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Suppression of DRR1 results in the accumulation of insoluble ubiquitinated proteins,which impairs drought stress tolerance

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Journal of Integrative Plant Biology 2021年第3期63卷 431-437页

作者： Seong Gwan Yu Na Hyun Cho Jong Hum Kim tae Rin oh Woo taek Kim Department of Systems Biology and Division of Life Science Yonsei UniversitySeoul 03722Korea Institute of Life Science and Biotechnology Yonsei UniversitySeoul 03722Korea

Drought stress has detrimental effects on *** the abscisic acid(ABA)-mediated drought response is well established,defensive mechanisms to cope with dehydration-induced proteotoxicity have been rarely ***1 was identified as an Arabidopsis drought-induced gene encoding an ER-localized RING-type E3 Ub *** of DRR1 markedly reduced tolerance to drought and proteotoxic stress without altering ABA-mediated germination and stomatal *** dehydration-induced insoluble ubiquitinated protein accumulation was more obvious in DRR1 loss-of-function plants than in wild-type *** results suggest that DRR1 is involved in an ABA-independent drought stress response possibly through the mitigation of dehydration-induced proteotoxic stress.

关键词： Arabidopsis drought stress E3 ligase proteotoxicity ubiquitination

SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee keun Bon Ku Gun Young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-Sun Yi Sangmi Jun Bum-tae Kim Jong-Won oh Aleem Siddiqui Seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

Increased susceptibility of ethanol-treated gastric mucosa to naproxen and its inhibition by DA-9601, an Artemisia asiatica extract

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World Journal of Gastroenterology 2005年第47期11卷 7450-7456页

作者： tae Young oh Gook Jun Ahn Seul Min Choi Byoung Ok Ahn Won Bae Kim Research Laboratories Dong-A Pharm. Co.Ltd.47-5SanggalKiheungYonginKyunggi449-905South Korea

AIM： To examine the effect of DA-9601, a new gastroprotective agent, on the vulnerability of ethanoltreated rat＇s stomach to naproxen （NAP）. METHODS： Male Sprague-Dawley rats were pretreated with 1 mL of 50% ethanol twice a day for 5 d and then NAP （50 mg/kg） was administered. DA-9601 was admin- istered 1 h before NAP. Four hours after NAP, the rats were killed to examine gross injury index （mm2）, histologic change and to determine mucosal levels of malondialdehyde （MDA）, prostaglandin E2 （PGE2）, glutathione （GSH） and myeloperoxidase （MPO）. RESULTS： Pretreatment of ethanol significantly increased NAP-induced gastric lesions, as well as an increase in NDA and MPO. On the contrary, mucosal PGE2 and GSH contents were decreased dramatically by ethanol pretreatment, which were aggravated by NAR DA-9601 significantly reduced NAP-induced gastric injury grossly and microscopically, regardless of pretreatment with ethanol. DA-9601 preserved, or rather, increased mucosal PGE2 and GSH in NAP-treated rats （P〈0.05）, with reduction in mucosal MDA and MPO levels. CONCLUSION： These results suggest that repeated alcohol consumption renders gastric mucosa more susceptible to NSAIDs though, at least in part, reduction of endogenous cytoprotectants including PGE2 and GSH, and increase in MPO activation, and that DA-9601, a new gastroprotectant, can reduce the increased vulnerability of ethanol consumers to NSAIDs-induced gastric damage via the mechanism in which PGE2 and GSH are involved.

关键词： DA-9601 Alcohol Naproxen Gastric damage Malondialdehyde Prostaglandin E2 Glutathione Myeloperoxidase NSAIDS

Combination-based nanomaterial designs in single and double dimensions for improved electrodes in lithium ion-batteries and faradaic supercapacitors

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Journal of Energy Chemistry 2019年第11期28卷 119-146页

作者： Tuyet Nhung Pham Duckshin Park Yongil Lee Il tae Kim Jaehyun Hur You-Kwan oh Young-Chul Lee Department of BioNano Technology Gachon University1342 SeongnamdaeroSujeong-guSeongnam-siGyeonggi-do 13120Republic of Korea Korea Railroad Research Institute(KRRI) 176 Cheoldobakmulkwan-roUiwang-si 16105Gyeonggi-doRepublic of Korea Department of Chemical and Biological Engineering Gachon UniversitySeongnam-siGyeonggi-do 13120Republic of Korea School of Chemical and Biomolecular Engineering Pusan National UniversityBusan 46241Republic of Korea

In the past decade, researchers in the fields of energy production have concentrated on the improvement of new energy storage devices. Lithium-ion batteries(LIBs) and faradaic supercapacitors(FSs) have attracted special attention as a result of the rapid development of new electrode nanomaterials, especially hybrid nanomaterials, which can meet the increasingly higher requirements for future energy, such as the capability to deliver high-power performance and an extremely long life cycle. In these hybrid nanostructures, a series of synergistic effects and unique properties arising from the combination of individual components are a major factor leading to improved charge/discharge capability, energy density, and system lifetime. This paper describes the most recent progress in the growth of hybrid electrode materials for LIBs and FSs systems, focusing on the combination of zero-dimensional(0 D), one-dimensional(1 D), two-dimensional(2 D), and three-dimensional(3 D) nanomaterials, respectively.

关键词： Hybrid nanomaterials Synergistic effects Zero-dimensional nanomaterials One-dimensional nanomaterials Two-dimensional nanomaterials Three-dimensional nanomaterials

Endoscopic ultrasound-guided biliary drainage with placement of a fully covered metal stent for malignant biliary obstruction

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World Journal of Gastroenterology 2012年第20期18卷 2526-2532页

作者： tae Hyeon Kim Seong Hun Kim Hyo Jeong oh Young Woo Sohn Seung Ok Lee Department of Internal Medicine School of MedicineWonkwang UniversityIksanChonbuk 570-749 South Korea Department of Internal Medicine Chonbuk National University Medical School and HospitalJeonjuChonbuk 561-712South Korea Department of Internal Medicine School of MedicineWonkwang UniversitySanbon Gyounggi 570-749South Korea

AIM:To determine the utility of endoscopic ultrasoundguided biliary drainage(EUS-BD)with a fully covered self-expandable metal stent for managing malignant biliary stricture. METHODS:We collected data from 13 patients who presented with malignant biliary obstruction and underwent EUS-BD with a nitinol fully covered selfexpandable metal stent when endoscopic retrograde cholangiopancreatography(ERCP)***-guided choledochoduodenostomy(EUS-CD)and EUS-guided hepaticogastrostomy(EUS-HG)was performed in 9 patients and 4 patients,respectively. RESULTS:The technical and functional success rate was 92.3%(12/13)and 91.7%(11/12),respectively. Using an intrahepatic approach(EUS-HG,n=4),there was mild peritonitis(n=1)and migration of the metal stent to the stomach(n=1).With an extrahepatic approach(EUS-CD,n=10),there was pneumoperitoneum(n=2),migration(n=2),and mild peritonitis (n=1).All patients were managed conservatively with *** follow-up(range,1-12 mo),there was re-intervention(4/13 cases,30.7%)necessitated by stent migration(n=2)and stent occlusion(n=2). CONCLUSION:EUS-BD with a nitinol fully covered self-expandable metal stent may be a feasible and effective treatment option in patients with malignant biliary obstruction when ERCP fails.

关键词： Endoscopic ultrasound-guided Biliary drainage Metal stent Biliary obstruction

Second to fourth digit ratio： a predictor of adult lung function

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Asian Journal of Andrology 2014年第1期16卷 140-145页

作者： I-Nae Park Ho-Kee Yum Sang Chul Lee Jin Kyu oh tae Beom Kim Department of Pulmonology Inje University Seoul Paik Hospital Seoul Korea Department of Urology Gachon University Gil Hospital Incheon Korea

Sex and sex hormones play a major role in lung physiology. It has been proposed that the ratio of the second to fourth digits （digit ratio） is correlated with fetal sex hormones. We therefore hypothesized that digit ratio might help predict lung function. We investigated the relationship between digit ratio and pulmonary function test （PFT） findings. A total of 245 South Korean patients （162 male, 83 female） aged from 34 to 90 years who were hospitalized for urological surgery were prospectively enrolled. Before administering the PFTs, the lengths of the second and fourth digits of the right hand were measured by a single investigator using a digital Vernier caliper. In males （n = 162）, univariate and multivariate analysis using linear regression models showed that digit ratio was a significant predictive factor of forced vital capacity （FVC） and forced expiratory volume in I second （FEV1）（FVC： r = 0.156, P = 0.047; FEVI： r = 0.160, P = 0.042）. In male ever-smokers （n = 69）, lung functions （FVC and FEV1） were correlated with smoking exposure rather than digit ratio. In female never-smokers （n = 83）, lung functions （FEV1 and FEVI/FVC ratio） were positively correlated with digit ratio on univariate analysis （FEVI： r = 0.242, P = 0.027; FEVI/FVC ratio： r = 0.245, P = 0.026）. Patients with lower digit ratios tend to have decreased lung function. These results suggest that digit ratio is a predictor of airway function.

关键词： airway function digit ratio sex hormone

Nutritional risk index as a predictor of postoperative wound complications after gastrectomy

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World Journal of Gastroenterology 2012年第7期18卷 673-678页

作者： Cheong Ah oh Dae Hoon Kim Seung Jong oh Min Gew Choi Jae Hyung Noh tae Sung Sohn Jae Moon Bae Sung Kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine50 Irwon-dongGangnamguSeoul 135-710South Korea

AIM： To investigate the correlation between the nutri- tional risk index （NRI） and postoperative wound com- plications.

关键词： Nutritional risk index Wound complication Gastric cancer

Isolation, identification, Pb(Ⅱ) biosorption isotherms and kinetics of a lead adsorbing Penicillium sp. MRF-1 from South Korean mine soil

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Journal of Environmental Sciences 2010年第7期22卷 1049-1056页

作者： Natarajan Velmurugan Grim Hwang Muthuswamy Sathishkumar tae Kie Choi Kui-Jae Lee Byung-taek oh Yang-Soo Lee Department of Forest Science and Technology Institute of Agriculture and Life SciencesChonbuk National University College of Agriculture and Life Sciences Seoul National University Singapore-Delft Water Alliance National University of Singapore2 Engineering Drive 2 Division of Biotechnology College of Environment and Bioresources SciencesChonbuk National University

A heavy metal contaminated soil sample collected from a mine in Chonnam Province of South Korea was found to be a source of heavy metal adsorbing biosorbents. Chemical analyses showed high contents of lead （Pb） at 357 mg/kg and cyanide （CN） at 14.6 mg/kg in the soil. The experimental results showed that Penicillium sp. MRF-1 was the best lead resistant fungus among the four individual metal tolerant fungal species isolated from the soil. Molecular characterization of Penicillium sp. MRF-1 was determined using ITS regions sequences. Effects of pH, temperature and contact time on adsorption of Pb（Ⅱ） by Penicillium sp. MRF-1 were studied. Favorable conditions for maximum biosportion were found at pH 4 with 3 hr contact time. Biosorption of Pb（Ⅱ） gradually increased with increasing temperature. Efficient performance of the biosorbent was described using Langmuir and Freundlich isotherms. Adsorption kinetics was studied using pseudo first-order and pseudo second-order models. Biosorbent Penicillium sp. MRF-1 showed the maximum desorption in alkali conditions. Consistent adsorption/desorption potential of the biosorbent in repetitive cycles validated the efficacy of it in large scale. SEM studies given notes on surface modification of fungal biomass under metal stress and FT-IR results showed the presence of amino groups in the surface structure of the biosorbent. In conclusion, the new biosorbent Penicillium sp. MRF- 1 may potentially be used as an inexpensive, easily cultivatable material for the removal of lead from aqueous solution.

关键词： heavy metal resistant fungus Penicillium sp. biosorption isotherms kinetics

Long-term observation of the mineral trioxide aggregate extrusion into the periapical lesion:a case series

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International Journal of Oral Science 2013年第1期5卷 54-57页

作者： Seok-Woo Chang tae-Seok oh WooCheol Lee Gary Shun-Pan Cheung Hyeon-Cheol Kim Department of Conservative Dentistry School of DentistryKyung Hee University Department of Conservative Dentistry The Institute of Oral Health ScienceSamsung Medical CenterSungkyunkwan University School of Medicine Department of Conservative Dentistry School of DentistryDental Research InstituteSeoul National University Area of Endodontics Faculty of Dentistrythe University of Hong Kong Department of Conservative Dentistry School of DentistryPusan National UniversityDental Research Institute

One-step apexification using mineral trioxide aggregate(MTA) has been reported as an alternative treatment modality with more benefits than the use of long-term calcium hydroxide for teeth with open ***,orthograde placement of MTA is a challenging procedure in terms of length *** case series describes the sequence of events following apical extrusion of MTA into the periapical area during a one-step apexification procedure for maxillary central incisor with an infected immature *** long-term observation revealed complete resolution of the periapical radiolucent lesion around the extruded *** cases revealed that direct contact with MTA had no negative effects on healing of the periapical ***,intentional MTA overfilling into the periapical lesion is not to be recommended.

关键词： extrusion immature apex mineral trioxide aggregate one-step apexification open apex periapical healing