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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第2期18卷 152-160页

作者： Eun-Hye PARK Won-Young BAE Su-Jin eom Kee-tae KIM Hyun-Dong PAIK Department of Food Sctence and Btotechnology of Animal Resources Konkuk University Seoul 05029 Korea Bio/Molecular Informatics Center Konkuk University Seoul 05029 Korea

Antioxidative and cytotoxic effects of chamomile（Matricaria chamomilla） fermented by Lactobacillus plantarum were investigated to improve their biofunctional activities. Total polyphenol（TP） content was measured by the Folin-Denis method, and the antioxidant activities were assessed by the 1,1-diphenyl-2-picrylhydrazyl（DPPH） method and β-carotene bleaching method. AGS, HeL a, LoV o, MCF-7, and MRC-5（normal） cells were used to examine the cytotoxic effects by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium（MTT） assay. The TP content of fermented chamomile reduced from 21.75 to 18.76 mg gallic acid equivalent（mg GAE）/g, but the DPPH radical capturing activity of fermented chamomile was found to be 11.1% higher than that of nonfermented chamomile after 72 h of fermentation. Following the β-carotene bleaching, the antioxidative effect decreased because of a reduction in pH during fermentation. Additionally, chamomile fermented for 72 h showed a cytotoxic effect of about 95% against cancer cells at 12.7 mg solid/ml of broth, but MRC-5 cells were significantly less sensitive against fermented chamomile samples. These results suggest that the fermentation of chamomile could be applied to develop natural antioxidative and anticancer products.

关键词： Chamomile Flavonoid Lactobacillus plantarum Matricaria chamomilla Antioxidant Cytotoxicity

Association between preoperative high sensitive troponin I levels and cardiovascular events after hip fracture surgery in the elderly

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Journal of Geriatric Cardiology 2018年第3期15卷 215-221页

作者： Bum Sung Kim tae-hoon Kim Jeong-Hwan Oh Chang Hee Kwon Sung Hea Kim Hyun-Joong Kim Heung Kon Hwang Sang-Man Chung in-gu Seoul Republic of Korea Department of Orthopedic surgery Konkuk University Medical Center 120-1 Neungdong-ro Hwayang-dong Gwangjin-guSeoulRepublic of Korea

Objective Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery （HFS）. We used high sensitive troponin I （hs-TnI） assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events （MACE） in elderly hip frac^u＇e patients. Method From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry. A total of 262 of these patients underwent HFS and hs-TnI assays. MACE was defined as postoperative all-cause deaths, heart failure （HF）, new-onset atrial fibrillation （AF）, myocardial infarction （MI） and cardiovascular re-hospitalization that occurred within 90 days postoperative. Results Of 262 HFS patients, MACE developed following HFS in 65 （24.8%）. Patients with MACE were older and had higher rates of renal insufficiency, coronary artery disease, prior HF, low left ventricular ejection fraction and use of beta blockers; higher levels of hs-Tnl and N-terminal pro-brain natriuretic peptide （NT-proBNP） and higher revised cardiac risk index. A preoperative hs-TnI≥ 6.5 ng/L was associated with high risk of postoperative HF, new-onset AF and MACE. In multivariable analysis, pre-operative independent predictors for MACE were age 〉 80 years [adjusted hazard ratio （HR）： 1.79, 95% confident interval （CI）： 1.03-3.13, P = 0.04], left ventricular ejection fraction （LVEF）〈 50% （adjusted HR： 3.17, 95% CI： 1.47-5.82, P 〈 0.01） and hs-TnI 〉 6.5 ng/L （adjusted HR： 3.75, 95% CI： 2.09~5.17, P 〈 0.01）. Conclusion In elderly patients with hip fracture who undergo HFS, a preoperative assessment of hs-TnI may help the risk refinement of cardiovascular complications.

关键词： Cardiovascular complication High sensitive troponin I Hip fracture surgery

Safety of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions: A single-center experience of 214 patients

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 562-568页

作者： Jin Ho Choi Sang Hyub Lee Young hoon Choi Min Su You Bang-Sup Shin Woo Hyun Paik Ji Kon Ryu Yong-tae Kim Department of Internal Medicine Liver Research Institute Seoul National University College of Medicine

Background:Endoscopic ultrasound-guided ethanol ablation(EUS-EA)for pancreatic cystic lesions(PCLs)has been used in recent years as a feasible treatment modality for low malignant probability PCLs or patients considered high-risk for *** present study aimed to confirm the safety of EUS-EA and to find predictive factors for adverse event(AE).Methods:A retrospective review was performed from the prospectively maintained database of patients who underwent EUS-EA for PCLs from June 2006 to April 2018 at Seoul National University *** primary outcomes of the study were the rates of AEs and severe AEs by *** secondary outcome was the predictive factors of AEs including acute pancreatitis and abdominal ***:A total of 214 patients were evaluated and the diagnoses of PCLs according to cystic fluid analysis and clinical features were as follows:serous cystic neoplasm(32.2%),mucinous cystic neoplasm(26.6%),branch duct type intraductal papillary mucinous neoplasm(BD-IPMN)(29.4%),and pseudocyst(11.7%).Three patients(1.4%)experienced severe ***,AEs occurred in 71(33.2%)***-IPMN(OR:2.87;95%CI:1.05–7.84;P=0.040),multilocular cysts(OR:3.59;95%CI:1.09–11.85;P=0.036),suspected ethanol leakage during procedure(OR:10.68;95%CI:1.98–57.53;P=0.006),and sticky cystic fluid(OR:3.83;95%CI:1.20–12.24;P=0.024)were predictive factors for post-procedural acute *** of uncinate process(OR:2.99;95%CI:1.22–7.35;P=0.017)and PCLs with exophytic portion(OR:3.70;95%CI:1.96–7.01;P<0.001)were predictive factors for post-procedural abdominal ***:EUS-EA is a safe procedure with a very low rate of severe *** seems possible to predict the AEs according to the features of the procedure and PCLs.

关键词： Pancreatic cyst EUS-guided ethanol ablation Adverse events

A Method to Obtain Auger Recombination Coefficient in an InGaN-Based Blue Light-Emitting Diode

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Chinese Physics Letters 2017年第1期34卷 107-109页

作者：汪莱孟骁 Jung-hoon Song tae-Soo Kim Seung-Young Lim 郝智彪罗毅孙长征韩彦军熊兵王健李洪涛 Tsinghua National Laboratory on Information Science and Technology and Department of Electronic EngineeringTsinghua UniversityBeijing 100084 Department of Physics Kongju National UniversityKongju 314701South Korea

We propose and demonstrate to derive the Auger recombination coefficient by fitting efficiency-current and carrier lifetime-current curves simultaneously, which can minimize the uncertainty of fitting results. The obtained Auger recombination coefficient is 1.0x10(-31) cm(6)s(-1) in the present sample, which contributes slightly to efficiency droop effect.

关键词： InGaN A Method to Obtain Auger Recombination Coefficient in an InGaN-Based Blue Light-Emitting Diode CIE

Low grade chondrosarcoma of the nasal septum

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World Journal of Clinical Cases 2013年第1期1卷 64-66页

作者： Dong hoon Lee Se Hee Jung tae Mi Yoon Joon Kyoo Lee Young Eun Joo Sang Chul Lim Department of Otolaryngology-Head and Neck Surgery Chonnam National University Medical School and Hwasun Hospital Hwasun Jeonnam 519-809 South Korea Department of Radiology Chonnam National University Medical School and Hwasun Hospital Hwasun Jeonnam 519-809 South Korea Department of Research Institute of Medical Sciences Chonnam National University Medical School and Hwasun Hospital Hwasun Jeonnam 519-809 South Korea

Chondrosarcoma of the nasal septum is extremely rare. In some cases, it may be diff icult to preoperatively differentiate low grade chondrosarcoma from benign cartilaginous tumors such as chondroma. We report a case of low grade chondrosarcoma of the nasal septum with characteristic radiologic f indings. Characteristic radiologic f indings such as calcif ications on computed tomography scan and a ring-and-arc pattern on enhanced T1 weighted image were useful in the preoperative diagnosis of low grade chondrosarcoma of the septum. Awareness of radiologic f indings of low grade chondrosarcoma can help to make an accurate diagnosis and perform appropriate excision, leading to successful local control.

关键词： Chondrosarcoma Nasal septum Endoscopic surgical procedure Computed tomography Radiology

Transarterial chemoembolization in Barcelona Clinic Liver Cancer Stage 0/A hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第3期20卷 745-754页

作者： Heung Cheol Kim Ki tae Suk Dong Joon Kim Jai hoon Yoon Yeon Soo Kim Gwang Ho Baik Jin Bong Kim Chang hoon Kim Hotaik Sung Jong Young Choi Kwang Hyub Han Seung Ha Park Department of Radiology Hallym University College of Medicine Department of Internal Medicine Hallym University College of Medicine College of Medicine Upstate Medical UniversityState University of New York Department of Biology Stanford University Department of Internal Medicine Catholic University College of Medicine Liver Cirrhosis Clinical Research Center Yonsei University College of Medicine Department of Internal Medicine Inje University College of Medicine

AIM: To evaluate the clinical characteristics of patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 and A hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE).

关键词： Carcinoma Hepatocellular Chemoembolization Therapeutic Survival Stage Efficacy

Ratio of metastatic lymph nodes is more important for rectal cancer patients treated with preoperative chemoradiotherapy

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World Journal of Gastroenterology 2015年第11期21卷 3274-3281页

作者： In Ja Park Chang Sik Yu Seok-Byung Lim Yong Sik Yoon Chan Wook Kim tae Won Kim Jong hoon Kim Jin Cheon Kim Department of colon and rectal Surgery University of Ulsan College of Medicine and Asan Medical Center Department of Medical Oncology University of Ulsan College of Medicine and Asan Medical Center Department of Radiation Oncology University of Ulsan College of Medicine and Asan Medical Center

AIM:To evaluate the predictive value of the lymph node(LN) ratio(LNR,number of metastatic LNs/ examined LNs) for recurrence in patients with rectal cancer and to compare its applicability according to preoperative chemoradiotherapy(PCRT).METHODS:From 2000 to 2009,967 patients with metastatic LNs after curative resection for locally advanced rectal cancer were *** were categorized according to PCRT(PCRT vs No PCRT).The cut-off LNR was determined based on the p N1 vs p N2 when the recommended number of LNs was *** 5-year recurrence-free survival(RFS) rates using the Kaplan-Meier method were compared according to p/yp N stage and the LNR in each ***:Among patients with the same p/yp N stage,the 5-year RFS rate differed according to the *** addition,the 5-year RFS rate was significantly different between p N and LNR groups in patients with No *** PCRT group,however,only LNR was associated with *** multivariate analysis,both p N and LNR were significant independent prognostic factors for 5-year RFS in the No PCRT *** the PCRT group,only LNR category was found to be associated with RFS(HR = 2.36,95%CI:1.31-3.84,and P = 0.001).CONCLUSION:The LNR is an important prognostic predictor of RFS in rectal cancer patients especially treated with *** p N categories could not discriminate between prognostic groups of RFS after PCRT.

关键词： Rectal cancer Preoperative chemoradiotherapy Lymph

Rosai-Dorfman disease in the spleen of a pediatric patient:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6032-6040页

作者： Hwaseong Ryu Jae-Yeon Hwang Yong-Woo Kim tae-Un Kim Joo-Yeon Jang Su-Eun Park Eu-Jeen Yang Dong-hoon Shin Department of Radiology Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Pediatrics Pusan National University Children’s HospitalYangsan 50612South Korea Department of Pathology Pusan National University Yangsan HospitalYangsan 50612South Korea

BACKGROUND Rosai–Dorfman disease(RDD)is a rare histiocytic proliferation of unknown etiology commonly found in children and *** common manifestation of RDD is massive and painless bilateral cervical lymphadenopathy with extranodal *** extranodal involvement in RDD is common,the spleen is an infrequent site of *** SUMMARY We report a 10-mo-old female infant with RDD presenting multiple splenic masses without cervical *** had fever,and blood tests showed leukocytosis,anemia,and elevated erythrocyte sedimentation rate and Creactive ***,computed tomography,and magnetic resonance images demonstrated multiple splenic *** antibiotic therapy,her symptoms were not *** underwent diagnostic splenectomy and was discharged with *** In pediatric patients with refractory infectious symptoms or hematological abnormalities,clinicians should suspect RDD,even in patients without significant lymphadenopathy.

关键词： Rosai–Dorfman disease Sinus histiocytosis with massive lymphadenopathy Ultrasonography Computed tomography Magnetic resonance imaging Case report

In situ staining of the primo vascular system in the ventricles and subarachnoid space of the brain by trypan blue injection into the lateral ventricle

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Neural Regeneration Research 2011年第28期6卷 2171-2175页

作者： Jingxing Dai Byung-Cheon Lee Ping An Zhendong Su Rongmei Qu Ki hoon eom Kwang-Sup Soh Department of Human Anatomy Southern Medical University Guangzhou 510515 Guangdong Province China Nano Primo Research Center Advanced Institute of Convergence Technology Seoul National University Seou1443-270 Korea Pharmacupuncture Medical Research Institute Korean Pharmacupuncture Institute Seoul Korea

We examined a new method for visualization of the primo vascular system in the rat brain involving lateral ventricle injection of trypan blue. Results showed that the primo vascular system in the lateral ventricles and arachnoid mater of the brain were preferentially stained relative to blood vessels and fascia. The primo-vessels along blood vessels in the brain were clearly exhibited. In addition, the primo vascular system was evident between the fourth ventricle and the quadrigeminal cistern. Our experimental findings indicate that this new technique of lateral ventricle injection of trypan blue can visualize the primo vascular system in lateral ventricles and arachnoid mater of rats in situ.

关键词： trypan blue primo vascular system fascia cerebral ventricles choroid plexus neuroanatomy neural regeneration

Organic X-Ray Image Sensors Using a Medium Bandgap Polymer Donor with Low Dark Current

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Energy & Environmental Materials 2024年第6期7卷 230-237页

作者： Jong-Woon Ha Seung Hun eom Bo Kyung Cha Seyeong Song Hyeong Ju Eun Jong H.Kim Jong Mok Park BongSoo Kim Byoungwook Park Seo-Jin Ko Sung Cheol Yoon Changjin Lee In Hwan Jung Do-hoon Hwang Department of Chemistry Chemistry Institute for Functional MaterialsPusan National UniversityBusan 46241Korea Division of Advanced Energy Materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Korea Electro-Medical Device Research Center Korea Electrotechnology Research Institute(KERI)Ansan 15588Korea Graduate School of Carbon Neutrality School of Energy and Chemical EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Molecular Science and Technology Ajou UniversitySuwon 16449Korea Research Center for Advanced Specialty Chemicals Korea Research Institute of Chemical TechnologyUlsan 44412Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Organic and Nano Engineering Human-Tech Convergence ProgramHanyang University222 Wangsimni-roSeongdong-guSeoul 04763Korea

The development of portable X-ray detectors is necessary for diagnosing fractures in unconscious patients in emergency ***,this is quite challenging because of the heavy weight of the scintillator and silicon *** weight and thickness of X-ray detectors can be reduced by replacing the silicon layer with an organic *** study presents a novel bithienopyrroledione-based polymer donor that exhibits excellent photodetection properties even in a thick photoactive layer(~700 nm),owing to the symmetric backbone and highly soluble molecular structure of *** ability of bithienopyrroledione-based polymer donor to strongly suppress the dark current density(Jd~10−10 A cm^(−2))at a negative bias(−2.0 V)while maintaining high responsivity(R=0.29 A W−1)even at a thickness of 700 nm results in a maximum shot-noise-limited specific detectivity of D_(sh)^(*)=2.18×10^(13)Jones in the organic *** organic photodetectors are developed by slot-die coating for use in X-ray detectors,which exhibit D_(sh)^(*)=2.73×10^(12)Jones with clear rising(0.26 s)and falling(0.29 s)response times upon X-ray *** reliability is also proven by linear response of the X-ray detector,and the X-ray detection limit is 3 mA.

关键词： low dark current low detection limit organic photodetector printable X-ray