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Ultrasmall,elementary and highly translational nanoparticle X-ray contrast media from amphiphilic iodinated statistical copolymers

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1660-1670页

作者： Lu Su Kellie S.Dalby Hannah Luehmann Sussana A.Elkassih Sangho Cho Xun He Lisa Detering Yen-Nan Lin Nari Kang Dennis A.Moore Richard laforest Guorong Sun Yongjian Liu Karen L.Wooley Department of Chemistry Department of Materials Science and Engineeringand Department of Chemical EngineeringTexas A&M UniversityCollege StationTX 77842USA Laboratory of Macromolecular and Organic Chemistry and Institute for Complex Molecular Systems Eindhoven University of TechnologyEindhovenMB 5600The Netherlands Mallinckrodt Institute of Radiology Washington University School of MedicineSaint LouisMO 63110USA Bayer AG Creve CoeurMO 63167USA

To expand the single-dose duration over which noninvasive clinical and preclinical cancer imaging can be conducted with high sensitivity,and well-defined spatial and temporal resolutions,a facile strategy to prepare ultrasmall nanoparticulate X-ray contrast media(nano-XRCM)as dual-modality imaging agents for positron emission tomography(PET)and computed tomography(CT)has been *** from controlled copolymerization of triiodobenzoyl ethyl acrylate and oligo(ethylene oxide)acrylate monomers,the amphiphilic statistical iodocopolymers(ICPs)could directly dissolve in water to afford thermodynamically stable solutions with high aqueous iodine concentrations(>140 mg iodine/mL water)and comparable viscosities to conventional small molecule *** formation of ultrasmall iodinated nanoparticles with hydrodynamic diameters of ca.10 nm in water was confirmed by dynamic and static light scattering *** a breast cancer mouse model,in vivo biodistribution studies revealed that the64Cu-chelator-functionalized iodinated nano-XRCM exhibited extended blood residency and higher tumor accumulation compared to typical small molecule imaging ***/CT imaging of tumor over 3 days showed good correlation between PET and CT signals,while CT imaging allowed continuous observation of tumor retention even after 10 days post-injection,enabling longitudinal monitoring of tumor retention for imaging or potentially therapeutic effect after a single administration of nano-XRCM.

关键词： Amphiphilic statistical iodocopolymer CT X-ray contrast media Ultrasmall nanoassembly PET/CT Longitudinal tumor monitoring

A Combinatorial Analysis of Tree-Like Sentences

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Open Journal of Discrete Mathematics 2015年第3期5卷 32-53页

作者： Gilbert Labelle Louise laforest Département de Mathématiques Université du Québec à Montréal Montreal Canada Département d’Informatique Université du Québec à Montréal Montreal Canada

A sentence over a finite alphabet A, is a finite sequence of non-empty words over A. More generally, we define a graphical sentence over A by attaching a non-empty word over A to each arrow and each loop of a connected directed graph (digraph, for short). Each word is written according to the direction of its corresponding arrow or loop. Graphical sentences can be used to encode sets of sentences in a compact way: the readable sentences of a graphical sentence being the sentences corresponding to directed paths in the digraph. We apply combinatorial equations on enriched trees and rooted trees, in the context of combinatorial species and Pólya theories, to analyze parameters in classes of tree-like sentences. These are graphical sentences constructed on tree-like digraphs.

关键词： Pólya Theory Combinatorial Species Digraphs Tree-Like Sentences

AN ADAPTIVE VERSION OF GLIMM'S SCHEME

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维普期刊数据库

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Acta Mathematica Scientia 2010年第2期30卷 428-446页

作者： H.Kim M.laforest D.Yoon Department of Mathematics Korea University Département de mathématiques et génie industriel cole Polytechnique de MontréalMontréalQuébec

This article describes a local error estimator for Glimm＇s scheme for hyperbolic systems of conservation laws and uses it to replace the usual random choice in Glimm＇s scheme by an optimal choice. As a by-product of the local error estimator, the procedure provides a global error estimator that is shown numerically to be a very accurate estimate of the error in L1 （R） for all times. Although there is partial mathematical evidence for the error estimator proposed, at this stage the error estimator must be considered ad- hoc. Nonetheless, the error estimator is simple to compute, relatively inexpensive, without adjustable parameters and at least as accurate as other existing error estimators. Numerical experiments in 1-D for Burgers＇ equation and for Euler＇s system are performed to measure the asymptotic accuracy of the resulting scheme and of the error estimator.

关键词： conservation laws finite difference methods adaptive error estimation aposteriori

Remediation of electric arc furnace dust leachate by the use of cementitious materials: A column-leaching test

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Chinese Journal Of Geochemistry 2006年第B8期25卷 99-99页

作者： Josee Duchesne Guylaine laforest Laval University Department of Geology and Geological Engineering Quebec City Canada

俯卧位脊柱手术的并发症:缺血性眶间隔综合征

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 58-59页

作者： Leibovitch I Casson R laforest C Selva D 王永强(译 ) Oculoplastic and Orbital Division Department of Ophthalmologyand Visual Sciences Royal Adelaide Hospital North Terrace Adelaide SA 5000 Australia 不详

Objectives: To report a patient with ischemic orbital compartment syndrome as a complication of spinal surgery in the prone position. Design: Interventional case report. Methods: An 80-year-oldman underwent a prolonged lumbar decompression laminectomy for spinal stenosis, under general anesthesia in the prone position. Several hours later, the patient complained of left periocular pain and reduced vision. Examination revealed significant facial edema, left proptosis, and a tight orbit, as well as no light perception and elevated intraocular pressure in the left eye, with complete internal and external ophthalmoplegia. Main Outcome Measures: Clinical course, imaging findings, management, and final outcome. Results: Magnetic resonance imaging confirmed the clinical diagnosis of a compartment syndrome with elevated intraorbital tension. A lateral canthotomy and cantholysis were performed, and high-dose IV steroids were started. The proptosis and facial swelling subsided gradually, but no improvement was noted in left visual acuity or left ocular movements. Conclusion: It is important to be familiar with this rare complication after prolonged surgery in the prone position. Although the prognosis seems to be poor, it is essential to monitor these patients perioperatively and to intervene surgically and medically once the diagnosis of orbital compartment syndrome is established.

关键词：俯卧位脊柱手术间隔综合征缺血性并发症左眼球突出眼内压增高男性患者影像检查外眼肌麻痹磁共振检查

日粮维生素和采精频率对公猪生产性能和精液品质的影响

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饲料博览 2009年第6期19卷 44-44页

作者： Audet I Bérubé N Bailey J L laforest J P Matte J J

试验旨在研究日粮中添加维生素对商品公猪维生素代谢和精液品质的相关性,同时评价添加维生素对公猪集中采精的效能。共分为两个试验:试验1,选择39头公猪随机分为2个处理,分别为对照组和试验组,对照组饲喂基础日粮,试验组在基础日粮的基... 详细信息

试验旨在研究日粮中添加维生素对商品公猪维生素代谢和精液品质的相关性,同时评价添加维生素对公猪集中采精的效能。共分为两个试验:试验1,选择39头公猪随机分为2个处理,分别为对照组和试验组,对照组饲喂基础日粮,试验组在基础日粮的基础上添加脂溶性和水溶性维生素。每个处理采取2种采精方式(即每2周3次和每1周3次),为期12周。然后将所有的公猪集中采精2周,再休息4周不采精,以后每周采精2次。此后把采精频率颠倒,直到集中采精期。试验2,选择252头公猪随机分为2个处理,分别为对照组和试验组,日粮组成同试验1,所有的公猪每周采精2次,为期6周。检测精液和精子质量,收集血样分析维生素的浓度。结果显示:试验1中,试验组公猪血液中的维生素浓度和精浆显著增加(P0.14)。试验组12周精液量显著增加(P0.28)。与2周采精3次相比,每周采精3次的公猪每次射精量显著减少(P0.61)。试验结果表明,日粮中添加脂溶性和水溶性维生素增加了可用于动物维生素的数量,采精频率对维生素状况无影响,此外日粮中添加维生素对精子的产生和质量无影响。

关键词：公猪采精频率精子维生素