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Optical delivery of multiple opsin-encoding genes leads to targeted expression and white-light activation

Light(Science & Applications) 2015年第1期4卷 129-136页

作者： Kamal Dhakal Subrata Batabyal Weldon Wright young-tae kim Samarendra Mohanty Biophysics and Physiology Lab The University of Texas at ArlingtonArlingtonTXUSA NanoScope Technologies LLCArlingtonTXUSA Department of Bioengineering The University of Texas at ArlingtonArlingtonTXUSA

In photodegenerative diseases such as retinitis pigmentosa(RP)and age-related macular degeneration(AMD),progressive loss of vision occurs as a result of degeneration of the periphery of the retina and the macula,*** optogenetic stimulation-based approaches to vision restoration offer the advantages of cellular specificity,high resolution,and minimal invasiveness over electrode arrays;however,the clinical translation of optogenetic activation suffers from the lack of a method for the delivery of opsins into spatially targeted regions of a retina that has ***-targeted opsin delivery through viral or non-viral methods to non-photodegenerated retinal areas will perturb these already functioning retinal ***,viral methods are subject to limitations on the delivery of large plasmids,such as fusion constructs of multiple spectrally separated opsins(e.g.,channelrhodopsin-2(ChR2),chimeric opsin variants(C1V1),ReaChR),which can provide higher photo-excitability than can a single narrow-band opsin under ambient light ***,we report the ultrafast near-infrared laser-based spatially targeted transfection of single and multiple opsins and present a comparison with the opsin expression distribution achieved using another non-viral,but non-targeted,transfection method,*** evaluation of cells transfected with multiple opsins using the laser method revealed a significantly higher white-light-induced photocurrent than in cells expressing a single opsin(ChR2).The laser-assisted targeted delivery of multiple opsin-encoding genes to the peripheral retina/macula is ideal for sensitizing retinal areas that have degenerated,thus paving the way toward the restoration of lost vision in RP/AMD patients.

关键词： gene delivery optogenetics optoporation vision restoration

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Programmed death ligand-1 expression and its prognostic role in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2016年第37期22卷 8389-8397页

作者： Ryul kim Bhumsuk Keam Dohee Kwon Chan-young Ock Miso kim tae Min kim Hak Jae kim Yoon Kyung Jeon In Kyu Park Chang Hyun Kang Dong-Wan kim young tae kim Dae Seog Heo Department of Internal Medicine Seoul National University HospitalSeoul 03080South Korea Cancer Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Pathology Seoul National University HospitalSeoul 03080South Korea Department of Radiation Oncology Seoul National University HospitalSeoul 03080South Korea Department of Thoracic and Cardiovascular Surgery Seoul National University HospitalSeoul 03080South Korea

AIM To investigate the expression and prognostic role of programmed death ligand-1(PD-L1) in locally advanced esophageal squamous cell carcinoma(ESCC).METHODS A total of 200 patients with ESCC who underwent radical esophagectomy with standard lymphadenectomy as the initial definitive treatment in Seoul National University Hospital from December 2000 to April 2013 were eligible for this analysis. Tissue microarrays were constructed by collecting tissue cores from surgical specimens, and immunostained with antibodies directed against PD-L1, p16, and c-Met. Medical records were reviewed retrospectively to assess clinical outcomes. Patients were divided into two groups by PD-L1 status, and significant differences in clinicopathologic characteristics between the two groups were assessed. RESULTS Tumor tissues from 67 ESCC patients(33.5%) were PDL1-positive. Positive p16 expression was observed in 21 specimens(10.5%). The H-score for c-Met expression was ≥ 50 in 42 specimens(21.0%). Although PDL1-positivity was not significantly correlated with any clinical characteristics including age, sex, smoking/alcoholic history, stage, or differentiation, H-scores for c-Met expression were significantly associated with PDL1-positivity(OR = 2.34, 95%CI: 1.16-4.72, P = 0.017). PD-L1 expression was not significantly associated with a change in overall survival(P = 0.656). In contrast, the locoregional relapse rate tended to increase(P = 0.134), and the distant metastasis rate was significantly increased(HR = 1.72, 95%CI: 1.01-2.79, P = 0.028) in patients with PD-L1-positive ESCC compared to those with PD-L1-negative *** PD-L1 expression is positively correlated with c-Met expression in ESCC. PD-L1 may play a critical role in distant failure and progression of ESCC.

关键词： Esophageal neoplasm Programmed death ligand-1 protein c-Met protein Prognosis p16INK4A protein

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Congenital ovarian anomaly manifesting as extra tissue connection between the two ovaries:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9318-9322页

作者： Myeong Gyun Choi Jong Woon kim Yoon Ha kim A Mi kim tae young kim Hyun Kyung Ryu Department of Obstetrics and Gynecology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Ovarian anomalies except for uni-or bilateral streak gonads are *** present a rare case of an ovarian anomaly in which both ovaries were connected by extra *** SUMMARY A 32-year-old,primipara with a twin pregnancy at 36 weeks of gestation was admitted to the hospital with severe *** underwent emergency cesarean section owing to persistent headache,blurred vision,and general *** a peritoneal incision,a thin rectangular-shaped tissue was seen in front of the *** delivery,the extra tissue was removed;no other anomalies were reported in either the ovaries or *** results of the removed tissue disclosed a well-vascularized loose stromal tissue with few follicles and scattered luteinized *** this case,to prevent pelvic adhesion or intestinal obstruction resulting from volvulus,strangulation,and torsion,the extra tissue was *** We report a case of a rare ovarian anomaly where both ovaries were connected by extra *** the extra tissue extends to the abdominal cavity,it should be removed to prevent pelvic adhesion or abdominal complications including intestinal volvulus,strangulation,and torsion.

关键词： Connected ovaries Extra tissue Ovarian anomaly Case report

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Prognostic implications of FGFR1 and MYC status in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2016年第44期22卷 9803-9812页

作者： Dohee Kwon Ji Yun Yun Bhumsuk Keam young tae kim Yoon Kyung Jeon Department of Pathology Seoul National University Hospital Seoul National University College of Medicine Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Department of Thoracic Surgery Seoul National University Hospital Cancer Research Institute Genomic Medicine Institute Seoul National University College of Medicine Seoul National University College of Medicine

AIM To investigate the clinicopathological features and prognostic implications of combined MYC and fibroblast growth factor receptor 1(FGFR1) status in esophageal squamous cell carcinomas(ESCCs). METHODS All patients with ESCC(n = 180) underwent surgical resection at Seoul National University Hospital sometime between 2000 and 2013. A tissue microarray was constructed using cores obtained from representative tumor areas of formalin-fixed, paraffin-embedded tissue blocks. FGFR1 and MYC copy numbers were quantified using fluorescence in situ hybridization. The level of MYC expression was determined using immunohistochemistry. FGFR1 and MYC amplification status was compared between primary and metastatic lymph nodes. Univariate and multivariate survival analyses were performed according to adjuvant therapy *** FGFR1 and MYC amplifications were observed in 21.4%(37/173) and 54.2%(91/168) of patients, respectively, while MYC expression was observed in 58.9%(106/180) of patients. There was a positive correlation between MYC amplification and overexpression(P = 0.002). Although FGFR1 amplification was not associated with MYC amplification or expression, 12.3%(20/163) of patients exhibited both FGFR1 amplification and MYC expression. There was also a correlation in FGFR1 amplification status between matched primary tumors and metastatic lymph nodes(P < 0.001). MYC expression was higher in ESCCs with p T1(P < 0.001) and in those with no lymph node metastasis(P = 0.023). MYC expression was associated with prolonged diseasefree survival(P = 0.036) and overall survival(OS)(P = 0.017) but was not an independent prognostic factor. FGFR1 amplification was an independent predictor for prolonged OS in all patients(P = 0.029) and in those who did not receive adjuvant therapy(P = 0.013). Combined FGFR1 amplification and MYC expression predicted better OS in patients who did not receive adjuvant therapy(P = 0.034) but not in those who did receive adjuvant ***

关键词： Receptor tyrosine kinase Fibroblast growth factor receptor 1 MYC Esophageal squamous cell carcinoma Gene amplification Prognosis Fluorescent in situ hybridization

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Predictors and prognostic impact of post-operative atrial fibrillation in patients with hip fracture surgery

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World Journal of Clinical Cases 2022年第11期10卷 3379-3388页

作者： Seong Jun Bae Chang Hee Kwon tae-young kim Haseong Chang Bum Sung kim Sung Hea kim Hyun-Joong kim Department of Internal Medicine Konkuk University Medical CenterSeoul 05030South Korea Department of Orthopaedic Surgery Konkuk University Medical CenterSeoul 05030South Korea

BACKGROUND Atrial fibrillation(AF)is the most common arrhythmia developing in postoperative *** data are available regarding pre-operative risk factors and prognostic impact of post-operative AF(POAF)following hip fracture surgery(HFS)in Korean *** We aimed to investigate the incidence,predictors,and hospital prognosis of POAF in HFS *** This study included 245 patients without history of AF who underwent HFS between August 2014 and November *** was defined as new-onset AF that occurred during hospitalization after *** Twenty patients(8.2%)experienced POAF after *** developed on median post-operative day 2(interquartile range,1–3).Multivariable logistic regression analysis showed that age[odds ratio(OR),1.111;95%confidence interval(CI),1.022–1.209],chronic obstructive pulmonary disease(COPD)(OR,6.352;95%CI,1.561–25.841)and E/e’ratio(OR,1.174;95%CI,1.002–1.376)were significant predictors of *** with POAF had a significantly higher intensive care unit admission rate(55.0%vs 14.7%,P<0.001)and incidence of congestive heart failure(45.0%vs 10.7%,P<0.001).In multivariable logistic regression analysis,POAF was significantly associated with increased incidence of congestive heart failure(OR,4.856;95%CI,1.437–16.411)and intensive care unit admission(OR,6.615;95%CI,2.112–20.718).CONCLUSION POAF was frequently developed in elderly patients following ***,COPD and elevated E/e’ratio were found as significant predictors of POAF in HFS *** with POAF significantly experienced intensive care unit admission and incident congestive heart failure during hospitalization.

关键词： Atrial fibrillation Post-operative Predictor Prognosis Hip fracture surgery

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World Journal of Clinical Cases 2020年第21期8卷 5341-5346页

作者： Eun-A Jang tae-young kim Eu-Gene Jung Seongtae Jeong Hong-Beom Bae Seongheon Lee Department of Anesthesiology and Pain Medicine Chonnam National University Medical SchoolChonnam National University HospitalGwangju 61469South Korea

BACKGROUND Donepezil is an acetylcholinesterase inhibitor used to improve cognition and delay disease progression in dementia patients by increasing acetylcholine *** drug may potentially interact with neuromuscular blocking agents(NMBAs)that act on muscular acetylcholine receptors during general ***,we present a case of inadequate neuromuscular blockade with rocuronium,a nondepolarizing NMBA,in a dementia patient who had taken *** SUMMARY A 71-year-old man was scheduled for laparoscopic *** had been taking donepezil 5 mg for *** anesthesia was induced with propofol and *** depth of neuromuscular blockade was monitored by train-of-four(TOF)*** the administration of rocuronium,the TOF ratio decreased at an unusually slow rate,and a TOF count of 0 was detected 7 min *** intubation,a TOF count of 1 was detected within 1 min,and a TOF ratio of 12%was detected within 2 *** TOF count remained at 4 even with an additional bolus and continuous infusion of rocuronium,suggesting resistance to this *** of propofol,an inhalation anesthetic was administered alongside another NMBA(cisatracurium).Then,the quality of neuromuscular blockade improved,and the TOF count remained at 0-1 for the next 70 *** further problems were encountered with respect to surgery or *** Donepezil may be responsible for inadequate neuromuscular blockade during anesthesia,especially when total intravenous anesthesia is used.

关键词： Donepezil Dementia General anesthesia Rocuronium Neuromuscular blocking agents Case report

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Tidal effects based on a GUP-induced effective metric

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Communications in Theoretical Physics 2024年第9期76卷 63-72页

作者： Soon-tae Hong Yong-Wan kim young-Jai Park Center for Quantum Spacetime and Department of Physics Sogang UniversitySeoul 04107Republic of Korea Department of Physics and Research Institute of Physics and Chemistry Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Physics Sogang UniversitySeoul 04107Republic of Korea

In this paper,we study tidal forces in the Schwarzschild black hole,whose metric explicitly includes a generalized uncertainty principle(GUP)*** also investigate interesting features of the geodesic equations and tidal effects that are dependent on the GUP parameterαrelated to a minimum ***,by solving the geodesic deviation equations explicitly with appropriate boundary conditions,we show thatαin the effective metric affects both the radial and angular components of the geodesic equation,particularly near the singularities.

关键词： generalized uncertainty principle geodesic deviation equation effective metric

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Adsorption Characteristics of 2,4-Dichlorophenoxybutric Acid Using Bamboo Activated Carbon in a Fixed Bed

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Journal of Agricultural Chemistry and Environment 2022年第3期11卷 184-195页

作者： tae young kim Sung Yong Cho Department of Environmental Energy Engineering Chonnam National University Gwangju Republic of Korea Department of Environmental Education Mokpo National University Jeollanamdo Republic of Korea

Adsorption and desorption characteristics of 2,4-dichlorophenoxybutyric acid (2,4-DB) from aqueous solution on bamboo activated carbon (BAC) were studied in a fixed bed adsorber. The adsorption equilibrium capacity of 2,4-DB on BAC increased with decreasing initial pH of the solution and with a maximum adsorption capacity of 1.61 mol/kg. The adsorption rate of 2,4-DB on BAC could be best fitted by the pseudo first-order model. The adsorption model based on the linear driving force approximation (LDFA) was used for simulating the adsorption behavior of the 2,4-DB in a fixed bed. More than 95% desorption of 2,4-DB was obtained using distilled water.

关键词： Adsorption Desorption 2 4-Dichlorophenoxybutric Acid Fixed Bed Kinetic

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Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy

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Bioactive Materials 2022年第12期7卷 433-445页

作者： Hyo-Jin Yoon Songhyun Lee tae young kim Seung Eun Yu Hye-Seon kim young Shin Chung Seyong Chung Suji Park Yong Cheol Shin Eun Kyung Wang Jihye Noh Hyun Jung kim Cheol Ryong Ku Hong Koh Chang-Soo kim Joon-Sang Park young Min Shin Hak-Joon Sung Department of Medical Engineering Yonsei University College of MedicineSeoul03722Republic of Korea School of Electrical and Electronic Engineering Yonsei UniversitySeoul03722Republic of Korea Department of Obstetrics and Gynecology Institution of Women’s Life Medical ScienceSeverance HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Biomedical Engineering The University of Texas at AustinAustinTX78712USA Department of Internal Medicine EndocrinologyInstitute of Endocrine ResearchYonsei University College of MedicineSeoul03722Republic of Korea Department of Pediatrics GastroenterologySeverance HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Computer Engineering Hongik UniversitySeoul04066Republic of Korea Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Numais Co. Ltd.Korea Seoul 04799Republic of Korea

All-in-one treatments represent a paradigm shift in future *** example,inflammatory bowel disease(IBD)is mainly diagnosed by endoscopy,which could be applied for not only on-site monitoring but also the intestinal lesion-targeted spray of injectable ***,molecular conjugation to the hydrogels would program both lesion-specific adhesion and drug-free *** study validated this concept of all-in-one treatment by first utilizing a well-known injectable hydrogel that underwent efficient solution-to-gel transition and nanomicelle formation as a translatable *** properties enabled spraying of the hydrogel onto the intestinal walls during ***,peptide conjugation to the hydrogel guided endoscopic monitoring of IBD progress upon adhesive gelation with subsequent moisturization of inflammatory lesions,specifically by *** peptide was designed to mimic the major component that mediates intestinal interaction with Bacillus subtilis flagellin during IBD ***,the peptide-guided efficient adhesion of the hydrogel nanomicelles onto Toll-like receptor 5(TLR5)as the main target of flagellin binding and *** peptide binding potently suppressed inflammatory signaling without drug loading,where TLR5 and Notch-1 operated collaboratively through downstream actions of tumor necrosis *** results were produced using a human colorectal cell line,clinical IBD patient cells,gut-on-a-chip,a mouse IBD model,and pig experiments to validate the translational utility.

关键词： Nanomicelle Injectable hydrogel Peptide display Theranostic All-in-one treatment Inflammatory bowel disease

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Recent progress and future research directions for electrochromic zinc-ion batteries

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Journal of Energy Chemistry 2024年第3期90卷 220-232,I0007页

作者： tae Gwang Yun Byungil Hwang Jun young Cheong Department of Molecular Science and Technology Ajou UniversitySuwon 16499Republic of Korea School of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Bavarian Center for Battery Technology(Bay Batt)and Department of Chemistry University of Bayreuth95447 BayreuthGermany

In recent times,future energy storage systems demand a multitude of functionalities beyond their traditional energy storage *** line with this technological shift,there is active research and development of electrochromic-energy storage systems designed to visualize electrochemical charging and discharging *** conventional electrochromic-energy storage devices primarily integrated supercapacitors,known for their high power density,to enable rapid color ***,the low energy density of supercapacitors restricts overall energy storage capacity,acting as a significant barrier to expanding the application range of such *** this review,we introduce electrochromic zinc(Zn)-ion battery systems,which effectively overcome the limitation of low energy density,and provide illustrative examples of their applicability across diverse *** many recent research works are present for electrochromic Zn-ion batteries,little review has so far taken *** objective is to discuss on the current progress and future directions for electrochromic Zn-ion batteries,which are applicable for wearable electronics applications and energy storage *** review provides an initial milestone for future researchers in electrochromic energy storage and zinc-ion batteries,which will lead to a stream of future works related to them.

关键词： Electrochromic Zn-ion battery Flexible Transition metal oxide Conductive polymer

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