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World Journal of Orthopedics 2017年第3期8卷 278-285页

作者： Tatsunori Ikemoto Hirofumi Miyagawa Yukiko Shiro Young-Chang Park Arai Machiko Akao Kenta Murotani takahiro ushida Masataka Deie Institute of Physical Fitness Sports Medicine and Rehabilitation Aichi Medical University Department of Physical Therapy Faculty of Rehabilitation Sciences Nagoya Gakuin University Department of Orthopedic Surgery Aichi Medical University Division of Biostatistics Clinical Research Center Aichi Medical University

AIM To investigate the correlations between clinical outcomes and biopsychological variables in female patients with knee osteoarthritis(OA).METHODS Seventy-seven patients with symptomatic knee OA were enrolled in this *** investigated the age,body mass index(BMI),pain catastrophizing scale(PCS)and radiographic severity of bilateral knees using a Kellgren-Lawrence(K-L)grading system of the ***,a multiple linear regression was conducted to determine which variables best correlated with main outcomes of knee OA,which were pain severity,moving capacity by measuring timed-up-and-go test and Japanese Knee Osteoarthritis Measure(JKOM).RESULTS We found that the significant contributor to pain severity was PCS(β=0.555)and BMI(β=0.239),to moving capacity was K-L grade(β=0.520)and to PCS(β=0.313),and to a JKOM score was PCS(β=0.485)and K-L grade(β=0.421),*** The results suggest that pain catastrophizing as well as biological factors were associated with clinical outcomes in female patients with knee OA,irrespective of radiographic severity.

关键词： Osteoarthritis Pain catastrophizing Knee pain Physical function Japanese Knee Osteoarthritis Measure

Strategies for Managing Chronic Pain: Case of a Skilled Orthopaedic Physician and Mini-Review

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Open Journal of Orthopedics 2015年第5期5卷 109-114页

作者： Tatsunori Ikemoto Young-Chang P. Arai Makoto Nishihara takahiro ushida Multidisciplinary Pain Center Aichi Medical University Nagakute Aichi Japan Institute of Physical Fitness Sports Medicine and Rehabilitation School of Medicine Aichi Medical University Nagakute Aichi Japan

Epidemiological surveys have recently revealed a high prevalence of chronic musculoskeletal pain in Japan;however, 30% of the patients in the survey were not satisfied with their pain treatment. This indicates that standard strategies in the management of chronic pain are poorly shared among physicians in Japan. Herein we report a case of a patient with intractable chronic pain who is a skilled orthopaedic physician. A 43-year-old man who was a skilled orthopaedic surgeon presented at our center complaining of severe buttock pain especially around the right hip region for more than three years. At begging of pain onset, he was diagnosed with femoacetabular impingement syndrome (FAI) with labral tear. Despite biophysical interventions including twice surgeries and alternative conservative treatment, his pain persisted, and he occasionally had to take a day off work due to the severe pain. Therefore we had to evaluate his pathological condition using a multidimensional approach based on a biopsychosocial model. We had provided him with cognitive behavioral therapy (CBT) approach, and simultaneously suggestion for short leaving from work. Three months after the start of CBT training, his disabilities had begun to improve. About six months later, he could continue to do his work. Finally, 19 months have passed since we started implementing the CBT approach;he has regained both his previous work-life balance and his health, although the pain has not completely subsided. In conclusion, we think it is important for physicians treating chronic pain to learn the management strategies for chronic pain and to re-consider their management policy when conventional biomedical interventions were not succeeded, even in cases where medication and surgical intervention are warranted.

关键词： Chronic Pain Cognitive Behavioral Therapy Biomedical Biopsychosocial

The 5αcondensate state in 20Ne

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Nuclear Science and Techniques 2024年第2期35卷 3-5页

作者： takahiro Kawabata Department of Physics Osaka UniversityToyonakaOsaka 560-0043Japan

Theclustering phenomenon,in which nucleons are arranged intoparticles(4 He nuclei)within a nuclear system,is one of the most intriguing aspects of nuclear *** has been observed in various light nuclei,such as^(8)Be,^(12)C,^(16)O,and^(20)Ne,and is responsible for many exotic and fascinating phenomena,such as the Hoyle state in^(12)C,which plays an essential role in stellar nucleosynthesis[1-6]as well as in heavy-ion collisions[7-9].

关键词： structure state

Simple and robust 3D MINFLUX excitation with a variable phase plate

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Light(Science & Applications) 2024年第7期13卷 1354-1363页

作者： takahiro Deguchi Jonas Ries European Molecular Biology Laboratory Cell Biology and BiophysicsHeidelbergGermany. Max Perutz Labs Vienna Biocenter Campus(VBC)ViennaAustria. University of Vienna Center for Molecular BiologyDepartment of Structural and Computational BiologyViennaAustria. University of Vienna Faculty of PhysicsViennaAustria

MINFLUX has achieved extraordinary resolution in superresolution imaging and single fluorophore *** is based on localizing single fluorophores by rapid probing with a patterned beam that features a local intensity *** implementations,however,are complex and expensive and are limited in speed and ***,we show that a combination of an electro-optical modulator with a segmented birefringent element such as a spatial light modulator produces a variable phase plate for which the phase can be scanned on the MHz *** or top-hat phase patterns generate high-contrast compact excitation point-spread functions for MINFLUX localization in the x,y,and z-direction,respectively,which can be scanned across a fluorophore within a microsecond,switched within 60 microseconds and alternated among different excitation *** discuss how to compensate for non-optimal performance of the components and present a robust 3D and multi-color MINFLUX excitation module,which we envision as an integral component of a high-performance and cost-effective open-source MINFLUX.

关键词： excitation phase switched

IASP关节痛文献资料,《中国疼痛医学杂志》组织翻译第十四篇:关节痛的可视化:扩散痛与痛敏的证据

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中国疼痛医学杂志 2016年第9期22卷 I0002-I0002页

作者： takahiro ushida 徐灵驰

关节痛的高发病率直接影响着患者的生活质量。退行性关节病（骨关节炎）是慢性痛的常见原因，对于老年人来说尤其如此。目前认为，软骨破坏、负重的生物力学改变以及与之相关的滑膜炎、关节周围肌性防御是关节痛的主要原因。然而，近期... 详细信息

关节痛的高发病率直接影响着患者的生活质量。退行性关节病（骨关节炎）是慢性痛的常见原因，对于老年人来说尤其如此。目前认为，软骨破坏、负重的生物力学改变以及与之相关的滑膜炎、关节周围肌性防御是关节痛的主要原因。然而，近期的研究结果表明，神经生理学机制在慢性关节痛的发展中也扮演着重要角色。

关键词：慢性关节痛可视化神经生理学机制证据痛敏扩散退行性关节病生活质量

Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

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World Journal of Gastroenterology 2024年第10期30卷 1368-1376页

作者： Nobukazu Agatsuma takahiro Utsumi Yoshitaka Nishikawa takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka takahiro Inoue Yuki Nakanishi takahiro Shimizu Mikako Ohno Akane Fukushima Takeo Nakayama Hiroshi Seno Department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 606-8507Japan Department of Gastroenterology and Hepatology Japanese Red Cross Wakayama Medical CenterWakayama 640-8558Japan Department of Health Informatics Kyoto University School of Public HealthKyoto 606-8501Japan Institute for Advancement of Clinical and Translational Science(iACT) Kyoto University HospitalKyoto 606-8507Japan Medical Support Section Medical Affairs DivisionKyoto University HospitalKyoto 606-8507Japan

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor *** efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside *** identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less *** the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related *** To clarify the stage at CRC diagnosis based on diagnostic *** We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two *** diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and *** early-stage was defined as Stages 0 or *** and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up *** adjusted covariates were age,sex,and tumor *** Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,*** the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,*** symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening gro

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis

Increased population exposures to extreme precipitation in Central Asia under 1.5℃and 2℃global warming scenarios

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Geography and Sustainability 2024年第3期5卷 343-356页

作者： Wei Wei Shan Zou Weili Duan Yaning Chen Shuai Li takahiro Sayama Jianyu Zhu State Key Laboratory of Desert and Oasis Ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsXinjiang Institute of Ecology and GeographyChinese Academy of SciencesÜrümqi 830011China University of Chinese Academy of Science Beijing 100049China Aksu National Station of Observation and Research for Oasis Agro-ecosystem Aksu 843017China Disaster Prevention Research Institute Kyoto UniversityKyoto 6110011Japan

The increase in extreme precipitation(EP)may pose a serious threat to the health and safety of population in arid and semi-arid *** current research on the impact of EP on population in Central Asia(CA)is insufficient and there is an urgent need for a comprehensive ***,we opted for precipitation and temperature data under two Shared Socioeconomic Pathways(SSP2-4.5 and SSP5-8.5)from ten Global Climate Models(GCMs),which were obtained from the NASA Earth Exchange Global Daily Downscaled Projections(NEX-GDDP-CMIP6).By integrating population data in 2020 and 2050(SSP2 and SSP5),we investigated the future changes in EP and population exposure in CA under 1.5℃and 2℃global warming scenarios(GWSs).Our analysis indicates that EP in CA is projected to increase with global *** the SSP5-8.5,the maximum daily precipitation(Rx1day)exhibits an average response rate to global warming of 3.58%/K(1.99-4.06%/K).With rising temperatures,an increasing number of areas and populations in CA will be impacted by EP,especially in the Fergana *** 25%of the population(land area)in CA is exposed to Rx1day with increases of more than 8.31%(9.32%)under 1.5℃GWS and 14.18%(13.25%)under 2℃*** temperature rise can be effective in reducing population exposures to *** instance,limiting the temperature increase to 1.5℃instead of 2℃results in a 2.79%(1.75%-4.59%)reduction in population exposure to ***,we found that climate change serves as the predominant factor influencing the population exposure to EP,while the role of population redistribution,although relatively minor,should not be *** for prolonged drought,the role of population redistribution manifests negatively.

关键词： Extreme precipitation Global warming Population exposure Central Asia

Enzyme-linked immunosorbent assay of 3 Screen Islet Cell Autoantibody in patients with autoimmune thyroid disease

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World Journal of Diabetes 2024年第5期15卷 935-944页

作者： Eiji Kawasaki Hidekazu Tamai takahiro Fukuyama Yoko Sagara Ryutaro Hidaka Aira Uchida Masayuki Tojikubo Narihito Tatsumoto Yuko Akehi Yuji Hiromatsu The Diabetes Thyroid and Endocrine CenterShin-Koga HospitalKurume 830-8577Japan

BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes(T1D).While it has been established that 20%-30%of T1D patients suffer from autoimmune thyroid disease(AITD),there is limited available data regarding the presence of anti-islet autoantibodies in AITD *** commercially available anti-islet autoantibodies,glutamic acid decarboxylase 65 autoantibodies(GADAs)are often the first marker measured in general clinical *** To investigate the frequency of anti-islet autoantibodies in AITD *** Our study involved four hundred ninety-five AITD patients,categorized into three distinct groups:AITD with T1D(n=18),AITD with phenotypic type 2 diabetes(T2D)(n=81),and AITD without diabetes(n=396),and the enzyme-linked immunosorbent assay(ELISA)was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody(3 Screen ICA),GADA,insulinoma-associated antigen-2 autoantibodies(IA-2As),and zinc transporter 8 autoantibodies(ZnT8As)within these *** The frequency of 3 Screen ICA in AITD patients with T1D,T2D,and those without diabetes were 88.9%,6.2%,and 5.1%,respectively,with no significant difference seen between the latter two ***,the frequency of 3 Screen ICA was 11.1%higher in AITD patients with T1D,1.3%higher in AITD patients with T2D,and 1.1%higher in AITD patients without diabetes compared to GADA,***,12.5%,20.0%,and 20.0%of the 3 Screen ICA-positive patients were negative for ***,1.3%of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual *** the 3 Screen ICA-positive patients,there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D com

关键词： Anti-islet autoantibodies Autoimmune thyroid disease Real-world practice Retrospective study Type 1 diabetes

Which characteristics are associated with changes in medication status for lower urinary tract symptoms among patients with prostate cancer receiving external beam radiotherapy?

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Current Urology 2024年第2期18卷 122-127页

作者： Yuki Kyoda Kohei Hashimoto Atsushi Takahashi TakeshiMaehana Kimihito Tachikawa Takashi Muranaka Shuichi Kato Tomoyo Kurisug Fumimasa Fukuta takahiro Kirisawa Manabu Okada Ko Kobayashi Toshiaki Tanaka Shiro Hinotsu Naoya Masumoria Department of Urology SapporoMedical University School of MedicineSapporoJapan Department of Urology Hakodate Goryoukaku HospitalHakodateJapan Department of Urology Muroran City General HospitalMuroranJapan Department of Urology NTT-East Sapporo HospitalSapporoJapan Department of Urology Sunagawa City Medical CenterSunagawaJapan Department of Urology Oji General HospitalTomakomaiJapan Department of Urology Steel Memorial Muroran HospitalMuroranJapan Department of Urology Obihiro Kyokai HospitalObihiroJapan Department of Medical Statistics Sapporo Medical University School of MedicineSapporoJapan

Background:We clarified the predictive factors for changes in the status ofmedications for lower urinary tract symptoms(LUTS)2 years after local radiotherapy for nonmetastatic prostate *** and methods:We retrospectively included patients who underwent local external radiotherapy for nonmetastatic prostate cancer in 8 institutions between April 2001 and March *** were divided into themedication and no-medication group based on the use of drugs for LUTS before *** defined improvement of LUTS as when the patient did not require medication for LUTS at 24 months after radiotherapy in the medication group and as deterioration whenmedication was required in the no-medication *** regression analysis was used to evaluate predictive factors for changes in medication ***:Altogether,505 patients were divided into a no-medication group(n=352)and a medication group(n=153).The number of patients with deterioration and improvement in LUTS was 49(14%)and 36(23%),*** the multivariate analysis,the predictive variables for deterioration were the International Prostate SymptomScore(≥8;odds ratio[OR],2.21;p=0.014)and the biopsy Gleason score(≤3+4=7;OR,2.430;p=0.008)in the no-medication group,whereas those for improvement were age(<75 years old;OR,5.81;p=0.002),the quality of life score(<3;OR,3.15;p=0.028),and a positive biopsy core rate(≥50%;OR,2.530;p=0.027)in the medication ***:These predictive factors for changes in the status ofmedications for LUTS at 2 years after external radiotherapymay help determine the definitive therapy for nonmetastatic prostate cancer.

关键词： Prostate cancer Radiotherapy Lower urinary tract symptoms Medications

Lithium Ion Transport Environment by Molecular Vibrations in Ion-Conducting Glasses

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Energy & Environmental Materials 2024年第3期7卷 133-142页

作者： Hiroki Yamada Koji Ohara Satoshi Hiroi Atsushi Sakuda Kazutaka lkeda takahiro Ohkubo Kengo Nakada Hirofumi Tsukasaki Hiroshi Nakajimai Laszlo Temleitner Laszlo Pusztai Shunsuke Ariga Aoto Matsuo Jiong Ding Takumi Nakano Takuya Kimura Ryo Kobayashi Takeshi Usuki Shuta Tahara Koji Amezawa Yoshitaka Tateyama Shigeo Mori Akitoshi Hayashi Diffraction and Scattering Division Japan Synchrotron Radiation Research Institute(JASRI)1-1-1 KoutoSayo-choSayo-gun Hyogo 679-5198Japan Faculty of Materials for Energy Shimane University1060Nishi-Kawatsu-ChoMatsue Shimane 690-8504Japan Department of Applied Chemistry Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Institute of Materials Structure Science High Energy Accelerator Research Organization(KEK)203-1 ShirakataTokai-muraNaka-gunlbaraki 319-1106Japan Graduate School of Engineering Chiba University 1-33 Yayoi-cho Inage-kuChiba 263-8522Japan Department of Materials Science Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Wigner Research Centre for Physics Konkoly Thegeút 29-33 H-1121Budapest Hungary International Research Organisation of Advanced Science and Technology(IROAST) Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Department of Applied Physics Nagoya Institute of TechnologyGokisoShowaNagoya 466-8555Japan Faculty of Science Yamagata University1-4-12 KojirakawaYamagata-shiYamagata 990-5860Japan Faculty of Science University of the Ryukyus1 SenbaruNishihara-choOkinawa 903-0213Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Center for Green Research on Energy and Environmental Materials(GREEN)and International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan

Controlling Li ion transport in glasses at atomic and molecular levels is key to realizing all-solid-state batteries,a promising technology for electric *** this context,Li_(3)PS_(4)glass,a promising solid electrolyte candidate,exhibits dynamic coupling between the Li^(+)cation mobility and the PS_(4)^(3-)anion libration,which is commonly referred to as the paddlewheel *** addition,it exhibits a concerted cation diffusion effect(i.e.,a cation-cation interaction),which is regarded as the essence of high Li ion ***,the correlation between the Li^(+)ions within the glass structure can only be vaguely determined,due to the limited experimental information that can be ***,this study reports that the Li ions present in glasses can be classified by evaluating their valence oscillations via Bader analysis to topologically analyze the chemical *** is found that three types of Li ions are present in Li_(3)PS_(4)glass,and that the more mobile Li ions(i.e.,the Li3-type ions)exhibit a characteristic correlation at relatively long distances of ***,reverse Monte Carlo simulations combined with deep learning potentials that reproduce X-ray,neutron,and electron diffraction pair distribution functions showed an increase in the number of Li3-type ions for partially crystallized glass structures with improved Li ion transport *** results show order within the disorder of the Li ion distribution in the glass by a topological analysis of their ***,considering the molecular vibrations in the glass during the evaluation of the Li ion valences is expected to lead to the development of new solid electrolytes.

关键词： electrolytes ionic conductors modeling molecular dynamics