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Assessment for the minimal invasiveness of laparoscopic liver resection by interleukin-6 and thrombospondin-1

World Journal of Hepatology 2022年第1期14卷 234-243页

作者： Takayoshi Kaida Hiromitsu Hayashi Hiroki Sato Shotaro Kinoshita Takashi Matsumoto Yuta Shiraishi Yuki Kitano takaaki higashi Katsunori Imai Yo-ichi Yamashita Hideo Baba Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto 860-8556Japan

BACKGROUND Laparoscopic surgery has been introduced as a minimally invasive technique for the treatment of various ***,there are few reports that have scientifically investigated the minimally invasive nature of laparoscopic liver resection(LLR).AIM To investigate whether LLR is scientifically less invasive than open liver *** During December 2011 to April 2015,blood samples were obtained from 30 patients who treated with laparoscopic(n=10,33%)or open(n=20,67%)partial liver resection for liver *** levels of serum interleukin-6(IL-6)and plasma thrombospondin-1(TSP-1)were measured using ELISA kit at four time points including preoperative,immediate after operation,postoperative day 1(POD1)and ***,we investigated the impact of the operative approaches during partial hepatectomy on the clinical time course including IL-6 and *** Serum level of IL-6 on POD1 in laparoscopic hepatectomy was significantly lower than those in open hepatectomy(8.7 vs 30.3 pg/mL,respectively)(P=0.003).Plasma level of TSP-1 on POD3 in laparoscopic hepatectomy was significantly higher than those in open hepatectomy(1704.0 vs 548.3 ng/mL,respectively)(P=0.009),and have already recovered to preoperative level in laparoscopic *** patients with higher IL-6 Levels on POD1,plasma level of TSP-1 on POD3 was significantly lower than those in patients with lower IL-6 Levels on *** analysis showed that open approach was the only independent factor related to higher level of IL-6 on POD1[odds ratio(OR),7.48;95%confidence interval(CI):1.28-63.3;P=0.02].Furthermore,the higher level of serum IL-6 on POD1 was significantly associated with lower level of plasm TSP-1 on POD3(OR,5.32;95%CI:1.08-32.2;P=0.04)in multivariate *** In partial hepatectomy,laparoscopic approach might be minimally invasive surgery with less IL-6 production compared to open approach.

关键词： Laparoscopic surgery Liver resection Hepatectomy Minimal invasiveness Interleukin-6 Thrombospondin-1

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Ectopic hepatocellular carcinoma mimicking a retroperitoneal tumor:A case report

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World Journal of Gastroenterology 2020年第18期26卷 2268-2275页

作者： Yuki Adachi Hiromitsu Hayashi Toshihiko Yusa Toru Takematsu Kazuki Matsumura takaaki higashi Kensuke Yamamura Takanobu Yamao Katsunori Imai Yo-ichi Yamashita Hideo Baba Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto 8608556Japan

BACKGROUND An ectopic hepatocellular carcinoma(EHCC)arises from the ectopic liver which is defined as a hepatic organ or tissue not connected to surrounding *** is a rare disease and it is difficult to diagnose ***,the clinical features are not fully *** SUMMARY A retroperitoneal tumor(6 cm)was located at the dorsal side of the pancreas head on abdominal ultrasonography in an 81-year old woman positive for hepatitis C virus *** enhanced-computed tomography and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging showed viable HCC patterns with early enhancement and delayed *** tumor markers-serum alphafetoprotein and alpha-fetoprotein-L3%-were increased to 30.1 ng/m L and83.1%,*** induced by vitamin K absence or antagonist-Ⅱwas within normal levels(17 m AU/m L).Positron emission tomography-computed tomography showed strong accumulation into the tumor(Standardized Uptake Value max:13.8),and the tumor cytology following endoscopic ultrasoundguided fine needle aspiration showed poorly differentiated *** extirpation was performed,and operative findings showed that the retroperitoneal tumor was disconnected from the pancreas and the *** lymph nodes near the tumor were histologically *** histological examination,the tumor was finally diagnosed as EHCC with Arginase-1 positive *** We report our experience of a rare EHCC which was difficult to diagnose,and we present a review of the literature.

关键词： Ectopic hepatocellular carcinoma Differential diagnosis Retroperitoneal tumor Case report

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Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms

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World Journal of Clinical Oncology 2022年第6期13卷 520-528页

作者： Yosuke Nakao Hiromitsu Hayashi Yo-ichi Yamashita Ofuchi Takashi Kazuki Matsumura Norio Uemura Fumimasa Kitamura Rumi Itoyama Toshihiko Yusa Katsunobu Taki Tatsunori Miyata takaaki higashi Shigeki Nakagawa Hirohisa Okabe Katsunori Imai Hideo Baba Department of Gastroenterological Surgery Kumamoto UniversityKumamoto 860-8556Japan

BACKGROUND Although PNENs generally have a better prognosis than pancreatic cancers,some PNENs display malignant behavior including lymph node(LN)*** tumor resection can be the only potentially curative treatment for patients with resectable ***,the indications for LN dissection are still *** the last decade,minimally invasive surgery such as laparoscopic pancreatic surgery(LPS)has been increasingly performed for pancreatic tumors including *** To investigate the risk factors for LN metastasis in PNENs and to select appropriate patients for limited surgery by *** From April 2001 to December 2019,92 patients underwent pancreatic resection for PNENs at Kumamoto University ***,82 patients were enrolled in this *** perioperative factors,we examined the predictive factors for LN metastasis in *** Among the 82 patients,the percentage of LN metastasis according to the pathological findings was 12%(10/82 cases).The median tumor size was 12 mm(range:5-90 mm).The median tumor size in the LN-positive group(37 mm)was significantly larger than that in the LN-negative group(12 mm)(P=0.0001).Multivariate analyses revealed that larger tumor size(≥20 mm)was an independent risk factor for LN metastasis(odds ratio 16.8,P=0.0062).In patients with small tumors(≤10 mm),LN metastasis was not *** Larger tumor size(≥20 mm)is an independent risk factor for LN metastasis in *** smaller PNENs(≤10 mm),we may be able to choose limited surgery without LN dissection.

关键词： Lymph node metastasis Pancreatic neuroendocrine neoplasms Risk factor Tumor size

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Linear seesaw model with a modular S_(4)flavor symmetry

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Chinese Physics C 2022年第5期46卷 11-19页

作者： takaaki Nomura Hiroshi Okada College of Physics Sichuan UniversityChengdu 610065China Asia Pacific Center for Theoretical Physics(APCTP)-Headquarters San 31 Hyoja-dongNam-guPohang 790-784Korea Department of Physics Pohang University of Science and TechnologyPohang 37673Korea

We discuss a linear seesaw model with a field content as minimum as possible,introducing a modular S_(4)using gauged U(1)_(B−L) *** to the rank two neutrino mass matrix,we obtain a vanishing neutrino mass eigenvalue,and only the normal mass hierarchy of neutrinos is favored via the modular S_(4)*** our numericalΔχ^(2)analysis,we especially determine a relatively sharp prediction on the sum of neutrino masses to be approximately 60 meV,in addition to other predictions.

关键词： neutrino mass linear seesaw mechanism modular S_(4)flavor symmetry

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东日本大地震后某校舍抗震加固改造与效果评估实验研究

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噪声与振动控制 2024年第3期44卷 246-252页

作者：李亮大久保孝昭杨建江张大英天津仁爱学院建筑工程学院天津301636 日本国立广岛大学工学研究科日本广岛7308511 郑州航空工业管理学院土木建筑学院郑州450000

2011年东日本大地震后,校舍建筑的抗震加固变得极为迫切。针对日本某校舍建筑的抗震加固工程展开计算分析及实验研究。首先阐述既有校舍建筑的结构特征及抗震鉴定结果,提出纵向采用钢支撑框架提高强度,首层横向新设剪力墙以及增厚楼梯... 详细信息

2011年东日本大地震后,校舍建筑的抗震加固变得极为迫切。针对日本某校舍建筑的抗震加固工程展开计算分析及实验研究。首先阐述既有校舍建筑的结构特征及抗震鉴定结果,提出纵向采用钢支撑框架提高强度,首层横向新设剪力墙以及增厚楼梯间楼板的加固方案。随后,利用无线振动测试系统在校舍建筑抗震加固前后进行常时微动测试实验,分别从整体与局部角度分析加固前后校舍建筑加速度响应、固有周期以及振型等参数变化。最后,对比分析有限元计算及测试结果,阐述抗震加固方法及位置对原有建筑的性能影响,验证抗震加固方法的有效性。结果表明:采用钢支撑框架的加固方法有效提高既有校舍建筑的强度,加固后加速度响应值约降低至加固前的1/3,加固方法起到提高整体强度、改善刚度分布及结构整体性作用;固有周期以及加速度响应放大倍率的变化与该校舍抗震加固方法较吻合,表明基于振动测试的研究方法能够有效评估抗震加固措施的效果。研究成果可为既有校舍建筑的抗震加固方案选取及性能评估提供参考。

关键词：振动与波校舍建筑钢支撑框架抗震加固常时微动结构计算

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The role of biomass energy in a 100%renewable energy system for Akita prefecture,Japan

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Energy Storage and Saving 2022年第3期1卷 148-152页

作者： takaaki Furubayashi Graduate School of Engineering Science Akita UniversityAkita0108502Japan

This study aims to add the biomass power to the 100%renewable energy system for Akita prefecture in the previous study,and to analyze the energy cost and availability of each *** was assumed that the onshore wind power potential would be installed,and the target area was *** heat and transportation demand were supplied using renewable electricity and carbon free *** renewable energies and electricity demand were analyzed,and the surplus electricity amount was *** the electricity demand cannot meet renewable energy,the shortage was supplied by *** scenarios were considered such as“no biomass”scenario that the biomass power was not installed,“supply shortage”scenario that the biomass power operated when the electricity demand could not meet other renewable energy,and“baseload”scenario that the biomass power operated *** a result,although installed biomass power capacity was much smaller than installed wind power,the biomass power reduced the required battery capacity and increased its *** energy costs of all demand sector in“baseload”scenario were smaller than“no biomass”scenario.

关键词： 100%renewable energy system Biomass power Battery Hydrogen Wind power Rural area

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Geographic distribution of arsenic contamination in the Himalayan Rivers flowing through Pakistan: Implications for its natural source and effects of anthropogenic activities

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International Journal of Sediment Research 2023年第4期38卷 543-555页

作者： Ishtiaque Hussain Hafiz Ur.Rehman takaaki Itai Junaid Ali Khattak Abida Farooqi Environmental Geochemistry Laboratory Department of Environmental Sciences Faculty of Biological Sciences Quaid-i-Azam University Department of Environmental Sciences University of Baltistan Skardu Graduate School of Sciences and Engineering Kagoshima University Department of Earth and Planetary Environmental Science (UG) Graduate School of Science The University of Tokyo Department of Earth and Planetary Physics (UG) Graduate School of Science The University of Tokyo Department of Earth and Planetary Science (GR) Graduate School of Science The University of Tokyo

Arsenic(As) in natural hydrological systems is known as a worldwide major environmental concern. A geochemical and sedimentological study was done to ascertain the origin and geographical distribution of As in surface water and fluvial sediment collected from the floodplains/basins of the River Indus and its four major tributaries that drain through the northern Pakistan. The hydrogeochemical compositions of all five rivers were similar with calcium(Ca2+) and bicarbonate(HCO3-) being the dominating ions. The concentration of As ranged from 0.62-24.05 μg/L(average 3.7 ± 3.5 μg/L, n = 61) in river water, 2.3-23.4 mg/kg(average 5.7 ± 3.9 mg/kg) in suspended sediment, and 2.0-13 mg/kg(average4.13 ± 2.3 mg/kg) in fluvial sediment. Various approaches were used, including mineralogical, sequential extraction, geochemical, and statistical analyses to investigate the distribution, behavior, and potential sources of As in the sediment. The effect of geological factors on the distribution of As was also *** noticeable changes in the relative abundance of minerals were observed in the sediment at different locations along the river. Both mineralogical and statistical analyses showed that silicate minerals like muscovite, biotite, and chloride are the main As reservoir while oxides minerals like hematite and magnetite, which are minor components in the sediment are second largest As carrier. A geochemical baseline, using the normalization and cumulative frequency distribution curves was constructed for *** estimated mean human contribution of As was 3.4% in the Indus River, 1.9% in the Jhelum River, 13.7%in the Chenab River, 17.5% in the Ravi River and 5.4% in the Sutlej River, indicating relatively higher effects of anthropogenic activity along the Chenab River and Ravi River. The almost negligible effects of anthropogenic activities were additionally confirmed through the pollution assessment parameters estimated from the geo-enrichment, contamination factors, and ac

关键词： Arsenic Indus basin Geochemical baseline Source Contamination assessment

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Material conversion from paper sludge ash in NaOH solution to synthesize adsorbent for removal of Pb^(2+),NH_4^+and PO_4^(3-) from aqueous solution

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Journal of Environmental Sciences 2011年第5期23卷 718-724页

作者： takaaki Wajima Kenzo Munakata Faculty of Engineering and Resource Sciences Akita University

Material conversion from paper sludge ash （PSA） in NaOH solution was attempted to synthesize the adsorbent for removal of inorganic pollutants, such as Pb^2＋, NH^4＋ and PO4^3- from aqueous solution. PSA of 0.5 g was added into 10 mL of 3 mol/L NaOH solution, and then heated at 80, 120, and 160℃ for 6-48 hr to obtain the product. PSA mainly composed of two crystalline phases, gehlenite （Ca2Al2SiO7） and anorthite （CaAl2Si2O8）, and amorphous phase. Hydroxysodalite （Na6Al6Si6O24-8H2O） was formed at 80℃, and anorthite dissolved, whereas gehlenite remained unaffected. Katoite （Ca3Al2SiO4（OH）8） was formed over 120℃, and hydroxycancrinite （Nas（OH）2Al6Si6O24·2H2O） was formed at 160℃, due to the dissolution of both gehlenite and anorthite. Specific surface areas of the products were almost same and were higher than that of raw ash. Cation exchange capacities （CECs） of the products were also higher than that of raw ash, and CEC obtained at lower temperature was higher. Removal abilities of products for Pb^2＋, NH4＋, and PO4^3- were higher than that of raw ash. With increasing reaction temperature, the removal efficiencies of Pb^2＋ and NH4＋ decreased due to the decrease of CEC of the product, while removal efficiency for PO4^3- was almost same. The concentrations of Si and AI in the solution and the crystalline phases in the solid during the reaction explain the formation of the product phases at each temperature.

关键词： paper sludge ash hydrothermal synthesis gehlenite anorhite heavy metal ion ammonium ion phosphate ion

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Balloon venoplasty for disdialysis syndrome due to pacemakerrelated superior vena cava syndrome with chylothorax postbacteraemia: A case report

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World Journal of Clinical Cases 2023年第35期11卷 8364-8371页

作者： Satomi Yamamoto Michitsugu Kamezaki Junichi Ooka Toru Mazaki Yoshiaki Shimoda takaaki Nishihara Yoko Adachi Department of Nephrology Kobe Central HospitalKobe 651-1145Japan Department of Cardiology Kobe Central HospitalKobe 651-1145Japan

BACKGROUND Although superior vena cava(SVC)syndrome has also been reported as a late complication of pacemaker(PM)implantation,acute onset of SVC syndrome caused by disdialysis syndrome in patients with PM implantation is very *** are no specific therapies or *** SUMMARY A 96-year-old woman receiving dialysis was implanted with a PM due to sick sinus *** was referred to our facility for chest discomfort experienced during *** examination,unilateral pleural effusion on the right side was cloudy with a foul *** patient was diagnosed with pyothorax and treated with *** the effusion was reduced,it gradually reaggravated and remained *** this case,SVC syndrome,which is generally considered a late complication after PM implantation,rapidly developed following the bacteraemia,resulting in impaired venous return,chylothorax,and disdialysis *** catheter intervention for SVC stenosis,the patient’s symptoms promptly *** patient has been recurrence-free for a *** Acute SVC syndrome can cause dysdialysis in PM-implanted *** intervention alone has improved this condition for a traceable period.

关键词： Superior vena cava syndrome Pacemaker implantation complications Disdialysis Case report

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Potentials of GHG reductions from wastewater treatment for the CDM

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Science China(Technological Sciences) 2011年第7期54卷 1649-1654页

作者： takaaki FURUBAYASHI Toshihiko NAKATA Department of Management Science & Technology Graduate school of Engineering Tohoku University

The study aims to evaluate the potential of GHG (greenhouse gas) reductions by installing an anaerobic digester in a wastewater treatment facility in Southeast Asia. Then the break-even point of additional investment to reduce GHG is obtained by exchanging carbon price as emissions credits. In the project scenario, the wastewater treatment system has the digester, where methane (biogas) is produced and recovered. Compared with the baseline scenario, the biogas has calorific value to produce heat and electricity, and can substitute fossil fuels for power generation. The objective of the study is to define the relationship between CERs (certified emission reductions) and investment costs, and the beak-even point, finding out the dominant parameters in the system. Financial parameters such as capital costs and operating costs are considered to evaluate the investment costs. The result shows that the methane recovery reduces 54% of GHG emissions. Although the substitution of the biogas for the fossil fuels reduces only 6% of the GHG emissions, the electricity output can satisfy the electricity consumption. The results also show that the maximum CER credit is 73000 t-CO 2 e/a, and the GHG reduction cost is 14 USD/t-CO 2 e.

关键词：温室气体排放量清洁发展机制污水处理废水处理系统盈亏平衡点投资成本废水处理设施温室气体减排

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