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Chinese Medical Journal 2013年第18期126卷 3598-3598页

作者： SHEA Yat-fung tsang hoi-lun helen YAP Yat-hin Desmond LI Lai-fung HO Wai-shing Wilson Department of Medicine Queen Mary tlospital The University of Hong Kong Hong Kong China Division of Neurosurgery Department of Surgery Queen Mary tlospital The University of Hong Kong Hong Kong China

To the editor： We report a tricky subarachnoid haemorrhage （SAH）. Our patient was a 59-year-old woman with generalizedheadache for 1 day, which was constricting in nature and rated grade 6/10. Her symptoms were aggravated by lying flat and improved with vomiting. The Glasgow coma scale was lull, blood pressure was 142/83 mmHg and pulse 75 beats/min. There was neither neck stiffness nor focal neurological deficit. Fundoscopic examination was normal. She was noted to have hyponatremia （sodium （Na） 122 mmol/L） with serum osmolarity 263 mmol/kg, urine osmolarity 582 mmol/kg, urine Na I 17 retool/L, nomaal thyroid stimulating hormone and cortisol level.

关键词： RED-BLOOD-CELLS LUMBAR PUNCTURE ANEURYSMS CT

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B-cell-targeted therapies in systemic lupus erythematosus

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Cellular & Molecular Immunology 2013年第2期10卷 133-142页

作者： Vera Sau-Fong Chan helen hoi-lun tsang Rachel Chun-Yee Tam Liwei Lu Chak-Sing Lau Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China

Autoreactive B cells are one of the key immune cells that have been implicated in the pathogenesis of systemic lupus erythematosus （SLE）. In addition to the production of harmful auto-antibodies （auto-Abs）, B cells prime autoreactive T cells as antigen-presenting cells and secrete a wide range of pro-inflammatory cytokines that have both autocrine and paracrine effects. Agents that modulate B cells may therefore be of potential therapeutic value. Current strategies include targeting B-cell surface antigens, cytokines that promote B-cell growth and functions, and B- and T-cell interactions. In this article, we review the role of B cells in SLE in animal and human studies, and we examine previous reports that support B-cell modulation as a promising strategy for the treatment of this condition. In addition, we present an update on the clinical trials that have evaluated the therapeutic efficacy and safety of agents that antagonize CD20, CD22 and B-lymphocyte stimulator （BLyS） in human SLE. While the results of many of these studies remain inconclusive, belimumab, a human monoclonal antibody against BLyS, has shown promise and has recently been approved by the US Food and Drug Administration as an indicated therapy for patients with mild to moderate SLE. Undoubtedly, advances in B-cell immunology will continue to lead us to a better understanding of SLE pathogenesis and the development of novel specific therapies that target B cells.

关键词： Systemic lupus erythematosus B-cell autoimmunity therapy

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Therapeutic targets in the pancreatic adenocarcinoma microenvironment: past challenges and opportunities for the future

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 448-465页

作者： Erica S.tsang Margaret A.Tempero helen Diller Family Comprehensive Cancer Center University of California San FranciscoSan FranciscoCA 94158USA

Pancreatic ductal adenocarcinoma(PDAC)remains a leading cause of cancer-related mortality,with cytotoxic chemotherapy still the mainstay of *** effective therapeutic agents alone,successful drug delivery is *** PDAC,the tumor microenvironment represents a physical barrier that limits in vivo drug delivery and *** this review,we highlight therapeutic targets in the tumor microenvironment,focusing on past challenges and opportunities for the *** discussed include the Hedgehog pathway,angiogenesis,hyaluronic acid,cancer-associated fibroblasts and associated cytokines,among *** the obstacles in successfully recapitulating promising lab results to practice-changing clinical results,many important lessons have been learned to improve clinical trial design within a highly engaged and motivated scientific *** collaborative efforts and the collective optimism will continue to propel the momentum forward to overcome these barriers and ultimately improve patient outcomes.

关键词： Pancreatic cancer PDAC tumor microenvironment pancreatic stroma

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香港与内地律师间的合作

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中国法律 2001年第2期 25-29页

作者：陳華增 helen Yu 香港陈华增律师行

1.引言1.1历史使命香港负有作为祖国世界之窗的使命,这使命在内地现代历史洪流里因文化渊缘、民族血缘、地理毗鄰和对祖国发展永不缺少的经济支持而不断得到强化。1.2美好互动从内地对外开放到即将进入世贸的区区20年期间,香港和内地民... 详细信息

1.引言1.1历史使命香港负有作为祖国世界之窗的使命,这使命在内地现代历史洪流里因文化渊缘、民族血缘、地理毗鄰和对祖国发展永不缺少的经济支持而不断得到强化。1.2美好互动从内地对外开放到即将进入世贸的区区20年期间,香港和内地民众之间互动得非常积极,谋求其共同

关键词：律师法律工作者香港

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