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The landscape of UBE2S in hepatocellular carcinoma: Prognostic significance, immuno-oncology feature and drug response

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Genes & Diseases 2023年第2期10卷 363-365页

作者： Lipeng Qiu Yue Wang Zhihuan Li zhigang tu Hanqing Liu School of Life Sciences Jiangsu UniversityZhenjiangJiangsu 212013China School of Pharmacy Jiangsu UniversityZhenjiangJiangsu 212013China

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide.1 E2 ubiquitin conjugating enzymes (UBE2) are potential therapeutic targets in tumors arising from genomic instability and tumor microenvironment (TME).2,3 UBE2S, an important UBE2, has demonstrated strong oncogenic activities in various malignant cancers, including HCC. However, a comprehensive study regarding its role in HCC is still absent, and its association with immunology and drug response of HCC is still unclear. In this study, we conducted a pan-cancer analysis of UBE2S expression and prognosis, carried out enrichment analysis of UBE2S-associated genes, and analyzed association between UBE2S expression and HCC microenvironment, stemness and drug response. Collectively, our results demonstrated that UBE2S expression was significantly increased in multiple types of cancer, including HCC, and harbors prognostic values for HCC. Potential function of UBE2S involves modulation of ubiquitin mediated proteolysis and cell cycle progression. Furthermore, in HCC, UBE2S expression was positively correlated with TME infiltration, microsatellite instability (MSI), DNA methylation, stemness and drug response. These findings highlighted the possible pivotal roles of UBE2S in HCC prognosis, precision immunotherapy and drug response.

关键词： drug prognosis cancer

Assessment of internal controls for data normalization of gene expression after different bacterial stimulation by quantitative real-time PCR in golden pompano Trachinotus blochii

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Journal of Oceanology and Limnology 2020年第2期38卷 480-489页

作者： CHEN Xiaojuan ZHANG Xiaoqi SUN Yun tu zhigang CAO Zhenjie WANG Shifeng ZHOU Yongcan State Key Laboratory of Marine Resource Utilization in South China Sea Hainan UniversityHaikou 570228China Hainan Academy of Ocean and Fisheries Sciences Haikou 570228China

Trachinotus blochii is one of the important commercial fish *** this study,we aim to confirm the reliability reference genes in *** during different bacterial challenge through quantitative real-time PCR(qRT-PCR).The expression of the seven selected genes in four immune organs(i.e.,spleen,kidney,intestine,and gill)stimulated with Vibrio harveyi,Edwardsiella tarda,and Streptococcus agalactiae were determined by *** PCR data was analyzed using the geNorm and NormFinder *** results showed the selection of the internal controls should be tissue specific when studying gene expression in response to bacterial *** 48 h of stimulation with ***,geNorm ranked EF1 A/Actin,18 S rRNA/B2M,UBCE/B2M,and 18 S rRNA/B2M,as the most stably expressed genes in spleen,kidney,intestine,and gill,*** 48 h of stimulation with ***,geNorm ranked 18 S rRNA/EF1 A,18 S rRNA/B2M,B2M/RPL13,and 18 S rRNA/EF1 A,as the most stably expressed genes in spleen,kidney,intestine,and gill,*** 48 h of stimulation with ***,18 S rRNA/EF1 A,18 S rRNA/B2 M,B2 M/Actin,and 18 S rRNA/B2M were ranked as the most stably expressed genes in spleen,kidney,intestine,and gill,*** to the results analyzed by geNorm,reference genes received similar rankings when using NormFinder *** results showed that the reference genes appeared to be not only tissue specific,but also specific to the infecting species of *** one gene is preferred when *** were infected by bacteria,18 S rRNA,B2M,B2M,18 S rRNA may be used in spleen,kidney,intestine,and gill,respectively.

关键词： Trachinotus blochii housekeeping gene expression stability reference gene

Transient HSP90 inhibition enhances the sensitivity of mantle cell lymphoma to poly(ADP-ribose)polymerase(PARP)inhibitors

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Genes & Diseases 2023年第5期10卷 1791-1794页

作者： Chaowen Shi Dewan Ren Yufeng Gao Ya-Mei Dang zhigang tu Hanqing Liu School of Life Sciences Jiangsu UniversityZhenjiangJiangsu 212013China School of Pharmacy Jiangsu UniversityZhenjiangJiangsu 212013China Department of Pathology Gansu Provincial HospitalLanzhouGansu 730000China

Mantle cell lymphoma(MCL)is an aggressive subtype of non-Hodgkin lymphoma(NHL)characterized by the overexpression of cyclin D1 and deregulated cell cycle.1 Ganetespib(STA-9090),a second-generation HSP90 inhibitor,dramatically disrupted oncogenic cellular processes resulting in the inhibition of client protein-derived tumors in preclinical studies.2 The synthetic lethal strategy using poly(ADP-ribose)polymerase(PARP)inhibitors(PARPis)has been reported as a powerful therapeutic intervention in MCL and their effectiveness can be increased by a deficiency in DNA damage repair(DDR),especially homologous recombination deficiency.3 Since we found earlier that transient ganetespib treatment can induce defects in DDR,we hypothesized that ganetespib treatment can possibly enhance the sensitivity of MCL cells to PARPis and HSP90 and PARP is can be demonstrated as promising combination therapies for MCL.

关键词： lymphoma PARP sized

A spatial attentive and temporal dilated(SATD)GCN for skeleton-based action recognition

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CAAI Transactions on Intelligence Technology 2022年第1期7卷 46-55页

作者： Jiaxu Zhang Gaoxiang Ye zhigang tu Yongtao Qin Qianqing Qin Jinlu Zhang Jun Liu State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina State Grid Wuhan Power Supply Company WuhanChina Shenzhen Infinova Ltd.Company ShenzhenChina Information Systems Technology and Design Pillar Singapore University of Technology and DesignSingapore

Current studies have shown that the spatial-temporal graph convolutional network(STGCN)is effective for skeleton-based action ***,for the existing STGCN-based methods,their temporal kernel size is usually fixed over all layers,which makes them cannot fully exploit the temporal dependency between discontinuous frames and different sequence ***,most of these methods use average pooling to obtain global graph feature from vertex features,resulting in losing much fine-grained information for action *** address these issues,in this work,the authors propose a novel spatial attentive and temporal dilated graph convolutional network(SATD-GCN).It contains two important components,that is,a spatial attention pooling module(SAP)and a temporal dilated graph convolution module(TDGC).Specifically,the SAP module can select the human body joints which are beneficial for action recognition by a self-attention mechanism and alleviates the influence of data redundancy and *** TDGC module can effectively extract the temporal features at different time scales,which is useful to improve the temporal perception field and enhance the robustness of the model to different motion speed and sequence ***,both the SAP module and the TDGC module can be easily integrated into the ST-GCN-based models,and significantly improve their *** experiments on two large-scale benchmark datasets,that is,Ntu-RGB+D and Kinetics-Skeleton,demonstrate that the authors’method achieves the state-of-the-art performance for skeleton-based action recognition.

关键词： classification. skeleton action

UDT:U-shaped deformable transformer for subarachnoid haemorrhage image segmentation

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 756-768页

作者： Wei Xie Lianghao Jin Shiqi Hua Hao Sun Bo Sun zhigang tu Jun Liu Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning Central China Normal UniversityWuhanChina School of Computer Science Central China Normal UniversityWuhanChina National Language Resources Monitoring and Research Center for Network Media Central China Normal UniversityWuhanChina The First Affiliated Hospital of Dalian Medical University DalianChina State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina Information Systems Technology and Design Pillar Singapore University of Technology and DesignSingaporeSingapore

Subarachnoid haemorrhage(SAH),mostly caused by the rupture of intracranial aneu-rysm,is a common disease with a high fatality *** lesions are generally diffusely distributed,showing a variety of scales with irregular *** complex characteristics of lesions make SAH segmentation a challenging *** cope with these difficulties,a u-shaped deformable transformer(UDT)is proposed for SAH ***,first,a multi-scale deformable attention(MSDA)module is exploited to model the diffuseness and scale-variant characteristics of SAH lesions,where the MSDA module can fuse features in different scales and adjust the attention field of each element dynamically to generate discriminative multi-scale ***,the cross deformable attention-based skip connection(CDASC)module is designed to model the irregular edge char-acteristic of SAH lesions,where the CDASC module can utilise the spatial details from encoder features to refine the spatial information of decoder ***,the MSDA and CDASC modules are embedded into the backbone Res-UNet to construct the proposed *** experiments are conducted on the self-built SAH-CT dataset and two public medical datasets(GlaS and MoNuSeg).Experimental results show that the presented UDT achieves the state-of-the-art performance.

关键词： image segmentation medical image processing

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考虑同时取送货的城市快递共同配送路径优化

重庆大学学报（自然科学版） 2017年第10期40卷 30-39页

作者：倪霖刘凯朋涂志刚重庆大学机械工程学院重庆400044

针对快递企业的配送车辆在城市配送过程中空载严重的问题,在多家快递企业实施共同配送的前提下,考虑车辆同时取送货对车辆装载率的影响,以配送系统总成本最小化为优化目标,建立考虑同时取送货的城市共同配送路径优化模型,并设计改进遗... 详细信息

针对快递企业的配送车辆在城市配送过程中空载严重的问题,在多家快递企业实施共同配送的前提下,考虑车辆同时取送货对车辆装载率的影响,以配送系统总成本最小化为优化目标,建立考虑同时取送货的城市共同配送路径优化模型,并设计改进遗传算法进行求解,最后通过算例分析验证了模型和算法的实用性与有效性。

关键词：快递企业空载城市共同配送同时取送货路径优化改进遗传算法

学习成对样本运动显著性的细粒度人体骨架动作识别

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中国科学：信息科学 2023年第12期53卷 2440-2457页

作者：李红艳涂志刚谢伟张嘉旭湖北经济学院信息工程学院武汉430205 武汉大学测绘遥感信息工程国家重点实验室武汉430072 华中师范大学计算机学院武汉430079

基于骨架数据的细粒度人体动作识别是一项重要的研究课题,但未被充分解决.由于骨架数据缺乏视觉表观信息,相似类别的人体动作很难被现有的深度网络模型识别.在这项工作中,我们提出了一个新型的运动显著性探测器(motion salience prober,... 详细信息

基于骨架数据的细粒度人体动作识别是一项重要的研究课题,但未被充分解决.由于骨架数据缺乏视觉表观信息,相似类别的人体动作很难被现有的深度网络模型识别.在这项工作中,我们提出了一个新型的运动显著性探测器(motion salience prober,MSP),并引入了配对学习(motion salience prober-incorporated pairwise-learning,MSP-PL)框架,以实现细粒度的骨架动作识别.我们的MSP-PL框架在构造成对的相似骨架运动样本基础上(查询样本与探测样本),利用运动显著性学习机制,促进编码器学习精细化的运动特征.其核心模块MSP可以在我们设计的探测样本和损失函数的帮助下,增强查询样本的显著性运动特征,并消除冗余的噪声.本文设计了3种探测样本构造策略来生成查询–探测样本对,辅助模型识别查询样本的动作,并测试了它们对模型性能的影响.在Ntu-RGB+D120数据集与Kinetics-Skeleton数据集上的大量实验表明,我们的MSP-PL框架是通用的,大多数骨架特征编码器可以无缝嵌入其中,并显著提高其准确性.5个主流的编码器对精细化动作的平均分类准确率提高了2.4%以上.此外,我们的MSP-PL框架在与最新的编码器相结合时,在骨架动作识别方面达到了最先进的性能.

关键词：骨架动作识别细粒度动作识别视觉注意力运动显著性学习对比学习

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水产养殖环境因子数据动力学分析与智能预测

系统仿真学报 2017年第5期29卷 1049-1056,1063页

作者：钟杰卓涂志刚杜文才吴慰海南大学信息科学技术学院海南海口570228 海南省海洋与渔业科学院海南海口570206 中国科学院三亚深海科学与工程研究所海南三亚572000

进行水质环境因素分析对水产养殖的效益极为重要。研究水体因素的三个主要参数:水温、p H值以及溶解氧。针对检测仪取样的数据存在缺失、不准确等问题,通过高阶曲线插值较好地修复了数据,同时运用滤波方法划分了系统误差以及参数的自身... 详细信息

进行水质环境因素分析对水产养殖的效益极为重要。研究水体因素的三个主要参数:水温、p H值以及溶解氧。针对检测仪取样的数据存在缺失、不准确等问题,通过高阶曲线插值较好地修复了数据,同时运用滤波方法划分了系统误差以及参数的自身节律;对不同水层、时间的参数分析,较好地吻合了实际水文情况,为工程养殖提供了可靠的依据;通过引入径向基函数神经网络方法跟踪主要参数的特征,弥补了非线性多项式插值的不足,实际数据证明了该方法全局跟踪有效以及局部节律刻画程度精细。

关键词：水产养殖水质动力学分析非线性预测人工智能神经网络

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Matlab与有限元程序设计

计算机应用与软件 2001年第7期18卷 61-64页

作者：熊洪槐柳和生涂志刚南昌大学机电学院南昌330029

详细比较了Matlab与其它高级语言进行有限元编程的优缺点,并讨论了Matlab有限元编程的方法及技巧。实践证明,Matlab是进行有限元工程计算编程的最高效的编程工具。

关键词： Matlab 有限元程序设计高级语言