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Incidence, prevalence and risk of stroke in patients with Takayasu arteritis: a nationwide population-based study in South Korea

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Stroke & Vascular Neurology 2022年第2期7卷 149-157页

作者： Sung Soo ahn Minkyung Han Yong-Beom Park Inkyung Jung Sang-Won Lee Department of Internal Medicine Yongin Severance HospitalYonsei University College of MedicineYonginSouth Korea Biostatistics Collaboration Unit Department of Biomedical Systems InformaticsYonsei University College of MedicineSeoulSouth Korea Division of Rheumatology Department of Internal MedicineYonsei University College of MedicineSeoulSouth Korea Institute for Immunology and Immunological Diseases Yonsei University College of MedicineSeoulSouth Korea Division of Biostatistics Department of Biomedical Systems InformaticsYonsei University College of MedicineSeoulSouth Korea

Background Takayasu arteritis(TAK)is a disease associated with increased risk of cardiovascular *** aimed to evaluate the incidence,prevalence and risk of stroke in patients with *** Data from 1065 patients were obtained from a national database(2010–2018).The annual incidence and prevalence per 100000 persons were estimated using the registration population in the midst of every year,and the standardised incidence ratio(SIR)of stroke was compared with the general population based on the data from the 2006 national report for cardiovascular and cerebrovascular ***-adjusted incidence rate ratio(IRR)of stroke based on the time interval after diagnosis was also calculated.A time-dependent Cox regression was conducted to investigate predictive factors of *** The overall incidence rate of TAK ranged between 0.2 and 0.3/100000 person-years annually;the prevalence of TAK gradually increased,reaching 3.25/100000 person-years in ***-three(6.9%)patients experienced stroke during follow-up,and the risk of developing stroke was higher than the general population(overall SIR 7.39,95%CI 5.79 to 9.29;men:SIR 5.70,95%CI 2.84 to 10.20;women:SIR 7.06,95%CI 5.41 to 9.05).Most stroke events(90.9%)were cerebral infarction for men,whereas the proportion of cerebral infarction was lower(62.9%)in *** half of stroke events occurred within 6 months after diagnosis,and stroke was more common within 6 months of diagnosis compared with after 3 years in women(IRR 13.46,95%CI 6.86 to 26.40).In Cox regression analysis,age was the sole predictor of stroke(adjusted HR 1.02,95%CI 1.00 to 1.04,p=0.043).Conclusions The annual incidence of TAK was similar to the previous studies from Asia,and the risk of stroke increased in *** patterns of subtype and incidence of stroke were found according to sex,although age was the only predictor.

关键词： prevalence patients diagnosis

Treatment of syringomyelia using uncultured umbilical cord mesenchymal stem cells: A case report and review of literature

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World Journal of Stem Cells 2022年第4期14卷 303-309页

作者： Hyunjun ahn Sang Yeon Lee Won-Ju Jung Kye-Ho Lee Stem Cell Treatment and Research Institute(STRI) bio Beauty and Health Company(bBHC)Seoul 04420South Korea Stem Cell Treatment 97.7 Beauty and Health ClinicSeoul 04420South Korea

BACKGROUND Syringomyelia is a disease caused by the formation of a cavity inside the spinal cord and is accompanied by such symptoms as pain,paresthesia,and urination and defecation disorders,and in severe cases causes various ***,there are only surgical methods for the treatment of syringomyelia,but these methods carry the possibility of failure,recurrence,and side *** SUMMARY The patient was a 59-year-old woman who suffered from pain due to *** treatment,the patient received transplant of uncultured umbilical cord-derived mesenchymal stem *** intended,the patient's pain was relieved after ***,an additional benefit was found in that the size of the cavity also *** 2 years from the last treatment,the patient's cavity had almost completely disappeared and her syringomyelia was deemed *** Using uncultured umbilical cord-derived mesenchymal stem cells may be a new treatment alternative for syringomyelia.

关键词： Syringomyelia Umbilical cord mesenchymal stem cells Cell therapy Allogenic stem cells Chiari malformations Case report

FLOWERING LOCUS M isoforms differentially affect the subcellular localization and stability of SHORT VEGETATIVE PHASE to regulate temperature-responsive flowering in Arabidopsis

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Molecular Plant 2022年第11期15卷 1696-1709页

作者： Suhyun Jin Sun Young Kim Hendry Susila Zeeshan Nasim Geummin Youn Ji Hoon ahn Department of Life Sciences Korea UniversitySeoul 02841Republic of Korea

Temperature is an important environmental cue that affects flowering time in *** MADS-box transcription factor FLOWERING LOCUS M(FLM)forms a heterodimeric complex with SHORT VEGETATIVE PHASE(SVP)and controls ambient temperature-responsive flowering in ***-βand FLM-δ,two major splice variants produced from the FLM locus,exert opposite effects on flowering,but the molecular mechanism by which the interaction between FLM isoforms and SVP affects temperature-responsive flowering remains poorly ***,we show that FLM-βand FLM-δplay important roles in modulating the temperature-dependent behavior,conformation,and stability of *** localization of SVP decreases as temperature ***-βis required for SVP nuclear translocation at low temperature,whereas SVP interacts with FLM-δmainly in the cytoplasm at high *** preferentially binds to FLM-βat low temperature in tobacco leaf *** shows high binding affinity to FLM-βat low temperature and to FLM-δat high *** undergoes similar structural changes in the interactions with FLM-βand FLM-δ;however,FLM-δlikely causes more pronounced conformational changes in the SVP ***-δcauses rapid degradation of SVP at high temperature,compared with FLM-β,possibly via *** of lysine 53 or lysine 165 in SVP causes increased abundance of SVP due to reduced ubiquitination of SVP and thus delays flowering at high *** findings suggest that temperature-dependent differential interactions between SVP and FLM isoforms modulate the temperature-responsive induction of flowering in Arabidopsis.

关键词： flowering ambient temperature SVP FLM FLM-β FLM-δ nuclear translocation

Regression of gastric endoscopic submucosal dissection induced polypoid nodular scar after Helicobacter pylori eradication:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12793-12798页

作者： Byung Chul Jin Ae Ri ahn Seong-Hun Kim Seung Young Seo Department of Internal Medicine Jeonbuk National University Medical SchoolResearch Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea Department of Pathology Jeonbuk National University Medical SchoolResearch Institute of Clinical Medicine of Jeonbuk National UniversityBiomedical Research Institute of Jeonbuk National University Hospitaland Research Institute for Endocrine SciencesJeonju 56445South Korea

BACKGROUND Endoscopic submucosal dissection(ESD)is the treatment of choice for early gastric cancer and premalignant gastric *** some cases,ESD induced ulcer heals as a polypoid nodular scar(PNS).These scars may make the physicians raise several clinical implications such as post-ESD neoplastic *** SUMMARY We described a case of gastric ESD induced PNS which is regressed after Helicobacter pylori(***)eradication.A 58-year-old male patient was referred to the outpatient clinic for evaluation and treatment of gastric low-grade dysplasia(LGD).ESD was performed.A PNS was developed at the ESD *** endoscopic biopsy was done and there was no histological evidence of remnant tumor or recurrence but a hyperplastic mucosal *** PNS showed increase in size in follow-up endoscopy,and the biopsy specimen demonstrated *** *** eradication was done and the PNS was *** *** eradication is considerable for the regression of PNS if *** infesta tion is confirmed.

关键词： Polypoid nodular scar Helicobacter pylori Endoscopic submucosal dissection Case report

Comparative studies on the binding site of anesthetics to GABA a receptors using in silico docking methods

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BIOCELL 2023年第7期47卷 1661-1673页

作者： SEUNGHYUN ahn JUNG-YEON LEE JIHA SUNG HYUN JOO KIM SEYEON PARK Department of Applied Chemistry Dongduk Women’s UniversitySeoul02748Korea Division of Applied Chemistry and Cosmetic Science Dongduk Women’s UniversitySeoul02748Korea Department of Anesthesiology and Pain Medicine Anesthesia and Pain Research InstituteYonsei University College of MedicineSeoul03722Korea

Although the GABAA receptor(GABAAR)has been proposed as the main action site for sevoflurane,isoflurane,halothane,enflurane,propofol,and benzodiazepines(BZDs),binding of these anesthetics with high-resolution structures of the GABAAR have been rarely examined by comparative docking ***,various combinations of ligands on more GABAARs with various subtypes need to be analyzed to understand the elaborate action mechanism of GABAARs better because some GABAA ligands showed specificity toward the distinct subtypes of the ***:We performed in silico docking analysis to compare the binding modes of sevoflurane,isoflurane,halothane,enflurane,propofol,and BZDs to the GABAAR based on one of the most recently provided 3D *** performed the docking analysis and the affinity-based ranking of the binding ***:Our docking studies revealed that isoflurane,halothane,and enflurane docked in an extracellular domain(ECD)on GABAARs,in contrast to ***:Our results supported a multi-site mechanism for the allosteric modulation of *** was bound to the pore or favored various subsites in the transmembrane domain(TMD).Our result confirmed that different chemically related BZD ligands interact via distinct binding modes rather than by using a common binding mode,as previously suggested.

关键词： GABAAR In silico docking Multi-binding site Anesthetics

Changes on optical coherence tomography angiography and fluorescein angiography in eyes with neovascular age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1837-1844页

作者： So Min ahn Mihyun Choi Cheolmin Yun Seong-Woo Kim Jaeryung Oh Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea

AIM:lo evaluate the changes on optical coherence tomography angiography(OCTA) and fluorescein angiography(FA) and their correlation in neovascular agerelated macular degeneration(nAMD) before and after intravitreal aflibercept injections(IAIs).METHODS:In 43 treatment-na?ve patients with nAMD,choroidal neovascularization(CNV) in OCTA were morphologically and quantitatively analyzed before and after IAIs to determine whether they are correlated with leakage on FA or *** combining CNV in OCTA and leakage in FA,lesions were characterized as three types:L+C+(with both CNV and leakage),L-C+(with CNV but without leakage),or L+C-lesion(with leakage outside CNV).RESULTS:Before IAI,while 27 eyes had L+C+lesion only,16 eyes had both L+C+and L-C+lesions *** capillaries and anastomosis in CNV were more developed in L+C+lesion,at 86.0% and58.1%,respectively,relative to 9.3% and 9.3% in L-C+lesions(P<0.001).After IAIs in 33 eyes,tiny capillaries and anastomosis were decreased in the lesions with cessation of leakage on FA(P<0.001 and P=0.001,respectively).In quantitative analysis,neovascularization length and numbers of junctions and endpoints were also significantly ***:Leakage on FA is associated with CNV morphology in OCTA and remained so after ***,by carefully assessing the morphological and quantitative changes of CNV in OCTA before and after treatment,activity of nAMD is expected even though CNV on OCTA is not completely matched with fluorescein leakage.

关键词： choroidal neovascularization fluorescein angiography leakage neovascular age-related macular degeneration optical coherence tomography angiography

Effects of phosvitin phosphopeptide-Ca complex prepared by efficient enzymatic hydrolysis on calcium absorption and bone deposition of mice

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Food Science and Human Wellness 2022年第6期11卷 1631-1640页

作者： Mengdie Zhao Dong Uk ahn Songming Li Wei Liu Shengwei Yi Xi Huang National Research and Development Center for Egg Processing College of Food Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Animal Science Department Iowa State UniversityAmes 50011USA Chongqing Institute for Food and Drug Control Chongqing 401121China

Phosvitin(PV)was treated with high-temperature,mild pressure(HTMP),and enzyme combination,and then phosvitin phosphopeptides-calcium(PPP-Ca)complexes were *** low-calcium specific pathogen free-Kunming(SPF-KM)mice were used to determine the effect of PPP-Ca complexes on intestinal calcium absorption and their utilization for bone *** serum calcium content was the highest with the HTMP-Enz-PPP-Ca treatment(2.19 mmol/L),and it significantly down-regulated the abnormal elevation of serum alkaline phosphatase(AKP)caused by calcium *** low-calcium control group had the lowest calcium deposited to the femur(80.41 mg/g)and the lowest femur bone mineral density(BMD)(0.17 g/cm^(3)),while HTMP-Enz-PPP-Ca significantly improved bone calcium content(94.33 mg/g)and BMD(0.29 g/cm^(3)).The micro-computed tomography(MCT)images showed that the femur with the normal control,PV-Ca,and HTMP-Enz-PPP-Ca treatments had a more compact,complete,and thicker trabecular network than the low-calcium and CaCl_(2)*** results indicated that the organic calcium(HTMP-Enz-PPP-Ca)promoted calcium absorption and bone deposition,and the effect of HTMP-Enz-PPP-Ca was better than the inorganic CaCl_(2).

关键词： Phosvitin phosphopeptide(PPP)-Ca complex SPF KM mice Calcium absorption Bone formation

Color Enhancement by Diffusion of Beryllium in Dark Blue Sapphire

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光谱学与光谱分析 2016年第5期36卷 1623-1628页

作者： Kyungjin Kim Yongkil ahn Division of Crafts Design Kongju National University 56 Gongjudaehak-Ro Gongju-Si Chungnam Province 314-701 Republic of Korea Department of Materials Science and Engineering Hanyang University 17 Haengdang-dongSeongdong-gu Seoul 133-791 Republic of Korea

Diffusion of beryllium was performed on dark blue sapphire from China and *** samples were heated with beryllium as a dopant in a furnace at 1 600℃ for 42 hin *** beryllium diffusion,samples were analyzed by UV-Vis,FTIR,and WD-XRF *** heat-treatment with Be as a catalyst,the irons of the ferrous state were changed to the ferric ***,reaction of Fe^(2+)/Ti^(4+) IVCT was *** absorption peaks at 3 309cm^(-1) attributed to OH radical were disappeared completely due to carry out heat ***,the intensity of absorption band was decreased in the visible ***,decreased absorption band in the vicinity of 570 nm was responsible for the lighter blue ***,we confirmed that the dark blue sapphires from China and Australia were changed to vivid blue.

关键词： Blue sapphire Beryllium Diffusion UV-Vis FTIR WD-XRF spectroscopy

Nuclear and chloroplast genome diversity revealed by low-coverage whole-genome shotgun sequence in 44 Brassica oleracea breeding lines

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Horticultural Plant Journal 2021年第6期7卷 539-551页

作者： Sampath Perumal Nomar Espinosa Waminal Jonghoon Lee Hyun-Jin Koo Boem-soon Choi Jee Young Park Kyounggu ahn tae-Jin Yang Department of Agriculture Forestry and BioresourcesPlant Genomics and Breeding Instituteand Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Global Institute for Food Security University of Saskatchewan421 Downey RoadSaskatoonSK S7N 4L8Canada Agriculture and Agri-Food Canada 107 Science PlaceSaskatoon S7N 0X2Canada Chromosome Research Institute Department of Life ScienceSahmyook UniversitySeoul 01795Republic of Korea Joeun Seeds.Co. LtdGoesan-GunChungcheongbuk-Do 367-833Republic of Korea Phyzen Genomics Institute 13Seongnam-daero 331beon-gilBundang-guSeongnam-siGyeonggi-do 13558Republic of Korea

Whole-genome shogun sequence(WGS)data generated by next-generation sequencing(NGS)platforms are a valuable resource for crop *** produced 5–6×WGS coverage of 44 Brassica oleracea breeding lines representing seven subspecies/morphotypes:cabbage,broccoli,cauliflower,kailan,kale,Brussels sprout,and kohlrabi to systematically evaluate the nuclear and chloroplast(Cp)diversity in the 44 *** breeding *** then exploited the impact of low-coverage NGS by evaluating nuclear genome diversity and assembly,annotation of complete chloroplast(Cp)genomes and 45 S nuclear ribosomal DNA(45S nrDNA)sequences,and copy number variation for major *** genome diversity analysis has revealed a total of 496463 SNPs and 37493 indels in the nuclear genome across the 44 ***,some SNPs showed subspecies enrichment at certain chromosomal *** assembly of complete Cp genomes contained 153361–153372 bp with 37 variants including SNPs and *** 45S nrDNA transcription unit was 5802 bp long with a total of 31 SNPs from the 44 *** phylogenetic tree inferred from the nuclear and Cp genomes coincided and clustered broccoli,cauliflower,and kailan in one group and cabbage,Brussels sprout,kale,and kohlrabi in another *** morphotypes diverged during the last 0.17 million *** Cp genome diversity reflected the unique cytoplasm of each subspecies,and revealed that the cytoplasm of many breeding lines was replaced and intermingled via inter-subspecies crosses during the breeding process *** polymorphic Cp markers provide a classification system for the cytoplasm types in ***,copy numbers of major transposable elements(TEs)showed high diversity among the 44 accessions,indicating that many TEs have become active ***,we demonstrated a comprehensive utilization of low-coverage NGS data and might shed light on the genetic diversity and evolution of diverse *** morphotypes.

关键词： Brassica oleracea subspecies Chloroplast genome Nuclear ribosomal DNA Genetic diversity Phylogeny