Caenorhabditis elegans mom-4 is required for the activation of the p38 MAPK signaling pathway in the response to Pseudomonas aeruginosa infection

作     者：Ajing Xu Guojun Shi Feng Liu Baoxue Ge 

作者机构：Department of PharmacologyXinhua HospitalSchool of MedicineShanghai 200092China Shanghai pulmonary hospitalTongji University School of MedicineShanghai 200092China Lab of Signal TransductionInstitute of Health SciencesShanghai Institutes for Biological SciencesChinese Academy of Sciences and Shanghai Jiao-Tong University School of MedicineShanghai 200025China Graduate School of the Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2013年第4卷第1期

页      面：53-61页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 0703[理学-化学] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学] 

基　　金：supported by the National Basic Research Program(973 Program)(Nos.2012CB578100 and 2011CB505000) National Natural Science Foundation of China(Grant No.31030028) the Science and Technology Commission of Shanghai Municipality(Program 10JC1416400 and 12XD1406700) the Innovation Program of Shanghai Municipal Education Commission(Project 12ZZ117) from Cross-fund of Biomedical Engineering of Shanghai Jiaotong University 

主　　题：C.elegans MAPK innate immunity p38 P.aeruginosa PA-14 MOM-4 

摘      要：The p38 mitogen-activated protein kinase(MAPK)plays an evolutionarily conserved role in the cellular re-sponse to microbial infection and environmental *** of p38 is mediated through phosphorylation by upstream MAPKK,which in turn is activated by *** the Caenorhabditis elegans,the p38 MAPK(also called PMK-1)signaling pathway has been shown to be required in its resistance to bacterial ***,how different upstream MAP2Ks and MAP3Ks specifically contribute to the activation of PMK-1 in response to bacterial infection still is not clearly *** using double-stranded RNA-mediated interference(RNAi)and genetic mutants of ***,we demonstrate that *** MOM-4,a mammalian TAK1 homolog,is required for the resistance of *** to a *** *** have also found that the MKK-4 of *** is required for *** resistance,but not through the regulation of *** summary,our results indicate that different upstream MAPKKKs or MAPKKs regulate the activation of PMK-1 in response to ***.