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World Journal of Gastroenterology 2014年第4期20卷 1119-1122页

作者： Osamu dohi Moyu dohi Ken Inoue Yasuyuki Gen Masayasu Jo Kazuhiko Tokita Department of Gastroenterology and Hepatology North Medical Center Kyoto Prefectural University of Medicine

A 63-year-old woman was referred to our hospital for further examination because of an incidental finding of early gastric *** submucosal dissection(ESD)was successfully performed for complete resection of the *** the first post-ESD day,the patient suddenly complained of abdominal pain after an episode of *** computed tomography(CT)showed delayed perforation after *** patient was conservatively treated with an intravenous proton pump inhibitor and *** the fifth post-ESD day,CT revealed a gastric wall abscess in the gastric *** revealed a gastric fistula at the edge of the post-ESD ulcer,and pus was found flowing into the *** intradrainage stent and an extradrainage nasocystic catheter were successfully inserted into the abscess for endoscopic transgastric *** the procedure,the clinical symptoms and laboratory test results improved *** months later,a follow-up CT scan showed no collection of ***,the intradrainage stent was *** the gastric wall abscess recurred 2 wk after stent removal,it recovered soon after endoscopic transgastric ***,after stent removal and oral antibiotic treatment for 1 mo,no recurrence of the gastric wall abscess was found.

关键词： Gastric wall abscess Transgastric drainage Delayed perforation Endoscopic submucosal dissection Early gastric cancer

A Neuro-Based Software Fault Prediction with Box-Cox Power Transformation

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Journal of Software Engineering and Applications 2017年第3期10卷 288-309页

作者： Momotaz Begum Tadashi dohi Department of Information Engineering Hiroshima University Hiroshima Japan

Software fault prediction is one of the most fundamental but significant management techniques in software dependability assessment. In this paper we concern the software fault prediction using a multilayer-perceptron neural network, where the underlying software fault count data are transformed to the Gaussian data, by means of the well-known Box-Cox power transformation. More specially, we investigate the long-term behavior of software fault counts by the neural network, and perform the multi-stage look ahead prediction of the cumulative number of software faults detected in the future software testing. In numerical examples with two actual software fault data sets, we compare our neural network approach with the existing software reliability growth models based on nonhomogeneous Poisson process, in terms of predictive performance with average relative error, and show that the data transformation employed in this paper leads to an improvement in prediction accuracy.

关键词： Software Reliability Artificial Neural Network Box-Cox Power Transformation Long-Term Prediction Fault Count Data Empirical Validation

Laparoscopic and endoscopic co-operative surgery for nonampullary duodenal tumors

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World Journal of Gastroenterology 2016年第47期22卷 10424-10431页

作者： Daisuke Ichikawa Shuhei Komatsu Osamu dohi Yuji Naito Toshiyuki Kosuga Kazuhiro Kamada Kazuma Okamoto Yoshito Itoh Eigo Otsuji Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine Department of Gastroenterology and Hepatology Kyoto Prefectural University of Medicine

AIM To assess the safety and feasibility of laparoscopic and endoscopic co-operative surgery(LECS) for early nonampullary duodenal *** Twelve patients with a non-ampullary duodenal tumor underwent LECS at our hospital. One patient had two mucosal lesions in the duodenum. The indication for this procedure was the presence of duodenal tumors with a low risk for lymph node metastasis. In particular, the tumors included small(less than 10 mm) submucosal tumors(SMT) and epithelial mucosal tumors, such as mucosal cancers or large mucosal adenomas with malignant suspicion. The LECS procedures, such as full-thickness dissection for SMT and laparoscopic reinforcement after endoscopic submucosal dissection(ESD) for epithelial tumors, were performed for the 13 early duodenal lesions in 12 patients. Here we present the short-term outcomes and evaluate the safety and feasibility of this new *** Two SMT-like lesions and eleven superficial epithelial tumor-like lesions were observed. Seven and Six lesions were located in the second and third parts of the duodenum, respectively. All lesions were successfully resected en bloc. The defect in the duodenal wall was manually sutured after resection of the duodenal SMT. For epithelial duodenal tumors, the ulcer bed was laparoscopically reinforced via manual suturing after ESD. Intraoperative perforation occurred in two out of eleven epithelial tumor-like lesions during ESD; however, they were successfully laparoscopically repaired. The median operative time and intraoperative estimated blood loss were 322 min and 0 mL, respectively. Histological examination of the tumors revealed one adenoma with moderate atypia, ten adenocarcinomas, and two neuroendocrine tumors. No severe postoperative complications(Clavien-Dindo classification grade Ⅲ or higher) were reported in this series, but minor leakage secondary to pancreatic fistula occurred in one *** LECS can be a safe and minimally invasive treatment

关键词： Non-ampullary tumor Laparoscopic and endoscopic cooperative surgery Early duodenal cancer

Availability Importance Measures for Virtualized System with Live Migration

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Applied Mathematics 2015年第2期6卷 359-372页

作者： Junjun Zheng Hiroyuki Okamura Tadashi dohi Department of Information Engineering Graduate School of Engineering Hiroshima University Higashi-Hiroshima Japan

This paper presents component importance analysis for virtualized system with live migration. The component importance analysis is significant to determine the system design of virtualized system from availability and cost points of view. This paper discusses the importance of components with respect to system availability. Specifically, we introduce two different component importance analyses for hybrid model (fault trees and continuous-time Markov chains) and continuous-time Markov chains, and show the analysis for existing probabilistic models for virtualized system. In numerical examples, we illustrate the quantitative component importance analysis for virtualized system with live migration.

关键词： Virtualized System Live Migration System Availability Component Importance Analysis Fault Tree Continuous-Time Markov Chain

Aperiodic Checkpoint Placement Algorithms—Survey and Comparison

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Journal of Software Engineering and Applications 2013年第4期6卷 41-53页

作者： Shunsuke Hiroyama Tadashi dohi Hiroyuki Okamura Department of Information Engineering Hiroshima University Hiroshima Japan

In this article we summarize some aperiodic checkpoint placement algorithms for a software system over infinite and finite operation time horizons, and compare them in terms of computational accuracy. The underlying problem is formulated as the maximization of steady-state system availability and is to determine the optimal aperiodic checkpoint sequence. We present two exact computation algorithms in both forward and backward manners and two approximate ones;constant hazard approximation and fluid approximation, toward this end. In numerical examples with Weibull system failure time distribution, it is shown that the combined algorithm with the fluid approximation can calculate effectively the exact solutions on the optimal aperiodic checkpoint sequence.

关键词： Checkpoint Placement Aperiodic Policy Availability Models Computation Algorithms Comparison

Quantitative Security Evaluation for Software System from Vulnerability Database

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Journal of Software Engineering and Applications 2013年第4期6卷 15-23页

作者： Hiroyuki Okamura Masataka Tokuzane Tadashi dohi Department of Information Engineering Graduate School of Engineering Hiroshima University Hiroshima Japan Japan Ground Self-Defense Force Kagoshima Japan.

This paper proposes a quantitative security evaluation for software system from the vulnerability data consisting of discovery date, solution date and exploit publish date based on a stochastic model. More precisely, our model considers a vulnerability life-cycle model and represents the vulnerability discovery process as a non-homogeneous Poisson process. In a numerical example, we show the quantitative measures for contents management system of an open source project.

关键词： Quantitative Security Evaluation Vulnerability Database Non-Homogeneous Poisson Process Contents Management System

Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice

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World Journal of Gastroenterology 2017年第13期23卷 2294-2307页

作者： Takuhito Sezaki Yuki Hirata Teruki Hagiwara Yuki I Kawamura Tadashi Okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko dohi Department of Gastroenterology Research Center for Hepatitis and ImmunologyResearch InstituteNational Center for Global Health and Medicine Research Center for Hepatitis and Immunology Research InstituteNational Center for Global Health and Medicine 2~(nd)Department of Internal Medicine Osaka Medical College Section of Animal Models Department of Infectious DiseasesResearch InstituteNational Center for Global Health and Medicine Communal Laboratory Research InstituteNational Center for Global Health and Medicine Biogen

AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced *** Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also ***5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects.

关键词： Cancer chemotherapy Interleukin-13 Interleukin-33 Interleukin-13 receptor α2

Development of the Japanese Medication Adherence Scale and Verification of Its Reliability and Validity in Hypertensive Patients

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Pharmacology & Pharmacy 2015年第3期6卷 118-124页

作者： Rika Shimada Yasuaki dohi Kazunori Kimura Satoshi Fujii Department of Critical Care Nursing Graduate School of Nursing Nagoya City University Nagoya Japan Department of Cardio-Renal Medicine and Hypertension Graduate School of Medicine Nagoya City University Nagoya Japan Pharmaceutical Department Nagoya City University Hospital Nagoya Japan Department of Laboratory Medicine Asahikawa Medical University Asahikawa Japan

A 32-Item Japanese Medication Adherence Scale had been developed as a tool for evaluating the medication-taking behavior of hypertensive patients and predicting therapeutic efficacy, and an Internet survey of 990 hypertensive patients throughout Japan was performed. As a result, factor 1 “Expectation of pharmacological efficacy” (9 items), factor 2 “Motivation to be self-controlled in taking medication” (6 items), and factor 3 “Negative feelings about taking medication” (4 items) were identified, comprising a total of 19 items. The scale was highly reliable. Because it proved capable of discriminating between the 2 groups with different medication-taking status and blood pressure, its validity had also been confirmed.

关键词： Drug Therapy Hypertension Measure Medication Adherence Scale

尿白蛋白水平作为预测普通人远期血压水平及高血压的指标

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中华高血压杂志 2015年第4期23卷 387-388页

作者： Takase H Sugiura T Ohte N dohi Y 曲浥晨叶鹏机构不详

高血压是心血管疾病发病及死亡的已知危险因素。尽管抗高血压治疗可降低心血管疾病风险,然而在普通人群中诊断出所有的高血压患者,并对其进行治疗仍十分困难。同时,超过一半的心血管事件发生在仅有轻微高血压或正常血压的人群中[1]。在... 详细信息

高血压是心血管疾病发病及死亡的已知危险因素。尽管抗高血压治疗可降低心血管疾病风险,然而在普通人群中诊断出所有的高血压患者,并对其进行治疗仍十分困难。同时,超过一半的心血管事件发生在仅有轻微高血压或正常血压的人群中[1]。在此情况下,对高血压的一级预防便成为了重要的公共健康目标。

关键词：抗高血压治疗普通人群血压水平蛋白水平心血管疾病预测高血压患者心血管事件