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Ore-forming age and tectonic setting of the linjiasandaogou gold deposit in the liaodong Peninsula,northeast China:constraints from geochronology and geochemistry

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Acta Geochimica 2022年第2期41卷 244-266页

作者： Xiaofeng Yao Tingjie Yan Zhicheng lü Chenggui lin Kuifeng mi Shenghui li Yang li Wange Du Development and Research Centre China Geological SurveyBeijing 100037China 103 Brigade of Non-Ferrous Geological Bureau of liaoning Province Liaoning 118008China China University of Geoscience Beijing 100083China Chengdu University of Technology Chengdu 610059China

The linjiasandaogou gold deposit is located in the Qingchengzi Orefield,North China Craton,China,and has not attracted many *** present geochronological,whole-rock geochemical,and Sr–Nd–Hf isotopic data to constrain the age and tectonic setting of the mineralization.U–Pb dating of zircon from pre-and post-ore dikes indicates the linjiasandaogou Au deposit formed at ca.227–226 *** granite porphyry(ca.227 Ma)and quartz diorite porphyry(ca.228 Ma),which are slightly older than the mineralization,have(;Sr/;Sr)i-=0.7127–0.7162,εNd(t)=–13.7 to–17.0,andεHf(t)=–14.6 to–16.9,and display enrichment in light rare earth elements and large ion lithophile elements and depletion in high field strength *** lamprophyres(226 and225 Ma),which are slightly younger than the mineralization,have higher(;Sr/;Sr)i(0.7165–0.7216),negativeεNd(t)(–11.2 to–14.3)andεHf(t)(–15.6 to–18.6)values,and are enriched in light rare earth elements but depleted in high field strength elements(Nb and ta).The geochemical characteristics of the granitoid and lamprophyres indicate a lower crustal and enriched mantle source,*** infer that the linjiasandaogou Au deposit formed in a postcollisional tectonic setting,following the collision between the North China,Yangtze craton,and Central Asian Orogeny in Triassic.

关键词： North China craton Qingchengzi linjiasandaogou Triassic mineralization Post-collisional setting

A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme

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Bioactive Materials 2023年第3期21卷 547-565页

作者： Fei Wei Craig J.Neal tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward Khoa minh ta Samuel Moxon Marco Molinari Jackson Asiatico michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup Biionix Cluster Department of Internal MedicineCollege of MedicineUniversity of Central FloridaOrlandoFLUSA Advanced Materials Processing and Analysis Centre Nanoscience Technology Center(NSTC)Materials Science and EngineeringCollege of MedicineUniversity of Central FloridaOrlandoFLUSA CMC Materials 870 North CommonsDrAuroraILUSA Department of Chemistry Oakland UniversityRochesterMIMIUSA School of Applied Sciences Department of Chemical SciencesUniversity of HuddersfieldUK Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA Engineering Research Center for Revolutionizing Biomaterials North Carolina A&T UniversityGreensboroNCUSA Department of Automatic Control and Systems Engineering Insigneo Institute for In Silico MedicineUniversity of SheffieldSheffieldS13JDUK

The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy *** radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing *** demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic *** reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic *** properties make cerium oxide nanomaterials *** show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and *** investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in ***,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in *** findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials.

关键词： Ionizing radiation Osteoporosis Nanozyme Cerium oxide Bone strength Bone resorption

Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy

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World Journal of Gastroenterology 2014年第11期20卷 2995-3001页

作者： Klaudia Farkas Péter lászló lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass lajos S Kiss Tibor Wittmann tamás Molnár First Department of Medicine University of SzegedH6720 SzegedHungary First Department of Medicine Semmelweis UniversityH1088 BudapestHungary Department of Medical Physics and Informatics University of SzegedH6720 SzegedHungary Faculty of Medicine Pediatrics DepartmentUniversity of SzegedH6720 SzegedHungary

AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were ***-four CD patients received infliximab,and 17 received *** endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in ***:Mucosal healing was achieved in 23 CD and7 UC *** therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with *** clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or ***:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped.

关键词： Crohn’s disease Ulcerative colitis Biological ther

Waist Circumference Reference Values for Screening Cardiovascular Risk Factors in Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2010年第1期23卷 21-31页

作者： GUAN-SHENG MA CHENG-YE JI JUN MA JIE mi R1ta YT SlING FENG XIONG WEI-lI YAN XIAO-QI HU YAN-PING lI SONG-M1NG DU HONG-YUN FANG AND J1NG-XIONG JIANG National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing100050 China Institute of Child and Adolescent Health Peking gniversi07 Health Science Center Beijing100191 China Capital Institute of Pediatrics Beijing 100020 China Department of Paediatrics TheChinese University of Hong Kong Hong Kong Special Administrative Re'on China The Children's Hospital of Chongqing Medical University Chongqing 400014 China School of Public Health Xinjiang Medical University Wulumuqi 830011 Xinjiang China National Center for Women and Childre's Health Chinese Center for Disease Control and Prevention Beijing 100013 China

Objectives To explore the optimal threshold values of waist circumference （WC） for detecting cardiovascular （CV） risk factors among Chinese children and adolescents. Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China. CV risk factors in this study included hypertension （blood pressure above 95 percentile levels）, dyslipidemia （with one or more of the following three indexes： TG ≥ 1.7 mmol/l, TC ≥ 5.18 mmol/l, and HDl-C ≤ 1.04 mmol/l） and elevated glucose level （fasting plasma glucose ≥5.6 mmol/l）. Receive-operating characteristic analysis （ROC） and logistic regression were employed to derive optimal age- and sex-specific waist circumference references for predicting CV risk factors. Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population, while a remarkable increasing trend occurred from the 90th percentile. The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls, which was at the 90th percentiles for detecting at least two of the above three CV risk factors. In comparison with children with waist circumference below the 75th percentile, the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile, and increased by 6 times among children with waist circumference above the 90th percentile. The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by Bmi category. Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents, respectively.

关键词： Waist circumference Cardiovascular disease risk factor China

拉萨地体南缘桑日地区晚白垩世火山岩的年代学、岩石地球化学及成因

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地球学报 2023年第3期44卷 467-484,I0001-I0006页

作者：杨同山郎兴海王旭辉邓煜霖吕娜董咪何青张相国梁海辉成都理工大学地球科学学院四川成都610059 西藏自治区地质矿产开发局区域地质调查大队西藏拉萨851400

拉萨地体南缘桑日地区中酸性火山岩出露广泛,多期次岩浆活动的叠加使得区内岩浆岩成分复杂、形成时代跨度大。为深入研究该地区火山岩的形成时代、构造背景和成因机制,本文选取桑日县西侧塔木村附近的中酸性火山岩为研究对象,开展锆石U... 详细信息

拉萨地体南缘桑日地区中酸性火山岩出露广泛,多期次岩浆活动的叠加使得区内岩浆岩成分复杂、形成时代跨度大。为深入研究该地区火山岩的形成时代、构造背景和成因机制,本文选取桑日县西侧塔木村附近的中酸性火山岩为研究对象,开展锆石U-Pb定年、全岩主微量及Sr-Nd同位素分析。锆石U-Pb年龄表明桑日地区塔木村火山岩形成于91.7~90.8 Ma,属于晚白垩世。桑日地区晚白垩世火山岩SiO_(2)含量为55.79%~74.26%,MgO含量为1.31%~4.34%,同时具有高Sr(平均含量为779×10^(-6))、低Y(8.36×10^(-6)~15.85×10^(-6))、Yb(0.92×10^(-6)~1.38×10^(-6))含量及高Sr/Y比值(36.28~105.59)的特征,表明桑日晚白垩世火山岩为埃达克质岩石。同时该地区晚白垩世火山岩富集大离子亲石元素Rb、Sr和Pb,亏损高场强元素Nb、ta和Ti,具有较低的87Sr/86Sr初始值(0.704152~0.704515)和较高的143Nd/144Nd初始值(0.512676~0.512750)。综合岩石地球化学特征和区域地质资料,桑日地区晚白垩世火山岩形成于新特提斯洋壳北向俯冲消减有关的活动大陆边缘环境,是新特提斯洋壳部分熔融的产物,洋壳熔体上升过程中伴有地幔楔物质的加入并经历了分离结晶作用。

关键词：拉萨地体南缘桑日地区晚白垩世新特提斯洋火山岩

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液质联用技术测定益母草碱的血浆蛋白结合率

广州化工 2017年第13期45卷 114-116页

作者：王建塔糜玲陈瑞汤磊贵州医科大学贵州贵阳550004

测定益母草碱在大鼠血浆中的血浆蛋白结合率,为临床安全用药及血浆蛋白测试方法研究提供依据。以超高效液相色谱-质谱联用为检测手段,采用超滤法考察益母草碱与大鼠血浆蛋白的结合情况。当益母草碱在大鼠血浆中质量浓度为40800μg/l时,... 详细信息

测定益母草碱在大鼠血浆中的血浆蛋白结合率,为临床安全用药及血浆蛋白测试方法研究提供依据。以超高效液相色谱-质谱联用为检测手段,采用超滤法考察益母草碱与大鼠血浆蛋白的结合情况。当益母草碱在大鼠血浆中质量浓度为40800μg/l时,大鼠血浆蛋白结合率较高且无浓度依赖性。结果证明建立的超滤法和超高效液相色谱-质谱联用的检测方法能够满足血浆蛋白结合率测定的要求。

关键词：益母草碱血浆蛋白结合率超滤法液质联用

微小RNA-19a-3p对人白血病叉头蛋白O1-Kruppel样因子2-鞘氨醇-1-磷酸受体1通路的影响探析

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世界临床药物 2022年第2期43卷 140-143页

作者：拓进宝宋超王丽萍延安大学附属医院血液科陕西延安716000 延安大学附属医院医学检验科陕西延安716000

目的探究微小 RNA(miR)-19a-3p 对人白血病叉头蛋白 O1(FoxO1)-Kruppel 样因子(Kruppel like factor,KlF)2-鞘氨醇-1-磷酸受体1(sphingosine-1-phosphate receptor 1,S1P1)通路的影响。方法选取人白血病T淋巴细胞,对细胞进行常规传代培养并分为实验组及对照组。实验组通过转染小干扰RNA敲低mi R-19a-3p的表达,对照组不进行任何刺激。检测mi R-19a-3p表达水平,细胞中Fox O1、KlF2、S1P1的表达情况及细胞增殖水平,对比两组相关指标表达情况。结果传代培养后,实验组及对照组细胞mi R-19a-3p表达分别为(2.44±0.21)、(1.53±0.15),差异有统计学意义(P lF2(1.92±0.48)、S1P1(1.45±0.15)表达水平显著高于对照组Fox O1(1.33±0.29)、KlF2(0.66±0.19)、S1P1(0.41±0.09),差异有统计学意义(P mi R-19a-3p在淋巴瘤组织中呈现高表达且对人白血病Fox O1-KlF2-S1P1通路有抑制作用,且抑制mi R-19a-3p的高表达可帮助激活Fox O1-KlF2-S1P1通道的正向调控。

关键词：微小RNA-19a-3p 人白血病叉头蛋白O1 Kruppel样因子2 鞘氨醇-1-磷酸受体1 细胞通路

Nested-PCR在人间布鲁氏菌病早期快速诊断中的探讨

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中国人兽共患病学报 2021年第2期37卷 188-192页

作者：刘志国王妙塔娜李晓燕尉瑞平米景川李丹崔步云李振军内蒙古自治区综合疾病预防控制中心呼和浩特010031 中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室北京102206 乌兰察布市地方病防治中心集宁012000

目的探讨Nested-PCR在布鲁氏菌病(布病)患者早期快速诊断中的可行性。方法用Nested-PCR对布鲁氏菌标准菌株的19生物型、4个疫苗株(M5、A19、S2和104M)和有血清交叉反应的菌株(人苍白杆菌、大肠杆菌O∶157、小肠结肠炎耶尔森氏菌O∶9)进... 详细信息

目的探讨Nested-PCR在布鲁氏菌病(布病)患者早期快速诊断中的可行性。方法用Nested-PCR对布鲁氏菌标准菌株的19生物型、4个疫苗株(M5、A19、S2和104M)和有血清交叉反应的菌株(人苍白杆菌、大肠杆菌O∶157、小肠结肠炎耶尔森氏菌O∶9)进行扩增,评价该方法的特异性;用Nested-PCR对倍比稀释的16M菌株DNA(100~10^(-7))进行扩增,评价该方法的分析敏感性。用Nested-PCR对临床采集的200份布病样本DNA进行检测,评价该方法在临床样本检测中的可行性。结果Nested-PCR能特异性的检出所有布鲁氏菌种,而与布鲁氏菌有血清学交叉反应的菌株和阴性对照未见扩增。试验表明该方法的分析敏感性至少为10-6(相当于43 fg/μl羊种布鲁氏菌DNA),明显高于BCSP31-PCR。该方法首轮引物的扩增阳性率为4.5%(9/200),次轮引物扩增的阳性率为75.5%(151/200),与血清学检测结果有较高的一致性。结论Nested-PCR可尝试用于布病患者的早期筛查,但尚需优化改进。

关键词：布病 Nested-PCR 早期诊断

牛羊猪种布鲁氏菌快速鉴别PCR方法的建立及评价

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中国人兽共患病学报 2019年第5期35卷 399-403页

作者：刘志国塔娜李晓燕王妙赵鸿雁朴东日蔚瑞平米景川李振军中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室北京102206 内蒙古自治区综合疾病预防控制中心呼和浩特010031 乌兰察布市地方病防治中心乌兰察布012000

目的建立一种可在一个反应体系中同时鉴别布鲁氏菌及牛羊猪种布鲁氏菌的快速PCR鉴别方法。方法将布鲁氏菌及牛羊猪种布鲁氏菌的扩增引物进行优化组合,建立全新的BAMS-PCR方法;随后对该方法的特异性和灵敏度进行评价,并对现场分离的219... 详细信息

目的建立一种可在一个反应体系中同时鉴别布鲁氏菌及牛羊猪种布鲁氏菌的快速PCR鉴别方法。方法将布鲁氏菌及牛羊猪种布鲁氏菌的扩增引物进行优化组合,建立全新的BAMS-PCR方法;随后对该方法的特异性和灵敏度进行评价,并对现场分离的219株布鲁氏菌进行鉴别,评价其在布鲁氏菌鉴别中的应用价值。最后,用该方法对临床标本中布鲁氏菌的DNA进行扩增,评价其在临床诊断中的实用性。结果 BAMS-PCR方法可在同一反应中同时鉴别布鲁氏菌及牛种(1,2,4型),羊种(1,2和3型)和猪种(1型)布鲁氏菌,并有较好的特异性和敏感性。布鲁氏菌属,牛种,猪种和羊种布鲁氏菌引物的检测灵敏度分别为10 pg/μl,100 pg/μl, 10 pg/μl和100 pg/μl。BAMS-PCR对219株临床分离菌株的鉴定结果和常规生物分型方法的鉴定符合率为100%。经BAMS-PCR检测,97份临床血清样本仅6份为阳性,全血和组织(羊脾)样本全部为阴性。结论 BAMS-PCR是一种简便、快速、高效、准确的布鲁氏菌鉴别方法,可作为临床分离菌株的首选鉴别方法。

关键词：布鲁氏菌聚合酶链式反应鉴别评价