检索结果-南通市图书馆

Recent updates and current issues of sentinel node navigation surgery for early gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2021年第2期33卷 142-149页

作者： Sung gon kim Bang Wool Eom Hong Man Yoon Chan Gyoo kim Myeong-Cherl Kook Young-Woo kim Keun Won Ryu Center for Gastric Cancer Research Institute&HospitalNational Cancer CenterGoyang-si 410-769Republic of Korea

With the increase in the incidence of early gastric cancer(EGC),several endoscopic and laparoscopic approaches,such as endoscopic submucosal dissection and function-preserving gastrectomy,have been accepted as standard *** node navigation surgery(SNNS)is an ideal surgical option for preservation of most parts of the stomach and consequent maintenance of normal gastric function to improve quality of life in patients with *** many previous studies and clinical trials have demonstrated the safety and feasibility of the sentinel node concept in gastric cancer,the clinical application of SNNS is *** issues regarding technical standardization and oncological safety need to be *** several studies to resolve these problems are being actively performed,and SNNS might be an important surgical option in the treatment of gastric cancer in the future.

关键词： Sentinel node navigation surgery function-preserving surgery early gastric cancer SENORITA

Origami multi-layer space shield for cylindrical space structure

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第10期37卷 294-312页

作者： Ji-Hun CHA Ji-Sub NOH Sarath Kumar SATHISH KUMAR Dohyeon JIN Dae-Young LEE Chun-gon kim Department of Aerospace Engineering Chosun UniversityGwangju 61452Republic of Korea Department of Aerospace and Software Engineering Gyeongsang National UniversityGyeongsangnam-do 52828Republic of Korea Department of Aerospace Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Aerospace Engineering KAISTDaejeon 34141Republic of Korea

The multidisciplinary space environment,encompassing orbital debris,cosmic radiation,and solar radiative heat,poses significant risks to spacecraft and astronauts,necessitating efficient and effective shielding solutions.A multi-layer shield with wide spacing has been proven to be an effective way to shield the spacecraft from space debris impact;however,due to the limited volume of the payload fairing,it was not feasible to apply a multi-layer shield to the spacecraft *** the origami design,the shield maintains a compact form during launch and subsequently expands in outer space to enhance *** geometric analysis,it has been confirmed that the deployable multi-layer space shield can occupy less space than conventional space shield structures while expanding into wider shield intervals and multiple *** hypervelocity impact experiments,it was confirmed that as the bumper spacing of the multi-layer space shield expands,its ballistic performance becomes superior to conventional space *** deployable multi-layer space shield can reduce not only hypervelocity impacts but also solar radiative heat using the same mechanism as multi-layer *** cosmic radiation dose analysis,it has been confirmed that the multi-layer space shield is effective in cosmic radiation shielding compared to conventional space structures.

关键词： Hybrid composite Origami Hypervelocity impact Space environment Space debris Cosmic radiation

Gastric cancer surgery in South Korea: Past, present, and future

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2023年第6期35卷 627-635页

作者： Sung gon kim Sang Eok Lee Bang Wool Eom Hong Man Yoon Young-Woo kim Keun Won Ryu Department of Surgery Konyang University HospitalDaejeon 35365Republic of Korea Center for Gastric Cancer Research Institute&HospitalNational Cancer CenterGoyang-si 410-769Republic of Korea

Gastric cancer remains a significant global health concern and its surgical management approaches have undergone significant changes in South Korea and worldwide. Subtotal or total gastrectomy with D2 lymph node dissection is well established as a standard surgical procedure for gastric cancer. With the active implementation of cancer screening in South Korea, the proportion of early gastric cancer cases has significantly increased over the past few decades, leading to a steady increase in the survival rate among patients. Furthermore, recent advances in surgical instruments and techniques have made minimally invasive surgery increasingly prevalent, not only for early but also for advanced gastric cancer. We aim to provide a comprehensive overview of the evolution and current status of gastric cancer surgery in South Korea.

关键词： Function-preserving surgery gastric cancer minimally invasive surgery surgery

SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第8期12卷 3281-3297页

作者： Baeksun kim Sung Hyun tag Eunjoo Nam Suji Ham Sujin Ahn Juhwan kim Doo-Wan Cho Sangjoon Lee Young-Su Yang Seung Eun Lee Yong Sik kim Il-Joo Cho Kwang Pyo kim Su-Cheol Han Heh-In Im Convergence Research Center for Diagnosis Treatment and Care System of Dementia(DTC)Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience KISTSeoul 02792Republic of Korea Animal Model Research Center Jeonbuk Department of Inhalation ResearchKorea Institute of Toxicology(KIT)Korea Research Institute of Chemical Technology(KRICT)Jeongeup 56212Republic of Korea Research Animal Resource Center KISTSeoul 02792Republic of Korea Department of Pharmacology Seoul National University College of MedicineSeoul 03080Republic of Korea Center for BioMicrosystems KISTSeoul 02792Republic of Korea Department of Applied Chemistry Kyung Hee UniversityGyeonggi-do 17104Republic of Korea

Abstinence from prolonged psychostimulant use prompts stimulant withdrawal *** adaptations within the dorsal striatum have been considered the main hallmark of stimulant abstinence. Here we explored striatal miRNA-target interaction and its impact on circulating miRNA marker as well as behavioral dysfunctions in methamphetamine(MA) abstinence. We conducted miRNA sequencing and profiling in the nonhuman primate model of MA abstinence, followed by miRNA qPCR,LC-MS/MS proteomics, immunoassays, and behavior tests in mice. In nonhuman primates, MA abstinence triggered a lasting upregulation of miR-137 in the dorsal striatum but a simultaneous downregulation of circulating miR-137. In mice, aberrant increase in striatal miR-137-dependent inhibition of SYNCRIP essentially mediated the MA abstinence-induced reduction of circulating miR-137. Pathway modeling through experimental deduction illustrated that the MA abstinence-mediated downregulation of circulating miR-137 was caused by reduction of SYNCRIP-dependent miRNA sorting into the exosomes in the dorsal striatum. Furthermore, diminished SYNCRIP in the dorsal striatum was necessary for MA abstinence-induced behavioral bias towards egocentric spatial learning. Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome.

关键词： Methamphetamine Abstinence Withdrawal Striatum miR-137 SYNCRIP Biomarker Behavior

Design of 32 kbit one-time programmable memory for microcontroller units

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2012年第12期19卷 3475-3483页

作者： JEON Hwang-gon CHOI In-hwa HA Pan-bong kim Young-hee Department of Electronic Engineering Changwon National University9 Sarim-DongChangwon 641-773Korea

A 32 kbit OTP(one-time programmable)memory for MCUs(micro-controller units)used in remote controllers was *** OTP memory is used for program and data *** is required to apply 5.5V to BL(bit-line)and 11V to WL(word-line)for a OTP cell of 0.35μm ETOX(EEPROM tunnel oxide)type by *** use 5V transistors on column data paths to reduce the area of column data paths since they require small *** addition,we secure device reliability by using HV(high-voltage)transistors in the WL ***,we change from a static logic to a dynamic logic used for the WL driver in the core ***,we optimize the WD(write data)switch ***,we can implement them with a small-area *** addition,we implement the address predecoder with a small-area logic *** area of the designed 32 kbit OTP with 5V and HV devices is 674.725μm×258.75μm(=0.1745mm2)and is 56.3% smaller than that using 3.3V devices.

关键词： one-time programmable memory micro controller unit EEPROM tunnel oxide small-area

Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2020年第1期6卷 927-938页

作者： Hae Gyun Lim Hsiao-Chuan Liu Chi Woo Yoon Hayong Jung Min gon kim Changhan Yoon Hyung Ham kim KKirk Shung Department of Creative IT Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea NIH Resource Center for Medical Ultrasonic Transducer Technology and Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Biomedical Engineering Inje UniversityGimhaeGyeongnam 50834Republic of Korea

Advancements in diagnostic systems for metastatic cancer over the last few decades have played a significant role in providing patients with effective treatment by evaluating the characteristics of cancer *** the progress made in cancer prognosis,we still rely on the visual analysis of tissues or cells from histopathologists,where the subjectivity of traditional manual interpretation *** paper presents the development of a dual diagnosis and treatment tool using an in vitro acoustic tweezers platform with a 50MHz ultrasonic transducer for label-free trapping and bursting of human breast cancer *** cancer cell detection and classification,the mechanical properties of a single cancer cell were quantified by single-beam acoustic tweezers(SBAT),a noncontact assessment tool using a focused acoustic ***-mimicking phantoms and agarose hydrogel spheres(AHSs)served to standardize the biomechanical characteristics of the *** on the analytical comparison of deformability levels between the cells and the AHSs,the mechanical properties of the cells could be indirectly measured by interpolating the Young’s moduli of the *** a result,the calculated Young’s moduli,i.e.,1.527kPa for MDA-MB-231(highly invasive breast cancer cells),2.650kPa for MCF-7(weakly invasive breast cancer cells),and 2.772 kPa for SKBR-3(weakly invasive breast cancer cells),indicate that highly invasive cancer cells exhibited a lower Young’s moduli than weakly invasive cells,which indicates a higher deformability of highly invasive cancer cells,leading to a higher metastasis ***-cell treatment may also be carried out by bursting a highly invasive cell with high-intensity,focused ultrasound.

关键词： diagnosis treatment weakly

Basic analysis of rock mechanical and thermal properties in South Korea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rock Mechanics Bulletin

Rock Mechanics Bulletin 2023年第3期2卷 66-77页

作者： Byung-gon Chae Eui-Seob Park Hyoung-Chan kim Korea Institute of Geoscience and Mineral Resources(KIGAM) Deep Subsurface Storage and Disposal Research Center34132DaejeonSouth Korea Korea Institute of Geoscience and Mineral Resources(KIGAM) Groundwater Environment Research Center34132DaejeonSouth Korea

This study analyzed the mechanical and thermal properties of various rock types found in South *** results showed that both igneous and metamorphic rocks possess higher strength compared to sedimentary *** Young's modulus of rocks is dependent on the extent of weathering they have *** average cohesion of granites was found to be relatively higher compared to other rock types,and their friction angle also exhibited a relatively high value with a considerable *** results of uniaxial compression strength testing with respect to depth revealed that rock strength generally increased with depth,however,there was a large variance in strength distribution in each depth *** on these findings,it can be concluded that South Korea can also secure HLW disposal sites and facilities in terms of rock mechanics by using crystalline rocks,similar to countries such as Sweden and Finland where disposal facilities are being *** the thermal properties of rocks,they are influenced by the distribution of the parent *** thermal conductivity is highly concentrated in the southwest and central regions of South Korea,while the geothermal gradient is high in the northeast,west,and some parts of the southeast *** southeast region of Korea has a high geothermal heat flow,and some central northern regions also exhibit relatively high geothermal heat *** light of these distributional characteristics,it is crucial to continue conducting precise studies on the mechanical and thermal properties of rocks in the future disposal depths of spent nuclear fuel.

关键词： Rock mechanics Thermal properties HLW disposal Crystalline rocks

Acute myelomonocytic leukemia during pembrolizumab treatment for non-small cell lung cancer: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第13期8卷 2833-2840页

作者： Hong-Beum kim Sang-gon Park Ran Hong Seong-Ho Kang Yong Sub Na Department of Premedical Course Chosun University School of MedicineGwangju 61452South Korea Department of Hemato-oncology Chosun University HospitalGwangju 61453South Korea Department of Pathology Chosun University HospitalGwangju 61453South Korea Department of Laboratory Medicine Chosun University HospitalGwangju 61453South Korea Department of Pulmonology and Critical Care Medicine Chosun University HospitalGwangju 61453South Korea

BACKGROUND Pembrolizumab is a highly selective IgG4 kappa isotype monoclonal antibody against the programmed cell death-1(PD-1)*** the treatment of nonsmall cell lung cancer(NSCLC),pembrolizumab has demonstrated significant efficacy,significant survival outcomes,long-lasting responses,and a good safety profile compared with cytotoxic *** SUMMARY A 79-year-old Korean male presented with a left side palpable neck *** ultrasound-guided core-needle biopsy of the largest neck mass was performed,and squamous cell carcinoma was confirmed based on the histological and immunohistochemical *** was diagnosed with squamous cell carcinoma of the lung with multiple lymph nodes and rib metastases(T1N3M1b,Stage IVA)using enhanced chest computed tomography and 18F-fluorodeoxyglucose positron emission/computed *** 4 cycles of gemcitabine and carboplatin,we clinically judged the disease as *** to the high PD-1 expression demonstrated by the patient,pembrolizumab was initiated(200 mg every 3 wk).After 3 cycles of pembrolizumab,a complete response was *** the 4th cycle of pembrolizumab,the white blood cell count was markedly *** blood smear analysis and bone marrow biopsy were *** patient was diagnosed with acute myelomonocytic *** We present the first report of acute myelomonocytic leukemia during pembrolizumab treatment in an NSCLC patient;the mechanism remains unknown.

关键词： Acute myeloid leukemia Immunotherapy Non-small cell lung cancer Adverse events Case report

Fabrication of Variable Optical Attenuator With Low Insertion Loss

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

光学学报 2003年第S1期23卷 305-306页

作者： Yone-gon Seo Yong-Tak kim Jemin kim Hyung-Do Yoon Young-Min Im Korea Electronics Technology Institute 455-6 MaSan-Ri JinWi-Myon PyungTaek-Si KyungGi-Do Korea Department of Advanced Materials Engineering Sungkyunkwan University Jangan-gu Suwon 440-746 Korea

A voltage-controlled variable optical attenuator (VOA) based on silica-based planar lightwave circuits (PLC) was fabricated by flame hydrolysis deposition (FHD). The variable attenuator with Cr heater achieves 20dB attenuation with 318mW electrical power at 1550 nm. The insertion loss and the polarization dependent loss (PDL) at 0 attenuation are 1dB and 0.23dB, respectively.

关键词： electrical power insertion loss