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World Journal of Gastroenterology 2005年第15期11卷 2249-2254页

作者： Makoto Okamoto takao kawabe Yutaka Yamaji Jun Kato Tsuneo Ikenoue Goichi Togo Haruhiko Yoshida Yasushi Shiratori Masao Omata Department of Gastroenterology

AIM: To review the risk of proximal colon cancer in patients undergoing ***: We estimated the risk of advanced proximal adenomas and cancers in 6 196 consecutive patients that underwent colonoscopy (mean age 60 years, 65% males,without prior history of colorectal examination). Neoplasms were classified as diminutive adenoma (5 mm or less),small adenoma (6-9 mm), advanced adenoma (10 mm or more, with villous component or high-grade dysplasia)and cancer (invasive adenocarcinoma). The sites of neoplasms were defined as rectosigmoid (rectum and sigmoid colon) and proximal colon (from cecum to descending colon).RESULTS: The trend of the prevalence of advanced proximal adenoma was to increase with severe rectosigmoid findings, while the prevalence of proximal colon cancer did not increase with severe rectosigmoid findings. Among the 157 patients with proximal colon cancer, 74% had no neoplasm in the rectosigmoid colon. Multivariate logisticregression analysis revealed that age was the main predictor of proximal colon cancer and existence of rectosigmoid adenoma was not a predictor of proximal colon ***: Sigmoidoscopy is inadequate for colorectal cancer screening, especially in older populations.

关键词：结肠肿瘤结肠镜检查手术入口耐受性

Inflammatory pseudotumor of the liver and peripheral eosinophilia in autoimmune pancreatitis

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World Journal of Gastroenterology 2005年第6期11卷 922-925页

作者： Naoki Sasahira takao kawabe Akira Nakamura Kenji Shimura Haruhisa Shimura Ei Itobayashi Manabu Asada Yasushi Shiratori Masao Omata Department of Gastroenterology

AIM: Inflammatory pseudotumor (IPT) of the liver is a rare benign lesion, the etiology of which remains *** is not associated with any particular diseases apart from phlebitis and Crohn's ***: A middle-aged male with hepatic IPT and peripheral eosinophilia associated with autoimmune pancreatitis (AIP) was selected for this study and review of ***: A 59-year-old male was admitted with obstructive jaundice, marked eosinophilia (1 343/mm3)and hypergammaglobulinemia (4 145 mg/dL). Imaging techniques revealed dilatation of the intrahepatic bile duct,stenosis of the common bile duct with diffuse wall thickening, gallbladder wall thickening, irregular narrowing of the pancreatic duct, and swelling of the pancreatic parenchyma. Multiple liver masses were also demonstrated and diagnosed as IPT by biopsy specimens. Six months later, the abnormal features of the biliary tree remarkably improved by the oral administration of prednisolone, and the liver masses disappeared. The swelling of the pancreatic head also improved. The peripheral eosinophil count normalized. IPT associated with AIP, as we know,has not been reported in the literature. The clinical features of the present case mimicked those of pancreatic cancer with liver metastasis. This case deserves to be documented to prevent misdiagnosis of similar cases.

关键词：嗜酸粒细胞增多症外周血自体免疫胰腺炎消化系统

Hepatic gene expression profiles associated with fibrosis progression and hepatocarcinogenesis in hepatitis C patients

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World Journal of Gastroenterology 2005年第13期11卷 1995-1999页

作者： Yujin Hoshida Motoyuki Otsuka Naoya Kato Ryosuke Tateishi Takuma Teratani Shuichiro Shiina Hiroyoshi Taniguchi Masaru Moriyama takao kawabe Masao Omata Department of Gastroenterology

AIM: To determine fibrosis progression and hepatocellular carcinoma (HCC), using simultaneous gene expression ***: Total RNA samples were extracted from liver biopsies from 19 patients with hepatitis C virus (HCV)infection and 3 patients without HCV infection. Among the 19 HCV-infected patients, 7 and 12 patients had grade F1-2 and F3-4 fibrosis, respectively. Of the 12 patients with F3-4 fibrosis, 8 had HCC. Gene expression in the liver samples was determined using an oligonucleotide microarray. The following comparisons were performed:normal livers vs HCV-infected livers; F1-2 vs F3-4; and F3-4 with HCC vs F3-4 without HCC. Genes that were differentially expressed between these groups were identified based on signal-to-noise ***: In the HCV-infected livers, genes involved in immune responses were highly expressed. Expression levels of genes for plasma proteins and drug-metabolizing enzymes were decreased and those of genes involved in the cell cycle and oncogenesis were increased in the F3-4 cases as compared to the F1-2 cases. Among the F3-4 cases, genes involved in carbohydrate metabolism tended to be more highly expressed in patients with HCC than in patients without ***: We identified genes that are associated with fibrosis progression and hepatocarcinogenesis. This information may be used to detect increased carcinogenic potential in the livers of patients with HCV infection.

关键词：肝纤维化丙型肝炎幽门螺杆菌基因表达

Utility of single and double balloon endoscopy in patients with difficult colonoscopy: A randomized controlled trial

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World Journal of Gastroenterology 2013年第29期19卷 4732-4736页

作者： Atsuo Yamada Hirotsugu Watabe Noriyuki Takano Goichi Togo Yutaka Yamaji Haruhiko Yoshida takao kawabe Masao Omata Kazuhiko Koike Department of Gastroenterology University of Tokyo Tokyo 113-8655 Japan

AIM: To compare the utility of single-balloon colonoscopy (SBC) or double-balloon colonoscopy (DBC) for difficult colonoscopies. METHODS: Between August 2008 and June 2010, patients in whom total colonoscopy failed within 30 min of insertion were assigned randomly to undergo either SBC or DBC. No sedatives were used. After the endoscopy, all patients were asked to evaluate pain during the procedure on a 10-point analog scale (1 = no pain; 10 = worst imaginable pain) with a questionnaire. The study outcomes were the cecal intubation rate and time, endoscopic findings, complications, and pain score. RESULTS: The SBC and DBC groups included 11 and 10 patients, respectively. All but one SBC patient achieved total colonoscopy successfully. The cecal intubation times were 18 min (range: 10-85 min) and 12.8 min (range: 9.5-42 min) in the SBC and DBC groups, respectively (P= 0.17). No difference was observed in the prevalence of colon polyps between the SBC and DBC groups (45% vs 30%, P = 0.66). SBC showed advanced colon cancer in the ascending colon, which was inaccessible using conventional colonoscopy. The respective pain scores were 5 (1-10) [median (range)] and 5 (1-6) in the SBC and DBC groups (P = 0.64). No complications were noted in any patient. CONCLUSION: The utility of singleand double-balloon endoscopy for colonoscopy seems comparable in patients with incomplete colonoscopy using a conventional colonoscope.

关键词： Difficult colonoscopy Double-balloon endoscopy Single-balloon endoscopy Double-balloon colonoscopy Single-balloon colonoscopy

Delayed development of hepatocellular carcinoma during long-term follow-up after eradication of hepatitis C virus by interferon therapy

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World Journal of Gastroenterology 2005年第45期11卷 7218-7221页

作者： Yukiko Ito Natsuyo Yamamoto Ryo Nakata Yoshihisa Kato Masashi Iori Keisuke Sakai Tamiko Takemura Ryosuke Tateishi Haruhiko Yoshida takao kawabe Masao Omata Department of Gastroenterology

A 42-year-old Japanese man with liver cirrhosis by hepatitis C virus (HCV) had successful interferon therapy in May 1991. Since then, serum HCV-RNA and liver function tests had been negative. He had continued to drink more than 100 g/d of alcohol as before. In June 2003, a 5-cm tumor was found in the posterior segment of the liver. The tumor was curatively resected and the surgical specimen showed a well-differentiated hepatocellular carcinoma (HCC). Non-cancerous lesions of the liver revealed fibrosis at stage F3 with minimal to mild inflammation of grade A1. Heavy drinking may retard the dissolution of fibrosis and accelerate HCC development in patients with sustained virological response.

关键词：肝细胞癌丙型肝炎病毒干扰素治疗

NF-κB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection

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World Journal of Gastroenterology 2005年第39期11卷 6134-6143页

作者： Wataru Shibata Yoshihiro Hirata Haruhiko Yoshida Motoyuki Otsuka Yujin Hoshida Keiji Ogura Shin Maeda Tomoya Ohmae Ayako Yanai Yuzo Mitsuno Naohiko Seki takao kawabe Masao Omata Department of Gastroenterology Graduate School of Medicine University of TokyoJapan Department of Functional Genomics Graduate School of Medicine University of ChibaJapan

AIM: To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Hellcobacter pylori (Hpylon) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type Ⅳ secretion system and the two pathways, nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinases (ERK) on wild-type H pylori-induced gene expression. METHODS: Gene expression profiles induced by H pylori were evaluated in AGS gastric epithelial cells using cDNA microarray, which were present in the 4 600 independent clones picked up from the human gastric tissue. We also analyzed the contribution of NF-κB and ERK signaling on H pylori-induced gene expression by using inhibitors of specific signal pathways. The isogenic mutant with disrupted capE (△cagE) was used to elucidate the role of capPAI-encoding type Ⅳ secretion system in the gene expression profile. RESULTS: According to the expression profile, the genes were classified into four clusters. Among them, the clusters characterized by continuous upregulation were most conspicuous, and it contained many signal transducer activity-associated genes. The role of cagPAI on cultured cells was also investigated using isogenic mutant cagE, which carries non-functional cagPAI. Then the upregulation of more than 80% of the induced genes (476/566) was found to depend on cagPAI. Signal transducer pathway through NF-κB or ERK are the major pathways which are known to be activated by cagPAI-positive H pylori. The role of these pathways in the whole signal activation by cagPAI- positive H pylori was analyzed. The specific inhibitors against NF-κB or ERK pathway blocked the activation of gene expression in 65% (367/566) or 76% (429/566) of the genes whose activation appealed to depend on cagPAI. CONCLUSION: These results suggest that more than half of the genes induced by cagPAI-positive H pylori depend on NF-κB and ERK signaling activation, and t

关键词： NF-κB 信号路径基因表达十二指肠疾病信号转导

Cancer-derived VEGF plays no role in malignant ascites formation in the mouse

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World Journal of Gastroenterology 2005年第35期11卷 5455-5459页

作者： Bayasi Guleng Keisuke Tateishi Fumihiko Kanai Amarsanaa Jazag Miki Ohta Yoshinari Asaoka Hideaki Ijichi Yasuo Tanaka Jun Imamura Tsuneo Ikenoue Yasushi Fukushima Keita-Morikane Makoto Miyagishi Kazunari Taira takao kawabe Masao Omata Department of Gastroenterology Graduate School of Medicine University of Tokyo 7-3-1 HongoBunkyo-ku Tokyo 113-8655 Japan Clinical Research Center University of Tokyo Hospital 7-3-1 Hongo Bunkyo-ku Tokyo113-8655 Japan Infectious Disease Surveillance Center NationalInstitute of Infectious Diseases 1-23-1 Toyama Shinjuku-ku Tokyo162-8640 Japan Department of Chemistry andBiotechnology Graduate School of Engineering University of TokyoTokyo 113-8656 Japan

AIM: Vascular endothelial growth factor (VEGF) is a potent mediator of peritoneal fluid accumulation following tumor progression. This study investigated the role of VEGF secreted by cancerous cells in the formation of malignant ***: VEGF expression was eliminated byknockdown in the pancreas cancer cell-line PancO2 using vector-based short-hairpin type RNA interference (RNAi).Malignant ascites formation in the mouse was analyzed by intraperitoneal injection of PancO2 cells expressing VEGF or with expression ***: The VEGF knockdown PancO2 cell was successfully established. Knockdown of VEGF did not affect cancer cell proliferation in vitro or in vivo. The volume of ascites following peritoneal expansion of the tumor in VEGF knockdown cells and control cells did not differ statistically in this in vivo study. Moreover, the VEGF concentration in the ascites did not differ ***: Malignant ascites formation might be mediated by VEGF production in noncancerous tissues,such as stromal compartments. An anti-VEGF strategy against malignant ascites could be applied to various tumors regardless of whether they secrete VEGF.

关键词：血管内皮生长因子癌症恶性腹水并发症小鼠动物实验

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小型柴油机突增负荷工况下的HC排放特性

农业机械学报 2005年第6期36卷 20-23页

作者：孙万臣刘巽俊宫本登小川英之河边隆夫吉林大学汽车工程学院日本国北海道大学工学部

应用自行开发的柴油机过渡工况控制系统及排气采集装置,模拟柴油机实际工作时的增负荷状态,对HC排放特性进行了试验研究。利用气相色谱仪对HC排放成分进行分析。研究结果表明,增负荷工况中HC排放量急剧增加,其中碳数在8以下的低沸点成... 详细信息

应用自行开发的柴油机过渡工况控制系统及排气采集装置,模拟柴油机实际工作时的增负荷状态,对HC排放特性进行了试验研究。利用气相色谱仪对HC排放成分进行分析。研究结果表明,增负荷工况中HC排放量急剧增加,其中碳数在8以下的低沸点成分占有很大的比例,对于总的HC排放特别是增负荷开始后的HC排放起着主导作用。在低沸点的HC排放成分中,乙烯和丙烯所占的比例最大,乙烯在各个循环中约占40%。

关键词：小型柴油机过渡工况排放特性燃烧特性增负荷工况

燃烧室参数对小型柴油机突增负荷工况燃烧及HC排放的影响

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燃烧科学与技术 2005年第4期11卷 336-340页

作者：孙万臣刘忠长刘巽俊宫本登小川英之河辺隆夫吉林大学内燃机工程系长春130025 北海道大学工学部

应用自行开发的柴油机瞬态工况控制系统及排气采集装置,对小型柴油机突增负荷工况下的燃烧及HC排放特性进行了实验研究,利用气相色谱仪分析了HC排放成分.设计了不同参数的燃烧室,研究了不同压缩比(13～19)和燃烧室形状对柴油机燃烧及HC... 详细信息

应用自行开发的柴油机瞬态工况控制系统及排气采集装置,对小型柴油机突增负荷工况下的燃烧及HC排放特性进行了实验研究,利用气相色谱仪分析了HC排放成分.设计了不同参数的燃烧室,研究了不同压缩比(13～19)和燃烧室形状对柴油机燃烧及HC排放的影响.研究结果表明,同一燃烧室在突增负荷工况,燃油开始增加后,THC排放量急剧增加,最大值达到稳态工况的100倍.随循环数的增加,滞燃期缩短,HC排放逐渐减少.HC排放成分中LHC占有很大比例,其中乙烯和丙烯最多.随压缩比的降低,滞燃期延长,HC排放明显增加.压缩比相同时适当缩小燃烧室直径,有助于降低HC排放.

关键词：柴油机突增负荷燃烧室燃烧排放

燃料特性对小型压燃式发动机增负荷工况燃烧及HC排放的影响

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吉林大学学报（工学版） 2005年第2期35卷 131-135,140页

作者：孙万臣刘忠长刘巽俊宫本登小川英之河辺隆夫吉林大学汽车工程学院长春130022 日本北海道大学工学部

应用自行开发的瞬态工况控制系统及排气采集装置,研究了具有不同理化特性的燃料对小型压燃式发动机冷态突增负荷工况下燃烧及 HC排放特性的影响;利用气相色谱仪分析了HC的排放成分。研究结果表明:对于普通柴油燃料,在突增负荷工况下,燃... 详细信息

应用自行开发的瞬态工况控制系统及排气采集装置,研究了具有不同理化特性的燃料对小型压燃式发动机冷态突增负荷工况下燃烧及 HC排放特性的影响;利用气相色谱仪分析了HC的排放成分。研究结果表明:对于普通柴油燃料,在突增负荷工况下,燃油开始增加后,总碳氢HCt 排放浓度急剧增加,最大值达到稳态工况的 100 倍左右。随循环数的增加,滞燃期缩短,HC排放逐渐降低。采用具有相同十六烷值、挥发性好的燃料,可有效改善冷态增负荷工况下的燃烧,降低HC排放。与燃烧柴油相比,采用挥发性好的正庚烷和 GTL燃料,HCt排放降低约80%。

关键词：动力机械与工程压燃式发动机燃料特性增负荷工况燃烧 HC排放