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CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： Wen-Qian ma Ming-Chang Miao Ping-An Ding Bi-Bo tan Wen-Bo Liu Shuo Guo Li-Mian er Zhi-Dong Zhang Qun Zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are unknown.AIM To investigate the role and mechanism of CALD1 in GC progression,invasion,and migration.METHODS In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by experiments.CALD1-siRNA was synthesized and used to trans-fect GC cells.Cell activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS Bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of GC.The prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and evaluated.The experimental results were consistent with the results of the bioinformatics analysis.The expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 cells.Cell activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 cells.The ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was altered.According to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely related to the PI3K-Akt signaling pathway.Experimen

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration Bioinformatics

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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

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Military Medical Research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam ta Zhou Zong-Rui ma Jia-Bao Sheng Victor CWtam Shara WYLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’anatomy.However,the interpretation of medical images can be highly subjective and dependent on the expertise of clinicians.Moreover,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical practice.In contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical endpoints.Studies have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized medicine.However,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical modeling.In this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with cancer.We focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical modeling.Furthermore,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of models.Finally,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

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Spark Plasma Sintering of Boron Carbide Using Ti_(3)SiC_(2) as a Sintering Additive

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Journal of Wuhan University of Technology(materials Science) 2024年第3期39卷 645-650页

作者： Hülya Biçer Mustafa Tuncer Hasan Göçmez Iurii Bogomol Valerii Kolesnichenko Andrey Ragulya Kutahya Dumlupinar University School of EngineeringDepartment of Metallurgical and Materials EngineeringKütahya 43100Tur-key Boron Based Advanced Ceramics Application and Research Center Kütahya Dumlupınar UniversityKütahya 43100Turkey Advanced Technologies Center(İLTEM) Kütahya Dumlupınar UniversityKütahya 43000Turkey Department of High-Temperature ma-terials and Powder Metallurgy National Technical University of Ukraine“Igor Sikorsky Kyiv Polytechnic Institute”Kyiv 03056Ukraine Frantsevich Institute for Problems of materials Science National Academy of Sciences of UkraineKyiv 03056Ukraine

Boron carbide has unique properties for wide application possibilities;however,poor sinterability limits its applications.One approach to overcome this limitation is the addition of secondary phases into boron carbide.Boron carbide based composite ceramics are produced by the direct addition of secondary phases into the structure or via reactive sintering using a sintering additive.The present study investigated the effect of Ti_(3)SiC_(2) addition to boron carbide by reactive spark plasma sintering in the range of 1700-1900℃.Ti_(3)SiC_(2) phase decomposed at high temperatures and reacted with B4C to form secondary phases of TiB2 and SiC.The results demonstrated that the increase of Ti_(3)SiC_(2) addition(up to 15 vol%)effectively promoted the densification of B4C and yielded higher hardness.However,as the amount of Ti_(3)SiC_(2) increased further,the formation of microstructural inhomogeneity and agglomeration of secondary phases caused a decrease in hardness.

关键词： reactive sintering SPS boron carbide maX phase

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Enhanced piezoelectric performance of Cr/ta non-equivalent co-doped Bi_(4)Ti_(3)O_(12)-based high-temperature piezoceramics

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Journal of Advanced Ceramics 2024年第3期13卷 263-271页

作者： Xuanyu Chen Ziqi ma Bin Li Yejing Dai School of materials Sun Yat-sen UniversityShenzhen 518107China

In this study,(Cr_(1/3)/ta_(2/3))non-equivalent co-doped Bi_(4)Ti_(3)O_(12)(BIT)ceramics were prepared to solve the problem that high piezoelectric performance,high Curie temperature,and high-temperature resistivity could not be achieved simultaneously in BIT-based ceramics.A series of Bi_(4)Ti_(3-x)(Cr_(1/3)ta_(2/3))_(x)O_(12)(x=0-0.04)ceramics were synthesized by the solid-state reaction method.The phase structure,microstructure,piezoelectric performance,and conductive mechanism of the samples were systematically investigated.The B-site non-equivalent co-doping strategy combining high-valence ta^(5+)and low-valence Cr^(3+)significantly enhances electrical properties due to a decrease in oxygen vacancy concentration.Bi_(4)Ti_(2.97)(Cr_(1/3)ta_(2/3))_(0.03)O_(12)ceramics exhibit a high piezoelectric coefficient(d_(33)=26 pC·N^(-1))and a high Curie temperature(TC=687℃).Moreover,the significantly increased resistivity(ρ=2.8×10^(6)Ω·cm at 500℃)and good piezoelectric stability up to 600℃are also obtained for this composition.All the results demonstrate that Cr/ta co-doped BIT-based ceramics have great potential to be applied in high-temperature piezoelectric applications.

关键词： high temperature piezoelectricity co-doped Bi_(4)Ti_(3)O_(12)(BIT)

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Petrogenesis and tectonic implications of the Silurian adakitic granitoids in the eastern segment of the Qilian Orogenic Belt,Northwest China

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Acta Geochimica 2024年第1期43卷 72-86页

作者： Jiao-Long Zhao Xiao-Jun Huang Pei-Qing Hu Zhen-Xi Yang Ying Fan er-Teng Wang Fu-Bo Yang Jing-Yu Zhang School of Earth Sciences Key Laboratory of Mineral Resources in Western China(Gansu Province)Lanzhou UniversityLanzhou 730000China Nuclear Industry 247 Brigade Tianjin North China Geological Survey BureauTianjin 301800China Fourth Institute of Geological and Mineral Exploration of Gansu Provincial Bureau of Geology and Mineral Resources Jiuquan 735000China

Geodynamic mechanism responsible for the generation of Silurian granitoids and the tectonic evolution of the Qilian orogenic belt remains controversial. In this study, we report the results of zircon U–Pb age, and systematic whole-rock geochemical data for the Haoquangou and Liujiaxia granitoids within the North Qilian orogenic belt and the Qilian Block, respectively, to constrain their petrogenesis, and the Silurian tectonic evolution of the Qilian orogenic belt. Zircon U–Pb ages indicate that the Haoquangou and Liujiaxia intrusions were emplaced at423 ± 3 ma and 432 ± 4 ma, respectively. The Haoquangou granodiorites are calc-alkaline, while the Liujiaxia granites belong to the high-K calc-alkaline series.Both are peraluminous in composition and have relatively depleted Nd isotopic [ε_(Nd)(t) =(-3.9 – + 0.6)] characteristics compared with regional basement rocks, implying their derivation from a juvenile lower crust. They show adakitic geochemical characteristics and were generated by partial melting of thickened lower continental crust. Postcollisional extensional regime related to lithospheric delamination was the most likely geodynamic mechanism for the generation of the Haoquangou granodiorite, while the Liujiaxia granites were generated in a compressive setting during continental collision between the Qaidam and Qilian blocks.

关键词： Silurian adakitic granitoids Petrogenesis Tectonic setting Qilian Orogenic Belt

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Insights into Nano-and Micro-Structured Scaffolds for Advanced Electrochemical Energy Storage

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Nano-Micro Letters 2024年第7期16卷 187-230页

作者： Jiajia Qiu Yu Duan Shaoyuan Li Huaping Zhao Wenhui ma Weidong Shi Yong Lei Fachgebiet Angewandte Nanophysik Institut Für Physik and IMN MacroNanoTechnische Universit.t Ilmenau98693 IlmenauGermany Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093People’s Republic of China School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013People’s Republic of China School of Science and Technology Pu’er UniversityPu’er 665000People’s Republic of China

Adopting a nano-and micro-structuring approach to fully unleashing the genuine potential of electrode active material benefits in-depth understandings and research progress toward higher energy density electrochemical energy stor-age devices at all technology readiness levels.Due to various challenging issues,especially limited stability,nano-and micro-structured(NMS)electrodes undergo fast electrochemical performance degradation.The emerging NMS scaffold design is a pivotal aspect of many electrodes as it endows them with both robustness and electrochemical performance enhancement,even though it only occupies comple-mentary and facilitating components for the main mechanism.However,extensive efforts are urgently needed toward optimizing the stereoscopic geometrical design of NMS scaffolds to minimize the volume ratio and maximize their functionality to fulfill the ever-increasing dependency and desire for energy power source supplies.This review will aim at highlighting these NMS scaffold design strategies,summariz-ing their corresponding strengths and challenges,and thereby outlining the potential solutions to resolve these challenges,design principles,and key perspectives for future research in this field.Therefore,this review will be one of the earliest reviews from this viewpoint.

关键词： Nano-and micro-structured Interconnected porous Scaffolds Electrode design Electrochemical energy storage

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Achieving exceptionally high strength and rapid degradation rate of Mg-er-Ni alloy by strengthening with lamellar γ' and bulk LPSO phases

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Journal of materials Science & Technology 2024年第1期168卷 88-102页

作者： Chaoneng Dai Jingfeng Wang Yuanlang Pan Kai ma Yinhong Peng Ye Wang Danqian Wang Chunhua Ran Jinxing Wang Yanlong ma College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China College of materials Science and Engineering Chongqing UniversityChongqing 400044China National Engineering Research Center for magnesium Alloys Chongqing 400044China College of materials Science and Engineering Chongqing University of TechnologyChongqing 400054China

As-extruded Mg-er-Ni alloys with different volume fractions of long-period stacking ordered(LPSO)phase and density of lamellar γ' phase were prepared,and the microstructure,mechanical,and degradation properties were investigated.Coupling the bulk LPSO phase and the lamellar γ' phase,and controlling the dynamic recrystallization processes during deformation by adjusting the volume fraction of LPSO and the density of the γ' phase,a synergistic increase in strength and degradation rate can be achieved.On the one hand,the increase in corrosion rate was related to the increased volume fraction of the bulk LPSO phase and the densities of the lamellar γ' phase,which provide more galvanic corrosion.Moreover,high densities of the lamellar γ' phase can provide more corrosion interface by inhibiting the recrystallization process to refine dynamic recrystallized(DRXed)grains during the hot extrusion.On the other hand,the ultimate tensile strength(UTS)and tensile yield strength(TYS)of the Mg-er-Ni alloy increased from 345 and 265 MPa to 514 MPa and 358 MPa,respectively,which was mainly attributed to grain boundary and texture strengthening,bulk LPSO phase and lamellar γ' phase strengthening.Overall,Mg^(-1)4er-4Ni alloy,which contains the highest volume fraction bulk LPSO phase and the densities of lamellar γ' phase,re-alized a synergistic enhancement of strength and degradation rate.The UTS,TYS,and degradation rate of Mg^(-1)4er-4Ni were 514 MPa,358 MPa,and 142.5 mg cm^(-2)h^(-1)(3 wt%KCl solution at 93◦C),respectively.This research provides new insight into developing Mg alloys with high strength and degradation rates for fracturing tool materials in the application of oil and gas exploitation in harsh environments.

关键词： Mg-er-Ni alloy Lamellarγ'and bulk LPSO phases Rapid degradation rate High strength Mechanical and corrosion mechanism

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Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 233-243页

作者： Hongmin LU Tiantian GUO Yue ZHANG Dewang LIU Lulu HOU Chengxue ma Mingwei XING College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 150040China

Microplastics(MPs)have attracted growing attention worldwide as an increasingly prevalent environmental pollutant.In addition,chicken meat is currently the most widely consumed kind of poultry in the global market.Consumer demand for chicken is on the rise both at home and abroad.As a result,the safety of chicken raising has also received significant attention.The lungs play an essential role in the physiological activities of chickens,and they are also the most vulnerable organs.Lung injury is difficult to repair after the accumulation of contaminants,and the mortality rate is high,which brings huge economic losses to farmers.The research on the toxicity of MPs has mainly focused on the marine ecosystem,while the mechanisms of toxicity and lung damage in chickens have been poorly studied.Thus,this study explored the effects of exposure to polystyrene microplastics(PS-MPs)at various concentrations for 42 d on chicken lungs.PS-MPs could cause lung pathologies and ultrastructural abnormalities,such as endoplasmic reticulum(er)swelling,inflammatory cell infiltration,chromatin agglutination,and plasma membrane rupture.Simultaneously,PS-MPs increased the expression of genes related to the heat shock protein family(Hsp60,Hsp70,and Hsp90),er stress signaling(activating) transcription factor 6(ATF0),ATF4,protein kinase RNA-like er kinase(PerK),and eukaryotic translation initiation factor 2 subunitα(eIF2a),pyroptosis-related genes(NOD)-,LRR-and pyrin domain-containing protein 3(NLRP3),apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),interleukin-1β(IL-1β),cysteinyl aspartate-specific proteinase 1(Caspasel),and gasdermin-D(GSDMD),and the inflammatory signaling pathway(nuclear factor-kB(NF-kB),inducible nitric oxide synthase(iNOS),and cyclooxygenase-2(COX-2).The above results showed that PS-MP exposure could result in lung stress,er stress,pyroptosis,and inflammation in broilers.Our findings provide new scientific clues for further research on the mechanisms of physical health and toxicolo

关键词： Polystyrene microplastics Endoplasmic reticulum stress Lung NLRP3 inflammasome Inflammation

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(Lu_(1/7)Yb_(1/7)Sc_(1/7)er_(1/7)Y_(1/7)Ho_(1/7)Dy_(1/7))_(2)Si_(2)O_(7)high entropy rare-earth disilicate with low thermal conductivity and excellent resistance to CmaS corrosion

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Journal of Advanced Ceramics 2024年第5期13卷 549-560页

作者： Xu Wang Mingyu Meng Feihan Xu Ling Liu Lihong Gao Shizhen Zhu Zhuang ma School of materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Science and Technology on materials under Shock and Impact Beijing 100081China tangshan Research Institute Beijing Institute of TechnologyTangshan 063000China

Low thermal conductivity,compatible thermal expansion coefficient,and good calcium–magnesium–aluminosilicate(CmaS)corrosion resistance are critical requirements for environmental barrier coatings used on silicon-based ceramics.RE2Si2O7(RE=rare earth)has been widely recognized as one of the most promising candidates for environmental barrier coatings due to its good water vapor corrosion resistance.However,the relatively high thermal conductivity and poor resistance to CmaS corrosion have limited its practical application.Inspired by the high entropy effect,in this work,a novel rare earth disilicate(Lu_(_(1/7))Yb_(_(1/7))Sc_(_(1/7))er_(_(1/7))Y_(_(1/7))Ho_(_(1/7))Dy_(_(1/7)))2Si2O7((7RE_(_(1/7)))2Si2O7)has been designed and synthesized by a solid reaction process.(7RE_(_(1/7)))2Si2O7 showed a low thermal conductivity of 1.81 W·m^(−1)·K^(−1)at 1273 K.Furthermore,the thermal expansion coefficient of(7RE_(_(1/7)))_(2)Si_(2)O_(7)(4.07×10^(−6)℃^(−1)from room temperature(RT)to 1400℃)is close to that of the SiC-based ceramic matrix composites(SiC-CMCs)((4.5–5.5)×10^(−6)℃^(−1)).Additionally,(7RE_(_(1/7)))2Si2O7 exhibited excellent resistance to CmaS corrosion.When exposed to CmaS at 1300℃for 48 h,the reaction layer thickness was 22μm.The improved performance of(7RE_(_(1/7)))2Si2O7 highlights its potential as a promising candidate for thermal/environmental barrier coatings.

关键词： high entropy disilicate (Lu_(1/7)Yb_(1/7)Sc_(1/7)er_(1/7)Y_(1/7)Ho_(1/7)Dy_(1/7))_(2)Si_(2)O_(7)((7RE_(1/7))_(2)Si_(2)O_(7)) high-temperature thermal properties calcium-magnesium-aluminosilicate(CmaS)corrosion

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洲滩湿地植物群落对水文地貌特征变化适应力的研究进展

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生态与农村环境学报 2024年第6期40卷 773-779页

作者：夏雪马学而李佳奕雷霆北京林业大学生态与自然保护学院北京100083 湖南洞庭湖湿地生态系统国家野外科学观测研究站湖南常德415904

水文地貌特征变化会造成生态水文因子及土壤因子的空间差异,影响洲滩植物群落的构建和演替趋势。明确水文地貌特征对洲滩植物群落的作用机制具有重要的理论和实践意义。该研究总结了洲滩湿地植物群落对水文地貌特征变化的适应力研究成果... 详细信息

水文地貌特征变化会造成生态水文因子及土壤因子的空间差异,影响洲滩植物群落的构建和演替趋势。明确水文地貌特征对洲滩植物群落的作用机制具有重要的理论和实践意义。该研究总结了洲滩湿地植物群落对水文地貌特征变化的适应力研究成果,阐述了湿地植物群落对水文地貌特征变化的适应策略,在此基础上提出以立地水深来衡量微尺度水文地貌特征,尝试探索生态环境因子-立地水深-植物功能多样性之间的级联关系,以准确评估水文地貌变化对洲滩湿地生态过程造成的影响;并以立地水深为核心,确定洲滩湿地植物水文地貌生态位,选择适应力和恢复力更强的植物物种组合方法;最后以典型洲滩湿地洞庭湖为例,阐述洲滩植物群落对水文地貌特征变化的适应力评估和应用。洞庭湖剧烈的水位波动常伴随着沉积物累积和冲蚀等机械干扰,继而产生多样化的微地貌。研究洲滩湿地植物群落对微尺度水位和地表高程变化的响应和适应力能够深入评估洲滩湿地植物群落演替趋势,评价湿地保护和修复工程的有效性。

关键词：立地水深地表高程测量平台植物功能性状水文地貌特征洞庭湖

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