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Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction

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Neural Regeneration Research 2015年第8期10卷 1251-1257页

作者： Ji Yun ahn Hyun-Jin tae Jeong-Hwi Cho In Hye Kim Ji Hyeon ahn Joon Ha Park Dong Won Kim Jun Hwi Cho Moo-Ho Won Seongkweon Hong Jae-Chul Lee Jeong Yeol Seo Department of Emergency Medicine Sacred Heart Hospital College of Medicine Hallym University Department of Emergency Medicine School of Medicine Kangwon National University Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Department of Neurobiology School of Medicine Kangwon National University Department of Emergency Medicine Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Surgery School of Medicine Kangwon National University

c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated the changes in c-Fos expression in the rat cingulate and piriform cortices after myocardial infarction. Neuronal degeneration in cingulate and piriform cortices after myocardial infarction was detected using cresyl violet staining, Neu N immunohistochemistry and Fluoro-Jade B histofluorescence staining. c-Fos-immunoreactive cells were observed in cingulate and piriform cortices at 3 days after myocardial infarction and peaked at 7 and 14 days after myocardial infarction. But they were hardly observed at 56 days after myocardial infarction. The chronological change of c-Fos expression determined by western blot analysis was basically the same as that of c-Fos immunoreactivity. These results indicate that myocardial infarction can cause the chronological change of immediate-early response gene c-Fos protein expression, which might be associated with the neural activity induced by myocardial infarction.

关键词： nerve regeneration paralimbic cortices myocardial infarction c-Fos cingulate cortex piriform cortex immunohistochemistry western analysis neural regeneration

Hybrid Friction Stir Welding of High-carbon Steel

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Journal of Materials Science & Technology 2011年第2期27卷 127-130页

作者： Don-Hyun Choi Chang-Yong Lee Byung-Wook ahn Jung-Hyun Choi Yun-Mo Yeon keun Song Seung-Gab Hong Won-Bae Lee Ki-Bong Kang Seung-Boo Jung School of Advanced Materials Science and Engineering Sungkyunkwan University 300 Cheoncheon-dongJangan-guSuwonGyeonggi-do 440-746South Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology 335 GwahangnoYuseong-guDaejeon 305-701South Korea Department of Advanced Materials Application Suwon Science College 9-10Botong-liJeongnam-myeonHwasungGyeonggi-do 445-742South Korea Technical Research Lab POSCO Corp.Goedong-dongNam-guPohangGyeongbuk790-785South Korea

A high-carbon steel joint,SK5（0.84 wt% C）,was successfully welded by friction stir welding（FSW）,both without and with a gas torch,in order to control the cooling rate during *** welding,the weld zone comprised gray and black regions,corresponding to microstructural variation：a martensite structure and a duplex structure of ferrite and cementite,*** volume fraction of the martensite structure and the Vickers hardness in the welds were decreased with the using of the gas torch,which was related with the lower cooling rate.

关键词： Friction stir welding High-carbon steel Transformation Martensite

Item Response Theory Based Ensemble in Machine Learning

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International Journal of Automation and computing 2020年第5期17卷 621-636页

作者： Ziheng Chen Hongshik ahn Department of Applied Mathematics and Statistics Stony Brook UniversityNew York 11794−3600USA

In this article,we propose a novel probabilistic framework to improve the accuracy of a weighted majority voting *** order to assign higher weights to the classifiers which can correctly classify hard-to-classify instances,we introduce the item response theory(IRT)framework to evaluate the samples′difficulty and classifiers′ability *** assigned the weights to classifiers based on their *** models are created with different assumptions suitable for different *** making an inference,we keep a balance between the accuracy and *** our experiment,all the base models are constructed by single trees via *** explain the models,we illustrate how the IRT ensemble model constructs the classifying *** also compare their performance with other widely used methods and show that our model performs well on 19 datasets.

关键词： Classification ensemble learning item response theory machine learning expectation maximization(EM)algorithm

Biphasic Nano-Domains of Planar Lipid Bilayer Complexed with Fluorogenic Polymer Reporter Tailored for Antimicrobial Detection

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CCS Chemistry 2022年第11期4卷 3637-3647页

作者： Jimin Hwang Woo Hyuk Jung Yeol Kyo Choi Dong June ahn Department of Chemical and Biological Engineering Korea UniversitySeoul 02841 Department of Biological Sciences Lehigh UniversityBethlehemPennsylvania 18015 KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841

We have fabricated an unexpected type of supported planar bilayer composed of receptor phospholipids and single-chained diacetylenes as fluorogenic reporters using protruded anchor moieties with a positive terminal *** topographical and surface thermodynamic analyses,as well as molecular dynamics simulations,revealed the coexistence of well-dispersed liquid-condensed(L_(c))domains forming nano-islands and liquid-expanded(L_(e))region in the planar bilayer,enhancing sensitivity against a prototype of ubiquitous membrane-associated antimicrobial peptides,*** L_(e)regions,acting as target receptors,enabled sensitive detection as the melittin adsorbed and inserted into these regions due to strong hydrophobic interactions between phospholipids and *** L_(c)domains,serving as signal reporters,enabled diacetylenes to assemble,polymerize,and fluoresce in response to the insertion of melittin into the L_(e)***,biphasic nanodomains of the planar lipid bilayer finally endowed this sensor system with a detection range of 100μMto 50 nM and a limit of detection(LOD)of∼37 nM for *** exceeded the operational performance of the colorimetric polydiacetylene vesicle solution 45 times,which reportedly ranged from 100 to 4μM with an LOD of∼1.7μM.

关键词： biphasic nano-domain supported lipid bilayer fluorogenic polymer reporter liquid-expanded region liquid-condensed domain

Optimal intensity and duration of cupping for minimizing possible mechanical skin deformation

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Journal of Traditional Chinese Medicine 2021年第5期41卷 817-825页

作者： Bummo ahn Soobyeong Kim Robotics R&BD Group Korea Institute of Industrial TechnologyAnsan 15588Republic of Korea Department of Robotics and Virtual Engineering University of Science and TechnologyAnsan 15588Republic of Korea Wellness Technology R&D Center Natural Arin Medi CorporationSejongsi 30127Republic of Korea

OBJECTIVE:To identify the optimal intensity and duration of cupping that would minimize mechanical skin ***:We developed an optical measurement probe and system for measuring skin color values in real *** applied cupping at the following five Bladder Meridian *** investigate optimal intensity,negative pressure intensity was increased every 2 min up to 80 k *** investigate optimal time,10 measurement sites were selected and negative pressure intensities of 30,60,and 80 k Pa were applied for 5 min *** color information was analyzed by the following skin color values:red color saturation,erythema index,and melanin ***:The red color saturation and erythema index increased steadily up to 60 kpa negative pressure intensity,then decreased between 60 and 80 k ***,maximal values were observed at 60 k *** melanin index consistently increased with increasing negative pressure *** red color saturation and erythema index did not change after 20 s at 60 k Pa negative pressure *** negative pressure intensities below 80 k Pa,significant changes in melanin index were not observed after 20 *** 80 k Pa negative pressure intensity,the melanin index exhibited an increasing pattern for200 s,then showed no ***:To minimize skin deformation,60 k Pa and 20 s were the appropriate intensity and duration when using red color saturation and erythema index as diagnostic *** of the increasing pattern up to 80 k Pa negative pressure intensity,the optimal intensity of melanin index could not be *** applying 80 k Pa negative pressure intensity and using melanin index as the diagnostic index,we recommend a duration of 200 s.

关键词： ecchymosis petechiae pigmentation erythema melanins

Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer

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Chinese Journal of Cancer Research 2020年第2期32卷 228-241页

作者： Hyuk Hur Min Soo Cho Woong Sub Koom Joon Seok Lim tae Il Kim Joong Bae ahn Hoguen Kim Nam Kyu Kim Division of Colon and Rectal Surgery Department of SurgerySeverance HospitalYonsei University College of MedicineSeoul 03722Korea Department of Radiation Oncology Severance HospitalYonsei University College of MedicineSeoul 03722Korea Departm ent of Radiology Research Institute of Radiological ScienceSeverance HospitalYonsei University College of MedicineSeoul 03722Korea Department of Internal Medicine Institute of Gastroenterology Department of Medical Oncology Severance HospitalYonsei University College of MedicineSeoul 03722Korea Department of Pathology Severance HospitalYonsei University College of MedicineSeoul 03722Korea

Objective:The aim of this study is to develop a nomogram for prediction of pathologic complete remission(p CR)after preoperative chemoradiotherapy(CRT)for rectal ***:m RNA expression levels of seven molecular markers[p53,p21,Ki-67,vascular endothelial growth factor(VEGF),CD133,CD24,CD44]were measured by reverse transcriptase polymerase chain reaction(RTPCR)in 120 rectal *** findings of clinical complete remission(c CR)and biologic variables were used to construct nomogram in the training group(n=80),which was validated in the validation group(n=40).Results:m RNA expression levels of four markers(p53,p21,Ki67,CD133)correlated with p CR(24/80,30.0%)in the training *** expression of p53 and/or high expression of p21,Ki67 and CD133 showed greater p CR rate.p CR was shown in 18(69.2%)of 26 cases showing endoscopic c CR in the training *** p CR rate was demonstrated in lower tumor location than middle tumor(19/49,38.8%vs.5/31,16.1%).A nomogram for prediction of p CR was developed from the multivariate prediction model using these six variables,which showed good discrimination ability in the training group[area under the curve(AUC)=0.945]and validation group(AUC=0.922).The calibration plot showed good agreement between actual and predicted p CR in both patient ***:Nomogram for assessment of p CR can be useful for making treatment decisions after CRT according to predicted responses.

关键词： Rectal cancer chemoradiotherapy treatment response molecular marker endoscopy nomogram

Facile synthesis of microporous carbonaceous materials derived from a covalent triazine polymer for CO2 capture

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Journal of Energy Chemistry 2017年第5期26卷 965-971页

作者： Pillaiyar Puthiaraj Wha-Seung ahn Department of Chemistry and Chemical Engineering Inha UniversityIncheon 402-751South Korea

Highly porous nitrogen-doped carbon materials were synthesized by the carbonization of a low-cost porous covalent triazine polymer, PCTP-3, which had been synthesized by the AlClcatalyzed FriedelCrafts reaction of readily available monomers. The nature of the bond and structure of the resulting materials were confirmed using various spectroscopic methods, and the effects of KOH activation on the textural properties of the porous carbon materials were also examined. The KOH-activated porous carbon（aPCTP-3c） materials possessed a high surface area of 2271 mgand large micro/total pore volumes of 0.87/0.95 cmg, respectively, with narrower micropore size distributions than the porous carbon prepared without activation（PCTP-3c）. The aPCTP-3c exhibited the best COuptakes of 284.5 and 162.3 mg gand CHuptakes of 39.6 and 25.9 mg gat 273 and 298 K/1 bar, respectively, which are comparable to the performance of some benchmark carbon materials under the same conditions. The prepared materials exhibited high CO/Nselectivity and could be regenerated easily.

关键词： Porous carbons Covalent triazine polymer Carbonization CO2 capture Selectivity

DC Motor Speed Regulator via Active Damping Injection and Angular Acceleration Estimation Techniques

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 641-647页

作者： Seok-Kyoon Kim Choon Ki ahn Department of Creative Convergence Engineering Hanbat National UniversityDaejeon 341-58Republic of Korea School of Electrical Engineering Korea UniversitySeoul 136-701Republic of Korea

This paper suggests a novel model-based nonlinear DC motor speed regulator without the use of a current *** current dynamics,machine parameters and mismatched load variations are *** proposed controller is designed to include an active damping term that regulates the motor speed in accordance with the first-order low-pass filter dynamics through the pole-zero ***,the angular acceleration and its reference are obtained from simple first-order estimators using only the speed *** effectiveness is experimentally verified using hardware comprising the QUBEServo2,myRIO-1900,and LabVIEW.

关键词： Active damping injection angular acceleration estimator DC motor(DCM) speed regulation

Endoscopic management of occluded metal biliary stents:Metal versus 10F plastic stents

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World Journal of Gastroenterology 2010年第42期16卷 5347-5352页

作者： Won Jae Yoon Ji Kon Ryu Jung Won Lee Dong-Won ahn Yong-tae Kim Yong Bum Yoon Sang Myung Woo Woo Jin Lee Division of Gastroenterology Department of Internal MedicineSeoul National University College of Medicine101 Daehang-roJongno-guSeoul110-744South Korea Center for Liver Cancer National Cancer Center323 Ilsan-roIlsandong-guGoyang-siGyeonggi-do410-769South Korea

AIM:To compare the efficacy of self-expandable metal stents(SEMSs) with 10F plastic stents(PSs) in the endoscopic management of occluded ***:We retrospectively reviewed the medical records of 56 patients who underwent SEMS insertion for palliation of unresectable malignant biliary obstruction between 2000 and 2007 and subsequent endoscopic retrograde biliary drainage(ERBD) with SEMS or PS for initial SEMS occlusion between 2000 and ***:Subsequent ERBD with SEMS was performed in 29 patients and with PS in *** median time to stent occlusion after subsequent ERBD was 186 d in the SEMS group and 101 d in the PS group(P= 0.118).Overall median stent patency was 79 d for the SEMS group and 66 d for the PS group(P = 0.379).The mean number of additional biliary drainage procedures after subsequent ERBD in patients that died(n = 50) during the study period was 2.54 ± 4.12 for the SEMS group and 1.85 ± 1.95 for the PS group(P = 0.457).The mean total cost of additional biliary drainage procedures after the occlusion of subsequent SEMS or PS was $410.04 ± 692.60 for the SEMS group and $630.16 ± 671.63 for the PS group(P = 0.260).Tumor ingrowth as the cause of initial SEMS occlusion was the only factor associated with a shorter time to subsequent stent occlusion(101 d for patients with tumor ingrowth vs 268 d for patients without tumor ingrowth,P = 0.008).CONCLUSION:Subsequent ERBD with PSs offered similar patency and number of additional biliary drainage procedures compared to SEMSs in the management of occluded SEMS.

关键词： Stents Biliary tract neoplasms Obstructive jaundice Endoscopy Endoscopic retrograde cholangiopancreatography