检索结果-南通市图书馆

Ferroptosis:a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第3期18卷 506-512页

作者： Qing-sheng Li Yan-Jie jia Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences Zhengzhou UniversityZhengzhouHenan ProvinceChina

Ferroptosis,a new non-necrotizing programmed cell death(PCD),is driven by iron-dependent phospholipid peroxidation.Ferroptosis plays a key role in secondary traumatic brain injury and secondary spinal cord injury and is closely related to inflammation,immunity,and chronic injuries.The inhibitors against ferroptosis effectively improve iron homeostasis,lipid metabolism,redox stabilization,neuronal remodeling,and functional recovery after trauma.In this review,we elaborate on the latest molecular mechanisms of ferroptosis,emphasize its role in secondary central nervous trauma,and update the medicines used to suppress ferroptosis following injuries.

关键词： ferroptosis immune response inflammation iron homeostasis lipid metabolism medicine programmed cell death spinal cord injury traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

《史记》位移动词“出”的句法功能考察

长春工程学院学报（社会科学版） 2013年第3期14卷 114-116页

作者：涂加胜皖西学院文化与传媒学院安徽237012

"出"在《史记》中是一个使用频率的位移动词。文章搜索出了"出"在《史记》中的用例并考察了"出"的句法环境,从"出"充当连动结构前项和后项的情况以及处所成分的配置方面对其句法功能进行了探讨。

关键词：连动结构处所成分句法标记

在线全文

学校读者我要写书评

暂无评论

注射用头孢呋辛钠中降解杂质的研究

中国抗生素杂志 2023年第1期48卷 62-68页

作者：谭胜连周从鹰张旭途刘佳广州白云山天心制药股份有限公司广州510300

目的对注射用头孢呋辛钠中4个未公开报道的降解杂质进行研究,并推导其化合物结构。方法采用YMC C8色谱柱(4.6 mm×50 mm,3μm);以0.005 mol/L醋酸铵溶液-乙腈为流动相梯度洗脱,流速0.5 mL/min。离子源:电喷雾离子(ESI)源。结果注射用头... 详细信息

目的对注射用头孢呋辛钠中4个未公开报道的降解杂质进行研究,并推导其化合物结构。方法采用YMC C8色谱柱(4.6 mm×50 mm,3μm);以0.005 mol/L醋酸铵溶液-乙腈为流动相梯度洗脱,流速0.5 mL/min。离子源:电喷雾离子(ESI)源。结果注射用头孢呋辛钠中4个未知杂质得到有效分离,使用Q EXACTIVE高分辨质谱确定了杂质的分子量,并依据头孢类化合物的裂解及降解理论推测出其结构与形成机理,与头孢类已知杂质相异,杂质Ⅳ为本品特有的氨降解杂质。结论本方法操作简便,灵敏度高,可用于评价注射用头孢呋辛钠中的未知杂质,同时,研究结果为注射用头孢呋辛钠的质量标准制订和质量控制提供了重要的参考依据。

关键词： LC-MS/MS 头孢呋辛降解杂质

在线全文

学校读者我要写书评

暂无评论

基于组氨酸的肿瘤靶向药物递送系统研究进展

药学学报 2022年第1期57卷 64-75,I0004页

作者：嵇梦陈大力涂家生孙春萌中国药科大学药用辅料及仿创药物研发评价中心药学院国家药品监督管理局药物制剂及辅料研究与评价重点实验室江苏南京210009

组氨酸作为一种碱性氨基酸,pK_(a)接近肿瘤弱酸微环境pH,其带电性和溶解性具有pH敏感性,在中性环境中,组氨酸不带电,表现为疏水特性,而在肿瘤酸性环境中,组氨酸可质子化带正电,同时转变为亲水特性,因此,组氨酸被广泛应用于靶向肿瘤弱酸... 详细信息

组氨酸作为一种碱性氨基酸,pK_(a)接近肿瘤弱酸微环境pH,其带电性和溶解性具有pH敏感性,在中性环境中,组氨酸不带电,表现为疏水特性,而在肿瘤酸性环境中,组氨酸可质子化带正电,同时转变为亲水特性,因此,组氨酸被广泛应用于靶向肿瘤弱酸性微环境的药物递送系统设计。本文全面综述了近年来基于组氨酸构建肿瘤靶向药物递送系统的研究进展,系统总结了利用组氨酸促进细胞摄取和调控药物释放的设计思路,并指出了相关研究工作的共性问题和未来发展方向。

关键词：组氨酸细胞穿膜肽肿瘤微环境药物递送系统药物治疗

Electroacupuncture alleviates ciliary muscle cell apoptosis in lens-induced myopic guinea pigs through inhibiting the mitochondrial signaling pathway

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2023年第12期16卷 1942-1951页

作者： Zhao-Hui Yang jia-Wen Hao Jin-Peng Liu Bo Bao tu-Ling Li Qiu-Xin Wu Ming-Guang He Hong-sheng Bi Da-Dong Guo Shandong University of Traditional Chinese Medicine Jinan 250014Shandong ProvinceChina Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine Shandong Provincial Clinical Medical Research Center of Optometry and Adolescent Low Vision Prevention and ControlJinan 250002Shandong ProvinceChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases Shandong Academy of Eye Disease Prevention and TherapyMedical College of Optometry and OphthalmologyShandong University of Traditional Chinese MedicineJinan 250002Shandong ProvinceChina

AIM:To investigate the effect of electroacupuncture(EA)on the mitochondria-dependent apoptotic signaling pathway in the ciliary muscle of guinea pigs with negative lensinduced myopia(LIM).METHODS:Guinea pigs were randomly divided into normal control(NC)group,LIM group,LIM+SHAM acupoint(LIM+SHAM)group,and LIM+EA group.Animals in the NC group received no intervention,while those in other three groups were covered with-6.0 diopter(D)lenses on right eyes.Meanwhile,animals in the LIM+EA group received EA at Hegu(LI4)combined with Taiyang(EX-HN5)acupoints,while those in the LIM+SHAM group were treated at sham points.After treatments for 1,2,and 4wk,morphological changes in ciliary muscles were observed with hematoxylin and eosin(H&E)staining and nick end labeling(tuNEL),and the expression of the mitochondrial apoptotic signaling pathway-related molecules in ciliary muscles was measured by real-time quantitative polymerase chain reaction(qPCR)and Western blot.Additionally,the adenosine triphosphate(ATP)contents were also determined in ciliary muscles.RESULTS:Axial length increased significantly in the LIM and LIM+SHAM groups and decreased in the LIM+EA group.The ciliary muscle fibers were broken and destroyed in both LIM and LIM+SHAM groups,whereas those in the LIM+EA group improved significantly.tuNEL assay showed the number of apoptotic cells increased in the LIM and LIM+SHAM groups,whereas reduced in the LIM+EA group.ATP contents showed a significant decrease in the LIM and LIM+SHAM groups,whereas increased after EA treatment.Compared with the NC group,the dynamin-related protein 1(DRP1),Caspase3,and apoptotic protease activator 1(APAF1)levels were significantly increased in the LIM group and decreased in the LIM+EA group.CONCLUSION:The results provide evidence of EA inhibiting the development of myopia by regulating the mitochondrial apoptotic signaling pathway.

关键词： myopia electroacupuncture ciliary muscle apoptosis mitochondrial signaling pathway guinea pigs

The one-pot process for the preparation of N-monoalkyl aromatic amines from nitroarene derivatives

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2009年第12期52卷 2171-2175页

作者： jia jianHong sheng Weijian HAN Liang LI YuJin GAO jianRong tu JunFei State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology Zhejiang University of TechnologyHangzhou 310014China

A series of N-monoalkyl aromatic amines are synthesized in high yields from corresponding nitroarene derivatives,aldehydes,and ammonium formate in the presence of Pd/C as a catalyst through one-pot operations at room temperature. Both the conversion and selectivity of the process are above 80%. Optimum reaction conditions are investigated,and it is found that the optimum molar ratio of nitroarene derivatives to ammonium formate and the optimum weight ratio of nitroarene derivatives to Pd/C are 1/4 and 1/0.10,respectively. These experiments provide a novel access for N-monoalkyl aromatic amines with advantages of simplicity,high selectivity,and environmental benignity.

关键词： N-monoalkylation one-pot process ammonium formate aldehyde Pd/C reduction

在线全文

学校读者我要写书评

暂无评论

环形燃烧室中圆台斜爆震燃烧特性研究

推进技术 2023年第12期44卷 119-129页

作者：张义宁金虹涂胜甲周林滕宏辉北京动力机械研究所北京100074 中国人民解放军93160部队北京100166 北京理工大学宇航学院北京100081

面向宽域爆震组合动力发展需求,首次提出适用于轴对称环形流道的圆台诱导斜爆震燃烧组织形式,通过数值模拟验证较低马赫数飞行工况下圆台诱导驻定斜爆震燃烧的可行性以及与斜劈、圆锥斜爆震燃烧的差异,从几何与来流参数两方面研究了圆... 详细信息

面向宽域爆震组合动力发展需求,首次提出适用于轴对称环形流道的圆台诱导斜爆震燃烧组织形式,通过数值模拟验证较低马赫数飞行工况下圆台诱导驻定斜爆震燃烧的可行性以及与斜劈、圆锥斜爆震燃烧的差异,从几何与来流参数两方面研究了圆台诱导斜爆震波的起爆与驻定特性。结果表明:在Ma7飞行工况,相比于圆锥和斜劈,环形燃烧室中圆台可以同时实现斜爆震波的加速起爆与稳定驻定。圆台上游的压缩作用以及下游的膨胀作用,使得圆台斜爆震波存在脱体而不前传的特殊起爆区结构。圆台内径、圆台角度、来流压缩程度以及当量比增大均有利于圆台诱导斜爆震波的起爆。同时,起爆区结构也会出现从渐变到突变再到稳定脱体的变化规律,相应的起爆距离逐渐缩短,爆震波角度逐渐增大。

关键词：环形燃烧室圆台斜爆震燃烧波系结构组合动力

非离子表面活性剂在脑靶向传递系统中的研究进展

在线全文

学校读者我要写书评

暂无评论

中国新药杂志 2015年第2期24卷 166-170页

作者：田宇沈雁涂家生中国药科大学药剂学教研室南京210009

由于血脑屏障的存在,限制了很多药物脑靶向的使用及疗效。研究者们使用非离子表面活性剂与载体偶联,通过吸收血液中的载脂蛋白促进受体介导的内吞作用,以及抑制P-糖蛋白外排等机制,或者用非离子表面活性剂连接相应配体和单克隆抗体等方... 详细信息

由于血脑屏障的存在,限制了很多药物脑靶向的使用及疗效。研究者们使用非离子表面活性剂与载体偶联,通过吸收血液中的载脂蛋白促进受体介导的内吞作用,以及抑制P-糖蛋白外排等机制,或者用非离子表面活性剂连接相应配体和单克隆抗体等方法,可以增加脑部对药物的摄取。本文综述了血脑屏障的结构特点,以及如何通过非离子表面活性剂的修饰使药物穿过血脑屏障,对实现脑靶向给药有重要意义。

关键词：脑靶向给药系统非离子表面活性剂聚山梨酯80 泊洛沙姆血脑屏障

Angiography-derived radial wall strain predicts coronary lesion progression in non-culprit intermediate stenosis

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2022年第12期19卷 937-948页

作者： Zhi-Qing WANG Bo XU Chun-Ming LI Chang-Dong GUAN Yue CHANG Li-Hua XIE Su ZHANG jia-Yue HUANG Patrick W Serruys William Wijns Liang-Long CHEN sheng-Xian tu Department of Cardiology Fujian Heart Medical CenterFujian Institute of Coronary Heart DiseaseFujian Medical University Union HospitalFujianChina Biomedical Instrument Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Cardiology National Clinical Research Center for Cardiovascular DiseasesFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina The Lambe Institute for Translational Medicine and Curam University of GalwayGalwayIreland

BACKGROUND Intermediate coronary lesions(ICLs)are highly prevalent but ported mixed prognosis.Radial strain has been associated with plaque vulnerability,yet its role in predicting lesion progression is largely unknown.The purpose of this study was to determine the predictive value of angiography-derived radial wall strain(RWS)for progression of untreated non-culprit ICLs.METHODS Post-hoc analysis was conducted in a study cohort including 603 consecutive patients with 808 ICLs identified at index procedure with angiographic follow-up of up to two years.RWS analysis was performed on selected angiographic frames with minimal foreshortening and vessel overlap.Lesion progression was defined as≥20%increase in percent diameter stenosis.RESULTS Lesion progression occurred in 49 ICLs(6.1%)with a median follow-up period of 16.8 months.Maximal RWS(RWSmax),frequently located at the proximal and throat plaque regions,distinguished progressive ICLs from silent ones.The largest area under the curve value of 0.75(95%CI:0.67–0.82,P12.6%.According to this threshold,178 ICLs were classified as having a high strain pattern.Exposure to a high strain amplitude with RWS_(max)>12.6%was independently associated with an increased risk of lesion progression(adjusted HR=6.82,95%CI:3.67–12.66,P<0.001).CONCLUSIONS Assessment of RWS from coronary angiography is feasible and provides independent prognostic value in patients with untreated ICLs.

关键词： coronary stenosis strain