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Chinese Journal of Natural Medicines 2018年第6期16卷 471-480页

作者： YU Ying-Lan LI Ya-Nan ZHANG Yong SUN Ru-Ning TU Jia-Sheng SHEN Yan Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Children's Hospital of Nanjing Medical University Nanjing 210008China Department of Professional Institute China Pharmaceutical UniversityNanjing 210009China

The therapeutic application of deoxypodophyllotoxin(DPT) is limited due to its poor water solubility and stability. In the present study, the micelles assembled by the amphiphilic block copolymers(m PEG-PDLLA) were constructed to improve the solubility and safety of DPT for their in vitro and in vivo application. The central composite design was utilized to develop the optimal formulation composed of 1221.41 mg m PEG-PDLLA, the weight ratio of 1 : 4(m PEG-PDLLA : DPT), 30 m L hydration volume and the hydration temperature at 40 oC. The results showed that the micelles exhibited uniformly spherical shape with the diameter of 20 nm. The drug-loading and entrapment efficiency of deoxypodophyllotoxin-polymeric micelles(DPT-PM) were about(20 ± 2.84)% and(98 ± 0.79)%, respectively, indicating that the mathematical models predicted well for the results. Compared to the free DPT, the cytotoxicity showed that blank micelles possessed great safety for Hela cells. In addition, the DPT loaded micelle formulation achieved stronger cytotoxicity at the concentration of 1 × 10^(-7) mol·L^(-1), which showed significant difference from free DPT(P tumor therapy with DPT.

关键词： Deoxypodophyllotoxin Central composite design Micelles Cytotoxicity

Liutex-based analysis of drag force and vortex in two-phase flow past 2-D square obstacle using LBM on GPU

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Journal of Hydrodynamics 2020年第5期32卷 820-833页

作者： Peng-xin Cheng Nan Gui Xing-tuan Yang Ji-yuan tu sheng-yao jiang Hai-jun jia Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy TechnologyKey Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China School of Engineering RMIT UniversityMelbourneAustralia

The two-phase flow past a square is a ubiquitous phenomenon widely encountered in industries and engineering,where the interaction of disparate phases coupled with the influence of the solid is rather complicated.In this context,the flow characteristics and the vortex field are investigated to reveal the mechanisms of the two-phase drag and the vortex variation.The lattice Boltzmann method(LBM)is utilized to study the multi-component two-phase flow.The computation implemented on the GPU is remarkably accelerated thanks to the natural parallelism of the LBM.The process of the two-phase flow past a square is thoroughly examined.The drag and lift forces,including the total force and the components caused by the dispersed phase and the continuous phase,respectively,are obtained,and their variation mechanisms are explained.Meanwhile,the vortex-identification approaches based on the Liutex as well as the traditional methods are compared.The relationship between the bubble breakup and coalescence processes and the extremums of different vortex identification variables is analyzed.

关键词： Two-phase flow flow past a square lattice Boltzmann method(LBM) vortex identification Liutex two-phase drag

Science Letters:Determination of benzalkonium chloride in viscous ophthalmic drops of azithromycin by high-performance liquid chromatography

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第12期10卷 877-882页

作者： Yan SHEN sheng-jie XU Shi-chun WANG jia-sheng tu Department of Pharmaceutics China Pharmaceutical University Nanjing 210009 China Productivity Center of jiangsu Province Nanjing 210042 China

一个高效的液体层析(HPLC ) 系统在 azithromycin 为 benzalkonium 氯化物(BKC ) 的决心在颠倒的阶段模式被使用粘滞眼的落下。Venusil-XBP (L)-C18(150 公里× 4 .6 公里， 5 μ m ) 列在 50 ° C 被使用。活动阶段由甲醇钾磷酸盐的混... 详细信息

一个高效的液体层析(HPLC ) 系统在 azithromycin 为 benzalkonium 氯化物(BKC ) 的决心在颠倒的阶段模式被使用粘滞眼的落下。Venusil-XBP (L)-C18(150 公里× 4 .6 公里， 5 μ m ) 列在 50 ° C 被使用。活动阶段由甲醇钾磷酸盐的混合物组成了(16:5， v/v ) 。二个样品准备方法被比较。结果建议与一个抽取过程相比，一个 deproteinization 过程快得多、更方便。用为样品准备的 deproteinization 过程，刻度曲线在范围是线性的 5.0 ∼50 μ g /ml。在内天和变化的内部天的系数是不到 10% 。平均恢复分别地在 10.0， 30.0，和 50.0 μ g /ml 的集中作为 96.70% ， 98.52% ，和 97.96% 被决定。在精确的可变性没超过 5% 。在结论，用一个简单样品处理过程的这个 HPLC 方法对在 azithromycin 监视 BKC 内容显得合适粘滞眼的落下。

关键词：高效液相色谱法阿奇霉素苯扎氯铵粘性眼科测定样品处理变异系数

Systematic review and meta-analysis of prophylactic abdominal drainage after pancreatic resection

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World Journal of Gastroenterology 2015年第18期21卷 5719-5734页

作者： Chang-Wei Dou Zhi-Kui Liu Yu-Li jia Xin Zheng Kang-sheng tu Ying-Min Yao Qing-Guang Liu Department of Hepatobiliary Surgery The First Affiliated Hospital of the Medical College of Xi’an jiaotong University Xi'an 710061 Shaanxi Province China

AIM: To investigate whether prophylactic abdominal drainage is necessary after pancreatic resection. METHODS: Pub Med, Web of Science, and the Cochrane Library were systematically searched to obtain relevant articles published before January 2014. Publications were retrieved if they met the selection criteria. The outcomes of interest included: mortality, morbidity, postoperative pancreatic fistula(POPF), clinically relevant pancreatic fistula(CRPF), abdominal abscess, reoperation rate, the rate of interventional radiology drainage, and the length of hospital stay. Subgroup analyses were also performed for pancreaticoduodenectomy(PD) and for distal pancreatectomy. Begg's funnel plot and the Egger regression test were employed to assess potential publication bias.RESULTS: Nine eligible studies involving a total of 2794 patients were identified and included in this meta-analysis. Of the included patients, 1373 received prophylactic abdominal drainage. A fixedeffects model meta-analysis showed that placement of prophylactic drainage did not have beneficial effects on clinical outcomes, including morbidity, POPF, CRPF, reoperation, interventional radiology drainage, and length of hospital stay(Ps > 0.05). In addition, prophylactic drainage did not significantly increase the risk of abdominal abscess. Overall analysis showed that omitting prophylactic abdominal drainage resulted in higher mortality after pancreatectomy(OR = 1.56; 95%CI: 0.93-2.92). Subgroup analysis of PD showed similar results to those in the overall analysis. Elimination of prophylactic abdominal drainage after PD led to a significant increase in mortality(OR = 2.39; 95%CI: 1.22-4.69; P = 0.01).CONCLUSION: Prophylactic abdominal drainage after pancreatic resection is still necessary, though more evidence from randomized controlled trials assessing prophylactic drainage after PD and distal pancreatectomy are needed.

关键词： Prophylactic abdominal drainage Pancreatic resection Systemic review Meta-analysis

会计稳健性一定降低债券融资成本吗?--来自我国信用债市场的证据

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中央财经大学学报 2022年第2期 54-64页

作者：杨尔稼李路肖土盛上海立信会计金融学院金融学院上海外国语大学国际金融贸易学院中央财经大学会计学院

债券市场作为多层次资本市场体系的重要组成,其持续健康发展对于优化市场资源配置功能至关重要。已有文献在研究企业会计信息质量与债务融资成本的关系时,普遍得出会计稳健性可以有效降低债务融资成本的结论。与之不同,本文以2010—201... 详细信息

债券市场作为多层次资本市场体系的重要组成,其持续健康发展对于优化市场资源配置功能至关重要。已有文献在研究企业会计信息质量与债务融资成本的关系时,普遍得出会计稳健性可以有效降低债务融资成本的结论。与之不同,本文以2010—2019年我国上市公司在沪深交易所及银行间市场发行的信用债为样本,实证研究发现:债券发行人的会计稳健性越高,其债券发行的信用利差也越高,意味着发债企业的会计稳健性将增加其债券融资成本。进一步研究发现,未来的债券合约重新谈判成本越高,发债企业的会计稳健性对其债券融资成本的不利影响越强,支持了债券合约的重新谈判成本是影响会计稳健性与债券融资成本之间关系的重要因素。上述研究结论深化了学术界对会计稳健性与债务融资成本之间关系的认识,亦为政府监管部门规范债券市场运行以提升会计信息质量在市场资源配置中的作用提供了政策启示。

关键词：会计稳健性信用利差协调成本债券信用评级

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聚山梨酯80组分与其溶血性的关系

中国药科大学学报 2012年第3期43卷 231-235页

作者：李畅涂家生中国药科大学药剂学教研室南京210009

研究聚山梨酯80(Tween 80)的溶血不良反应与其成分的母体结构间的关系。Tween 80合成第一步中可能会产生3种相关母核结构:山梨醇、一失水山梨醇酐和二失水异山梨醇酐。经与油酸酯化、聚氧乙烯化后形成多成分混合物。本文通过质谱法以及... 详细信息

研究聚山梨酯80(Tween 80)的溶血不良反应与其成分的母体结构间的关系。Tween 80合成第一步中可能会产生3种相关母核结构:山梨醇、一失水山梨醇酐和二失水异山梨醇酐。经与油酸酯化、聚氧乙烯化后形成多成分混合物。本文通过质谱法以及溶血性考察对单一母核合成物山梨醇聚氧乙烯油酸酯(polyoxyethylene sorbitol oleate,POS)和异山梨醇酐聚氧乙烯油酸酯(polyoxyethylene isosorbide oleate,POI)进行了成分和溶血性比较。结果证明:山梨醇聚氧乙烯油酸酯具有极低的溶血不良反应,而异山梨醇酐聚氧乙烯油酸酯具有极高的溶血性。同时,萃取法进一步证明上述结果的正确性。

关键词：聚山梨酯80 溶血性山梨醇聚氧乙烯油酸酯异山梨醇酐聚氧乙烯油酸酯

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论巴西证券监管改革对我国监管转型的借鉴

河北法学 2015年第7期33卷 43-52页

作者：马其家涂晟李敏对外经济贸易大学北京100029 中国政法大学北京100088

在市场化改革背景下,如何推动我国证券监管转型是亟待解决的关键问题。本世纪初,巴西证券监管的市场化改革成绩卓著,促进了其国内金融体系和资本市场的快速发展。由于我国与巴西同为"新兴加转轨"国家,且两国有着相似的市场发展模式、市... 详细信息

在市场化改革背景下,如何推动我国证券监管转型是亟待解决的关键问题。本世纪初,巴西证券监管的市场化改革成绩卓著,促进了其国内金融体系和资本市场的快速发展。由于我国与巴西同为"新兴加转轨"国家,且两国有着相似的市场发展模式、市场结构、发展瓶颈,及监管的"路径依赖"问题,巴西监管改革的实践对我国证券监管转型具有重要借鉴意义。巴西的证券监管改革主要从在证券交易所推出"新板市场"、增加巴西证监会自主权和执法力量,以及加强监管合作的"多重执法模式"这三方面展开。据此,我国应该利用多层次资本市场的上市规则,强化公司治理水平;赋予证券监管部门更多的独立性,以加强监管执法力度;并积极与其他政府部门和自律组织开展监管合作,以提高监管执法效率。

关键词：巴西证券市场监管转型监管执法市场化改革证券监管

Ferroptosis:a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

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Neural Regeneration Research 2023年第3期18卷 506-512页

作者： Qing-sheng Li Yan-Jie jia Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences Zhengzhou UniversityZhengzhouHenan ProvinceChina

Ferroptosis,a new non-necrotizing programmed cell death(PCD),is driven by iron-dependent phospholipid peroxidation.Ferroptosis plays a key role in secondary traumatic brain injury and secondary spinal cord injury and is closely related to inflammation,immunity,and chronic injuries.The inhibitors against ferroptosis effectively improve iron homeostasis,lipid metabolism,redox stabilization,neuronal remodeling,and functional recovery after trauma.In this review,we elaborate on the latest molecular mechanisms of ferroptosis,emphasize its role in secondary central nervous trauma,and update the medicines used to suppress ferroptosis following injuries.

关键词： ferroptosis immune response inflammation iron homeostasis lipid metabolism medicine programmed cell death spinal cord injury traumatic brain injury

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《史记》位移动词“出”的句法功能考察

长春工程学院学报（社会科学版） 2013年第3期14卷 114-116页

作者：涂加胜皖西学院文化与传媒学院安徽237012

"出"在《史记》中是一个使用频率的位移动词。文章搜索出了"出"在《史记》中的用例并考察了"出"的句法环境,从"出"充当连动结构前项和后项的情况以及处所成分的配置方面对其句法功能进行了探讨。

关键词：连动结构处所成分句法标记

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注射用头孢呋辛钠中降解杂质的研究

中国抗生素杂志 2023年第1期48卷 62-68页

作者：谭胜连周从鹰张旭途刘佳广州白云山天心制药股份有限公司广州510300

目的对注射用头孢呋辛钠中4个未公开报道的降解杂质进行研究,并推导其化合物结构。方法采用YMC C8色谱柱(4.6 mm×50 mm,3μm);以0.005 mol/L醋酸铵溶液-乙腈为流动相梯度洗脱,流速0.5 mL/min。离子源:电喷雾离子(ESI)源。结果注射用头... 详细信息

目的对注射用头孢呋辛钠中4个未公开报道的降解杂质进行研究,并推导其化合物结构。方法采用YMC C8色谱柱(4.6 mm×50 mm,3μm);以0.005 mol/L醋酸铵溶液-乙腈为流动相梯度洗脱,流速0.5 mL/min。离子源:电喷雾离子(ESI)源。结果注射用头孢呋辛钠中4个未知杂质得到有效分离,使用Q EXACTIVE高分辨质谱确定了杂质的分子量,并依据头孢类化合物的裂解及降解理论推测出其结构与形成机理,与头孢类已知杂质相异,杂质Ⅳ为本品特有的氨降解杂质。结论本方法操作简便,灵敏度高,可用于评价注射用头孢呋辛钠中的未知杂质,同时,研究结果为注射用头孢呋辛钠的质量标准制订和质量控制提供了重要的参考依据。

关键词： LC-MS/MS 头孢呋辛降解杂质