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Chinese Medical Journal 2012年第17期125卷 3098-3103页

作者： Soo Young Park Joo Young Lee Won Young tak Young Oh Kweon mi Suk Lee Department of Internal Medicine Liver Research Institute Graduate School of Medicine Kyungpook National University Daegu Korea

Background In addition to hematopoietic effect, the erythropoietin is known as a multifunctional cytokine with anti-fibrosis and organ-protective activities. The purpose of this study was to evaluate the effect of recombinant human erythropoietin （rhEPO） on hepatic fibrosis and hepatic stellate cells （HSCs）. Methods Carbon tetrachloride （CCI4） induced hepatic fibrosis mice models were used for in vivo study and HSCs line for in vitro study. CCI4 and rhEPO （0,200 or 1000 U/kg） was injected intraperitoneally in BALB/c mice three times a week for 4 weeks. Immunohistochemistry and immunoblotting were performed to evaluate expressions of transforming growth factor-β1 （TGF-β1）, α-smooth muscle actin （α-SMA）, and fibronectin in explanted liver. Immunoblotting of α-SMA, phophorylated Smad-2 and Smad-2/3 was performed in HSCs treated with TGF-β1 and/or rhEPO. Results Expressions of TGF-β1, α-SMA, and fibronectin were increased in CCI4 injected mice livers, but significantly attenuated by co-treatment with CCI4 and rhEPO. Co-treatment of rhEPO markedly suppressed fibrosis in Masson＇s trichrome compared with treatment of only CCI4. TGF-β1 increased phosphorylated α-SMA, Smad-2 expressions in HSCs, which were decreased by rhEPO co-treatment. Conclusions Treatment of rhEPO effectively suppressed fibrosis in CCI4-induced liver fibrosis mice models. Anti-fibrosis effect of rhEPO could be related to inhibition of TGF-β1 induced activation of HSCs.

关键词： fibrosis erythropoietin transforming growth factor-beta hepatic stellate cell animal model

Overview of the Shenzhen Emergency Medical Service Call Pattern

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World Journal of Emergency Medicine 2012年第4期3卷 251-256页

作者： Shuk Man Lo Yi min Yu Lap Yip Larry Lee mi Ling Eliza Wong Sck Ying Chair Edward J Kalinowski tak Shing Jimmy Chan Accident and Emergency Department Alice Ho Miu Ling Nethersole Hospital Hong Kong China 120 Despatching Department 120 Despatching Department of Shenzhen Medical Emergency Center Shenzhen China The Nethersole School of Nursing Faculty of Medicine The Chinese University ofHong Kong Hong Kong China Department of EmergencyMedical Services Kapiolani Community College University of Hawaii USA

BACKGROUND：In Shenzhen, the Emergency Medical Service （EMS） system has been in service since 1997. This study aims to examine the operation of Shenzhen 120 EMS center and to identify the reasons of calling ***：In this retrospective quantitative descriptive study, the data from the Shenzhen 120 EMS registry in 2011 were ***：Shenzhen 120 EMS center is a communication command center. When the number of 120 are dialed, it is forwarded to the closest appropriate hospital for ambulance dispatch. In 2011, the Shenzhen 120 EMS center received 153 160 ambulance calls, with an average of 420 calls per day. Calling emergency services was mainly due to traffic accidents. Trauma and other acute diseases constituted a majority of ambulance transports. The adult patients aged 15-60 years are the principal users of EMS. There are no recognized ＇paramedic＇ doctors and nurses. The pre-hospital emergency service is under the operation of emergency departments of hospitals. Shenzhen at present does not have specialized pre-hospital training for doctors and nurses in posttrauma management. Moreover, specialized pre-hospital training, financial support, and public health education on proper use of EMS should be ***：The Shenzhen 120 EMS center has its own epidemiology characteristics. Traumatic injury and traffic accident are the main reasons for calling ambulance service. In-depth study emphasizing the distribution and characteristics of trauma patients is crucial to the future development of EMS.

关键词： Emergency Medical Service System Shenzhen Pre-hospital emergency care

Positive regulation of cell proliferation by the miR-1290-EHHADH axis in hepatocellular carcinoma

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Cancer Communications 2024年第6期44卷 705-709页

作者： Jinkwon Lee Gyeonghwa Kim Tae-Su Han Eunsun Jung Taesang Son Kwangho Kim Kiyoon Kwon Yuna Roh Tae Young Ryu In Hwan Tae Yunsang Kang Byungheon Lee Yu Rim Lee Soo Young Park Won Young tak Dae-Soo Kim mi-Young Son Keun Hur Hyun-Soo Cho Stem Cell Convergence Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea Department of Bioscience Korea University of Science and TechnologyDaejeonRepublic of Korea Department of Biochemistry and Cell Biology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Biological Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Internal Medicine School of MedicineKyungpook National University HospitalDaeguRepublic of Korea Department of Biomedical Convergence Science and Technology School of ConvergenceKyungpook National UniversityDaeguRepublic of Korea

Hepatocellular carcinoma(HCC)is the second most common cancer and the third leading cause of cancer-related death worldwide[1].Recently,HCC incidence and mortality rates have further increased due to changes in the global social environment and dietary habits[2].HCC is treated by surgical resection or combination chemotherapy,but the overall survival rate of HCC patients has not improved,and the recurrence rate is still high due to strong invasiveness and resistance to chemotherapy[3].

关键词： chemotherapy mortality cancer

tak1 is essential for MAIT cell development and the differentiation of MA/T1 and MA/T17

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Cellular & Molecular Immunology 2023年第7期20卷 854-856页

作者： Rachel Krevh Jie Wang Bobby Zuniga Jugmohit Toor Kalpana Subedi Li Zhou Qing-Sheng mi Center for Cutaneous Biology and Immunology Research Department of DermatologyHenry Ford HealthDetroitMUSA Immunology Research Program Henry Ford Cancer InstituteHenry Ford HealthDetroitMIUSA Department of Internal Medicine Henry Ford HealthDetroitMIUSA Department of Medicine College of Human MedicineMichigan State UniversityEast LansingMI 48824USA

Mucosal-associated invariant T(MAIT)cells are unconventional T cells that have been conserved throughout mammalian evolution,displaying innate and effector-like qualities[1,2].MAIT cells express a semi-invariant T-cell receptor,which recognizes vitamin B metabolites produced by various bacteria and yeast organisms,presented on the restriction molecule major histocompatibility complex(MHC)-related protein-1(MR1)[3].In mice,MAIT cells undergo three developmental stages in the thymus,giving rise to two subsets,MAIT1 and MAIT17,which secrete IFN-and IL-17 to combat infections[4,5].

关键词： vitamin invariant giving

Coronary bifurcation angle from 3-D predicts clinical outcomes after stenting bifurcation lesions

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Chinese Medical Journal 2012年第12期125卷 2083-2088页

作者： CHEN Shao-liang Teguh Santoso ZHANG Jun-jie YE Fei XU Ya-wei FU Qiang KAN Jing Chitprapai Paiboon ZHOU Yong DING Shi-qing tak W Kwan Department of Cardiology Nanjing First Hospital NanjingMedical University Nanjing Jiangsu 210006 China Department of Cardiology Medistra Hospital University ofIndonesia Medical School Jakarta Indonesia Department of Cardiology Shanghai 10th People＇s HospitalShanghai 200072 China Department of Cardiology Xuzhou Central Hospital XuzhouJiangsu 221009 China Department of Cardiology Bangkok General Hospital BangkokThailand Department of Cardiology Zhangjiagang People＇s HospitalZhangjiagang Jiangsu 215600 China Department of Cardiology Huainan Xinhua Hospital HuainanAnhui 232038 China Department of Cardiology Beth Israel Hospital NewYork USA

Background The predictive value of bifurcation angle （BA） for worse events after stenting bifurcation lesions remains to be unknown. The present study was to investigate the dynamic change of BA and clinical relevance for patients with coronary bifurcation lesions treated by drug-eluting stent （DES）. Methods BA was calculated by 3-D quantitative coronary analysis from 347 patients in DKCRUSH-II study. Primary endpoint was the occurrence of composite major adverse cardiac events （MACE） at 12-month, including cardiac death, myocardial infarction （mi） and target vessel revascularization （TVR）. Secondary end points were the rate of binary restenosis and stent thrombosis at 12-month. Results Stenting was associated with the reduction of distal BA. The cut-off value of distal BA for predicting MACE was 60°. Distal BA in 〈60° group had less reduction after stenting （（-1.96＋13.58）°vs. （-12.12±23.58）°, P 〈0.001）; two-stent technique was associated with significant reduction of distal BA （△（-4.05±14.20）°）, compared to single stent group （4＋1.55±11.73, P=0.003）; the target lesion revascularization （TLR）, TVR and MACE rate was higher in one-stent group （16.5%, 19.0% and 21.5%）, compared to two-stent group （3.8%, P=0.002; 7.5%, P=0.016; and 9.8%, P=0.024）, respectively. Among patients in ≥60° group, there were no significant differences in distal BA, stent thrombosis （ST）, mi, MACE, death, TLR, TVR between one- and two-stent groups; after stenting procedure, there was only slight change of distal BA in left anterior descending （LAD）-Ieft circumflex （LCX） subgroup （from （88.54±21.33）° at baseline to （82.44±31.72）° post-stenting）, compared to either LAD-diagonal branch （Di）, or LCX-obtuse marginal branch （OM）, or IRCA distal （RCAd）（all P 〈0.001 ）. Conclusion Two-stent technique was associated with significant reduction of distal BA. DK crush stenting had reduced rate of MACE in patients in 〈60° group, compared to one-stent technique.

关键词： coronary bifurcation lesions bifurcation angle major adverse cardiac events ROC curve

Comparison of paclitaxal vs. sirolimus eluting stents with bio-degradable polymer for the treatment of coronary bifurcation lesions： subgroup analysis from DKCRUSH-I and DKCRUSH-II studies

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Chinese Medical Journal 2012年第19期125卷 3382-3387页

作者： CHEN Shao-liang Gary mintz Teguh Santoso ZHANG Jun-jie YE Fei XU Ya-wei FU Qiang KAN Jing Chitprapai Paiboon ZHOU Yong DING Shi-qin tak W Kwan Department of Cardiology Nanjing hrst Hospital NanjlngMedical University Nanjing 210006 China Cardiovascular Research Foundation New York NY US Department of Cardiology Medistra Hospital University ofIndonesia Medical School Jakarta Indonesia Department of Cardiology Shanghai 10th People's HospitalShanghai 200072 China Department of Cardiology Xuzhou Central Hospital XuzhouJiangsu 221009 China Department of Cardiology Bangkok General Hospital BangkokThailand Department of Cardiology Zhangjiagang People's HospitalZhangjiagang Jiangsu 215600 China Department of Cardiology Huainan Xinhua Hospital HuainanAnhui 232038 China Department of Cardiology Beth Israel Hospital NewYork USA

Background The difference in clinical outcome between paclitaxal-eluting stents （PES） and sirolimus-eluting stents with bio-degradable polymer （SES-BDP） for bifurcation lesions remains unclear. The present study aimed to investigate the one-year clinical outcome after DK crush stenting using PES （maxusTM） MS. SES-BDP （ExcelTM） from our database. Methods A total of 275 patients （90 from the DKCRUSH-I and 185 from the DKCRUSH-II study） were studied. The primary endpoint was the occurrence of major adverse cardiac events （MACE） at 12 months; including cardiac death, myocardial infarction （mi）, or target vessel revascularization （TVR）. The rate of binary restenosis and stent thrombosis served as secondary endpoints. Results At follow-up, minimal luminal diameter （MLD） in the Taxus group was （2.11＋0.66） mm, with resultant increased target lesion revascularization （TLR） 12.2% and TVR 14.4%, significantly different from the Excel group; （2.47±0.56） mm, P 〈0.001, 3.2%, P=0.006, 4.9%, P=0.019, respectively. As a result there was a significant difference in MACE between the Taxus （20.0%） and Excel （10.3%, P=0.038） groups. Overall stent thrombosis was monitored in 11 patients （4.0%）, with five in the Excel group （2.7%） and six in the Taxus group （6.7%）. All stent thrombosis in the Excel group was classified as early, and all were defined as late in the Taxus group. Conclusion The Excel stent had lower rate of stent thrombosis, TLR, TVR, and composite MACE at 12-month after an indexed stenting procedure, compared to the Taxus stent.

关键词： paclitaxal-eluting stent sirolimus-eluting stent bio-degradable polymer," coronary bifurcation lesions

叙事视角下的中国景点典故翻译研究——以曲阜“三孔”景点为例

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成都师范学院学报 2016年第8期32卷 41-46页

作者：弭宁曲阜师范大学公共外语教学部曲阜273165

典故具有浓郁的文化特色、深厚的历史渊源、丰富的民族文化知识,是各民族历史的沉淀。以曲阜"三孔"景点中的典源故事为例,从叙事学角度对旅游宣传解说这类应用文体中的典源故事翻译进行研究,探讨典故叙事的翻译原则和策略。在向外国游... 详细信息

典故具有浓郁的文化特色、深厚的历史渊源、丰富的民族文化知识,是各民族历史的沉淀。以曲阜"三孔"景点中的典源故事为例,从叙事学角度对旅游宣传解说这类应用文体中的典源故事翻译进行研究,探讨典故叙事的翻译原则和策略。在向外国游客介绍景点所引用的典源故事时,应遵循叙事接受的原则,采用内外视角融合,将客观展现景点信息与主观情感融入完美结合;深入研读典源,有的放矢地选择文本素材,采用概述、省译、缩译的方式处理典源故事。得体恰当的中国景点典故翻译,对中国传统文化的传播具有重大意义。

关键词：叙事典故翻译景点

考虑水-结构-土相互作用下深水圆柱的地震响应分析

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振动工程学报 2021年第4期34卷 730-738页

作者：黄义铭赵密王丕光杜修力刘晶波北京工业大学建筑工程学院北京100124 清华大学土木系北京100084

以水中圆柱体为模型,考虑水⁃结构⁃土的相互作用,研究柱体结构在地震和波浪共同作用下的动力响应。采用有限元法将柔性柱体结构离散为欧拉⁃伯努利梁单元,水⁃结构相互作用通过附加质量代替,土⁃结构相互作用通过线性弹簧代替。基于结构自... 详细信息

以水中圆柱体为模型,考虑水⁃结构⁃土的相互作用,研究柱体结构在地震和波浪共同作用下的动力响应。采用有限元法将柔性柱体结构离散为欧拉⁃伯努利梁单元,水⁃结构相互作用通过附加质量代替,土⁃结构相互作用通过线性弹簧代替。基于结构自振频率分析,讨论土⁃结构和水⁃结构相互作用对结构自振频率的影响。研究土⁃结构相互作用、地震动水力和波浪力对柱体结构动力响应的影响。

关键词：地震响应水⁃结构⁃土相互作用圆形柱体附加质量波浪力

沥青质沉积对油井产能影响的模拟分析——以南海北部湾盆地W-1油田为例

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中国海上油气 2016年第6期28卷 53-58页

作者：高达张乔良米洪刚中海石油(中国)有限公司湛江分公司广东湛江524057

油田开发过程中油藏压力、温度等变化会导致原油中沥青质析出并沉积,从而对储层造成伤害并使油井产能降低。以南海北部湾盆地W-1油田为例,利用油藏数值模拟方法模拟了衰竭式开发及注水开发方式下沥青质析出与沉积的过程以及对油井产能... 详细信息

油田开发过程中油藏压力、温度等变化会导致原油中沥青质析出并沉积,从而对储层造成伤害并使油井产能降低。以南海北部湾盆地W-1油田为例,利用油藏数值模拟方法模拟了衰竭式开发及注水开发方式下沥青质析出与沉积的过程以及对油井产能的影响情况。由于采油井近井地带压力下降幅度最大,沥青质析出与沉积现象最为显著,造成原油黏度升高和渗透率下降的幅度也最大,从而导致油井产能下降。通过模拟分析,提出了针对由于压力下降导致的沥青质沉积伤害的主要开发对策:一是降低采油井生产压差,如采油井采用小排量生产或者水平井开发;二是提高采油井附近的能量补充速度,如注水井超注、加密注采井距等。基于模拟分析认识提出的水平调整井方案已在W-1油田实施,并取得了一定的增产效果。

关键词：沥青质沉积储层伤害油井产能数值模拟开发对策北部湾盆地

急性髓系白血病患者tak1、p38基因表达及其临床意义

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白血病．淋巴瘤 2015年第11期24卷 658-661页

作者：袁芳芳米瑞华陈琳魏旭东郑州大学附属肿瘤医院河南省肿瘤医院血液科450008

目的了解不同亚型急性髓系白血病（AML）患者tak1、p38基因的表达差异，并分析tak1、p38基因不同表达水平患者的临床特征。方法以GAPDH为内参，14名健康人为对照组，采用实时定量聚合酶链反应方法检测87例AML患者骨髓tak1、p38基因的表... 详细信息

目的了解不同亚型急性髓系白血病（AML）患者tak1、p38基因的表达差异，并分析tak1、p38基因不同表达水平患者的临床特征。方法以GAPDH为内参，14名健康人为对照组，采用实时定量聚合酶链反应方法检测87例AML患者骨髓tak1、p38基因的表达，对结果进行统计学分析。结果AML患者tak1、p38基因表达均高于对照组（相对表达量：0．194±0．125比0．015±0．008，0．233±0．140比0．010．±0．005，均P〈0．001）。M4患者takImRNA表达高于M2、M3、M5（P=0．005、0．000、0．002），M2高于M3（P=0．022）；M4患者p38mRNA表达高于Ml、M2、M3、M5（P=0．013、0．035、0．000、0．045），M2高于M，（P=0．001），M，高于M，（P=0．012）。tak1高表达组CD56阳性率、外周血白细胞数均高于tak1低表达组，p38低表达组CDl9阳性率高于p38高表达组，差异均有统计学意义（均P〈0．05）。结论AML患者tak1、1338基因表达升高，其表达上调可能在AML发病中起重要作用。

关键词：白血病髓样急性基因 tak1 基因 p38