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Supra-angular biopsy is more reliable for atrophy recognization:analysis of 1598 cases for gastric mucosal histological examination

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World Journal of Gastroenterology 2000年第6期6卷 893-897页

作者： Nobutaka yamada Department of Pathology First Hospital of Nippon Medical SchoolTokyoJapan

INTRODUCTIONChronic gastritis might be a disease of the highestmorbidity in the *** Warren and Marshallsuccessfully isolated and cultured Helicobacter pylori(***)from a gastric antrum biopsy,intensive researches produ... 详细信息

关键词： Helicobacter pylori gastric mucosa/pathology biopsy gastroscopy gastritis atrophic/pathology metaplasia

Micropulse laser trabeculoplasty under maximal tolerable glaucoma eyedrops:treatment effectiveness and impact of surgical expertise

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International Journal of Ophthalmology(English edition) 2021年第3期14卷 388-392页

作者： Shinji Kakihara Takao Hirano Akira Imai taihei Kurenuma Yoshiaki Chiku Toshinori Murata Department of Ophthalmology Shinshu University School of MedicineMatsumotoNagano 390-8621Japan

AIM:To evaluate the effectiveness of micropulse laser trabeculoplasty(MLT)for eyes with open angle glaucoma(OAG)under maximal tolerable glaucoma eyedrops and to assess the effect of expertise performing MLT on its clinical ***:Medical records of 42 consecutive eyes of 34 patients diagnosed with OAG who underwent MLT were retrospectively *** effectiveness was determined using the Kaplan-Meier survival *** was defined as an intraocular pressure(IOP)reduction of21 mm Hg during two consecutive follow-up visits,or surgical intervention for *** determine the impact of MLT surgical expertise on clinical effectiveness,the eyes were divided into two groups according to whether the procedure was conducted by an experienced specialist(defined as a glaucoma specialist who had conducted at least ten MLT procedures)or a less experienced glaucoma *** difference in expertise was determined using a log-rank ***:MLT was conducted by three glaucoma *** overall survival rates were 0.76,0.48,and 0.44 at 1,3,and 6 mo,*** survival rates for MLT performed by a less experienced glaucoma specialist were 0.62,0.31,and 0.25(n=21 eyes)at 1,3,and 6 mo,respectively,whereas the survival rates for MLT performed by an experienced glaucoma specialist were 0.90,0.64,and 0.64(n=21 eyes)at 1,3,and 6 mo,*** log-rank test showed a significant difference in the survival curves of the two groups(P=0.0061).CONCLUSION:The 6-month effectiveness of MLT for controlling IOP is relatively limited in eyes with OAG using maximal tolerable glaucoma ***,its effectiveness may be improved if performed by a glaucoma specialist with sufficient MLT experience.

关键词： micropulse laser trabeculoplasty open angle glaucoma inter-operator variability

Development of a digital zenith telescope for advanced astrometry

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Science China(Physics,Mechanics & Astronomy) 2012年第4期55卷 723-732页

作者： HANADA Hideo ARAKI Hiroshi TAZAWA Seiichi TSURUTA Seiitsu NODA Hirotomo ASARI Kazuyoshi SASAKI Sho FUNAZAKI Ken'ichi SATOH Atsushi TANIGUCHI Hideo KIKUCHI Mamoru TAKAHASHI Tomoe YAMAZAKI Atsumu PING JinSong KAWANO Nobuyuki PETROVA Natalia GOUDA Naoteru YANO taihei yamada Yoshiyuki NIWA Yoshito KONO Yusuke IWATA Takahiro National Astronomical Observatory of Japan Iwate-ken 0230861Japan Department of Engineering Department Iwate UniversityIwate 0208550Japan National Astronomical Observatory Chinese Academy of SciencesBeijing 100012China Oshu Space&Astronomy Museum Iwate-ken 0230861Japan Department of Astronomy Kazan State UniversityKazan 420008Russia Section of Graduate School of Science Division of Physics and Astronomy Kyoto UniversityKyoto 6068501Japan Japan Aerospace Exploration Agency Kanagawa 2525210Japan

Like other optical astrometric techniques,the Photographic Zenith Tube(PZT) has played a key role in the past observations of the Earth rotation,and it also has a potential to be applied to several other observations by taking advantage of automatic observations with self compensation of tilt of the *** here propose In-situ Lunar Orientation Measurement(ILOM) to study lunar rotational dynamics by direct observations of the lunar rotation from the lunar surface by using a small telescope like PZT with an accuracy of 1 milli-seconds of arc(1 mas) in the post-SELENE *** second application is to obtain local gravity field on the Earth by combining deflection of the vertical measured by PZT and the position measured by Global Positioning System(GPS) or Global Navigation Satellite System(GNSS).The accuracy required for this purpose is not as strict as *** have already developed a Bread Board Model(BBM) of the telescope for ILOM and made some experiments in order to know the performance of the driving mechanism under a similar condition to the lunar environment showing high vacuum,large temperature change and dusty *** have also shown that it is possible to correct the effects of uniform temperature change upon the optical system by using a simple model with an accuracy of better than 1 *** model has the potential to attain the accuracy of 1 mas,based on the results of the experiments and the simulations.

关键词： high accuracy orbit determination SAR LRS SELENE

Environmental pressure rather than ongoing hybridization is responsible for an altitudinal cline in the morphologies of two oaks

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Journal of Plant Ecology 2020年第4期13卷 413-422页

作者： Ichiro Tamaki Yae yamada Gifu Academy of Forest Science and Culture 88 SodaiMinoGifu 501-3714Japan

Aims In a contact zone between related taxa,phenotypic variation can result from genetic and/or environmental *** study aimed to clarify the cause of phenotypic variation in leaf morphology of two Quercus crispula varieties—crispula(QCC)and mongolicoides(QCM)—in their contact zone along an altitudinal *** We measured 6 morphological traits of leaves and recorded genotypes of 13 nuclear microsatellite loci for 48 individuals in the contact zone and 24 individuals in each of the reference populations of QCC and *** constructed a model explaining the phenotypic variation(leaf morphology)in relation to environmental(altitude)and genetic(ancestry from the reference population)*** Findings Both morphological and genetic markers distinguished the two varieties in the reference populations *** were able to confirm the power of both morphological and genetic *** within the contact zone population had intermediate ancestry that was slightly biased to QCM ancestry,and the distribution of their morphologies overlapped with those of the two varieties in the reference *** effect of altitude on leaf morphological traits was significant,while that of ancestry was *** of ancestry and interclass heterozygosity in the contact zone population resembled those in F2 or later generation *** results indicate that in the contact zone between QCC and QCM,there is no ongoing hybridization,but environmental pressure has created an altitudinal gradient in morphological traits through phenotypic plasticity and/or variation in functional genes.

关键词： Quercus crispula Quercus mongolica leaf morphologies microsatellites hybrid zone

Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer

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World Journal of Gastroenterology 2022年第2期28卷 188-198页

作者： Kohji yamada Kiyotsugu Yoshida Department of Biochemistry The Jikei University School of MedicineTokyo 105-8461Japan

Protein kinase Cδ(PKCδ)is a member of the PKC family,and its implications have been reported in various biological and cancerous processes,including cell proliferation,cell death,tumor suppression,and tumor *** liver cancer cells,accumulating reports show the bi-functional regulation of PKCδin cell death and ***δfunction is defined by various factors,such as phosphorylation,catalytic domain cleavage,and subcellular ***δhas multiple intracellular distribution patterns,ranging from the cytosol to the *** recently found a unique extracellular localization of PKCδin liver cancer and its growth factor-like function in liver cancer *** this review,we first discuss the structural features of PKCδand then focus on the functional diversity of PKCδbased on its subcellular localization,such as the nucleus,cell surface,and extracellular *** findings improve our knowledge of PKCδinvolvement in the progression of liver cancer.

关键词： Protein kinase Cδ Liver cancer Subcellular localization Tumor suppression Tumor progression

A novel approach in preventing vascular leakage and angiogenesis in wet age-related macular degeneration

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Neural Regeneration Research 2022年第8期17卷 1751-1752页

作者： Kaori H.yamada Department of Pharmacology and Regenerative Medicine Department of Ophthalmology and Visual SciencesUniversity of Illinois College of MedicineChicagoILUSA

Vascular leakage and angiogenesis in diseases:The vascular system carries blood throughout the body to supply oxygen and nutrients to tissues and remove waste from *** of the vascular system worsens many *** this perspective,vascular function in blinding eye diseases,current therapies,and our developing approach will be *** blood vessels are composed of the monolayer of the endothelial cells,and the outer layer made by pericytes and smooth muscle cells provide structural support and shape to the *** monolayers function as a *** barrier function of endothelial monolayers controls plasma protein uptake and the infiltration of immune cells by regulating adherence of cell-cell *** leakage causes unwanted plasma leak,accumulation of immune cells,and tissue inflammation.

关键词： degeneration approach remove

Self-/conspecific discrimination and superparasitism strategy in the ovicidal parasitoid Echthrodelphax fairchildii （Hymenoptera： Dryinidae）

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Insect Science 2014年第6期21卷 741-749页

作者： Emi Ito Yoshihiro Y. yamada Insect Ecology Laboratory Graduate School of Bioresources Mie University Tsu Mie Japan

Superparasitism in solitary parasitoids results in fatal competition between the immature parasitoids, and consequently only one individual can emerge. In the semisoli- tary ovicidal parasitoid Echthrodelphaxfairchildii （Hymenoptera： Dryinidae）, 2 adults can emerge under superparasitism with a short interval （〈24 h） between the first and second ovipositions. We determined the female parasitoid＇s behavioral responses under self- and conspecific superparasitism bouts with first-to-second oviposition intervals of 〈2 h. The self- and conspecific superparasitizing frequencies increased up to an oviposition interval of 0.75 h, with the former remaining lower than the latter, particularly for oviposition intervals of _〈0.25 h, suggesting the existence of self-/conspecific discrimination. The superparasitizing frequency plateaued for oviposition intervals of _〉0.75 h, with no dif- ference between self- and conspecific superparasitism. The ovicidal-probing frequency did not differ under self- and conspecific superparasitism, and was usually 〈20%. The females exhibited no preference for the oviposition side （i.e., ovipositing on the side with or without the first progeny） and almost always laid female eggs for any oviposition in- terval under self- and conspecific superparasitism. The sex ratio was not affected by the type of superparasitism, oviposition sides, or the occurrence of ovicidal probing. These observed results about the oviposition side, ovicidal probing, and sex ratios differed from the predictions obtained assuming that the females behave optimally. Possible reasons for the discrepancies are discussed： likely candidates include the high cost of selecting oviposition sides and ovicidal probing, and, for the sex ratio, the low frequency of encountering suitable hosts before superparasitism bouts.

关键词： infanticide ovicide plant hopper self-recognition sex ratio

A variant form of autoimmune pancreatitis successfully treated by steroid therapy, accompanied by von Meyenburg complex

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World Journal of Gastroenterology 2009年第5期15卷 622-627页

作者： Hideaki Miura Shigehiro Kitamura Haruki yamada Department of Internal Medicine Social Insurance Central General Hospital 3-22-1 Hyakunin-cho Shinjuku-ku Tokyo 169-0073 Japan Department of Pathology Social Insurance Central General Hospital 3-22-1 Hyakunin-cho Shinjuku-ku Tokyo 169-0073 Japan

Diagnostic criteria for autoimmune pancreatitis （AIP） have been proposed and used clinically because, despite its unique clinicopathological features, AIP does not have disease-specific serological tests for confirmation. However, diagnosis of a patient with pancreatic lesions mimicking cancer who deviates from these diagnostic criteria is still difficult. We present herein a patient with a variant form of AIP successfully diagnosed by fine-needle biopsy, whose response to steroid therapy was excellent. A 55-year-old Japanese man was admitted to hospital because of jaundice and pancreatic head mass. AIP was considered as one of the differential diagnoses; however, as the patient showed neither pancreatic duct narrowing nor immunological abnormalities, he did not meet the Japanese diagnostic criteria for AIP. Histopathology of the pancreatic mass demonstrated abundant infiltration by lymphocytes and interstitial fibrosis, which suggested AIP. Immunoreaction to IgG4, which is supposed to be specific to AIP, was not observed; however, response to subsequent prednisolone therapy was good, with dramatic pancreatic head mass regression. Aside from the pancreatic head mass, diffusely spreading small lesions were observed throughout the liver. The likelihood of a potential association with extrapancreatic lesions of AIP was considered and led us to carry out a liver biopsy, which revealed biliary hamartoma, also called yon Meyenburg complex （VMC）. As IgG4-positive plasma cell infiltration was not demonstrated in the hamartomatous regions, the hepatic condition was thought to have occurred incidentally; however, to the best of our knowledge, this is the first report in which the association between AIP and VMC was investigated and discussed.

关键词： Autoimmune pancreatitis Diagnosticcriteria IgG4 Biliary hamartoma von Meyenburgcomplex

Improvement of aerodynamic stability of suspension bridges with H-shaped simplified stiffening girder

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Frontiers of Structural and Civil Engineering 2016年第1期10卷 93-102页

作者： Hiroshi KATSUCHI Hitoshi yamada Mayuko NISHIO Yoko OKAZAKI Department of Civil Engineering Yokohama National University Yokohama 240-8501 Japan

Wind-tunnel study on the improvement of aerodynamic stability of simplified suspension-bridge girder structures was conducted with using a 1/40-scaled section model. Objective of the study is the development of an economically superior suspension bridge with 500-1,000 m center span length. The wind-tunnel test showed that an edge-girder type cross section exhibited large amplitude torsional vortex-induced vibration as well as torsional flutter at a low wind speed. Accordingly, aerodynamic countermeasures of open grating deck and triangular fating, and structural countermeasures of center stay, diagonal bracing and mass increase were tried to improve the aerodynamic stability. Finally, feasibility of the best combination to a full-scale bridge was examined by structural analysis.

关键词： suspension bridge aerodynamics simplified girder wind-tunnel test