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Improving Friend Recommendation for Online Learning with Fine-Grained Evolving Interest

Journal of Computer Science & Technology 2022年第6期37卷 1444-1463页

作者： Ming-Min Shao Wen-Jun Jiang Jie Wu Yu-Qing shi tak.shing Yum Ji Zhang College of Computer Science and Electronic Engineering Hunan UniversityChangsha 410082China Department of Computer and Information Sciences Temple UniversityPhiladelphia 19122U.S.A. School of Computer Science and Engineering Northeastern UniversityShenyang 110819China Department of Information Engineering Chinese University of Hong KongHong Kong 999077China Department of Mathematics and Computing University of Southern QueenslandBrisbaneQLD 4350Australia

Friend recommendation plays a key role in promoting user experience in online social networks(OSNs).However,existing studies usually neglect users’fine-grained interest as well as the evolving feature of interest,which may cause unsuitable *** particular,some OSNs,such as the online learning community,even have little work on friend *** this end,we strive to improve friend recommendation with fine-grained evolving interest in this *** take the online learning community as an application scenario,which is a special type of OSNs for people to learn courses *** partners can help improve learners’learning effect and improve the attractiveness of *** propose a learning partner recommendation framework based on the evolution of fine-grained learning interest(LPRF-E for short).We extract a sequence of learning interest tags that changes over ***,we explore the time feature to predict evolving learning ***,we recommend learning partners by fine-grained interest *** also refine the learning partner recommendation framework with users’social influence(denoted as LPRF-F for differentiation).Extensive experiments on two real datasets crawled from Chinese University MOOC and Douban Book validate that the proposed LPRF-E and LPRF-F models achieve a high accuracy(i.e.,approximate 50%improvements on the precision and the recall)and can recommend learning partners with high quality(e.g.,more experienced and helpful).

关键词： online social network friend recommendation fine-grained interest evolving feature tag online learning community

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Structural, densitometric and biomechanical evaluations of Chinese patients with long-term bisphosphonate treatment

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Chinese Medical Journal 2013年第1期126卷 27-33页

作者： LEUNG Kwok-sui TANG Ning James Griffith CHOY tak-Kee HUNG Vivian Wing-Yin MOK Hoi-Wa shi Lin LEUNG Ping-Chung CHEUNG Wing-Hoi Department of Orthopaedics and Traumatology and Bone Quality and Health Center The Chinese University of Hong Kong Shatin Hong Kong SAR China Department of Imaging and Interventional Radiology The Chinese University of Hong Kong Shatin Hong Kong SAR China The Jockey Club Center for Osteoporosis Care and Control The Chinese University of Hong Kong Shatin Hong Kong SAR China Orthopaedic Research Laboratory of Translational MedicineResearch and Development Center Institute of Biomedical andHealth Engineering Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences China

Background The association of long-term bisphosphonate treatment for osteoporosis and related safety problems such as atypical fractures were not clearly defined. This study was to evaluate the structural, densitometric and biomechanical properties of the prolonged bisphosphonate-loaded bones. Methods Bone mineral density （BMD） at hip and femoral midshaft, bone cross-sectional area, moment of inertia of both femurs, bone formation and resorption biochemical markers were compared between 28 elderly with at least 4 years of bisphosphonate treatment from 2002 through 2006 and age-matched group of 37 elderly. Results The total hip BMD and t-score were found not different between two groups. However, bisphosphonate treated patients were found to have significantly lower bone mineral content in the femoral shaft （P 〈0.05）; morphological study showed lower cross-sectional area in subtrochanteric and mid-diaphyseal region and thus significantly lower moment of inertia （P 〈0.01）. High resolution-peripheral quantitative computed tomography showed significantly decreased trabeculardensity, bone volume ratio, trabecular number but increased trabecular spacing in tibia and distal radius. Finite element analysis further confirmed significantly lower stiffness and failure load in tibia. Biochemical studies also showed lower bone resorption and severely suppressed bone formation activity （P 〈0.001）. Conclusions The unchanged total hip BMD between two groups confirmed the beneficial effects of bisphosphonate on trabecular bone, thus preventing osteoporotic fractures at large in previous studies. However, the inferior structural, densitometric and biomechanical properties at cortical bones, especially femur midshaft, need a special attention to look into the association between long-term bisphosphonate intake and the occurrence of stress fractures. When patients taking bisphosphonate complain of proximal thigh pain or discomfort, plain X-ray film can be the first line screening. All

关键词： bisphosphonate bone mineral density moment of inertia HR-pQCT cortical bone

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Caenorhabditis elegans mom-4 is required for the activation of the p38 MAPK signaling pathway in the response to Pseudomonas aeruginosa infection

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Protein & Cell 2013年第1期4卷 53-61页

作者： Ajing Xu Guojun shi Feng Liu Baoxue Ge Department of Pharmacology Xinhua HospitalSchool of MedicineShanghai 200092China Shanghai pulmonary hospital Tongji University School of MedicineShanghai 200092China Lab of Signal Transduction Institute of Health SciencesShanghai Institutes for Biological SciencesChinese Academy of Sciences and Shanghai Jiao-Tong University School of MedicineShanghai 200025China Graduate School of the Chinese Academy of Sciences Beijing 100049China

The p38 mitogen-activated protein kinase(MAPK)plays an evolutionarily conserved role in the cellular re-sponse to microbial infection and environmental *** of p38 is mediated through phosphorylation by upstream MAPKK,which in turn is activated by *** the Caenorhabditis elegans,the p38 MAPK(also called PMK-1)signaling pathway has been shown to be required in its resistance to bacterial ***,how different upstream MAP2Ks and MAP3Ks specifically contribute to the activation of PMK-1 in response to bacterial infection still is not clearly *** using double-stranded RNA-mediated interference(RNAi)and genetic mutants of ***,we demonstrate that *** MOM-4,a mammalian tak1 homolog,is required for the resistance of *** to a *** *** have also found that the MKK-4 of *** is required for *** resistance,but not through the regulation of *** summary,our results indicate that different upstream MAPKKKs or MAPKKs regulate the activation of PMK-1 in response to ***.

关键词： C.elegans MAPK innate immunity p38 P.aeruginosa PA-14 MOM-4

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Coronary bifurcation angle from 3-D predicts clinical outcomes after stenting bifurcation lesions

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Chinese Medical Journal 2012年第12期125卷 2083-2088页

作者： CHEN Shao-liang Teguh Santoso ZHANG Jun-jie YE Fei XU Ya-wei FU Qiang KAN Jing Chitprapai Paiboon ZHOU Yong DING shi-qing tak W Kwan Department of Cardiology Nanjing First Hospital NanjingMedical University Nanjing Jiangsu 210006 China Department of Cardiology Medistra Hospital University ofIndonesia Medical School Jakarta Indonesia Department of Cardiology Shanghai 10th People＇s HospitalShanghai 200072 China Department of Cardiology Xuzhou Central Hospital XuzhouJiangsu 221009 China Department of Cardiology Bangkok General Hospital BangkokThailand Department of Cardiology Zhangjiagang People＇s HospitalZhangjiagang Jiangsu 215600 China Department of Cardiology Huainan Xinhua Hospital HuainanAnhui 232038 China Department of Cardiology Beth Israel Hospital NewYork USA

Background The predictive value of bifurcation angle （BA） for worse events after stenting bifurcation lesions remains to be unknown. The present study was to investigate the dynamic change of BA and clinical relevance for patients with coronary bifurcation lesions treated by drug-eluting stent （DES）. Methods BA was calculated by 3-D quantitative coronary analysis from 347 patients in DKCRUSH-II study. Primary endpoint was the occurrence of composite major adverse cardiac events （MACE） at 12-month, including cardiac death, myocardial infarction （MI） and target vessel revascularization （TVR）. Secondary end points were the rate of binary restenosis and stent thrombosis at 12-month. Results Stenting was associated with the reduction of distal BA. The cut-off value of distal BA for predicting MACE was 60°. Distal BA in 〈60° group had less reduction after stenting （（-1.96＋13.58）°vs. （-12.12±23.58）°, P 〈0.001）; two-stent technique was associated with significant reduction of distal BA （△（-4.05±14.20）°）, compared to single stent group （4＋1.55±11.73, P=0.003）; the target lesion revascularization （TLR）, TVR and MACE rate was higher in one-stent group （16.5%, 19.0% and 21.5%）, compared to two-stent group （3.8%, P=0.002; 7.5%, P=0.016; and 9.8%, P=0.024）, respectively. Among patients in ≥60° group, there were no significant differences in distal BA, stent thrombosis （ST）, MI, MACE, death, TLR, TVR between one- and two-stent groups; after stenting procedure, there was only slight change of distal BA in left anterior descending （LAD）-Ieft circumflex （LCX） subgroup （from （88.54±21.33）° at baseline to （82.44±31.72）° post-stenting）, compared to either LAD-diagonal branch （Di）, or LCX-obtuse marginal branch （OM）, or IRCA distal （RCAd）（all P 〈0.001 ）. Conclusion Two-stent technique was associated with significant reduction of distal BA. DK crush stenting had reduced rate of MACE in patients in 〈60° group, compared to one-stent technique.

关键词： coronary bifurcation lesions bifurcation angle major adverse cardiac events ROC curve

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Comparison of paclitaxal vs. sirolimus eluting stents with bio-degradable polymer for the treatment of coronary bifurcation lesions： subgroup analysis from DKCRUSH-I and DKCRUSH-II studies

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Chinese Medical Journal 2012年第19期125卷 3382-3387页

作者： CHEN Shao-liang Gary Mintz Teguh Santoso ZHANG Jun-jie YE Fei XU Ya-wei FU Qiang KAN Jing Chitprapai Paiboon ZHOU Yong DING shi-qin tak W Kwan Department of Cardiology Nanjing hrst Hospital NanjlngMedical University Nanjing 210006 China Cardiovascular Research Foundation New York NY US Department of Cardiology Medistra Hospital University ofIndonesia Medical School Jakarta Indonesia Department of Cardiology Shanghai 10th People's HospitalShanghai 200072 China Department of Cardiology Xuzhou Central Hospital XuzhouJiangsu 221009 China Department of Cardiology Bangkok General Hospital BangkokThailand Department of Cardiology Zhangjiagang People's HospitalZhangjiagang Jiangsu 215600 China Department of Cardiology Huainan Xinhua Hospital HuainanAnhui 232038 China Department of Cardiology Beth Israel Hospital NewYork USA

Background The difference in clinical outcome between paclitaxal-eluting stents （PES） and sirolimus-eluting stents with bio-degradable polymer （SES-BDP） for bifurcation lesions remains unclear. The present study aimed to investigate the one-year clinical outcome after DK crush stenting using PES （maxusTM） MS. SES-BDP （ExcelTM） from our database. Methods A total of 275 patients （90 from the DKCRUSH-I and 185 from the DKCRUSH-II study） were studied. The primary endpoint was the occurrence of major adverse cardiac events （MACE） at 12 months; including cardiac death, myocardial infarction （MI）, or target vessel revascularization （TVR）. The rate of binary restenosis and stent thrombosis served as secondary endpoints. Results At follow-up, minimal luminal diameter （MLD） in the Taxus group was （2.11＋0.66） mm, with resultant increased target lesion revascularization （TLR） 12.2% and TVR 14.4%, significantly different from the Excel group; （2.47±0.56） mm, P 〈0.001, 3.2%, P=0.006, 4.9%, P=0.019, respectively. As a result there was a significant difference in MACE between the Taxus （20.0%） and Excel （10.3%, P=0.038） groups. Overall stent thrombosis was monitored in 11 patients （4.0%）, with five in the Excel group （2.7%） and six in the Taxus group （6.7%）. All stent thrombosis in the Excel group was classified as early, and all were defined as late in the Taxus group. Conclusion The Excel stent had lower rate of stent thrombosis, TLR, TVR, and composite MACE at 12-month after an indexed stenting procedure, compared to the Taxus stent.

关键词： paclitaxal-eluting stent sirolimus-eluting stent bio-degradable polymer," coronary bifurcation lesions

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cFLIPS regulates alternative NLRP3 inflammasome activation in human monocytes

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Cellular & Molecular Immunology 2023年第10期20卷 1203-1215页

作者： Yuhui Gao shi Yu Mengdan Chen Xun Wang Lei Pan Bin Wei Guangxun Meng School of Life Sciences Shanghai UniversityShanghai200444China The Center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology&ImmunologyUniversity of Chinese Academy of SciencesShanghai200031China Shanghai Blood Center Shanghai200051China Pasteurien College Soochow UniversitySuzhou215006JiangsuChina Nanjing Advanced Academy of Life and Health Nanjing211135JiangsuChina Department of Basic Research Guangzhou LaboratoryGuangzhou International Bio-lslandGuangzhou 510o05 GuangdongChina

The innate immune responses,including inflammasome activation,are paramount for host defense against pathogen *** contrast to canonical and noncanonical inflammasome activation,in this study,heat-killed gram-negative bacteria(HK bacteria)were identified as single-step stimulators of the NLRP3 inflammasome in human monocytes,and they caused a moderate amount of IL-1βto be released from *** course experiments showed that this alternative inflammasome response was finished within a few *** analysis showed that the intrinsically limited NLRP3 inflammasome activation response was due to the negative regulation of caspase-8 by the short isoform of cFLIP(cFLIPs),which was activated by NF-κ*** contrast,overexpressed cFLIPS,but not overexpressed cFLIPL,inhibited the activation of caspase-8 and the release of IL-1βin response to HK bacteria infection in human ***,we demonstrated that tak1 activity mediated the expression of cFLIPs and was upstream and essential for the caspase-8 cleavage induced by HK bacteria in human *** functional specificity of cFLIPs and tak1 revealed unique responses of human monocytes to a noninvasive pathogen,providing novel insights into an alternative regulatory pathway of NLRP3 inflammasome activation.

关键词： cFLIPS gram-negative bacteria NLRP3 inflammasome human monocyte

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Electroacupuncture Attenuates Immune-Inflammatory Response in Hippocampus of Rats with Vascular Dementia by Inhibiting TLR4/MyD88 Signaling Pathway

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Chinese Journal of Integrative Medicine 2022年第2期28卷 153-161页

作者： BU Yu LI Wen-shuang LIN Ji WEI Yu-wei SUN Qiu-ying ZHU shi-jie TANG Zhong-sheng School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang(550025)China Department of Hematology the Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang(550025)China

Objective:To investigate whether electroacupuncture(EA)alleviates cognitive impairment by suppressing the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)signaling pathway,which triggers immune-inflammatory responses in the hippocampus of rats with vascular dementia(VaD).Methods:The experiments were conducted in 3 parts and in total the Sprague-Dawley rats were randomly divided into 8 groups by a random number table,including sham,four-vessel occlusion(4-VO),4-VO+EA,4-VO+non-EA,sham+EA,4-VO+lipopolysaccharide(LPS),4-VO+LPS+EA,and 4-VO+tak-242 *** VaD model was established by the 4-VO *** days later,rats were treated with EA at 5 acupoints of Baihui(DV 20),Danzhong(RN 17),Geshu(BL 17),Qihai(RN 6)and Sanyinjiao(SP 6),once per day for 3 consecutive *** subsets,lymphocyte transformation rates,and inflammatory cytokines interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)were measured to assess immune function and inflammation in VaD *** electron microscopy was used to observe the ultrastructure of nerve cells in the *** levels of TLR4,MyD88,IL-6,and TNF-αwere detected after EA ***4/MyD88 signaling and cognitive function were also assessed after intracerebroventricular injection of TLR4 antagonist tak-242 or TLR4 agonist LPS with or without ***:Compared with the 4-VO group,EA notably improved immune function of rats in the 4-VO+EA group,inhibited the protein and mRNA expressions of TLR4 and MyD88 in the hippocampus of rats,reduced the expressions of serum IL-6 and TNF-α(all Ptak-242 and 4-VO+EA groups(P>0.05).Conclusions:EA attenuated cognitive impairment associated with immune inflammation by inhibition of the TLR4/MyD88 signaling ***,EA may be a promising alternative therapy for the treatment of VaD.

关键词： electroacupuncture vascular dementia immune-inflammation toll-like receptor 4/myeloid differentiation factor 88 signaling pathway

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Determinants for asthma control, quality of life and use of complementary and alternative medicine in asthmatic pediatric patients in four cities

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World Journal of Pediatrics 2018年第5期14卷 482-491页

作者： Kam Lun Hon Yan Min Bao Kate C.Chan Kin Wai Chau Rong-Shan Chen Kun Tat Gary Cheok Wa Keung Chiu Li Deng Chun-Hui He Kin Mui Ieong Jeng Sum C.Kung Ping Lam Shu Yan David Lam Qun Ui Lee So Lun Lee Ting Fan Leung Theresa N.H.Leung Lei shi Ka Ka Siu Wei-Ping Tan Maggie Haitian Wang tak Wai Wong Bao-Jing Wu Ada Y.F.Yip Yue-Jie Zheng Daniel K.Ng Department of Pediatrics The Chinese University of Hong Kong 6/F Prince of Wales HospitalRoom 84042ShatinN.THong Kong SARChina Department ofR espiratory Diseases Shenzhen Children’s HospitalShenzhen 518026China Hong Kong Society of P ediatric Respirology and Aller gy Hong K ong S ARChina Pediatric Respiratory andSleep Disorders Center Room 1315DArgyle Centre Phase 1688 Nathan RoadMongkokKowloonHong K ong S ARChina Department of R espiration Guangzhou Women and Children’s Medical CenterGuangzhou 510623China Department of P ediatrics Kiang Wu HospitalMacaoChina Department of P ediatrics and A dolescent Medicine United Christian Hospital130Hip Wo StreetKwun TongHong K ong S ARChina Department of P ediatrics Central Hospital Conde S.JanuarioMacaoChina Department of P ediatrics and A dolescent Medicine Caritas Medical Center111Wing Hong StreetSham Shui PoHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Tuen Mun Hospital23 Tsing Chung Koon RoadTuen MunNewT erritoriesHongK ongS ARChina Department of P ediatrics and A dolescent Medicine Princess Margaret Hospital2-10 Princess Margaret Hospital RoadLai Chi KokKowloonHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Queen Mary Hospital102Pokfulam RoadHong K ong S ARChina Department of P ediatrics and A dolescent Medicine The University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Pamela Youde Nethersole Eastern Hospital3Lok Man RoadChaiwanHong K ong S ARChina Department of P ediatrics The University of Hong Kong-Shenzhen Hospital1Haiyuan 1st RoadFutianShenzhenChina Department of P ediatrics and A dolescent Medicine Kwong Wah Hospital25 Waterloo RoadKLN Hong K ong S ARChina Department of P ediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China JC School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescen

Background Asthma is a significant chronic health problem worldwide. Management aims at disease control by reducing functional impairment and exacerbations and improving quality of life (QoL). We report a multi-center study to survey asthma control and QoL in four cities in the Pearl River Delta. Methods The conjoint survey involved ten Hong Kong pediatric hospitals/units, two Shenzhen hospitals, two Macao hos-pitals, and two Guangzhou hospitals on asthma control (using Asthma Control Test) and QoL (Pediatric Allergic Disease Quality of Life Questionnaire, PADQLQ). Acceptability of a treatment is graded as very good/good/fair/poor. Results Good asthma control was only reported in 80% subjects in Hong Kong, but higher in sister cities (85–94%, P<0.001). Allergic rhinitis, 'incense burning', and 'smoker in family' were prevalent among the four cities. Logistic regres-sion showed better control of asthma was associated with better PADQLQ (B=?0.029, P < 0.001), better acceptability of bronchodilator (B=?1.488, P = 0.025), negatively with 'smoker in family' (B=?0.83, P = 0.015) and various PADQLQ domains. Conversely, worse PADQLQ was associated with allergic rhinitis severity (B=4.77, P <0.001), poor control of asthma (B=7.56, P <0.001), increased frequency of traditional Chinese medicine use (B=1.7, P < 0.05), increased fre-quency of bronchodilator usage (B=1.05, P < 0.05), 'smoker in family' (B=4.05, P < 0.05), and incense burning at home (B=3.9, P < 0.05). Conclusions There are some clinical and cultural differences among the four southern Chinese cities within the Guangdong province. This study identifies potentially modifiable environmental and treatment factors associated with poor asthma control and QoL for health-care interventions. Having a smoker in the family is independently associated with poor asthma control and QoL.

关键词： Asthma Complementary and alternative medicine Control Inhaled bronchodilator Inhaled corticosteroid Pediatric Allergic Disease Quality of Life Questionnaire Smoking Traditional Chinese medicine

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驱动力矩对汽车转向驱动分岔的影响分析

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汽车工程 2017年第10期39卷 1176-1186,1216页

作者：王宪彬施树明东北林业大学交通学院哈尔滨150040 吉林大学交通学院长春130025

为研究驱动力矩对汽车动力学稳定性的影响,以引入驱动力矩的5自由度汽车二维非线性动力学模型为基础,利用前轮转角作为中间变量,建立了相应的7自由度自治系统模型,分析了不同驱动方式下,驱动力矩对汽车转向驱动分岔的动力学特征的影响... 详细信息

为研究驱动力矩对汽车动力学稳定性的影响,以引入驱动力矩的5自由度汽车二维非线性动力学模型为基础,利用前轮转角作为中间变量,建立了相应的7自由度自治系统模型,分析了不同驱动方式下,驱动力矩对汽车转向驱动分岔的动力学特征的影响。以前轮驱动汽车为例,利用相空间、状态变量时间序列、功率谱密度和李雅普诺夫指数分析了驱动力矩对转向驱动分岔特征影响的动力学演变过程。结果表明:驱动力矩的大小将直接影响汽车动力学系统的分岔特征,在分析汽车的动力学分岔特征时应同时考虑前轮转角和驱动力矩两个分岔参数的影响。

关键词：汽车非线性动力学驱动力矩转向驱动耦合工况分岔混沌

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tak1 Deficiency in Macrophages Increases Host Susceptibility to Leishmania Infection

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Infectious Microbes & Diseases 2023年第3期5卷 127-136页

作者： Xiankai Cao Kossiwa C.Kokou shi Yu Mengdan Chen Junling Niu HervéLecoeur Eric Prina Gerald F.Späth Guangxun Meng The Center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology&ImmunologyUniversity of Chinese Academy of SciencesShanghaiChina Institute Pasteur Paris City UniversityINSERM U1201Molecular Parasitology and Signalling UnitParisFrance Pasteurien College Soochow UniversitySuzhouChina Nanjing Advanced Academy of Life and Health NanjingChina.

Leishmania parasites mainly infect macrophages and may cause severe immunopathologies in their host,which are called *** the current work,we infected human and mouse macrophages in vitro with Leishmania major,an etiological agent of cu-taneous leishmaniasis,and found that inhibition or deletion of the transforming growth factorβ–activated kinase 1(tak1)gene re-sulted in increased parasite *** vivo,following a challenge with ***,mice with a macrophage-specific deletion of tak1 showed increased clinical signs and higher parasite loads compared with wild-type ***1 deficiency in mouse macro-phages led to biased Th2 cell responses during the acute stage of infection,characterized by a decrease in interferon-γexpression,and increased expression of IL-4,IL-5 and ***,we found that,in the late stage of *** infection,excessive Th2-related cytokines led to high arginase 1 expression in mouse tissues and a significant reduction of NO production both locally and system-ically,resulting in compromised control of *** findings suggest that tak1 plays a vital role in host resistance to Leish-mania infection.

关键词： tak1 macrophage Leishmania major arginase 1 nitric oxide

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