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Synthesis and phosphorescent properties of two novel iridium (Ⅲ) complexes bearing bulky tert-butyl substituents

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Chinese Chemical Letters 2007年第9期18卷 1119-1123页

作者： Rong Huang Xiao Qiang Wei tai ping zhang Zhi Yun Lu Ming Gui Xie College of Chemistry Sichuan UniversityChengdu 610064China School of Optic-electronic Information University of Electronic Science and Technology of ChinaChengdu 610054China

The synthesis and phosphorescence properties of two novel Ir(Ⅲ)complexes bearing tert-butyl substituents,bis(4-tert-butyl-2- phenylbenzothiozolato-N,C^(2′))iridium(Ⅲ)(acetylacetonate)[(tbt)_2Ir(acac)]and bis(4-tert-butyl-1-phenyl-1H-benzimidazolato- N,C^(2′))iridium(Ⅲ)(acetylacetonate)[(tpbi)_2Ir(acac)],are reported,their molecular structures are confirmed by^1H NMR,ESI-MS and elementary ***(PL)studies revealed that they can emit strong green and orange phosphorescence in high quantum *** to their prototypes lacking of tert-butyl substituents,the two novel iridium(Ⅲ)complexes both have shorter lifetimes and improved or nearly similar PL quantum efficiencies,implying that the exciton quenching is inhibited effectively when molecular steric hindrance *** two chelates have great potential to be used as electrophosphorescent materials.

关键词： Synthesis tert-Butyl substituent Phosphorescence Electrophosphorescence

Diagnostic accuracy of K-ras mutation for pancreatic carcinoma:a meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 458-464页

作者： Shang-Long Liu Ge Chen Yu-Pei Zhao Wen-Ming Wu tai-ping zhang Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND:The conventional tests for the diagnosis of early stage pancreatic carcinoma are not *** metaanalysis is to evaluate the accuracy of K-ras mutation for the diagnosis of pancreatic *** SOURCES:A systemic search of all relevant literature was performed in Web of Science,EMBASE,Cochrane Database,and MEDLINE(PubMed as the search engine) prior to June 1,***-four studies fulfilled the inclusion criteria and data were pooled for ***:The pooled estimates for K-ras mutation in diagnosis of pancreatic carcinoma were as follows:sensitivity 0.68(95% CI:0.66-0.71),specificity 0.87(95% CI:0.85-0.88),positive likelihood ratio 4.54(95% CI:3.47-5.94),negative likelihood ratio 0.37(95% CI:0.30-0.44) and diagnostic odds ratio 14.90(95% CI:10.02-22.15).Summary receiver operating characteristic analysis demonstrated that the maximum joint sensitivity and specificity was 0.79,and the overall area under the curve was ***:Diagnostic accuracy of K-ras mutation was not superior to that of conventional ***,K-ras mutation analysis alone is not recommended for the diagnosis of pancreatic carcinoma.

关键词： cancer diagnosis K-ras pancreatic carcinoma meta-analysis

Risk factors for the occurrence of insulinoma: a case-control study

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Hepatobiliary & Pancreatic Diseases International 2013年第3期12卷 324-328页

作者： Han-Xiang Zhan Lin Cong Yu-Pei Zhao tai-ping zhang Ge Chen Department of General Surgery Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences

BACKGROUND: The etiology of insulinoma is poorly understood. Few studies investigated the possible roles of environmental factors and lifestyle in the pathogenesis of insulinoma. The aim of this study is to identify risk factors associated with occurrence of insulinoma in the Chinese population. METHODS: This study consisted of 196 patients with insulinoma and 233 controls. Demographic information of the patients and controls and risk factors of the disease were analyzed. Univariate and unconditional multivariable logistic regression analyses were made to estimate odds ratios (ORs) and possible risk factors. RESULTS: Approximately 68.88% (135/196) of the patients were from rural areas in contrast to 10.30% (24/233) of the controls (P<0.0001). This difference was confirmed by the multivariate analysis (OR=4.950; 95% CI: 2.928-8.370). Family history of pancreatic endocrine tumor (OR=16.754; 95% CI: 2.125-132.057) and other cancers (OR=2.360; 95% CI: 1.052-5.291) was also related to a high-risk population of insulinoma. CONCLUSION: Rural residents or people who have a family history of pancreatic endocrine tumor and other cancers are a high-risk population of insulinoma.

关键词： insulinoma risk factors case-control study family history

Recent studies of 5-fluorouracil resistance in pancreatic cancer

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World Journal of Gastroenterology 2014年第42期20卷 15682-15690页

作者： Wei-Bin Wang Yu Yang Yu-Pei Zhao tai-ping zhang Quan Liao Hong Shu Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Resistance to 5-fluorouracil(5-FU), an important anticancer drug, is a serious challenge in the treatment of pancreatic cancer. Equilibrative nucleoside transporter 1 and multidrug-resistance protein(MRP) 5 and MRP8, rather than P-glycoprotein, play important roles in 5-FU transport. Thymidylate synthase, dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidine phosphorylase are four key enzymes involved in 5-FU metabolism. Other metabolic enzymes, including uridine monophosphate synthetase, also contribute to chemoresistance. Intracellular signaling pathways are an integrated network, and nuclear factor kappa-light-chain-enhancer of activated B cells, AKT and extracellular signal-regulated kinases are signaling pathways that are particularly relevant to 5-FU resistance. In addition, recent reports indicate that STAT-3 is a crucial survival protein. Proteomic assays provide a powerful tool for identifying target proteins and understanding the role of micro RNAs and stromal factors to facilitate the development of strategies to combat 5-FU resistance.

关键词： 5-fluorouracil Resistance Transporters Metabolic enzyme Signaling pathway Stromal factors MicroRNA Proteomic investigation

Effect of Blumgart anastomosis in reducing the incidence rate of pancreatic fistula after pancreatoduodenectomy

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World Journal of Gastroenterology 2019年第20期25卷 2514-2523页

作者： Ya-Tong Li Han-Yu zhang Cheng Xing Cheng Ding Wen-Ming Wu Quan Liao tai-ping zhang Yu-Pei Zhao Meng-Hua Dai Department of General Surgery Peking Union Medical College Hospital

BACKGROUND Pancreatic fistula is one of the most serious complications after pancreatoduodenectomy for treating any lesions at the pancreatic head. For years, surgeons have tried various methods to reduce its incidence. AIM To investigate and emphasize the clinical outcomes of Blumgart anastomosis compared with traditional anastomosis in reducing postoperative pancreatic fistula. METHODS In this observational study, a retrospective analysis of 291 patients who underwent pancreatoduodenectomy, including Blumgart anastomosis (201 patients) and traditional embedded pancreaticojejunostomy (90 patients), was performed in our hospital. The preoperative and perioperative courses and longterm follow-up status were analyzed to compare the advantages and disadvantages of the two methods. Moreover, 291 patients were then separated by the severity of postoperative pancreatic fistula, and two methods of pancreaticojejunostomy were compared to detect the features of different anastomosis. Six experienced surgeons were involved and all of them were proficient in both surgical *** The characteristics of the patients in the two groups showed no significant differences, nor the preoperative information and pathological diagnoses. The operative time was significantly shorter in the Blumgart group (343.5 ± 23.0 vs 450.0 ± 40.1 min, P = 0.028), as well as the duration of pancreaticojejunostomy drainage tube placement and postoperative hospital stay (12.7 ± 0.9 d vs 17.4 ± 1.8 d, P = 0.031;and 21.9 ± 1.3 d vs 28.9 ± 1.3 d, P = 0.020, respectively). The overall complications after surgery were much less in the Blumgart group than in the embedded group (11.9% vs 26.7%, P = 0.002). Patients who underwent Blumgart anastomosis would suffer less from severe pancreatic fistula (71.9% vs 50.0%, P = 0.006), and this pancreaticojejunostomy procedure did not have worse influences on long-term complications and life quality. Thus, Blumgart anastomosis is a feasible pancreaticojejunost

关键词： Blumgart anastomosis Pancreaticojejunostomy Postoperative pancreatic fistula Pancreatoduodenectomy Incidence

Reliability ensemble averaging reduces surface wind speed projection uncertainties in the 21st century over China

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Advances in Climate Change Research 2024年第2期15卷 222-229页

作者： Zheng-tai zhang Chang-Ai XU Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China

Accurate prediction of future surface wind speed(SWS)changes is the basis of scientific planning for wind *** studies have projected SWS changes in the 21st century over China on the basis of the multi-model ensemble(MME)of the 6th Coupled Model Intercomparison Project(CMIP6).However,the simulation capability for SWS varies greatly in CMIP6 multi-models,so the MME results still have large *** this study,we used the reliability ensemble averaging(REA)method to assign each model different weights according to their performances in simulating historical SWS changes and project the SWS under different shared socioeconomic pathways(SSPs)in *** results indicate that REA considerably improves the SWS simulation capacity of CMIP6,eliminating the overestimation of SWS by the MME and increasing the simulation capacity of spatial *** spatial correlations with observations increased from 0.56 for the MME to 0.85 for ***,REA could eliminate the overestimation of the SWS by 33%in *** for southeastern China,the SWS generally decreases over China in the near term(2020-2049)and later term(2070-2099),particularly under high-emission *** SWS reduction projected by REA is twice as high as that by the MME in the near term,reaching-4%to-3%.REA predicts a larger area of increased SWS in the later term,which expands from southeastern China to eastern *** study helps to reduce the projected SWS uncertainties.

关键词： Surface wind speed Uncertainty Multi-model ensemble Reliability ensemble averaging CMIP6

Advances in early diagnosis and therapy of pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2011年第2期10卷 128-135页

作者： Qiang Xu, tai-ping zhang and Yu-Pei ZhaoDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medial Sciences, Beijing 100730, China Department of General Surgery Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medial Sciences

BACKGROUND: Pancreatic cancer remains a devastating disease with a 5-year survival rate of less than 5%. Recent advances in diagnostic methods and therapeutic approaches have increased the possibility of improving the existing poor prognosis. DATA SOURCES: English-language articles reporting early diagnosis and therapy of pancreatic cancer were searched from the MEDLINE and PubMed databases, Chinese-language articles were from CHKD (China Hospital Knowledge Database) RESULT: The current literature about pancreatic cancer was reviewed from three aspects: statistics, screening and early detection, and therapy. CONCLUSIONS: Early detection and screening of pancreatic cancer currently should be limited to high risk patients Surgical resection is the only curative approach available, with some recent improvement in outcomes. Gemcitabine has been a standard treatment during the last decade. Gemcitabine based combination treatment, especially combined with newer molecular targeted agents, is promising. The rationale for radiotherapy is controversial, but with the recent development of modern radiation delivery techniques, radiotherapy should be intensified. Patients with borderline pancreatic cancer could benefit from neoadjuvant therapy but more evidence is needed and the best neoadjuvant regimen is still to be determined.

关键词： pancreatic neoplasm early diagnosis biomarkers surgery adjuvant therapy neoadjuvant therapy borderline resectable tumor

Prognostic significance of epidermal growth factor-like domain 7 in pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 523-528页

作者： Li Zhou Jian Li Yu-Pei Zhao Jun-Chao Guo Quan-Cai Cui Wei-Xun Zhou tai-ping zhang Wen-Ming Wu Lei You Hong Shu Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences/Peking Union Medical College Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences/Peking Union Medical College

BACKGROUND： Recent studies have shown the clinical significance of epidermal growth factor-like domain 7（EGFL7）in a variety of cancers. However, the relationship between EGFL7 and the prognosis of pancreatic cancer（PC） remains unclear. The present study was undertaken to investigate the role of EGFL7 in the prognosis of ***： The expression of EGFL7 in nine PC cell lines was first determined by Western blotting analysis. Tissue microarray-based immunohistochemical staining was performed in paired formalin-fixed paraffin-embedded tumor and non-tumor samples from 83 patients with PC. Finally,correlations between EGFL7 expression and clinicopathological variables as well as overall survival were ***： EGFL7 was widely expressed in all PC cell lines ***7 expression in tumor tissues was significantly higher than that in non-tumor tissues（P0.040）. In addition, univariate analysis revealed that high EGFL7 expression in tumor tissues was significantly associated with poor overall survival,accompanied by several conventional clinicopathological variables, such as gender, histological grade and lymph node metastasis. In a multivariate Cox regression test, EGFL7 expression was identified as an independent marker for longterm outcome of ***： Our data showed that EGFL7 is extensively expressed in PC and that EGFL7 is associated with poor prognosis.

关键词： epidermal growth factor-like domain 7 pancreatic cancer prognosis Western blotting immunohistochemistry tissue microarray

Luminescence properties and optical sensing behaviors of Sr_(2)GdSbO_(6):Eu^(3+) phosphors

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Journal of Rare Earths 2024年第8期42卷 1458-1469,I0002页

作者： Youfa tai Ruirui Cui Jun zhang Chunkai Wang Tingyu Zhao Beiqiao zhang Chaoyong Deng Key Laboratory of Functional Composite Materials of Guizhou Province College of Big Data and Information EngineeringGuizhou UniversityGuiyang550025China College of Computer and Information Engineering Guizhou University of CommerceGuiyang550014China School of Electronics and Information Engineering Guiyang UniversityGuiyang550005China

Novel orange-red Sr_(2)GdSbO_(6):xEu^(3+)(x=0,0.05,0.1,0.2,0.3,0.4,0.5 and 0.6) phospho rs were successfully prepared by the traditional high-temperature solid-state *** results of Rietveld refinement,energy dispersive spectroscopy(EDS) spectrum and elemental mapping demonstrate that Eu^(3+) successfully replaces the Gd^(3+) sites and distributes uniformly in the particles of *** luminescence properties of Sr_(2)GdSbO_(6):Eu_(3+)phosphors were investigated in *** emission spectra of the strongest emission peak is the ^(5)D_(0)→^(7)F_(1)(593 nm) transition,which can emit orange-red light under393 nm *** the doping concentration of Eu3+ions is x=0.2,the luminescence intensity of the phosphors reaches the *** detailed mechanism of concentration quenching is attributed to dipole-dipole *** thermal stability values of Sr_(2)GdSbO_(6):0.2Eu^(3+) phosphors are 87%,82% and114% under 393,467 and 527 nm excitations,*** causes of the abnormal thermal quenching under 527 nm excitation were *** on the abnormal thermal quenching under527 nm excitation,the optical thermometry properties of Sr_(2)GdSbO_(6):0.2Eu^(3+)phosphors were investigated by fluorescence intensity ratio(FIR) technique,and appreciable relative sensitivity was *** results suggest that Sr_(2)GdSbO_(6):0.2Eu^(3+)phosphors can be potentially applied to w-LEDs and optical thermometers.

关键词： Sr_(2)GdSbO_(6):Eu^(3+) Phosphors Luminescence properties Abnormal thermal quenching Rare earths