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Possible effect of blonanserin on gambling disorder:A clinical study protocol and a case report

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World Journal of Clinical Cases 2021年第11期9卷 2469-2477页

作者： Akihiro Shiina tadashi Hasegawa Masaomi Iyo Division of Medical Treatment and Rehabilitation Chiba University Center for Forensic Mental HealthChiba 260-8670Japan Department of Psychiatry Chiba University HospitalChiba 260-8670Japan Department of Psychiatry Chiba University Graduate School of MedicineChiba 260-8670Japan

BACKGROUND Gambling disorder is characterized by excessive and recurrent gambling and can have serious negative social *** several psychotherapeutic and pharmacological approaches have been used to treat gambling disorder,new treatment strategies are *** evidence suggests that dopamine D3 receptor plays a specific role in the brain reward *** To investigate if blonanserin,a dopamine D3 receptor antagonist,would be effective in reducing gambling impulses in patients with gambling *** We developed a study protocol to measure the efficacy and safety of blonanserin as a potential drug for gambling disorder,in which up to 12 mg/d of blonanserin was prescribed for 8 *** A 37-year-old female patient with gambling disorder,intellectual disability,and other physical diseases participated in the pilot *** case showed improvement of gambling symptoms without any ***,blonanserin was discontinued owing to excessive saliva *** This case suggests that blonanserin is potentially an effective treatment for patients with gambling disorder who resist standard therapies,but it also carries a risk of adverse effects. Further studies are needed to confirm the findings.

关键词： Blonanserin Gambling disorder Medication Clinical trial protocol D3 receptor Case report

Influence evaluation of loading conditions during pressurized thermal shock transients based on thermal-hydraulics and structural analyses

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Frontiers of Mechanical Engineering 2018年第4期13卷 563-570页

作者： Jinya KATSUYAMA Shumpei UNO tadashi WATANABE Yinsheng LI Japan Atomic Energy Agency Ibaraki 319-1195 Japan Mizuho Information & Research Institute Inc. Tokyo 101-8443 Japan Fukui University Fukui 914-0055 Japan

The thermal hydraulic （TH） behavior of coo- lant water is a key factor in the structural integrity assessments on reactor pressure vessels （RPVs） of pressurized water reactors （PWRs） under pressurized thermal shock （PTS） events, because the TH behavior may affect the loading conditions in the assessment. From the viewpoint of TH behavior, configuration of plant equipment and their dimensions, and operator action time considerably influence various parameters, such as the temperature and flow rate of coolant water and inner pressure. In this study, to investigate the influence of the operator action time on TH behavior during a PTS event, we developed an analysis model for a typical Japanese PWR plant, including the RPV and the main components of both primary and secondary systems, and performed TH analyses by using a system analysis code called RELAP5. We applied two different operator action times based on the Japanese and the United States （US） rules： Operators may act after 10 min （Japanese rules） and 30 min （the US rules） after the occurrence of PTS events. Based on the results of TH analysis with different operator action times, we also performed structural analyses for evaluating thermal-stress distributions in the RPV during PTS events as loading conditions in the structural integrity assessment. From the analysis results, it was clarified that differences in operator action times significantly affect TH behavior and loading conditions, as the Japanese rule may lead to lower stresses than that under the US rule because an earlier operator action caused lower pressure in the RPV.

关键词： structural integrity reactor pressure vessel pressurized thermal shock thermal hydraulic analysis pressurized water reactor weld residual stress

Intraspecific Variations of Phosphorus Absorption and Remobilization, P Forms, and Their Internal Buffering in Brassica Cultivars Exposed to a P-Stressed Environment

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Journal of Integrative Plant Biology 2008年第6期50卷 703-716页

作者： M. Shahbaz Akhtar Yoko Oki tadashi Adachi Department of Environmental Management Engineering Faculty of Environmental Science and Technology Graduate School of Environmental Science Okayama University CADGK and Institute of Soil and Environmental Sciences University of Agriculture Faisalabad Pakistan

Translocation of absorbed phosphorus （P） from metabolically inactive sites to active sites in plants growing under P deprivation may increase its P utilization efficiency （PUE）. Acclimation to phosphate （Pi） starvation may be caused by a differential storage pool of vacuolar P, its release, and the intensity of re-translocation of absorbed P as P starvation inducible environmental cues （PSlEC） from ambient environment. Biomass assay and three P forms, namely inorganic （Pi）, organic （Po）, and acid-soluble total （Ptas） were estimated in Brassica cultivars exposed to 10 d P deprivation in the culture media. Considering that -aPi/at denotes the rate of Pi release, Pi release velocity （RSPi） was determined as the tangent to the equations obtained for Pi f（t） at the mean point in the period of greatest Pi decrease, whereas the inverse of the RSPi was an estimate of the internal Pi buffering capacity （IBCPi）. Inter cultivar variations in size of the non-metabolic Pi pool, RSPi, re-translocation of Pi from less to more active metabolic sites, and preferential Pi source and sink compartments were evaluated under P starvation. The cultivar ＇Brown Raya＇ showed the highest Pi storage ability under adequate external P supply, and a more intensive release than ＇Rain Bow＇ and ＇Dunkled＇ under P stress. Cultivar ＇B.S.A＇ was inferior to ＇Con-l＇ in its ability to store and use Pi. Roots and upper leaves were the main sink of Pi stored in the lower and middle leaves of all cultivars and showed lower IBCPi and larger RSPi values than lower and middle leaves. In another trial, six cultivars were exposed to P-free nutrition for 29 d after initial feeding on optimum nutrition for 15 d. With variable magnitude, all of the cultivars re-translocatad P from the above ground parts to their roots under P starvation, and [P] at 44 d after transplanting was higher in developing leaves compared with developed leaves. Under P deprivation, translocation of absorbed P from metabolically inactive to ac

关键词： Brassica internal Pi buffering capacity P absorption and remobilization Pi homeostasis Pi release velocity vacuolar P

Mechanisms of resistance to spinosad in the western flower thrip, Frankliniella occidentalis （Pergande）（Thysanoptera： Thripidae）

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Insect Science 2008年第2期15卷 125-132页

作者： Shu-Yun Zhang Satoshi Kono Tamotsu Murai tadashi Miyata Laboratory of Applied Entomology Graduate School of Bioagricultural Sciences Nagoya University Chikusa Department of EnvironmentalConservation Hyogo Prefectural Institute of Agnculture Forestry and Fisheries Kasai Hyogo-Prefecture National Institute of FruitTree Science Fujimoto Tsukuba Ibaragi-Prefecture Japan

Cross-resistance, resistance mechanisms, and mode of inheritance of spinosad resistance were studied in the western flower thrip, Frankliniella occidentalis （Pergande）. Spinosad （naturalyte insecticide） showed low cross-resistance to prothiophos （organophosphorus insecticide） and chlorphenapyr （respiratory inhibitor） showed some cross-resistance to thiocyclam （nereistoxin）. The synergists PBO （piperonyl butoxide）, DEM （diethyl maleate）, and DEF （s,s,s-tributyl phosphorotrithioate） did not show any synergism on the toxicity of spinosad in the resistant strain （ICS）, indicating that metabolic- mediated detoxification was not responsible for the spinosad resistance, suggesting that spinosad may reduce sensitivity of the target site： the nicotinic acetylcholine receptor and GABA receptor. Following reciprocal crosses, dose-response lines and dominance ratios indicated that spinosad resistance was incompletely dominant and there were no maternal effects. The results of backcross showed that spinosad resistance did not fit a single-gene hypothesis, suggesting that resistance was influenced by several genes.

关键词： inheritance resistance spinosad synergism western flower thrip

Comparison of Effect of Brassinosteroid and Gibberellin Biosynthesis Inhibitors on Growth of Rice Seedlings

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Rice science 2016年第1期23卷 51-55页

作者： tadashi MATUSMOTO Kazuhiro YAMADA Yuko YOSHIZAWA Keimei OH Department of Biotechnology Akita Prefectural University

Brassinosteroid（BR） and gibberellin（GA） are two predominant plant hormones that regulate plant cell elongation. Mutants disrupt the biosynthesis of these hormones and display different degrees of dwarf phenotypes in rice. Although the role of each plant hormone in promoting the longitudinal growth of plants has been extensively studied using genetic methods, their relationship is still poorly understood. In this study, we used two specific inhibitors targeting BR and GA biosynthesis to investigate the roles of BR and GA in growth of rice seedlings. Yucaizol, a specific inhibitor of BR biosynthesis, and Trinexapac-ethyl, a commercially available inhibitor of GA biosynthesis, were used. The effect of Yucaizol on rice seedlings indicated that Yucaizol significantly retarded stem elongation. The IC_（50） value was found to be approximately 0.8 μmol/L. Yucaizol also induced small leaf angle phenocopy in rice seedlings, similarly to BR-deficient rice, while Trinexapac-ethyl did not. When Yucaizol combined with Trinexapac-ethyl was applied to the rice plants, the mixture of these two inhibitors retarded stem elongation of rice at lower doses. Our results suggest that the use of a BR biosynthesis inhibitor combined with a GA biosynthesis inhibitor may be useful in the development of new technologies for controlling rice plant height.

关键词： brassinosteroid gibberellin plant hormone plant growth regulator rice

Fluorescence quantum yield of Gd_(0.9-x)R_xEu_(0.1)OOH(R=Y, La) crystals

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Journal of Rare Earths 2015年第12期33卷 1256-1260页

作者： Hiroaki Samata Katsutoshi Kobayashi Masashi Hanioka tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University Materials Development Group Superconducting Properties Unit National Institute for Materials Science

*** （R=Y, La） crystals were synthesized by a flux method using a mixture of NaOH and KOH as the flux. X-ray diffraction data were well refined using the Rietveld method assuming that the crystals had a monoclinic structre belonging to the P21/m space group. The unit cell volumes of the Gdo.9 *** crystals increased with increasing x, whereas those of *** decreased with increasing x. The Commission Internationale de IEclairage （CIE） chromaticity coordinates of Gdo.9 *** （R=Y, La） crystals were located in the red region and were nearly constant over the range ofx values considered. The fluorescence quantum yield Dr monotonically decreased with increasing x regardless of the ionic radii of the substitute ions. The fact that the Dr value of Lao.9EuoAOOH was greater than that of *** indicated that the observed decrease in the values of the Gdo.9-,LaxEuo.1OOH crystals up to x=0.3 could not be attributed to an increase in the distance between Eu3＋ ions or to a decrease in the Gd3＋ content. The decrease might be due to an increase of killer centers introduced by elemental substitutions with the larger ion.

关键词： rare-earth oxyhydroxide phosphor elemental substitution fluorescence quantum yield

Yellow luminescence of co-doped gadolinium oxyhydroxide

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Journal of Rare Earths 2015年第7期33卷 712-716页

作者： Hiroaki Samata Shungo Imanaka Masashi Hanioka tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University Fukaeminami International Center for Materials Nanoarchitectonics National Institute for Materials Science

Crystals of co-doped gadolinium oxyhydroxide （GdOOH）, Gd0.98Eu0.02-xTbxOOH and Gd1-y-zDyyBizOOH, were synthesized by a flux method. The color coordinates in the Commission Internationale de I＇Eelairage （CIE） chromaticity diagram of Gd0.98Eu0.02-xTbxOOH, obtained under 254 nm irradiation, shifted along a straight line with the changing values ofx to include the yellow region. The CIE coordinates of Dy^3＋ doped in GdOOH were located in the yellow region, while the emission intensity of Dy^3＋ under 286 nm irradiation increased by more than 40 times when co-doped with Bi^3＋.

关键词： gadolinium oxyhydroxide phosphor co-doping yellow luminescence rare earths

Accelerated biodegradation of nitrophenols in the rhizosphere of Spirodela polyrrhiza

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Journal of Environmental Sciences 2012年第5期24卷 800-807页

作者： Risky Ayu Kristanti Masahiro Kanbe tadashi Toyama Yasuhiro Tanaka Kazuhiro Mori Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi 4-3-11 Takeda Kofu Yamanashi 400-8511 Japan

We investigated the biodegradation of 2-nitrophenol （2-NP）, 4-nitrophenol （4-NP）, and 2,4-dinitrophenol （2,4-DNP） in the rhizosphere of Spirodela polyrrhiza plants by conducting degradation experiments with three river water samples supplemented with each nitrophenol （NP）. We then isolated NP-degrading bacteria both from the S. polyrrhiza roots and from the river water. In the river water samples, removal of the three NP was accelerated in the presence of S. polyrrhiza plants. The three NPs persisted in an autoclaved solution with sterile plants suggests that NP removal was accelerated largely by bacterial NP biodegradation rather than by adsorption and uptake by the plants. We isolated 8 strains of NP-degrading bacteria： 6 strains from the S. polyrrhiza roots and 2 strains from river water without the plants. The 2-NP- and 2,4-DNP-degrading bacteria were isolated only from the S. polyrrhiza roots. The 4-NP- degrading bacteria different from those isolated from the river water samples were also found on S. polyrrhiza roots. The 2-NP- and 4-NP-degrading strains isolated from the roots utilized the corresponding NP （0.5 mmol/L） as the sole carbon and energy source. The 2,4-DNP-degrading strains isolated from the roots showed substantial 2,4-DNP-degrading activity, but the presence of other carbon and energy sources was required for their growth. The isolated NP-degrading bacteria from the roots must have contributed to the accelerated degradation of the three NPs in the rhizosphere of S. polyrrhiza. Our results suggested that rhizoremediation with S. polyrrhiza may be effective for NP-contaminated surface water.

关键词： Spirodela polyrrhiza rhizosphere nitrophenol biodegradation

Loss on Ignition-Based Indices for Evaluating Organic Matter Characteristics of Littoral Sediments

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Pedosphere 2017年第5期27卷 978-984页

作者： Narong TOUCH tadashi HIBINO Hiroki TAKATA Satoshi YAMAJI Coastal Engineering Laboratory Department of Civil and Environmental Engineering Hiroshima University

Understanding organic matter characteristics （e.g., amount and state） of sediments is necessary for evaluating both the sediment and water environments; however, methods that have been proposed to investigate these characteristics are relatively expensive. This study attempted to evaluate the organic matter characteristics of littoral sediments by employing solely the loss on ignition （LOI） method, which is the most economical and accessible method in developing countries. Different types of sediments were first oven dried at 100 ~C and then continuously burned at 200, 300, 400, 500, and 600 ~C for 4 h at each temperature. The mass LOI at each temperature was calculated and compared with the 100 ℃oven-dried weight. Our results suggested that the mass LOI across the temperature range of 200-300 ℃（LOI200-300）：mass LOI at 600 ℃ （LOI600） ratio （LOI200-300/LOI600） could represent different types of sediments as well as the organic matter：organic C ratio. Compared with the sediments unaffected by wastewater, the sediments that were more influenced by the inflow of domestic wastewater had a higher LOI200-300/LOI600. Interestingly, LOI200-300/LOI600 could also represent changes in the organic matter characteristics as a function of organic matter decomposition in sediments. In conclusion, the organic matter characteristics of littoral sediments could be evaluated using solely the LOI method, particularly with LOI200 - 300/LOI600.

关键词： C loss decomposition mass loss on ignition organic matter state sediment type