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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

Milita.y Medical Research 2024年第1期11卷 115-147页

作者： yuan-Peng Zhang Xin-yun Zhang yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam ta Zhou Zong-Rui Ma Jia-Bao Sheng Victor CWtam Shara WyLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

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Duplication of the Urethra in Boys: A Case Report

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Open Journal of Urology 2024年第6期14卷 353-358页

作者： Mamadou Tidiani Coulibaly Falaye Sissoko Moumine Diarra Adama Toutou Diallo Issa Amadou Amadou Berthé Sory koné CHU Gabriel Tour Urology Department Bamako University of Science Technology and Engineering Bamako Mali Lafiabougou Reference Health Center Bamako University of Science Technology and Engineering Bamako Mali CHU Gabriel Tour Pediatric Surgery Bamako University of Science Technology and Engineering Bamako Mali Korofina Reference Health Center Bamako University of Science Technology and Engineering Bamako Mali Segou Regional Hospital Bamako University of Science Technology and Engineering Bamako Mali

Supernumerary urethra in boys is a very rare anatomical entity. Sagittal urethral duplications are classified into four groups: epispadias, hypospadias, fusiform and y-shaped urethra. The most widely used classification is that of Effmann and Lebowitz, which describes 6 types, one of the rarest being the ‘y’ subtype IIA2, which corresponds to a duplicated urethral path from the vesical neck to an ectopic perineal or anal outlet. We report here the case of a 4-year-old child presenting with subtype IIA2 with a perineal orifice and no other urinary disorders.

关键词： Duplicity Ureter Malformation

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COVID-19 and the Vascular Elderly Subject: Illustration of Therapeutic Management with Corticosteroids in an Elderly Diabetic Patient with COVID-19

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Open Journal of Clinical Diagnostics 2024年第1期14卷 1-6页

作者： Ibrahima Amadou Dembele Abrar-Ahmad Zulfiqar Romuald Nounga Nyanke Sékou Landoure Stéphane Loique Djeugoue Adama Sinayoko Nouhoum kone Paul Antoni Amadou Nouroudine Rosunee Ahsveen yacouba koné Aoua Diarra tania Mekuiko Ngeupi Mamadou Cissoko Mamadou Mallé Keïta Kaly Djibril Sy Djénébou Traoré Didier Mukéba Tshialala Assétou Soukho Kaya Emmanuel Andres Internal Medicine Department Medical Clinic B University Hospital Center of Strasbourg Strasbourg France Internal Medicine Department University Hospital Center Point G Bamako Mali Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali Faculty of Medicine Pharmacy and Public Health University of Mbuji-Mayi Democratic Republic of Congo

Introduction: The severity of Sars-Cov-2 infection is associated with the development of acute respiratory distress syndrome (ARDS). The progression to ARDS appears to be driven by a major inflammatory mechanism potentially sensitive to corticosteroids. Observation: This article describes the case of an elderly patient was admitted to emergency departments for intense asthenia, accompanied by motor diarrhoea, dyspnoea with desaturation in ambient air, in a context of strong suspicion of infection linked to COVID-19. The article also reviews the existing literature on the diagnosis and treatment of this severe form of the disease. Conclusion: Corticosteroids, and in particular dexamethasone, have been shown to be effective in the management of patients with COVID-19, an oxygen-releasing disease.

关键词： COVID-19 Diabetes Mellitus Elderly person Corticosteroids Internal Medicine

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超晶格La-Mg/y-Ni复合储氢合金晶体结构及性能研究进展

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复合材料学报 2024年第3期41卷 1204-1214页

作者：张晓杰田晓张颖韩家乐杨艳春塔娜内蒙古师范大学物理与电子信息学院呼和浩特010022 内蒙古师范大学稀土功能新能源储能材料内蒙古自治区工程研究中心呼和浩特010022 内蒙古师范大学功能材料物理与化学自治区重点实验室呼和浩特010022

超晶格La-Mg/y-Ni复合储氢合金具有放电容量大、能量密度高和成本低等优点,是一种重要的氢能存储和转换材料,目前主要用做镍氢电池负极材料和直接硼氢化物燃料电池阳极催化剂。La-Mg-Ni复合合金最初是在La-Ni基储氢合金的基础上,通过用... 详细信息

超晶格La-Mg/y-Ni复合储氢合金具有放电容量大、能量密度高和成本低等优点,是一种重要的氢能存储和转换材料,目前主要用做镍氢电池负极材料和直接硼氢化物燃料电池阳极催化剂。La-Mg-Ni复合合金最初是在La-Ni基储氢合金的基础上,通过用部分Mg替代La而发展起来的。由于La-Mg-Ni复合合金中金属Mg熔点、沸点低,易挥发,导致采用常规熔炼法很难制备;同时合金中的Mg在碱性电解液中容易腐蚀、氧化,导致合金的循环稳定性差。为克服La-Mg-Ni复合合金制备困难和循环稳定性差等问题,研究者又在La-Ni基储氢合金的基础上,通过用部分y替代La开发出了La-y-Ni合金。La-Mg-Ni和La-y-Ni复合合金具有非常相似的超晶格结构,均能表现出很好的储氢性能,均属于同一类新型超晶格结构储氢合金。本文对La-Mg/y-Ni储氢合金近20多年的研究成果进行了梳理。本文首先介绍超晶格La-Mg-Ni和La-y-Ni复合合金的相结构组成及相结构的演变规律,同时分析了Mg元素和y元素部分替代La元素分别对La-Mg/y-Ni合金结构和性能的影响,然后讨论了La-Mg/y-Ni复合合金中的相结构对合金性能的影响。最后,指出了超晶格La-Mg/y-Ni复合储氢合金未来所面临的挑战和发展方向。

关键词：储氢材料 La-Mg-Ni复合储氢合金 La-y-Ni复合储氢合金相结构电化学性能

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Beyond boundaries:Neuroprotective effects of steroids and ecdysteroids in SH-Sy5y cells-A systematic review

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Neuroprotection 2024年第2期2卷 151-166页

作者： Bizhar Ahmed tayeb Isaac Kinyua Njangiru Renata Minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of SzegedSzegedHungary

Steroids and ecdysteroids have been shown to exhibit a range of biological effects,including anti-inflammatory,anticancer,and *** systematic review aims to highlight the evidence-based neuroprotective and antioxidant effects of steroids and ecdysteroids in SH-Sy5y neuroblastoma cells.A comprehensive literature search was conducted on May 11,2023,without publication source restrictions,using various electronic databases,including PubMed,Web of Science(WoS),Scopus,and Cumulative Index toNursing and Allied Health *** 103articles,only20 studies were included for investigating the neuroprotective effects of steroids and ecdysteroids in SH-Sy5y cells exposed to oxidative stress or neurotoxic *** risk of bias and quality assessment of the included studies were evaluated in accordance with the Nature Publication Quality Improvement Project specific *** selected studies reported the antioxidant effects of the tested compounds on SH-Sy5y cells and demonstrated their ability to scavenge free radicals and prevent lipid *** findings suggest that neurosteroids have potential therapeutic applications for the prevention and treatment of neurodegenerative diseases characterized by oxidative stress and neuronal *** studies have investigated the molecular mechanisms underlying the neuroprotective and antioxidant effects of steroids and ecdysteroids in SH-Sy5y *** mechanisms include the activation of antioxidant enzymes,such as superoxide dismutase and glutathione peroxidase,and the modulation of various signaling pathways,including the phosphoinositide 3-kinase/protein kinase B and mitogen-activated protein kinase/extracellular signal-regulated kinase *** review provides evidence that the tested compounds have remarkable neuroprotective and antioxidant effects in human neuroblastoma SH-Sy5y cells.

关键词： antiapoptotic cytoprotective neuroblastoma neurosteroids oxidative stress SH-Sy5y cells

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Discrepancy among microsatellite instability detection methodologies in non-colorectal cancer:Report of 3 cases

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World Journal of Clinical Cases 2023年第13期11卷 3105-3113页

作者： ElifŞenocak taşçı İbrahim yıldız Sibel Erdamar LeylaÖzer Department of Medical Oncology Acıbadem MAA UniversityIstanbul 12345Turkey Department of Pathology Acıbadem MAA UniversityIstanbul 12345Turkey

BACKGROUND Microsatellite instability(MSI)is a predictive biomarker for cancer *** tumor-agnostic nature of MSI makes it a denominator for immunotherapy in several solid *** can be assessed using next-generation sequencing(NGS),fluorescent multiplex PCR,and immunohistochemistry(IHC).CASE SUMMARy Here,we report 3 cases with discordant MSI results detected using different methods.A cholangiocellular carcinoma case revealed proficient mismatch repair(MMR)by IHC but high MSI(MSI-H)by liquid NGS.A cervical cancer case revealed deficient MMR by IHC,microsatellite stable by PCR,and MSI-H by ***,an endometrial cancer case revealed proficient MMR by IHC but MSI-H by *** IHC for MMR status is the first choice due to several ***,in cases of indeterminate IHC results,molecular testing by MSI-PCR is ***,NGS-based MSI assays are being widely used to detect MSI-H *** three methods have high accuracy;however,the inconsistencies between them may lead to misdiagnosis.

关键词： Discordance Immunohistochemistry Microsatellite instability Nextgeneration sequencing Case report

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Current trends in perioperative treatment of resectable gastric cancer

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 323-337页

作者： İbrahim yıldız Leyla Özer Elif Şenocak taşçı İbrahim Vedat Bayoglu Erman Aytac Department of Medical Oncology Acıbadem MAA Universityİstanbul 34567Turkey Department of Medical Oncology Acıbadem Universityİstanbul 34567Turkey Department of Medical Oncology Marmara Universityİstanbul 12345Turkey Department of Surgery Acibadem University School of MedicineIstanbul 34567Turkey

In the last few decades,the treatment strategy for locally advanced resectable gastric cancer(GC)has shifted to a multimodal approach,which potentially decreases recurrence risk and improves survival *** therapy leads to downstaging,increased curative resection rates,and prolonged disease-free and overall survival,by preventing micrometastases in patients with resectable *** of neoadjuvant therapy provides information about tumor biology and in vivo sensitivity.A consensus regarding the therapeutic approach for non-metastatic GC does not exist,and many clinical trials aim to clarify this *** in precision medicine and the role of immunotherapy have been the focus of research in GC ***,the current status and possible future developments of perioperative therapy for locally advanced resectable GC are reviewed,based on the most recent randomized clinical trials.

关键词： Perioperative treatment Immunotherapy Neoadjuvant Chemotherapy Gastric cancer Adjuvant

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基于光声谱分析的大鼠慢性前列腺炎评价

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声学学报 2024年第3期49卷 424-430页

作者：王憧朱云开董琪李博艺封婷李颖陈亚青他得安复旦大学信息科学与工程学院生物医学工程系上海200438 上海交通大学医学院附属新华医院上海200092 复旦大学工程与应用技术研究院生物医学工程技术研究所上海200433

探究了使用光声谱参数评价慢性前列腺炎的可行性。通过对大鼠注射弗氏完全佐剂构建大鼠慢性前列腺炎症模型,使用光声显微仪器扫描前列腺组织切片获取原始光声信号。计算信号的功率谱参数(斜率、截距、平均谱功率和频谱质心偏移量),对获... 详细信息

探究了使用光声谱参数评价慢性前列腺炎的可行性。通过对大鼠注射弗氏完全佐剂构建大鼠慢性前列腺炎症模型,使用光声显微仪器扫描前列腺组织切片获取原始光声信号。计算信号的功率谱参数(斜率、截距、平均谱功率和频谱质心偏移量),对获得的谱参数进行了分析统计和参数成像,并讨论了不同频带的选择对评价结果的影响。实验结果表明,炎症组织与正常组织谱参数的统计结果和成像结果均存在显著性差异,使用频谱质心偏移量(SCS)成像可以区分炎症组织和正常组织,且在带宽固定的情况下,斜率参数和平均谱功率参数分别在高频谱段和低频谱段成像结果清晰,不同频带对截距参数成像的影响较小。

关键词：光声显微光声谱分析前列腺炎组织表征

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超声背散射法在孕妇松质骨骨密度测量中的应用价值

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医学临床研究 2024年第2期41卷 185-187,191页

作者：白博周毓青他得安上海市长宁区妇幼保健院超声医学科上海200040 华东师范大学附属妇幼保健院超声医学科上海200040 复旦大学电子工程系上海200433

【目的】探讨超声背散射法在孕妇松质骨骨密度(BMD)测量中的应用价值。【方法】选取2017年6月至2018年7月在上海市长宁区妇幼保健院进行常规产检的235例孕妇,所有孕妇同时采用超声背散射法与超声透射法测量松质骨的BMD与超声传导速度(SO... 详细信息

【目的】探讨超声背散射法在孕妇松质骨骨密度(BMD)测量中的应用价值。【方法】选取2017年6月至2018年7月在上海市长宁区妇幼保健院进行常规产检的235例孕妇,所有孕妇同时采用超声背散射法与超声透射法测量松质骨的BMD与超声传导速度(SOS),比较两种方法测量结果的差异;根据孕周不同将所有孕妇分为早孕组(28周)三组,比较不同孕周孕妇超声背散射法测量的BMD与SOS。【结果】超声背散射法、超声透射法测量的孕妇BMD与SOS比较,差异无统计学意义(P>0.05)。早孕组超声背散射法所测BMD与SOS值明显高于中孕组与晚孕组(P<0.05),且中孕组明显高于晚孕组(P<0.05)。【结论】超声背散射法测量的BMD、SOS与超声透射法测量值比较,差异无统计学意义,可反映孕妇BMD随孕周的变化,可用于临床监测孕妇BMD。

关键词：孕妇松质骨/影像诊断骨密度

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Giant Aneurysmal Bone Cyst of the Right Femur about a Case

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Open Journal of Radiology 2023年第3期13卷 139-145页

作者： Cheick Oumar Keïta Aboudramane konaté yacouba Drissa Traoré youssouf koné Abdoulaye koné Issa Diarra Ilias Guindo Salia Coulibaly Mahamadou Diallo Siaka Sidibé Radiology Department Mohammed VI Perinatal Clinic Bamako Mali Radiology Department County Hospital of Sikasso Sikasso Mali Radiology Department CNAM Bamako Mali Radiology Department Jacques Boutard Hospital Center Saint Yrieix La Perche France Medical Imaging Department University Hospital of Point G Bamako Mali Medical Imaging Department University Hospital of Kati Kati Mali Medical Imaging Department Gabriel Touré University Hospital Bamako Mali

Aneurysmal bone cyst (ABC) is a rare bone tumor accounting for 1% - 4% of benign bone tumors. Its etiopathogenesis remains unknown. The main site is the metaphysis of the long bones. ABC occurs almost exclusively in young people, with a slight female predominance. We report an exceptional case of ABC of the femur with involvement of the right hip in a 16-year-old girl in the Medical Imaging Department of Pr Bocar Sidy Sall Hospital of Kati (Mali). We will discuss the clinical and radiological aspects of this pathology. Observation: Mrs N C., aged 16, was referred to the orthopaedic-traumatology department for an X-ray of the right thigh, indicated as having a large, disabling thigh. Clinical examination revealed a large thigh measuring 890 mm in circumference, compared with 300 mm on the contralateral side. Radiographically, the femur showed a blown appearance, with the cortex thinned and broken in places. Exceptionally, the lesion affected the entire femur. On CT scan, we found a voluminous fluid collection occupying the entire right femur, including the right femoral head and homolateral ischium. The cortex was interrupted in places, and the adjacent soft tissues were thinned or laminated, but not infiltrated. Histology revealed haemorrhagic and inflammatory elements compatible with the diagnosis of ABC. Conclusion: ABC is a tumor entity that is often difficult to diagnose. Medical imaging, topographical distribution and histology form an indissociable whole to establish a diagnosis of certainty.

关键词： Aneurysmal Bone Cyst Medical Imaging Femur

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