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Circulating RNAs as new biomarkers for detecting pancreatic cancer

World Journal of Gastroenterology 2015年第28期21卷 8527-8540页

作者： takahiro Kishikawa Motoyuki Otsuka Motoko Ohno Takeshi Yoshikawa Akemi Takata Kazuhiko Koike Department of Gastroenterology Graduate School of Medicine The University of Tokyo Japan Science and Technology Agency PRESTO

Pancreatic cancer remains difficult to treat and has a high mortality *** is difficult to diagnose early mainly due to the lack of screening imaging modalities and specific ***,it is important to develop biomarkers that enable the detection of early stage *** evidence is accumulating that tumor cells release substantial amounts of RNA into the bloodstream that strongly resist RNases in the blood and are present at sufficient levels for quantitative *** circulating RNAs are upregulated in the serum and plasma of cancer patients,including those with pancreatic cancer,compared with healthy *** majority of RNA biomarker studies have assessed circulating microRNAs(miRs),which are often *** are few reports of the tumorspecific upregulation of other types of small noncoding RNAs(ncRNAs),such as small nucleolar RNAs and Piwi-interacting *** ncRNAs(IncRNAs),such as HOTAIR and MALAT1,in the serum/plasma of pancreatic cancer patients have also been reported as diagnostic and prognostic *** tissuederived RNAs,some miRs show increased expression even in pre-cancerous tissues,and their expression profiles may allow for the discrimination between a chronic inflammatory state and ***,some miRs and IncRNAs have been reported with significant alterations in expression according to disease progression,and they may thus represent potential candidate diagnostic or prognostic biomarkers that may be used to evaluate patients once detection methods in peripheral blood are well ***,recent innovations in high-throughput sequencing techniques have enabled the discovery of unannotated tumor-associated ncRNAs and tumor-specific alternative splicing as novel and specific biomarkers of *** much work is required to clarify the release mechanism,origin of tumor-specific circulating RNAs,and selectivity of carrier complexes,and technical advances must also be

关键词： MicroRNA Non-coding RNA Pancreaticcancer Biomarkers Early detection

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Interactions among dwarf bamboo, litter and consumption by small vertebrates place multiple constraints on the establishment of native tree seedlings in a Japanese agricultural landscape

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Journal of Plant Ecology 2019年第2期12卷 292-305页

作者： Yoshinori Tokuoka Kentaro Ohigashi Koji Watanabe Hiroshi Yamaguchi takahiro Ara Nobukazu Nakagoshi Division of Biodiversity Institute for Agro-Environmental SciencesNational Agriculture and Food Research Organization3-1-3KannondaiTsukuba-shiIbaraki 305-8604Japan Division of Informatics and Inventory Institute for Agro-Environmental SciencesNational Agriculture and Food Research Organization3-1-3KannondaiTsukuba-shiIbaraki 305-8604Japan Department of Planning and Coordination Tsukuba Technical Support CenterNational Agriculture and Food Research Organization3-1-3KannondaiTsukuba-shiIbaraki 305-8604Japan Graduate School for International Development and Cooperation Hiroshima University1-5-1 KagamiyamaHigashi-Hiroshima 739-8529Japan

Aims Faunal assemblage alterations due to anthropogenic impacts have changed herbivore-vegetation relationships in various ecosystems,but the influences of small vertebrates on revegetation processes remain *** a peri-urban agricultural landscape in eastern Japan that lacks large ungulates but supports small generalist herbivores,fewer native seedlings have become established in thickets dominated by native dwarf bamboo,Pleioblastus chino(*** Sav.)*** mechanisms limiting tree seedling establishment are *** aim here was to evaluate the influence of interactions among the dwarf bamboo,its litter cover and small vertebrate herbivores on the micro-site conditions governing the establishment of native tree seedlings from different successional stages in an old field in temperate *** First,seedling emergence and survival of seeded Pinus densiflora Siebold et Zucc.,Celtis sinensis Pers.,Aphananthe aspera(Thunb.)Planch.,Quercus serrata Murray,Quercus myrsinifolia Blume and Castanopsis sieboldii(Makino)*** *** Mashiba were observed in a factorial design that accounted for the presence or absence of dwarf bamboo and its litter cover,as well as the exclu-sion or access of small vertebrate fauna,in 2009 and *** identify small vertebrate herbivores that reduced the emergence or survival of tree seedlings in the first experiment,reseeding experi-ments using ***,***,*** and *** were conducted by video trapping in 2011 and video and still-cam-era trapping in *** Findings The abiotic conditions under the dwarf bamboo were lethal to early-to mid-successional ***,***,*** and *** but led to better survival-although spindly growth-of late-succes-sional *** and *** main consumers and the plants they found palatable differed between the bamboo thickets and the intervening *** by mice appeared to have severely limited the emergence of

关键词： bamboo cover farmland abandonment microsite limitation selective herbivory Pleioblastus chino

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Impact of blanching pretreatment on the drying rate and energy consumption during far-infrared drying of Paprika(Capsicum annuum L.)

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Food Quality and Safety 2018年第2期2卷 97-103页

作者： takahiro Orikasa Naoki Ono Takashi Watanabe Yasumasa Ando Takeo Shiina Shoji Koide Faculty of Agriculture Iwate UniversityMorioka IARC Kenpoku Agricultural Research Institute KunoheIwate Food Research Institute NAROTsukubaIbaraki Graduate School of Horticulture Chiba UniversityMatsudoJapan

We incorporated a superheated steam blanching pretreatment step into a paprika drying process and compared the far-infrared(FIR)drying rates,hardness of the sample surfaces,cell membrane stabilities,and energy consumption of blanched and non-blanched *** average drying rate of blanched paprika samples during FIR drying was higher than that of non-blanched *** hardness and cell membrane stability of dried blanched samples were lower than those of non-blanched *** estimated that the softening of the sample surfaces and injury to the cell membranes caused the drying rate to *** total energy consumption of the FIR drying of paprika was reduced by approximately 30%by introducing the blanching *** findings contribute to the development of environmentally friendly FIR drying techniques for paprika.

关键词： blanching cell membrane stability,energy consumption far-infrared drying hardness.

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Repeat laparoscopic anatomical liver resection in a hepatocellular carcinoma patient:a case report

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Hepatoma Research 2022年第1期8卷 248-253页

作者： Kazuharu Igarashi Kohei Mishima takahiro Ozaki Go Wakabayashi Department of Surgery Ageo Central General HospitalAgeoSaitama 362-8588Japan Department of General-Pediatric Hepatobiliary Pancreatic Surgery Kitasato University School of MedicineSagamiharaKanagawa 252-0374Japan

Anatomical resection(AR)has been reported to achieve better long-term outcomes than non-anatomical resection for the treatment of hepatocellular carcinoma(HCC).The surgical feasibility and oncological significance of laparoscopic AR(LAR),especially“subsegment resection”,“cone unit resection”,and repeat LAR for HCC,remain *** present a 67-year-old patient with alcoholic liver cirrhosis and HCC who underwent full LAR three times,focusing on the technical aspects of the Glissonean *** LAR for recurrent HCC could be a safe and feasible ***,HCC recurred in the neighboring segment twice,even though pathological vascular invasion and marginal remnants were not *** should investigate the oncological significance and advancements in subsegmentectomy and cone unit resection,in the future.

关键词： Repeat laparoscopic anatomical liver resection HCC Glissonean approach subsegmentectomy cone unit resection

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Influence of pulsed electric field on enzymes, bacteria and volatile flavor compounds of unpasteurized sake

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Plasma Science and Technology 2018年第4期20卷 51-56页

作者： Takamasa OKUMURA Taro YAEGASHI takahiro FUJIWARA Katsuyuki TAKAHASHI Koichi TAKAKI Tomo KUDO Institute of Fluid Science Tohoku University Department of Systems Innovation Engineering Iwate University Washinoo Co. Ltd

A pulsed electric field(PEF) was applied to unpasteurized sake at constant temperatures, at which α-amylase was not inactivated. We adjusted the input energy to be identical for the temperatures by changing the number of PEF application, because the current significantly increased with the temperature, even the amplitude of the applied voltage was identical. As a result, the α-amylase was seemed to be inactivated by PEF application, not due to thermal *** glucoamylase was significantly inactivated by PEF. Moreover, the acid carboxypeptidase was inactivated by PEF at 4 °C but significantly activated at 25 °C. These results show that the sensitivity of enzyme to PEF application differs depending on the types of enzyme and treatment temperature. On the other hand, the colony number of bacteria was remarkably decreased, but the amount of the volatile flavor compounds was not decreased by PEF application.

关键词： pulsed electric field enzyme activity bacteria inactivation vulnerable molecules unpasteurized sake electroporation

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Characteristics of In-Hospital Patients with Congenital Heart Disease Requiring Rapid Response System Activations: A Japanese Database Study

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Congenital Heart Disease 2022年第1期17卷 31-43页

作者： Taiki Haga Tomoyuki Masuyama Yoshiro Hayashi takahiro Atsumi Kenzo Ishii Shinsuke Fujiwara Department of Pediatric Critical Care Medicine Osaka City General HospitalOsaka534-0021Japan Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical CenterSaitama330-8503Japan Department of Intensive Care Medicine Kameda Medical CenterChiba296-8602Japan Department of Emergency Medicine Seirei Hamamatsu General HospitalShizuoka430-8558Japan Department of Anesthesiology Intensive Care UnitFukuyama City HospitalHiroshima721-8511Japan Department of Emergency Medicine NHO Ureshino Medical CenterSaga843-0393Japan

Objectives:This study aimed to study the characteristics of in-hospital deterioration in patients with congenital heart disease who required rapid response system activation and identify risk factors associated with 1-month ***:We retrospectively analysed data from a Japanese rapid response system registry with 35 participating *** included consecutive patients with congenital heart disease who required rapid response system activation between January 2014 and March *** regression analyses were performed to examine the associations between 1-month mortality and other patient-specific ***:Among 9,607 patients for whom the rapid response system was activated,only 82(0.9%)had congenital heart *** few patients with congenital heart disease were being treated at the cardiology and cardiovascular surgery departments(12.3%and 9.9%,respectively).Moreover,the incidences of rapid-response events after intensive care unit discharge or surgery were low(6.8% and 12.2%,respectively).The most common reason for rapid response system activation was respiratory dysfunction(desaturation:35.4%,tachypnoea:25.6%,and new dyspnoea:19.5%).Rapid response system interventions and intensive care unit transfers were required for 65.9% and 20.7%of patients,*** mortality rate was 1.2% at the end of the rapid response system intervention and 11.0% after 1 ***,decreased respiratory rate and decreased heart rate at rapid response system activation were associated with increased 1-month *** adjusted odds ratio was 1.10(95% confidence interval 1.02–1.19)and 1.02(95% confidence interval,1.00–1.04) for respiratory rate and heart rate,***:Rapid response systems were rarely activated after cardiac surgery and intensive care unit discharge,which were situations with a high risk of sudden deterioration in patients with congenital heart ***,encouraging the use of the rapid response sys

关键词： Heart defects congenital emergencies clinical deterioration hospital rapid response team critical care This

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Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer

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World Journal of Gastrointestinal Oncology 2016年第11期8卷 786-792页

作者： takahiro Tsuchikawa Shintaro Takeuchi Toru Nakamura Toshiaki Shichinohe Satoshi Hirano Department of Gastro-enterological Surgery Ⅱ Hokkaido University Graduate School of Medicine

A perioperative multimodal strategy including combination chemotherapy and radiotherapy, in addition to surgical resection, has been acknowledged to improve patient prognosis. However chemotherapy has not been actively applied as an immunomodulating modality because of concerns about various immunosuppressive effects. It has recently been shown that certain chemotherapeutic agents could modify tumor microenvironment and host immune responses through several underlying mechanisms such as immunogenic cell death, local T-cell infiltration and also the eradication of immune-suppressing regulatory cells such as regulatory T cells(Tregs) and myeloid-derived suppressor cells. With the better understanding of the cell components in the tumor microenvironment and the effect of chemotherapy to improve tumor microenvironment, it has been gradually clear that the chemotherapeutic agents is two-edged sword to have both immune promoting and suppressing effects. The cellular components of the tumor microenvironment include infiltrating T lymphocytes, dendritic cells, regulatory T cells, tumor associated macrophages, myeloid derived suppressor cells and cancer associated fibroblasts. Based on the better understanding of tumor microenvironment following chemotherapy, the treatment protocol could be modified as personalized medicine and the prognosis of pancreas cancer would be more improved utilizing multimodal chemotherapy. Here we review the recent advances of chemotherapy to improve tumor microenvironment of pancreatic cancer, introducing the unique feature of tumor microenvironment of pancreatic cancer, interaction between anti-cancer reagents and these constituting cells and future prospects.

关键词： Pancreas cancer Microenvironment Chemotherapy Immune cells Immunomodulation

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Secretory carcinoma——impact of translocation and gene fusions on salivary gland tumor

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Chinese Journal of Cancer Research 2017年第5期29卷 379-384页

作者： Ryoko Inaki Masanobu Abe Liang Zong takahiro Abe Aya Shinozaki-Ushiku Tetsuo Ushiku Kazuto Hoshi Department of Oral & Maxillofacial Surgery University of Tokyo Hospital Division for Health Service Promotion University of Tokyo Graduate School of Medicine University of Tokyo Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Department of Pathology Graduate School of Medicine University of Tokyo

Secretory carcinoma（SC）, previously described as mammary analogue secretory carcinoma（MASC）, is a recently described salivary gland tumor which morphologically resembles mammary secretory carcinoma. The first description of SC/MASC, reported by Skálová et al. in 2010, was as a rare salivary carcinoma imitating secretory carcinoma of the breast. SC/MASC is a unique salivary gland tumor with morphological overlap with acinic cell carcinoma（Aci CC）, mucoepidermoid carcinoma（MEC）, and adenocarcinoma not otherwise specified（ADCNOS）. SC/MASC shares similar clinicopathological features with Aci CC. As a critical difference between SC/MASC and Aci CC, SC/MASC characteristically has the chromosomal translocation t（12;15）（p13;q25） which leads to a fusion gene between the ETV6 gene on chromosome 12 and the NTRK3 gene on chromosome 15. This genetic background is an important differential diagnostic finding for excluding other salivary gland tumors and may be a critical factor determining the prognosis for patients with SC/MASC. Research in recent years has provided a large body of new data on SC/MASC and suggests the possibility that the ETV6-NTRK3 translocation could be a therapeutic target. Here, we review the morphological and clinicopathological features of SC/MASC and discuss new directions for therapy.

关键词： Secretory carcinoma mammary analogue secretory carcinoma MASC ETV6-NTRK3 fusion gene salivary gland tumor

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The TLR Expression Pattern on Monocyte-Derived Macrophages for Lipopolysaccharid Stimulation of Calves

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Agricultural Sciences in China 2009年第7期8卷 864-871页

作者： GUO Yi-jie ZHAO Guo-Qi HUO Yong-jiu Sachi Tanaka Hisashi Aso takahiro Yamaguchi Laboratory of Animal Nutrition Graduate School of Animal Science and Technology Yangzhou University Yangzhou 225009 P.R. China Laboratory of Functional Morphology Graduate School of Agricultural Science Tohoku University 1-1 Tsutsumidori-Amamiyamachi Aobaku 981-8555 Sendai Japan

In this paper, toll-like receptor expression pattern in monocytes-derived macrophages by lipopolysaccharid （LPS） stimulation was examined. Jugular venous blood samples from 4 Japanese calves were obtained and the peripheral blood mononuclear cells （PBMC） were isolated. The PBMC were cultured for 7 d so as to collect monocytes-derived macrophages in Repcell. The PBMC were stimulated by LPS for 24 h and the mRNA expression pattern of TLR and cytokines in monocytes-derived macrophages （Mod-Mφ） was analyzed. Results showed that LPS stimulation of Mod-Mφ could increase the mRNA levels of the genes of TNF-α, IL-6, and IL-8. In addition, the mRNA levels of the genes of TNF-α and IL-6 in the group of LPS stimulation were most significantly （P 〈 0.01） higher than those in control group and the mRNA levels of TLR1, 3, 5, 8, and 10 were significantly （P 〈 0.05） decreased after LPS stimulation. There was no difference in the mRNA expressions of TLR2, 4, 6, and 7 between the groups of the control and LPS stimulation. Besides, expression of TLR9 was not found. It suggested that monocytes-derived macrophages could respond to LPS and they might take an important role in the innate immunity. The important function of the cells might contribute to better disease treatment.

关键词： TLR bovine macrophage LPS

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Myocardial Segmentation of Area at Risk Based on Coronary Computed Tomography Angiography and Voronoi Diagram in Comparison with Magnetic Resonance Perfusion Imaging

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Open Journal of Radiology 2017年第1期7卷 9-22页

作者： Naoki Fukuyama Teruhito Kido Akira Kurata Yuki Tanabe Tomoyuki Kido takahiro Yokoi Ryo ogawa Hikaru Nishiyama Teruyoshi Uetani Teruhito Mochizuki Department of Radiology Ehime University Graduate School of Medicine Toon Japan Department of Cardiology Ehime University Graduate School of Medicine Toon Japan

Purpose: To assess the clinical feasibility of automated segmentation of the myocardial area at risk (MAAR) using coronary computed tomography angiography (CT-MAAR), as compared to stress magnetic resonance myocardial perfusion imaging (MR-MPI). Materials and Methods: Thirty patients who underwent coronary computed tomography angiography (CTA) and stress MR-MPI were retrospectively evaluated. The myocardial territory of the left ventricle (LV) distal to coronary artery stenosis (≥50% or ≥70% stenosis on coronary CTA) was three-dimensionally quantified using a Voronoi diagram. The ratio of all stenosis-related territories to the LV volume was defined as CT-MAAR (%-LV volume). The proportion of segments with perfusion defects in stress MR-MPI to the total of 16 segments (range: 0% - 100%;with a 6.3%-interval scale) was defined as the reference. Correlation was assessed using Spearman’s test. The capability of CT-MAAR to predict the ischemic burden was assessed. Results: Stress MR-MPI depicted a median ischemic burden of 25.2% (range: 18.9% - 44.1%) in 30 patients without myocardial infarction. When CTA stenosis criteria of ≥50% (n = 30) and ≥70% (n = 27) were applied to estimate CT-MAAR, the median CT-MAAR values were 48.2% (31.6% - 64.3%) and 32.5% (23.7% - 51.9%), respectively. The correlations between the CT-MAAR values and the MR-based ischemic burden were significant (0.73 and 0.97 for ≥50% and ≥70% stenosis, respectively). CT-MAAR predicted the MR-based ischemic burden within ±1 segment of %-LV (6.3%) in 40% (12/30) of patients with ≥50% stenosis, and in 81.5% (22/27) of patients with ≥70% stenosis. Conclusions: Comprehensive assessment of resting coronary CTA combined with Voronoi diagram-based myocardial segmentation may help predict the myocardial ischemic burden in patients with severe coronary CTA stenosis.

关键词： Computed Tomography Ischemia Myocardial Area at Risk

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