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Adaptive-sampling near-Doppler-limited terahertz dual-comb spectroscopy with a free-running single-cavity fiber laser

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Advanced Photonics 2020年第3期2卷 50-60页

作者： Jie Chen Kazuki Nitta Xin Zhao takahiko mizuno TakeoMinamikawa Francis Hindle Zheng Zheng Takeshi Yasui Beihang University School of Electronic and Information EngineeringBeijingChina Tokushima University Graduate School of Advanced Technology and ScienceTokushimaJapan JST ERATO MINOSHIMA Intelligent Optical SynthesizerTokushimaJapan Tokushima University Institute of Post-LED PhotonicsTokushimaJapan Tokushima University Graduate School of TechnologyIndustrial and Social SciencesTokushimaJapan Tokushima University Research Cluster on“Multi-scale VibrationalMicroscopy forComprehensive Diagnosis and Treatment of Cancer”TokushimaJapan Universitédu Littoral Côte d’Opale Laboratoire de Physico-Chimie de l’AtmosphèreDunkerqueFrance Beihang University Beijing Advanced Innovation Center for Big Data-based Precision MedicineBeijingChina

Dual-comb spectroscopy(DCS)is an emerging spectroscopic tool with the potential to simultaneously achieve a broad spectral coverage and ultrahigh spectral resolution with rapid data ***,the need for two independently stabilized ultrafast lasers significantly hampers the potential application of *** demonstrate mode-resolved DCS in the THz region based on a free-running singlecavity dual-comb fiber laser with the adaptive sampling *** the use of a free-running single-cavity dual-comb fiber laser eliminates the need for two mode-locked lasers and their frequency control,the adaptive sampling method strongly prevents the degradation of spectroscopic performance caused by the residual timing jitter in the free-running dual-comb ***-limit-approaching absorption features with linewidths down to 25 MHz are investigated for low-pressure acetonitrile/air mixed gas by comb-mode-resolved THz *** successful demonstration clearly indicates its great potential for the realization of lowcomplexity,Doppler-limited THz spectroscopy instrumentation.

关键词： optical comb terahertz dual-comb spectroscopy molecular spectroscopy

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Facial aesthetics is shaped not only by genetic predispositions but also by the cultural norms and values

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World Journal of Clinical Cases 2024年第34期12卷 6684-6686页

作者： takahiko Nagamine Psychiatric Internal Medicine Sunlight Brain Research CenterHofu 7470066YamaguchiJapan

The positioning of teeth is of significant importance,both in terms of function and *** is a subjective matter,and there is often a discrepancy between the perceptions of patients and those of medical *** act of wearing a mask has been demonstrated to impair the ability to evaluate facial attractiveness,thereby reaffirming the visual importance of the oral cavity in the context of facial *** notion that a face perceived as beautiful is inherently exceptional is a *** average face is defined as one that exhibits characteristics that are common to the ***,cultural mutations occur at a faster rate than genetic *** regard to changes in facial aesthetics,cultural differences have a more immediate effect than genetic *** advent of the internet meme may herald the advent of an era in which the average face that defines a beautiful face is determined by the internet.

关键词： Orthodontics Mask Genetics Culture Average face

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Pedestrian trajectory prediction method based on the Social-LSTM model for vehicle collision

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Transportation Safety and Environment 2024年第3期6卷 140-151页

作者： Yong Han Xujie Lin Di Pan Yanting Li Liang Su Robert Thomson Koji mizuno School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen 361024China Fujian Province Key Laboratory of Advanced Design and Manufacturing of Buses Xiamen 361024China Engineering Research Institute of Xiamen Kinglong United Automobile Industry Co. Ltd.Xiamen 361000China Chalmers University of Technology Gothenburg 41296Sweden Department of Mechanical Systems Engineering Nagoya UniversityNagoya 464-8603Japan

Techniques for predicting the trajectory of vulnerable road users are important to the development of perception systems for autonomous vehicles to avoid *** most effective trajectory prediction methods,such as Social-LSTM,are often used to predict pedestrian trajectories in normal passage ***,they can produce unsatisfactory prediction results and data redundancy,as well as difficulties in predicting trajectories using pixel-based coordinate systems in collision avoidance *** is also a lack of validations using real vehicle-to-pedestrian *** address these issues,some insightful approaches to improve the trajectory prediction scheme of Social-LSTM were proposed,such methods included transforming pedestrian trajectory coordinates and converting image coordinates to world *** YOLOv5 detection model was introduced to reduce target loss and improve prediction *** DeepSORT algorithm was employed to reduce the number of target transformations in the tracking *** Perspective Transformation(IPT)and Direct Linear Transformation(DLT)theories were combined to transform the coordinates to world coordinates,identifying the collision location where the accident could *** performance of the proposed method was validated by training tests using MS COCO(Microsoft Common Objects in Context)and ETH/UCY *** results showed that the target detection accuracy was more than 90%and the prediction loss tends to decrease with increasing training steps,with the final loss value less than 1%.The reliability and effectiveness of the improved method were demonstrated by benchmarking system performance to two video recordings of real pedestrian accidents with different lighting conditions.

关键词： vehicle-to-pedestrian collisions pedestrian trajectory prediction YOLOvB DeepSORT Social-LSTM

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Pedestrian trajectory prediction method based on the Social-LSTM model for vehicle collision

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Transportation Safety and Environment 2024年第03期 158-169页

作者： Yong Han Xujie Lin Di Pan Yanting Li Liang Su Robert Thomson Koji mizuno School of Mechanical and Automotive Engineering Xiamen University of Technology Fujian Province Key Laboratory of Advanced Design and Manufacturing of Buses Engineering Research Institute of Xiamen Kinglong United Automobile Industry Co. Ltd. Chalmers University of Technology Department of Mechanical Systems Engineering Nagoya University

Techniques for predicting the trajectory of vulnerable road users are important to the development of perception systems for autonomous vehicles to avoid *** most effective trajectory prediction methods,such as Social-LSTM,are often used to predict pedestrian trajectories in normal passage ***,they can produce unsatisfactory prediction results and data redundancy,as well as difficulties in predicting trajectories using pixel-based coordinate systems in collision avoidance *** is also a lack of validations using real vehicle-to-pedestrian *** address these issues,some insightful approaches to improve the trajectory prediction scheme of Social-LSTM were proposed,such methods included transforming pedestrian trajectory coordinates and converting image coordinates to world *** YOLOv5 detection model was introduced to reduce target loss and improve prediction *** DeepSORT algorithm was employed to reduce the number of target transformations in the tracking *** Perspective Transformation(IPT) and Direct Linear Transformation(DLT) theories were combined to transform the coordinates to world coordinates,identifying the collision location where the accident could *** performance of the proposed method was validated by training tests using MS COCO(Microsoft Common Objects in Context) and ETH/UCY *** results showed that the target detection accuracy was more than 90% and the prediction loss tends to decrease with increasing training steps,with the final loss value less than 1%.The reliability and effectiveness of the improved method were demonstrated by benchmarking system performance to two video recordings of real pedestrian accidents with different lighting conditions.

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Two Tightly Linked Genes at the hsal Locus Cause Both F1 and F2 Hybrid Sterility in Rice

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Molecular Plant 2016年第2期9卷 221-232页

作者： takahiko Kubo Plant Genetics Laboratory National Institute of Genetics Mishima Shizuoka 411-8540 Japan Department of Genetics SOKENDAI (the Graduate University for Advanced Science) Mishima Shizuoka 411-8540 Japan STAY GREEN Co. Ltd. Kisarazu Chiba 292-0818 Japan Bioscience and Biotechnology Center Nagoya University Nagoya Aichi 464-8601 Japan Plant Breeding Laboratory Division of Genetics and Plant Breeding Department of Applied Genetics and Pest Management Faculty of Agriculture Kyushu University Fukuoka 812-8581 Japan These authors contributed equally to this article

Molecular mechanisms of hybrid breakdown associated with sterility (F2 sterility) are poorly understood as compared with those of F1 hybrid sterility. Previously, we characterized three unlinked epistatic loci, hybrid sterility-a1 (hsa1), hsa2, and hsa3, responsible for the F2 sterility in a cross between Oryza sativa ssp. indica and japonica. In this study, we identified that the hsa1 locus contains two interacting genes, HSA1a and HSA1b, within a 30-kb region. HSA1a-j (japonica allele) encodes a highly conserved plant-specific domain of unknown function protein (DUF1618), whereasthe indica allele (HSA1a-is) has two deletion mutations that cause disruption of domain structure. The second gene, HSA1b-is, encodes an uncharacterized proteinwith some similarity to a nucleotide-binding protein. Homozygous introgression of indica HSA1a-is-HSA1b-is alleles into japonica showed female gamete abortion at an early mitotic stage. The fact that the recombinant haplotype HSA1a-j-HSA1b-is caused semi-sterility in the heterozygous state with the HSA1a-is-HSA1b-is haplotype suggests that variation in the hsa1 locus is a possible cause of the wide-spectrum sterility barriers seen in F1 hybrids and successive generations in rice. We propose a simple genetic model to explain how a single causal mechanism can drive both F1 and F2 hybrid sterility.

关键词： hybrid sterility epistasis Oryza sativa DUF1618 protein embryo sac abortion

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Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

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Cerebral spinal fluid biomarker profiles in CNS infection associated with HSV and VZV mimic patterns in Alzheimer's disease

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Translational Neurodegeneration 2021年第1期10卷 12-14页

作者： Makiko Shinom oto Takashi Kasai Harutsugu Tatebe Fukiko Kitani-Morii Takuma Ohmichi Yuzo Fujino David Allsop Toshiki mizuno takahiko Tokuda Departm ent of Neurology Kyoto Prefectural University of MedicineKyoto 602-0841Japan Departm ent of Functional Brain Imaging Research National Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Division of Biomedical and Life Sciences Faculty of Health and MedicineLancaster UniversityLancaster LAI 4YQUK

Alzheimer’s disease(AD)is the most common cause of *** AD was initially considered to be a cell autonomous neurodegenerative disorder,marked neuroinflammation has been observed in brains of AD *** and molecular biological findings have suggested the central nervous system(CNS)inflammatory processes to be involved in the etiopathogenesis of AD,in which the activated microglia play a key role.

关键词： Alzheimer inflammation infection

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Two-step Design of Critical Control Systems Using Disturbance Cancellation Integral Controllers

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International Journal of Automation and computing 2011年第1期8卷 37-45页

作者： Tadashi Ishihara takahiko Ono Faculty of Science and Technology Fukushima University Graduate School of Information Sciences Hiroshima City University

An efficient critical control system design is proposed in this paper. The key idea is to decompose the design problem into two simpler design steps by the technique used in the classical loop transfer recovery method （LTR）. The disturbance cancellation integral controller is used as a basic controller. Since the standard loop transfer recovery method cannot be applied to the disturbance cancellation controller, the nonstandard version recently found is used for the decomposition. Exogenous inputs with constraints both on the amplitude and rate of change are considered. The majorant approach is taken to obtain the analytical sufficient matching conditions. A numerical design example is presented to illustrate the effiectiveness of the proposed design.

关键词： Critical control systems principle of inequalities principle of matching majorants disturbance cancellation controller integral controller loop transfer recovery (LTR).

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Actively-controlled Beds for Ambulances

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International Journal of Automation and computing 2009年第1期6卷 1-6页

作者： takahiko Ono Hikaru Inooka Graduate School of Information Sciences Hiroshima City University Asaminami-ku Research House LOGOS Aoba-ku

During transportation by ambulance, a patient is exposed to inertial acceleration when an ambulance decelerates or turns a corner. Such acceleration often gives a patient physical stress such as blood pressure variation or body sway, which causes strong pain, feeling of discomfort or sometimes critical damage for seriously injured persons. To reduce this undesirable effect of the acceleration, the authors developed the actively-controlled bed （ACB） which controls the posture of a stretcher in real time to reduce foot-to-head and lateral acceleration acting on a supine person. This paper describes development of the ACB, including control system design and performance evaluation. The control system is designed by Zakian＇s framework, which comprises the principle of matching and the method of inequalities, so that the design specifications on the tracking error and the motor torque are satisfied. From the results of driving experiments and simulation, it is estimated that the ACB can reduce the acceleration acting on a patient by 65% in the foot-to-head direction and by 75% in the lateral direction.

关键词： Control systems mechanical systems motor control acceleration control position control.

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Role of animal models in glaucoma research

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Neural Regeneration Research 2020年第7期15卷 1257-1258页

作者： Atsuko Kimura takahiko Noro Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical Science

Glaucoma is a neurodegenerative disease of the eye,and it presents with visual field defects accompanied by progressive degeneration of the optic nerve and retinal ganglion cells(RGCs).It is one of the major causes of blindness worldwide and affects 1 in 20 people over the age of *** is caused by multiple factors,but it is usually associated with elevated intraocular pressure(IOP).Extensive studies have been carried out to discover therapeutic targets and to develop new drugs to treat ocular hypertension using experimental models of rodents(rats and mice)and non-human primates(e.g.,cynomologus,rhesus,or marmoset monkeys).

关键词： elevated degeneration drugs

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