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Cerebral spinal fluid biomarker profiles in CNS infection associated with HSV and VZV mimic patterns in Alzheimer's disease

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Translational Neurodegeneration 2021年第1期10卷 12-14页

作者： Makiko Shinom oto Takashi Kasai Harutsugu Tatebe Fukiko Kitani-Morii Takuma Ohmichi Yuzo Fujino David Allsop Toshiki Mizuno takahiko tokuda Departm ent of Neurology Kyoto Prefectural University of MedicineKyoto 602-0841Japan Departm ent of Functional Brain Imaging Research National Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Division of Biomedical and Life Sciences Faculty of Health and MedicineLancaster UniversityLancaster LAI 4YQUK

Alzheimer’s disease(AD)is the most common cause of *** AD was initially considered to be a cell autonomous neurodegenerative disorder,marked neuroinflammation has been observed in brains of AD *** and molecular biological findings have suggested the central nervous system(CNS)inflammatory processes to be involved in the etiopathogenesis of AD,in which the activated microglia play a key role.

关键词： Alzheimer inflammation infection

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers

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Translational Neurodegeneration 2020年第2期9卷 168-177页

作者： Nour K.Majbour Jan O.Aasly Eldbjørg Hustad Mercy A.Thomas Nishant N.Vaikath Naser Elkum Wilma D.Jvan de Berg takahiko tokuda Brit Mollenhauer Henk W.Berendse Omar M.A.El-Agnaf Neurological Disorders Research Center Qatar Biomedical Research InstituteHamad Bin Khalifa UniversityQatar FoundationP.O.Box 5825DohaQatar Department of Neuroscience Norwegian University of Science and Technology(NTNU)TrondheimNorway Department of Neurology St.Olav’s HospitalUniversity Hospital of TrondheimTrondheimNorway Clinical Epidemiology Sidra Medical and Research CenterDohaQatar Department of Anatomy and Neurosciences Neuroscience Campus AmsterdamVU University Medical CentreAmsterdamthe Netherlands Department of Neurology Research Institute for GeriatricsKyoto Prefectural University of MedicineKyoto602-0841Japan Paracelsus-Elena-Klinik KlinikstraßeKasseland University Medical Center GöttingenDepartment of NeurologyGöttingenGermany Department of Neurology Amsterdam UMClocation VU University Medical CentreAmsterdamThe Netherlands

Background Asymptomatic carriers of leucine-rich repeat kinase 2(LRRK2)gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease(PD).In this study,we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRK2 mutation *** We measured the levels of CSF total-(t-),oligomeric(o-)and phosphorylated S129(pS129-)α-syn,total-tau(tTau),phosphorylated threonine 181 tau(pTau),amyloid-beta 40(Aβ-40),amyloid-beta-42(Aβ-42)and 40 inflammatory chemokines in symptomatic(n=23)and asymptomatic(n=51)LRRK2 mutation carriers,subjects with a clinical diagnosis of PD(n=60)and age-matched healthy controls(n=34).General linear models corrected for age and gender were performed to assess differences in CSF biomarkers between the *** that varied significantly between the groups were then analyzed using backward-elimination logistic regression analysis to identify an ideal biomarkers panel of prodromal *** Discriminant function analysis revealed low levels of CSF t-α-syn,high levels of CSF o-α-syn and TNF-αbest discriminated asymptomatic LRRK2 mutation carriers from both symptomatic PD and healthy *** the discriminative power using receiver operating curve analysis,an area under the curve>0.80 was *** The current study suggests that CSF t-,o-α-syn and TNF-αare candidate risk biomarkers for the detection of PD at the prodromal *** findings also highlight the dynamic interrelationships between CSF proteins and the importance of using a biomarkers’panel approach for an accurate and timely diagnosis of PD.

关键词： Parkinson's disease LRRK2 mutation carriers Alpha-synuclein oligomers Biomarkers Inflammatory markers

Required amounts of medium and fertilizer for potted culture of zucchini

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Application of virtual reality technology improves the functionality of brain networks in individuals experiencing pain

Agricultural Sciences 2012年第6期

作者： Hiromi Ikeura takahiko tokuda Yasuyoshi Hayata

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World Journal of Clinical Cases 2025年第3期13卷 66-68页

作者： takahiko Nagamine Department of Psychiatric Internal Medicine Sunlight Brain Research CenterHofu 7470066YamaguchiJapan

Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and ***,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)*** has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been *** precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be ***,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain *** salience network is diminished,while the default mode network is ***,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and *** research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.

关键词： Virtual reality Pain Anxiety Salience network Default mode network

Efficient Fixation of Carbon Dioxide by Electrolysis——Facile Synthesis of Useful Carboxylic Acids

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Journal of Natural Gas Chemistry 2006年第4期15卷 275-281页

作者： Masao tokuda Division of Molecular Chemistry Graduate School of EngineeringHokkaido UniversitySapporo 060-8628Japan

Electrochemical fixation of atmospheric pressure of carbon dioxide to organic compounds is a useful and attractive method for synthesizing of various carboxylic acids. Electrochemical fixation of carbon dioxide, electrochemical carboxylation, organic halides, organic triflates, alkenes, aromatic compounds, and carbonyl compounds can readily occur in the presence of an atmospheric pressure of carbon dioxide to form the corresponding carboxylic acids with high yields, when a sacrificial anode such as magnesium or aluminum is used in the electrolysis. The electrochemical carboxylation of vinyl bromides was successfully applied for the synthesis of the precursor of nonsteroidal anti-inflammatory agents such as ibuprofen and naproxen. On the other hand, supercritical carbon dioxide （scCO2） has significant potential as an environmentally benign solvent in organic synthesis and it could be used both as a solvent and as a reagent in these electrochemical carboxylations by using a small amount of cosolvent.

关键词： carbon dioxide fixation supercritical carbon dioxide electrolysis sacrificial anode carboxylic acid

Two Tightly Linked Genes at the hsal Locus Cause Both F1 and F2 Hybrid Sterility in Rice

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Molecular Plant 2016年第2期9卷 221-232页

作者： takahiko Kubo Plant Genetics Laboratory National Institute of Genetics Mishima Shizuoka 411-8540 Japan Department of Genetics SOKENDAI (the Graduate University for Advanced Science) Mishima Shizuoka 411-8540 Japan STAY GREEN Co. Ltd. Kisarazu Chiba 292-0818 Japan Bioscience and Biotechnology Center Nagoya University Nagoya Aichi 464-8601 Japan Plant Breeding Laboratory Division of Genetics and Plant Breeding Department of Applied Genetics and Pest Management Faculty of Agriculture Kyushu University Fukuoka 812-8581 Japan These authors contributed equally to this article

Molecular mechanisms of hybrid breakdown associated with sterility (F2 sterility) are poorly understood as compared with those of F1 hybrid sterility. Previously, we characterized three unlinked epistatic loci, hybrid sterility-a1 (hsa1), hsa2, and hsa3, responsible for the F2 sterility in a cross between Oryza sativa ssp. indica and japonica. In this study, we identified that the hsa1 locus contains two interacting genes, HSA1a and HSA1b, within a 30-kb region. HSA1a-j (japonica allele) encodes a highly conserved plant-specific domain of unknown function protein (DUF1618), whereasthe indica allele (HSA1a-is) has two deletion mutations that cause disruption of domain structure. The second gene, HSA1b-is, encodes an uncharacterized proteinwith some similarity to a nucleotide-binding protein. Homozygous introgression of indica HSA1a-is-HSA1b-is alleles into japonica showed female gamete abortion at an early mitotic stage. The fact that the recombinant haplotype HSA1a-j-HSA1b-is caused semi-sterility in the heterozygous state with the HSA1a-is-HSA1b-is haplotype suggests that variation in the hsa1 locus is a possible cause of the wide-spectrum sterility barriers seen in F1 hybrids and successive generations in rice. We propose a simple genetic model to explain how a single causal mechanism can drive both F1 and F2 hybrid sterility.

关键词： hybrid sterility epistasis Oryza sativa DUF1618 protein embryo sac abortion

Flow Behavior in Z-Path Fluidized-Moving Bed with Inclined Perforated Plate

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Journal of Iron and Steel Research International 2002年第1期9卷 19-24页

作者： GUO Zhan-cheng tokuda Masanori Institute of Process Engineering CAS Center for Northeast Asia Studies Tohoku University

Much researches on the operation and structure of tundish were carried out at Xiangtan Iron and Steel Co Ltd to increase the yield of grade 20 carbon steel on the continuous casting production line. Through analyzing formation mechanism of pinholes and non metallic inclusions in billets and describing pattern of the flow of molten steel in tundish by a mathematic model, it was shown that the structure and operation of tundishes play an important part in product quality. So some measures were taken as follows: (1) Optimizing the tundish construction to decrease the impact of liquid steel and lengthening the residence time of liquid steel for homogenization of liquid steel; (2) Improving the influent and effluent operation of liquid steel to avoid the contact of liquid steel with air in order to decrease reoxidation; (3) Reducing over heat during continuous casting. After above measures being taken, the yield of grade 20 carbon steel and the service life of equipment were improved remarkably.

关键词： carbon steel continuous casting quality tundish

Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis?

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Translational Neurodegeneration 2020年第3期9卷 421-436页

作者： Yoshiaki Furukawa Eichi tokuda Department of Chemistry Laboratory for Mechanistic Chemistry of BiomoleculesKeio University3-14-1 HiyoshiKohokuYokohamaKanagawa 223-8522Japan Present address:Laboratory of Clinical Medicine School of PharmacyNihon University7-7-1 NarashinodaiFunabashiChiba 274-8555Japan

Amyotrophic lateral sclerosis(ALS)is characterized by adult-onset progressive degeneration of upper and lower motor *** numbers of genes are found to be associated with ALS;among those,the first identified gene,SOD1 coding a Cu/Zn-superoxide dismutase protein(SOD1),has been regarded as the gold standard in the research on a pathomechanism of *** accumulation of misfolded SOD1 in affected spinal motor neurons has been established as a pathological hallmark of ALS caused by mutations in SOD1(SOD1-ALS).Nonetheless,the involvement of wild-type SOD1 remains quite controversial in the pathology of ALS with no SOD1 mutations(non-SOD1 ALS),which occupies more than 90%of total ALS *** vitro studies have revealed post-translationally controlled misfolding and aggregation of wild-type as well as of mutant SOD1 proteins;therefore,SOD1 proteins could be a therapeutic target not only in SOD1-ALS but also in more prevailing cases,non-SOD1 *** order to search for evidence on misfolding and aggregation of wild-type SOD1 in vivo,we reviewed pathological studies using mouse models and patients and then summarized arguments for and against possible involvement of wild-type SOD1 in non-SOD1 ALS as well as in SOD1-ALS.

关键词： Amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase Protein misfolding

Solvent Extraction of Niobium from Alkali Solution by Methyltrioctylammonium Chloride

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Journal of Central South University 2000年第4期12卷 175-177页

作者： ZHOU Kang-gen tokuda Masanori Metallurgical Separation Science and Engineering Lab. Central South UniversityChangsha 410083China Tohoku University Sendai 980-77Japan

For the purpose of developing an alkali leaching solvent extraction directly from alkali solution process, the extraction of niobium from alkali solution by long chain alkyl quaternary ammonium salt (methyltrioctylammonium chloride R 4NCl) in toluene was investigated. The experiments were carried out under conditions of 25 ℃, Nb(Ⅴ) concentration 0.01 mol/L, pH 10.7 13.8, R 4NCl concentration 0.02 0.14 mol/L. It has been found that the distribution ratio of niobium increases with increasing R 4NCl concentration and with decreasing KCl concentration, but it shows maximum value at pH value of about 12 and decreases below or above this pH value. Distribution ratio of niobium goes up to over 1 000 in appropriate conditions, and so it has been proved that R 4NCl is an effective extractant for extraction of niobium from alkali solution.

关键词： niobium solvent extraction distribution ratio methyltrioctylammonium chloride