the characteristics of the magnetic resonance imaging features of hepatocellular carcinoma(HCC)that developed early after the eradication of hepatitis C virus(HCV)by direct-acting antiviral(DAA)***:This study included 26 patients who achieved sustained viral response with DAA and developed HCC thereafter within one year(DAA-SVR HCC).The radiologic characteristics of these patients were evaluated by contrast-enhanced magnetic resonance imaging,including diffusion-weighted imaging(DWI)and T2-weighted imaging(T2WI).For comparison,80 HCC patients with positive HCV RNA(HCV-positive HCC)were *** 42 patients where tumor biopsy was available,histological grade and radiologic findings were ***:The rates of high intensity on DWI and T2WI were significantly higher in DAA-SVR HCC compared to HCV-positive HCC(DWI:100%vs.67.5%,P<0.001T2WI:92.6%vs.67.5%,P=0.01).HCC with high intensity on DWI or T2WI was more likely to have moderately or poorly differentiated HCC compared to well-differentiated HCC(DWI:69.7%vs.30.3%,P=0.02;T2WI:66.7%vs.27.3%,P=0.03).Conclusion:High intensity on DWI and hyperintensity on T2WI were distinctive features of HCC that developed within one year after the end of DAA treatment.

关键词： Hepatocellular carcinoma direct-acting antivirals sustained viral response contrast enhanced magnetic resonance imaging

Measurement of Tryptophan Metabolites in Healthy Old Men and Patients of Type 2 Diabetes Mellitus (T2DM)

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Food and Nutrition Sciences 2018年第10期9卷 1206-1220页

作者： Akikazu Takada Fumiko shimizu Tetsuya takao Junichi Masuda International Projects on Food and Health (NPO) Tokyo Japan Faculty of Life and Environmental Sciences Showa Women’s University Tokyo Japan Global Application Development Center Shimadzu Corporation Kyoto Japan

Background: Plasma levels of tryptophan (TRP) metabolites have not been measured extensively in patients of type 2 diabetes mellitus (T2DM). Methods: Metabolites analysis was performed by a liquid chromatograph tandem mass spectrometer, the LCMS-8060 quadrupole mass spectrometer combined with Nexera X2 liquid chromatograph system (Shimadzu Corporation, Kyoto, Japan). Body mass index (BMI) and TRP metabolites have been measured in healthy old men (n = 20) and patients of T2DM (n = 20). TRP metabolites were measured by using the ultrahigh speed liquid chromatography-mass spectros-copy (Shimadzu Corporation). Results: The plasma levels of 5-hydroxytryptophan (5-HTRP), 5-hydroxyindoleacetic acid (5-HIAA), kynurenic acid (KNA), 3-hydroxykynurenine (3-HKN), and 3-hydroxyanthranilic acid (3-HAA) were higher in patients of T2DM than healthy old men. Since 5HTRP and 5-HIAA belong to the serotonin pathway, and KNA, 3-HKN, and 3-HAA belong to the KN pathway of TRP metabolism, these pathways were activated more in the patients of T2DM. Since plasma levels of Indole-3-acetic acid were not elevated in T2DM, that pathway was not activated more in T2DM. Serotonin levels were not increased but 5-HIAA levels were increased in the plasma of T2DM patients, which may mean that serotonin was quickly metabolized to 5-HIAA in the patients of T2DM. Conclusion: Plasma levels of tryptophan metabolites in serotonin and kynurenine pathways increased in T2DM patients. Obesity expressed by BMI may not influence tryptophan metabolism in healthy old men and T2DM patients. These results indicate that our new method of the simultaneous measurements of all the tryptophan metabolites is the powerful measure to identify factor related to endogenous stresses seen in DM.

关键词： Tryptophan Serotonin 5-Hydroxyindole Acetic Acid Kynurenine 3-Hydroxykynurenine Kynurenic Acid

True left-sided gallbladder with variations of bile duct and cholecystic vein

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World Journal of Gastroenterology 2015年第21期21卷 6754-6758页

作者： Hiromichi Ishii Akinori Noguchi Mie Onishi Koji takao Takahiro Maruyama Hiroaki Taiyoh Yasunobu Araki Takeshi shimizu Hiroyuki Izumi Naoki Tani Masahide Yamaguchi Tetsuro Yamane Department of Surgery Matsushita Memorial Hospital

A left-sided gallbladder without a right-sided round ligament,which is called a true left-sided gallbladder,is extremely rare.A 71-year-old woman was referred to our hospital due to a gallbladder *** tomography(CT) revealed not only a gallbladder polyp but also the gallbladder located to the left of the round ligament connected to the left umbilical *** portography revealed that the main portal vein diverged into the right posterior portal vein and the common trunk of the left portal vein and right anterior portal *** cholangiography revealed that the infraportal bile duct of segment 2 joined the common bile *** cholecystectomy was performed for a gallbladder polyp,and the intraoperative finding showed that the cholecystic veins joined the round ligament.A true left-sided gallbladder is closely associated with several anomalies; therefore,surgeons encountering a true left-sided gallbladder should be aware of the potential for these anomalies.

关键词： True left-sided gallbladder Infraportal bileduct of segment 2 Anomaly of the cholecystic vein Anomaly of the portal vein Laparoscopic cholecystectomy

Uniqueness of Tryptophan in the Transport System in the Brain and Peripheral Tissues

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Food and Nutrition Sciences 2023年第5期14卷 401-414页

作者： Mutsumi Ogawa Fumiko shimizu Yukie Ishii Tetsuya takao Akikazu Takada Faculty of Food and Health Sciences Showa Women’s University Tokyo Japan International Projects on Food and Health (NPO) Tokyo Japan

Amino acids are important substances that must be transported to tissues such as the brain and muscles. The process is considered insulin dependent. It is not known whether all the amino acids are almost equally dependent in their transportation to tissues. We want to know whether some important amino acids are transported differently from other amino acids. Especially tryptophan is important because it is converted to serotonin, melatonin or kynurenine. Results showed that Amino acids levels in the plasma were measured after the intakes of 50 grams of glucose or sucrose to young (18 - 22 years old) and old (≥50 years old) men. Total amino acids in the plasma decreased after the intakes of glucose. Total amino acids levels decreased more significantly in old men after the administration of sucrose. Total and non-essential amino acids in the plasma decreased significantly at 120 min after the intakes of glucose in young and old men, but only sucrose caused their decreases in both aged and young men. Both glucose and sucrose intakes decreased significantly the plasma levels of the total essential and branched amino acids in young and old men. Surprisingly, plasma levels of tryptophan did not decrease upon the administration of glucose but only slightly decreased upon the administration of sucrose in young men. In conclusion, not all the amino acids were transported well into tissues upon the administration of glucose or sucrose. Tryptophan seems to be relatively resistant for insulin to facilitate the transportation into tissues.

关键词： Glucose Sucrose Insulin Amino Acids Transporter mTORC1

Foods Intakes and Their Influences on BMI (Body Mass Index) in Young and Middle Aged Women in Japan

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Food and Nutrition Sciences 2022年第4期13卷 349-357页

作者： Akikazu Takada Fumiko shimizu Yukie Ishii Mutsumi Ogawa Tetsuya takao International Projects on Food and Health (NPO) Tokyo Japan Faculty of Human Life and Environmental Sciences Showa Women’s University Tokyo Japan

Background: Japanese women’s body mass index (BMI) was known to be the lowest among people in OECD countries. We wanted to compare foods intakes and relationships between intakes of particular food species and BMI. Methods: We asked young and middle-aged women to participate and used a brief-type self-administered diet history questionnaire (BDHQ) to know the amounts of various food species they took. Results: Weights and BMI of young and middle-aged women were not different. Middle-aged women took almost all species of foods and energy more than young women. Except for cholesterol of soluble dietary fibers, there was no correlation between foods intakes and BMI. Conclusion: Both young and middle-aged Japanese women are lean (BMI;around 22). Middle-aged women took more energy, and proteins, carbohydrates, and lipids compared with young women. Middle-aged women spend more energy on house workings than young women in Japan.

关键词： Body Mass Index BDHQ Protein Carbohydrate Lipid Cardiovascular Disease Diabetes Mellitus Obesity Overweight

Plasma Levels of Amino Acids in Japanese Men and Their Changes after the Administration of Glucose and Sucrose

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Food and Nutrition Sciences 2019年第1期10卷 51-63页

Background: It is not known whether plasma amino acids levels are different between young and old men in Japan. No research has been reported about changes in plasma levels of amino acids after the administration of glucose or sucrose to young and aged men. Objective: We want to know whether there are age differences in plasma levels of amino acids and if the administration of glucose or sucrose influences their levels. Results: Old people had lower plasma levels of most of amino acids, especially essential and branched-chain amino acids than young men. Plasma levels of amino acids were measured after the administration of 50 grams of glucose or sucrose to young (18 - 22 years old) and aged (≥50 years old) male adults. Plasma levels of total amino acids decreased after the administration of glucose. Decrease in the total amino acid levels was significant in aged men after the administration of sucrose. A significant decrease in plasma levels of total non-essential amino acids was observed at 120 min after the administration of glucose but not sucrose in both aged and young men. Both glucose and sucrose administrations resulted in a significant decrease in the plasma levels of the total essential amino acid levels and branched amino acids in young and aged men. Conclusion: These results suggest that there are age differences in plasma levels of amino acids. Upon the administration of glucose or sucrose amino acids, particularly essential amino acids, decreased in plasma. These amino acids may be transported from the blood soon after the administration of sugar (glucose or sucrose) to the tissues, such as muscles, possibly due to an increase in the insulin levels.

关键词： Amino Acids Branched Chain Amino Acids Tryptophan Serotonin Leucine Appetite Feeding

Comparison of Various Foods Intakes and Their Relationships with Body Mass Index in Japanese Old Men and Women

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Food and Nutrition Sciences 2021年第6期12卷 591-601页

作者： A. Takada F. shimizu Y. Ishii M. Ogawa T. takao International Projects on Food and Health (NPO) Tokyo Japan Faculty of Human Life and Environmental Sciences Showa Women’s University Tokyo Japan

Objective: Obesity is an important health problem, leading to many metabolic diseases such as type2 diabetes mellitus, cardiovascular diseases, cancer etc. There are many diet proposals to combat obesity. Since obesity is relatively rare in Japan, we wanted to know what kinds of foods influence body mass index (BMI) in old Japanese people. Methods: Healthy participants were given self-administered diet history questionnaires and described answers on each item by recollection of diets they took (7 days dietary recall). We used a brief-type self-administered diet history questionnaire (BDHQ) by using which the Japanese Ministry of Health, Labour and Welfare reports national Nutrition Surveys. From these questionnaires, we calculated the intakes of energy, carbohydrate, fat, protein or other foods. Results: Men take more alcohol, salt fruit, beans, and eggs than women. Intakes of majo

关键词： Carbohydrate Protein Fish Glucose Insulin BMI (Body Mass Index) Obesity

Effects of Various Foods Intakes on Plasma Levels of Trans Fatty Acids in Japanese Old Men

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Food and Nutrition Sciences 2018年第7期9卷 797-805页

作者： F. shimizu Y. Ishii M. Ogawa T. takao S. Koba A. Takada Faculty of Life and Environmental Sciences Showa Women’s University Tokyo Japan Division of Cardiology Department of Medicine Showa University School of Medicine Tokyo Japan International Projects on Food and Health (NPO) Tokyo Japan

Background: Trans fatty acids are said to be formed by the partial hydrogenation of vegetable oils. Some amounts are produced in digestive organs of ruminants and present in dairy products or meat. In Japan, use of trans fatty acids in the foods is prohibited, thus trans fatty acids must come from foods or microbes in the digestive organs. Methods: Plasma levels of fatty acids including trans forms of healthy old men are measured by gas chromatography and correlations between various foods intakes and plasma levels of trans fatty acids such as palmitoelaidic, elaidic and linoelaidic acids are examined. Results: No correlations between various foods intakes and trans fatty acids were found except between intake of preference drinks such as tea or coffee and plasma levels of palmitoelaidic and linoelaidic acids. Conclusion: Since palmitoelaidic acid is cardioprotective, increase in plasma levels of palmitoelaidic acid may indicate that intakes of tea and coffee may be beneficial for heath by increasing palmitoelaidic acids.

关键词： Fatty Acid Trans Fatty Acid Palmitoelaidic Acid Elaidic Acid Linoelaidic Acid Saturated Fatty Acid Unsaturated Fatty Acid ω Fatty Acid DHA (Docosahexanoic Acid) EPA (Eicosapentanoic Acid) AA (Arachidonic Acid)