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En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer

World Journal of Gastrointestinal Oncology 2017年第9期9卷 372-378页

作者： Yuji Kaneda Hiroshi Noda Yuhei Endo Nao Kakizawa Kosuke Ichida Fumiaki Watanabe takaharu kato Yasuyuki Miyakura Koichi Suzuki Toshiki Rikiyama Department of Surgery Saitama Medical CenterJichi Medical UniversitySaitama 330-8503Japan

AIM To assess the usefulness of en bloc right hemicolectomy with pancreaticoduodenectomy(RHCPD) for locally advanced right-sided colon cancer(LARCC).METHODS We retrospectively reviewed the database of Saitama Medical Center, Jichi Medical University, between January 2009 and December 2016. During this time, 299 patients underwent radical right hemicolectomy for right-sided colon cancer. Among them, 5 underwent RHCPD for LARCC with tumor infiltration to adjacent organs. Preoperative computed tomography(CT) was routinely performed to evaluate local tumor infiltration into adjacent organs. During the operation, we evaluated the resectability and the amount of infiltration into the adjacent organs without dissecting the adherent organs from the cancer. When we confirmed that radical resection was feasible and could lead to R0 resection, we performed RHCPD. The clinical data were carefully reviewed, and the demographic variables, intraoperative data, and postoperative parameters were *** The median age of the 5 patients who underwent RHCPD for LARCC was 70 years. The tumors were located in the ascending colon(three patients) and transverse colon(two patients). Preoperative CT revealed infiltration of the tumor into the duodenum in all patients, the pancreas in four patients, the superior mesenteric vein(SMV) in two patients, and tumor thrombosis in the SMV in one patient. We performed RHCPD plus SMV resection in three patients. Major postoperative complications occurred in 3 patients(60%) as pancreatic fistula(grade B and grade C, according to International Study Group on Pancreatic Fistula Definition) and delayed gastric empty. None of the patients died during their hospital stay. A histological examination confirmed malignant infiltration into the duodenum and/or pancreas in 4 patients(80%), and no patients showed any malignant infiltration into the SMV. Two patients were histologically confirmed to have tumor thrombosis in the SMV. All of the tumors had c

关键词： Locally advanced right-sided colon cancer Right hemicolectomy Malignant infiltration Inflammatory adhesion Pancreaticoduodenectomy

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Fabrication of Mie-resonant silicon nanoparticles using laser annealing for surface-enhanced fluorescence spectroscopy

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Microsystems & Nanoengineering 2024年第2期10卷 133-141页

作者： Tatsuya Fukuta Ryo kato Takuo Tanaka Taka-aki Yano Institute of Post-LED Photonics Tokushima University2-1 Minami-JosanjimaTokushima770-8506Japan Innovative Photon Manipulation Research Team RIKEN Center for Advanced PhotonicsWakoSaitama351-0198Japan Metamaterials Laboratory RIKEN Cluster for Pioneering ResearchWakoSaitama351-0109Japan

Silicon nanostructures with unique Mie resonances have garnered considerable attention in the field of ***,we present a simple and efficient method for the fabrication of silicon(Si)nanoparticle substrates using continuous-wave(CW)laser *** resulting silicon nanoparticles exhibit Mie resonances in the visible region,and their resonant wavelengths can be precisely ***,laser-annealed silicon nanoparticle substrates show a 60-fold enhancement in *** tunable and fluorescence-enhancing silicon nanoparticle platform has tremendous potential for highly sensitive fluorescence sensing and biomedical imaging applications.

关键词： nanoparticles annealing resonant

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Twisted fiber microfluidics:a cutting-edge approach to 3D spiral devices

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Microsystems & Nanoengineering 2024年第1期10卷 193-202页

作者： Shunsuke kato Daniel W.Carlson Amy Q.Shen Yuanyuan Guo Department of Electrical Information and Physics EngineeringSchool of EngineeringTohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Micro/Bio/Nanofluidics Unit Okinawa Institute of Science and TechnologyOnnaKunigami-gun 904-0495 OkinawaJapan Frontier Research Institute for Interdisciplinary Sciences(FRIS) Tohoku UniversityAoba-kuSendai 980-0845 MiyagiJapan Graduate School of Biomedical Engineering Tohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Department of Physiology Graduate School of MedicineTohoku UniversityAoba-kuSendai 980-8575 MiyagiJapan

The development of 3D spiral microfluidics has opened new avenues for leveraging inertial focusing to analyze small fluid volumes,thereby advancing research across chemical,physical,and biological *** traditional straight microchannels rely solely on inertial lift forces,the novel spiral geometry generates Dean drag forces,eliminating the necessity for external fields in fluid ***,fabricating 3D spiral microfluidics remains a labor-intensive and costly endeavor,hindering its widespread ***,conventional lithographic methods primarily yield 2D planar devices,thereby limiting the selection of materials and geometrical *** address these challenges,this work introduces a streamlined fabrication method for 3D spiral microfluidic devices,employing rotational force within a miniaturized thermal drawing process,termed as *** innovation allows for rapid prototyping of twisted fiber-based microfluidics featuring versatility in material selection and heightened geometric *** validate the performance of these devices,we combined computational modeling with microtomographic particle image velocimetry(uTPiM)to comprehensively characterize the 3D flow *** results corroborate the presence of a steady secondary flow,underscoring the effectiveness of our *** 3D spiral microfluidics platform paves the way for exploring intricate microflow dynamics,with promising applications in areas such as drug delivery,diagnostics,and lab-on-a-chip systems.

关键词： thereby straight twisted

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PdPtCuNiP高熵非晶合金蠕变机理研究

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力学学报 2024年

作者：段亚娟徐宗睿郝奇 H.kato 乔吉超西北工业大学力学与土木建筑学院加泰罗尼亚理工大学能源技术研究所物理系日本东北大学材料研究所

本研究以Pd20Pt20Cu20Ni20P20高熵非晶合金作为研究载体,通过蠕变循环加载及循环加载-回复实验,着重考察了蠕变变形、准稳态蠕变速率、蠕变应力指数和弛豫时间分布谱演变规律,系统探索了温度、循环加载及回复时间对其蠕变行为的影响.研... 详细信息

本研究以Pd20Pt20Cu20Ni20P20高熵非晶合金作为研究载体,通过蠕变循环加载及循环加载-回复实验,着重考察了蠕变变形、准稳态蠕变速率、蠕变应力指数和弛豫时间分布谱演变规律,系统探索了温度、循环加载及回复时间对其蠕变行为的影响.研究结果表明，该合金的蠕变行为明显依赖于温度和应力，低温及低应力环境下合金表现出较好的抗蠕变性能，主要以弹性变形为主.随着温度增加，合金抗蠕变能力减弱，粘弹性（粘塑性）变形成为主导.循环应力在低温下对蠕变变形影响较小，而在高温下其影响显著，表明循环载荷能加剧蠕变行为，导致准稳态蠕变速率上升.回复时间对合金的瞬时弹性变形和滞弹性变形有显著影响，但对粘塑性变形的调节作用有限.卸载后合金变形能力逐渐增强，蠕变抑制得到缓解.此外，变形单元弛豫时间的广泛分布和对循环应力的敏感反应，揭示了蠕变机制的复杂性和多时间尺度的结构演化.本研究通过系统的实验和分析，深化了对高熵非晶合金蠕变行为及其调控机制的理解.为高性能高熵非晶合金的设计和应用提供了重要的理论依据和实践指导，对未来开发更具抗蠕变能力的先进材料具有一定意义.

关键词：高熵非晶合金蠕变滞弹性变形动力学微观结构非均匀性

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Correlating dynamic relaxation and viscoelasticity in metallic glasses

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 81-90页

作者： GuangHui Xing Qi Hao Fan Zhu Yun-Jiang Wang Yong Yang Hidemi kato Eloi Pineda Si Lan JiChao Qiao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China Department of Mechanical Engineering College of EngineeringCity University of Hong KongHong Kong 999077China Department of Materials Science and Engineering College of EngineeringCity University of Hong KongHong Kong 999077China Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Department of Physics Institute of Energy TechnologiesUniversitat Politècnica de CatalunyaBarceona 9Spain School of Material Science and Engineering Herbert Gleiter Institute of NanoscienceNanjing University of Science and Technology.Nanjing 210094China State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment Northwestern Polytechnical UniversityXi'an 710072China

Relaxation dynamics,essential for the structural evolution of non-equilibrium systems like glassy materials,remain ***,we explore relaxation dynamics and viscoelastic properties in three types of metallic glasses with distinctβrelaxation *** systems with significantβrelaxation,stress relaxation and creep experiments reveal a transition from two-step to one-step relaxation with rising ***,such a phenomenon is absent in systems with weakerβ*** model the two-step relaxation process using a double Kohlrausch-Williams-Watts equation,and the obtained relaxation times elegantly adhere to the Arrhenius *** combining fitted activation energies with theoretical analysis,we conclusively attribute these relaxation processes toβrelaxation andαrelaxation,***,we analyze the relaxation time spectra of two processes and establish a comprehensive picture linking dynamic relaxation with *** study provides new strategies for probing the complex relaxation behaviors of glasses from the perspective of viscoelasticity.

关键词： creep relaxation glasses

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The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan

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Cancer Biology & Medicine 2024年第1期21卷 29-44页

作者： Teruhiko Yoshida Yasushi Yatabe Ken kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer *** the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and *** CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of *** back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be *** quantity and quality of these samples will be compatible with omics *** biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer.

关键词： Cancer genomic medicine biobank patient-derived xenograft multi-gene panel test whole genome sequencing

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DPY19L3 promotes vasculogenicmimicry by its C-mannosyltransferase activity

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Oncology Research 2024年第4期32卷 607-614页

作者： HASSAN BAYDOUN YUJI kato HIROKI KAMO ANNA HÜSCH HAYATO MIZUTA RYOTA KAWAHARA SIRO SIMIZU Department of Applied Chemistry Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department of Pharmacy and Biochemistry Faculty of ScienceUniversity of TübingenTübingen72074Germany

C-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic *** humans,biosynthesis of C-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the DPY19 family;nonetheless,biological functions of protein C-mannosylation are not yet fully understood,especially in tumor *** mimicry(VM)is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells,enabling the tumors to form matrix-embedded vasculogenic structures,containing plasma and blood cells to meet the metabolic demands of rapidly growing *** this study,we focused on DPY19L3,a C-mannosyltransferase,and aimed to unravel its role in *** of DPY19L3 inhibited the formation of VM in HT1080 human fibrosarcoma ***-expression of wild-type DPY19L3 recovered VM formation;however,DPY19L3 isoform2,an enzymatic activity-defect mutant,did not restore it,suggesting that the C-mannosyltransferase activity of DPY19L3 is crucial to its ***,the knockdown of DPY19L3 in MDA-MB-231 breast cancer cells hindered its network formation ***,our findings suggest that DPY19L3 is required for VM formation and stipulate the relevance of C-mannosylation in oncogenesis.

关键词： C-mannosylation Vasculogenic mimicry DPY19L3

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Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)高熵金属玻璃的热稳定性和热塑成形性

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稀有金属材料与工程 2024年第1期53卷 1-7页

作者： Cardinal Sandrine Pelletier Jean-Marc kato Hidemi 里昂大学里昂国立应用科学学院法国里昂F-69621 东北大学金属材料研究所日本仙台980-8577

采用差示扫描量热法、X射线衍射和热力学分析研究了Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)高熵金属玻璃(HEMG)的热稳定性和热力学性能。结果表明,与其他经典贵金属基金属玻璃相比,Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)HEMG具有相当的性能... 详细信息

采用差示扫描量热法、X射线衍射和热力学分析研究了Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)高熵金属玻璃(HEMG)的热稳定性和热力学性能。结果表明,与其他经典贵金属基金属玻璃相比,Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)HEMG具有相当的性能和鲜明的特点。

关键词：高熵合金金属玻璃热塑性成形结晶

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Natural history of asymptomatic gallbladder stones in clinic without beds:A long-term prognosis over 10 years

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World Journal of Clinical Cases 2024年第1期12卷 42-50页

作者： Yuji Sakai Toshio Tsuyuguchi Hiroshi Ohyama Junichiro Kumagai Takashi Kaiho Masayuki Ohtsuka Naoya kato Tadao Sakai Department of Gastroenterology Sakai ClinicKimistu 299-1162Japan Department of Gastroenterology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Gastroenterology Chiba Prefectural Sawara HospitalChiba Prefectural Sawara HospitalSawara 287-0003Japan Department of Gastroenterology Kimitsu Central HospitalKisarazu 292-8535Japan Department of Surgery Kimitsu Central HospitalKisarazu 292-8535Japan Department of General Surgery Graduate School of MedicineChiba UniversityChiba 260-8677Japan

BACKGROUND Several studies have explored the long-term prognosis of patients with asymp-tomatic gallbladder *** reports were primarily conducted in facilities equipped with beds for addressing symptomatic *** To report the long-term prognosis of patients with asymptomatic gallbladder stones in clinics without bed *** We investigated the prognoses of 237 patients diagnosed with asymptomatic gallbladder stones in clinics without beds between March 2010 and October *** symptoms developed,patients were transferred to hospitals where appropriate treatment was *** investigated the asymptomatic and survival periods during the *** Among the 237 patients,214(90.3%)remained asymptomatic,with a mean asymptomatic period of 3898.9279±46.871 d(50-4111 d,10.7 years on average).Biliary complications developed in 23 patients(9.7%),with a mean survival period of 4010.0285±31.2788 d(53-4112 d,10.9 years on average).No patient died of biliary *** The long-term prognosis of asymptomatic gallbladder stones in clinics without beds was *** the condition became symptomatic,the patients were transferred to hospitals with beds that could address it;thus,no deaths related to biliary complications were *** finding suggests that follow-up care in clinics without beds is possible.

关键词： Gallbladder stone Acute cholangitis Acute cholecystitis Asymptomatic gallbladder stone Symptomatic gallbladder stone

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Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

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