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Frontiers of Medicine 2024年第4期18卷 757-761页

作者： Juan Wang Dongni Shi Yaochen Wang Xuanqi Zhang Han Li Xihong Wang Shufeng Luo Lihan Hu Jiashuai Deng Lin Zhang Chung tai Lau Chung Wah Cheng Fei Han Ji Li ping Wang Aiping Lyu Zhaoxiang Bian Xuan Zhang Institute for Research and Continuing Education Hong Kong Baptist UniversityShenzhen518057China Chinese EQUATOR Centre Hong Kong Baptist UniversityHKSAR999077China School of Traditional Chinese Medicine Tianjin University of Chinese MedicineTianjin301617China School of Chinese Medicine Beijing University of Chinese MedicineBeijing100105China School of Chinese Medicine Hong Kong Baptist UniversityHKSAR999077China Department of Pediatrics Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing100091China Centre for Chinese Herbal Medicine Drug Development Hong Kong Baptist UniversityHKSAR999077China

To enhance the clarity and transparency of reporting in trials involving Chineseherbal medicine(CHM)formulas,the CONSORT extension specifically tailored for CHM formulas(CONSORT-CHM Formulas 2017)was introduced in 2017[1].This statement,along with its corresponding checklist,outlines key elements essential for reporting in randomized controlled trials(RCTs)related tothe rationale,design,analysis,and interpretation of interventions using CHM *** CONSORT-CHM Formulas 2017 elaborated on 7 of 25 CONSORT checklist items,namely title,abstract and keywords,backgrounds and objectives,participants,interventions,outcomes,generalizability,and interpretation.

关键词： formulas statement rational

Influence of perinatal factors on full-term low-birth-weight infants and construction of a predictive model

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World Journal of Clinical Cases 2024年第26期12卷 5901-5907页

作者： Liang Xu Xue-Juan Sheng Lian-ping Gu Zu-Ming Yang Zong-tai Feng Dan-Feng Gu Li Gao Department of Neonatology Suzhou Ninth People's HospitalSuzhou 215200Jiangsu ProvinceChina Department of Obstetrics Suzhou Ninth People's HospitalSuzhou 215200Jiangsu ProvinceChina Department of Neonatology Suzhou Municipal HospitalSuzhou 215008Jiangsu ProvinceChina

BACKGROUND Being too light at birth can increase the risk of various diseases during *** To explore the effect of perinatal factors on term low-birth-weight(LBW)infants and build a predictive *** model aims to guide the clinical management of pregnant women’s healthcare during pregnancy and support the healthy growth of *** A retrospective analysis was conducted on data from 1794 single full-term pregnant women who gave *** were grouped based on birth weight:Those with birth weighttained as follows:Logit(P)=0.348×maternal education level+1.067×number of prenatal examinations+1.307×insufficient weight gain during pregnancy+0.563×irregular calcium supplementation during pregnancy+0.785×pregnancy hypertension syndrome−*** area under the ROC curve for this model was 0.853,with a sensitivity of 0.852 and a specificity of *** Hosmer–Leme show test yieldedχ^(2)=2.185,P=0.449,indicating a good *** overall accuracy of the clinical validation model was 81.67%.CONCLUSION The occurrence of full-te

关键词： Pregnant women Perinatal care Low-birth-weight infants Influencing factors Prediction model

Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan Grace Gar-lee Yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

Novel compound heterozygous mutations in the hemojuvelin gene in a juvenile hemochromatosis patient:A case report

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World Journal of Clinical Cases 2024年第19期12卷 3961-3970页

作者： Ling-Ding Xie Xiao-Mu Kong Jing-Xia Shen tai-Ling Wang Jing Ma Yun-Fen Zhang Xiao-ping Chen Department of Endocrinology China-Japan Friendship HospitalBeijing 100029China Department of Tumor Radiotherapy and Chemotherapy Qian’an People’s HospitalQian’an 064400Hebei ProvinceChina Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Endocrinology Aksu First People's HospitalAksu Region 843000Xinjiang Uygur Autonomous RegionChina Department of Metabolic Diseases Qian’an Traditional Chinese Medical HospitalQian’an 064400Hebei ProvinceChina

BACKGROUND Juvenile hemochromatosis(JH)is an early-onset,rare autosomal recessive disorder of iron overload observed worldwide that leads to damage in multiple *** mutations in the hemojuvelin(HJV)gene are the major cause of *** SUMMARY A 34-year-old male Chinese patient presented with liver fibrosis,diabetes,hypogonadotropic hypogonadism,hypophysis hypothyroidism,and skin *** test revealed a markedly elevated serum ferritin level of 4329μg/L and a transferrin saturation rate of 95.4%.Targeted exome sequencing and Sanger sequencing revealed that the proband had a novel mutation c.863G>A(p.R288Q)in the HJV gene which was transmitted from his father,and two known mutations,c.18G>C(p.Q6H)and c.962_963delGCinsAA(p.C321*)in cis,which were inherited from his *** p.R288W mutation was previously reported to be pathogenic for hemochromatosis,which strongly supported the pathogenicity of p.R288Q reported for the first time in this *** 72 wk of intensive phlebotomy therapy,the patient achieved a reduction in serum ferritin to 160.5μg/*** patient's clinical symptoms demonstrated a notable *** This study highlights the importance of screening for hemochromatosis in patients with diabetes and hypogonadotropic *** also suggests that long-term active phlebotomy could efficiently improve the prognosis in severe JH.

关键词： Juvenile hemochromatosis Liver cirrhosis Diabetes Iron overload Phlebotomy Case report

Apple SINA11-JAZ2 module is involved in jasmonate signaling response

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Journal of Integrative Plant Biology 2024年第7期66卷 1270-1273页

作者： Di Ai Lei Zhao Chun-Xiang You Yuepeng Han Jian-ping An State Key Laboratory of Plant Diversity and Specialty Crops CAS Key Laboratory of Plant Germplasm Enhancement and Specialty AgricultureWuhan Botanical Garden of Chinese Academy of SciencesWuhan 430074China Hubei Hongshan Laboratory Wuhan 430070China University of Chinese Academy of Sciences Beijing 100049China Apple Technology Innovation Center of Shandong Province College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-An 271018China

Jasmonic acid(JA)is an important phytolipid hormone involved in regulating many processes of plant growth and development,and plays a key role in plant resistance to biotic and abiotic *** the first discovery of methy... 详细信息

关键词： nat Apple involv

An experimental study of a novel external fixator based on universal joints for the rapid initial stabilization of mandibular comminuted fractures

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Chinese Journal of Traumatology 2024年第5期27卷 254-262页

作者： Zhi-Qiang Hu tai-Qiang Dai Lu Zhao Xun Li Xu Gong Hao Jia Hai-Tao Kong Bo-Lei Cai Shi-ping Chang Lei Tian State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Clinical Research Center for Oral DiseasesDepartment of Oral and MaxillofacialSchool of StomatologyThe Fourth Military Medical UniversityXi'an710032China The 80th Group Army Hospital of PLA Weifang261000Shandong provinceChina The Third Affiliated Hospital The Air Force Military Medical UniversityXi'an710038China State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Clinical Research Center for Oral DiseasesDepartment of Dental MaterialsSchool of StomatologyThe Fourth Military Medical UniversityXi'an710032China

Purpose:Shaping and assembling contemporary external fixators rapidly for the severe mandibular fractures remains a challenge,especially in emergency *** designed a novel external fixator that incorporates universal joints to provide the stabilization for mandibular comminuted *** study aims to confirm the efficacy of this novel external fixator through biomechanical tests in vitro and animal ***:In vitro biomechanical tests were conducted using 6 fresh canine with mandibular defect to simulate critical comminuted *** mandibles were stabilized by the novel external fixator and other mandibles were fixed by 2.5 mm reconstruction *** fixed mandibles were subjected to loads of 350 N on the anterior regions of teeth and 550 N on the first molar of the unaffected *** stability was evaluated based on the maximum displacement and the slope of the load-displacement *** animal experiments,9 beagles with comminuted mandibular fractures were divided into 3 groups,which were treated with the novel external fixation,reconstruction plate,and dental arch bar,*** general observation,the changes in animals’weight,and the surgical duration were recorded and compared among 3 *** CT scans were performed at various intervals of 0 day(immediately after the surgery),3 days,7 days,14 days,21 days,and 28 days to analyze the displacement of feature points on the canine mandible and situation of fracture healing at 28 *** statistical significance was assessed by the two-way analysis of variance test followed by the Bonferroni test,enabling multiple comparisons for all tests using GraphPad Prism10.1.0(GraphPad Inc,USA).Results:The outcomes of the biomechanical tests indicated that no statistically significant differences were found in terms of the maximum displacement(p=0.496,0.079)and the slope of load displacement curves(p=0.374,0.349)under 2 load modes between the external and internal fixation grou

关键词： External fixation Mandibular fracture Battle injuries Damage control

Paclitaxel induces human KOSC3 oral cancer cell apoptosis through caspase pathways

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BIOCELL 2024年第7期48卷 1047-1054页

作者： YU-YAN LAN TSUN-CHIH CHENG YI-ping lee CHIA-YIH WANG BU-MIIN HUANG School of Medicine College of MedicineI-Shou UniversityKaohsiung82445Taiwan Department of Otolaryngology An Nan HospitalChina Medical UniversityTainan70965Taiwan Department of Cell Biology and Anatomy College of MedicineNational Cheng Kung UniversityTainan70101Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402Taiwan

Background:Paclitaxel is a compound derived from Paciﬁc yew bark that induces various cancer cell ***,whether it also has anticancer activities in KOSC3 cells,an oral cancer cell line,is ***:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide,ﬂow cytometry,and western blotting assays were carried out to assess cell viability,subG1 phase of the cell cycle,and apoptosis-related protein expression,***:Ourﬁndings indicate that paclitaxel could inhibit cell viability and increase the expression of apoptotic markers,including plasma membrane blebbing and the cleavage of poly ADP-ribose polymerase in KOSC3 ***,the treatment with paclitaxel remarkably elevated the percentage of the subG1 phase in KOSC3 *** addition,treatment with a pan-caspase inhibitor could recover paclitaxel-inhibited cell ***,caspase-8,caspase-9,caspase-7,and BH3 interacting domain death agonist(Bid)were activated in paclitaxel-treated KOSC3 ***:Paclitaxel induced apoptosis through caspase cascade in KOSC3 cells.

关键词： Paclitaxel Oral cancer KOSC3 cells Apoptosis Caspase pathways

MdbHLH162 connects the gibberellin and jasmonic acid signals to regulate anthocyanin biosynthesis in apple

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Journal of Integrative Plant Biology 2024年第2期66卷 265-284页

作者： Jian-ping An Rui-Rui Xu Xiao-Na Wang Xiao-Wei Zhang Chun-Xiang You Yuepeng Han Apple technology innovation center of Shandong Province College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-An 271018China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenHubei Hongshan LaboratoryThe Innovative Academy of Seed Design of Chinese Academy of SciencesWuhan 430074China College of Biology and Oceanography Weifang UniversityWeifang 261061China

Anthocyanins are secondary metabolites induced by environmental stimuli and developmental *** positive regulators of anthocyanin biosynthesis have been reported,whereas the anthocyanin repressors have been *** the signal transduction pathways of gibberellin(GA)and jasmonic acid(JA)and their regulation of anthocyanin biosynthesis have been investigated,the cross-talk between GA and JA and the antagonistic mechanism of regulating anthocyanin biosynthesis remain to be *** this study,we identified the anthocyanin repressor MdbHLH162 in apple and revealed its molecular mechanism of regulating anthocyanin biosynthesis by integrating the GA and JA ***162 exerted passive repression by interacting with MdbHLH3 and MdbHLH33,which are two recognized positive regulators of anthocyanin ***162 negatively regulated anthocyanin biosynthesis by disrupting the formation of the anthocyanin-activated MdMYB1-MdbHLH3/33complexes and weakening transcriptional activation of the anthocyanin biosynthetic genes MdDFR and MdUF3GT by MdbHLH3 and *** GA repressor MdRGL2a antagonized MdbHLH162-mediated inhibition of anthocyanins by sequestering MdbHLH162 from the MdbHLH162-MdbHLH3/33 *** JA repressors MdJAZ1 and MdJAZ2 interfered with the antagonistic regulation of MdbHLH162 by MdRGL2a by titrating the formation of the MdRGL2a-MdbHLH162 *** findings reveal that MdbHLH162 integrates the GA and JA signals to negatively regulate anthocyanin *** study provides new information for discovering more anthocyanin biosynthesis repressors and explores the cross-talk between hormone signals.

关键词： anthocyanin biosynthesis bHLH transcription factor gibberellin jasmonic acid regulatory network transcriptional regulation

Unraveling the mechanism of malancao in treating ulcerative colitis:A multi-omics approach

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World Journal of Clinical Cases 2024年第17期12卷 3105-3122页

作者： Xing-Long Huang Lu-Na Wu Qin Huang Yue Zhou Lei Qing Feng Xiong Hui-ping Dong tai-Min Zhou Kai-Li Wang Jue Liu Hospital of Traditional Chinese Medicine in Qijiang District Chongqing 401420China Qijiang Health Center for Maternal and Child Care Chongqing 401420China College of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina

BACKGROUND Malancao(MLC)is a traditional Chinese medicine with a long history of utilization in treating ulcerative colitis(UC).Nevertheless,the precise molecular mechanisms underlying its efficacy remain *** study leveraged ultrahigh-performance liquid chromatography coupled with exactive mass spectrometry(UHPLC-QE-MS),network pharmacology,molecular docking(MD),and gene microarray analysis to discern the bioactive constituents and the potential mechanism of action of MLC in UC *** To determine the ingredients related to MLC for treatment of UC using multiple databases to obtain potential targets for *** This research employs UHPLC-QE-MS for the identification of bioactive compounds present in MLC plant ***,the study integrates the identified MLC compound-related targets with publicly available databases to elucidate common drug disease ***,the R programming language is utilized to predict the central targets and molecular pathways that MLC may impact in the treatment of ***,MD are conducted using AutoDock Vina software to assess the affinity of bioactive components to the main targets and confirm their therapeutic *** Firstly,through a comprehensive analysis of UHPLC-QE-MS data and public database resources,we identified 146 drug-disease cross targets related to 11 bioactive *** Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis highlighted that common disease drug targets are primarily involved in oxidative stress management,lipid metabolism,atherosclerosis,and other *** also affect AGE-RAGE and apoptosis signaling ***,by analyzing the differences in diseases,we identified key research *** core targets are related to 11 active substances,including active ingredients such as quercetin and ***,MD analysis revealed the stability of compound-protein binding,particularly between JUNLuteolin,JUN-Quercetin,HSP90A

关键词： Malancao Ulcerative colitis Mass spectrum Network pharmacology Molecular docking

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急性胰腺炎基础及临床转化研究进展

中国实用外科杂志 2024年第5期44卷 594-597,600页

作者：刘涛刘悦泽张太平中国科学医学院北京协和医学院北京协和医院基本外科北京100730

急性胰腺炎(AP)起病急、并发症发生率高,是普通外科常见急症之一,如干预不及时,可向危重症转变,严重影响病人预后。目前临床上以支持治疗和手术为主要治疗方式,然而当前并无有效药物能够逆转AP发生发展。AP的发病机制包括胰蛋白酶原异... 详细信息

急性胰腺炎(AP)起病急、并发症发生率高,是普通外科常见急症之一,如干预不及时,可向危重症转变,严重影响病人预后。目前临床上以支持治疗和手术为主要治疗方式,然而当前并无有效药物能够逆转AP发生发展。AP的发病机制包括胰蛋白酶原异常激活、病理性钙信号传导、线粒体功能障碍、自噬异常、内质网应激、炎症和免疫调节等,以此为基础,在AP病因、治疗靶点、临床转化及临床试验等方面均进行了大量的研究,为今后的临床转化提供参考。

关键词：急性胰腺炎病因发病机制药物靶点临床转化临床试验