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Oligodendrocyte progenitor cells in Alzheimer’s disease:from physiology to pathology

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Translational Neurodegeneration 2023年第1期12卷 134-153页

作者： Peibin Zou Chongyun Wu timon cheng-yi liu Rui Duan Luodan Yang Laboratory of Exercise and Neurobiology School of Physical Education and Sports ScienceSouth China Normal UniversityGuangzhou 510006China Department of Neurology Louisiana State University Health Sciences Center1501 Kings HighwayShreveportLA 71103USA

Oligodendrocyte progenitor cells(OPCs)play pivotal roles in myelin formation and phagocytosis,communicating with neighboring cells and contributing to the integrity of the blood-brain barrier(BBB).However,under the pathological circumstances of Alzheimer’s disease(AD),the brain’s microenvironment undergoes detrimental changes that significantly impact OPCs and their *** with OPC functions,we delve into the transformation of OPCs to myelin-producing oligodendrocytes,the intricate signaling interactions with other cells in the central nervous system(CNS),and the fascinating process of phagocytosis,which influences the function of OPCs and affects CNS ***,we discuss the essential role of OPCs in BBB formation and highlight the critical contribution of OPCs in forming CNS-protective *** the context of AD,the deterioration of the local microenvironment in the brain is discussed,mainly focusing on neuroinflammation,oxidative stress,and the accumulation of toxic *** detrimental changes disturb the delicate balance in the brain,impacting the regenerative capacity of OPCs and compromising myelin *** pathological conditions,OPCs experience significant alterations in migration and proliferation,leading to impaired differentiation and a reduced ability to produce mature ***,myelin degeneration and formation become increasingly active in AD,contributing to progressive ***,we summarize the current therapeutic approaches targeting OPCs in *** to revitalize OPC senescence,modulate signaling pathways to enhance OPC differentiation,and explore other potential therapeutic avenues are promising in alleviating the impact of AD on OPCs and CNS *** conclusion,this review highlights the indispensable role of OPCs in CNS function and their involvement in the pathogenesis of *** intricate interplay between OPCs and the AD brain microenvironment underscores the complex

关键词： Oligodendrocyte progenitor cells Alzheimer’s disease Senescence Microenvironment

APPLICATIONS OF INTRANASAL LOW INTENSITY LASER THERAPY IN SPORTS MEDICINE

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Journal of Innovative Optical Health Sciences 2010年第1期3卷 1-16页

作者： timon cheng-yi liu DE-FENG WU ZHI-QIANG GU MIN WU Lab of Laser Sports Medicine College of Life Science South China Normal University GuangzhouGD510006China

Function-specific homeostasis(FSH)has been defined as a negative-feedback response of a biosystem to maintain its interior function-specific conditions so that the function is perfectly *** is no photobiomodulation of intranasal low intensity laser therapy(ILILT)on a function in its FSH,but ILILT could modulate a function far from its *** rehabilitation has been found to be mediated by the ratio of intracellular nicotinamide adenine dinucleotide(NAD+)and its reduced form NADH,NAD+/NADH,and then sirtuin 1(SIRT1).There might be FSH-specific NAD+/NADH(FSN)and SIRT1 activity(FSA).ILILT might enhance NAD+/NADH and SIRT1 activity until they arrive at FSN and FSA,*** NAD+/NADH and SIRT1 activity of related cells of many athletic diseases such as upper respiratory tract infection,asthma,osteoarthritis,exercise-induced muscle damage,wound,traumatic brain injury,and osteoporosis are lower than FSN and FSA,***,there may be therapeutic effects of ILILT on those athletic ***,many phenomena and the ILILT mechanism have been integrated to support the prophylaxis effects of ILILT on the swine-origin influenza A(H1N1).

关键词： Photobiomodulation homeostasis nicotinamide adenine dinucleotide sirtuin 1 sports medicine

Microglial SIRPα Deletion Facilitates Synapse Loss in Preclinical Models of Neurodegeneration

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Neuroscience Bulletin 2022年第2期38卷 232-234页

作者： Chongyun Wu Luodan Yang Hannah Youngblood timon cheng-yi liu Rui Duan Laboratory of Regenerative Medicine in Sports Science School of Physical Education and Sports ScienceSouth China Normal UniversityGuangzhou 510006China Department of Neuroscience and Regenerative Medicine Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA Department of Cellular Biology and Anatomy Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA

Microglia,the principal immune cells in the brain,play a vital role in the development and homeostasis of the central nervous system[1,2].During early brain development,microglia-mediated synapse pruning contributes to eliminating excess synapses that are unnecessary in adulthood[3].Excessive microglia-mediated pruning in the adult brain is implicated in neurodegeneration-associated behav・ioral deficits[4,5].

关键词： degeneration homeostasis clinical

Photobiomodulation:A Potential Non-invasive Method to Alleviate Neurological Events Following COVID-19 Infection

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Neuroscience Bulletin 2023年第10期39卷 1595-1597页

作者： Chongyun Wu timon cheng-yi liu Rui Duan Luodan Yang College of Physical Education and Sport Science South China Normal UniversityGuangzhou 510006China

In the past several months,confirmed cases have surged as many countries have loosened their bans on Coronavirus disease 2019(COVID-19)epidemic prevention and *** a respiratory infectious disease caused by a novel coronavirus called SARS-CoV-2,COVID-19 emerged in late December 2019 and lasted for more than three years worldwide[1].

关键词： prevention respiratory cases

EXTRAOCULAR CELLULAR PHOTOTRANSDUCTION

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Journal of Innovative Optical Health Sciences 2009年第1期2卷 93-100页

作者： LING ZHU timon cheng-yi liu MINWU JIAN-QIN YUAN TONG-SHENG CHEN Laboratory of Laser Sports Medicine South China Normal University Guangzhou GD 510006China MOE Key Laboratory of Laser Life Science South China Normal University Guangzhou GD 510631China

Photobiomodulation(PBM)is a modulation of monochromatic light or laser irradiation(LI)on *** is reviewed from the viewpoint of extraocular phototransduction in this *** was found that LI can induce extraocular phototransduction,and there may be an exact correspondence relationship of LI at different wavelengths and in different dose zones,and cellular signal transduction *** signal transduction pathways can be classified into two types so that the Gs protein-mediated pathways belong to pathway 1,and the other pathways such as protein kinase Cs-mediated pathways and mitogen-activated protein kinase-mediated pathways belong to pathway *** all the present pathways found to mediate PBM belong to pathway 2,but there should be a pathway 1-mediated *** previous studies were rather preliminary,and therefore further work should be done.

关键词： Phototransduction photobiomodulation homeostasis

PHOTOBIOMODULATION-MEDIATED PATHW AY DIAGNOSTICS

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Journal of Innovative Optical Health Sciences 2013年第1期6卷 18-28页

作者： timon cheng-yi liu LING ZHU XIANG-BO YANG Laboratory of Laser Sports Medicine South China Normal University Guangzhou GD 510006P.R.China

Cellular pathways are ordinarily diagnosed with pathway inhibitors,related gene regulation,or fuorescent protein *** are also suggested to be diagnosed with pathway activation modulation of photobiomod ulation(PBM)in this paper.A PBM on a biosystem function depends on whether the biosystem is in its function-specific homeostasis(FSH).An FSH,a negative feedback response for the function to be performed perfectly,is maintained by its FSH-essential subfunctions and its FSH-non-essential subfunctions(FNSs).A function in its FSH or far from its FSH is called a normal or dysfunctional function.A direct PBM may self-adaptatively modulate a dysfunctional function until it is normal so that it can be used to discover the optimum pathways for an FSH to be *** indirect PBM may self adaptatively modulate a dysfunctional FNS of a normal function until the FNS is normal,and the normal function is then upgraded so that it can be used to discover the redundant pathways for a normal function to be upgraded.

关键词： Signal transd uction pathway photobiomodulation homeostasis redundancy

EFFECTS OF RED LIGHT AT 640nm FROM LIGHT EMITTING DIODES ON THE RESPIRATORY BURST OF HUMAN NEUTROPHILS

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Journal of Innovative Optical Health Sciences 2008年第2期1卷 285-294页

作者： MIN WU LING ZHU BINA HU timon cheng-yi liu DONG-LIANG RONG TONG-SHENG CHEN Laboratory of Laser Sports Medicine South China Normal University Guangzhou GD 510006China MOE Key Laboratory of Laser Life Science South China Normal University GuangzhouGD 510631China

Photobiomodulation(PBM)has been reported to have effects on respiratory burst of polymorphonuclear neutrophils(PMNs),but little focus was on the individual differences of human *** latter was investigated in this *** PMNs were isolated from peripheral blood of 13 volunteers(10 ordinary persons,3 athletes)and treated by red light(640±15 nm)from light emitting diodes(RLED)at 50,100,300,500 and 1000 J/m^(2)for 100 seconds,*** samples of athletes were extracted at different running stages in 10 km non-interrupted long-distance running,before running,1 hour after running began,just finishing the running,resting for 1 hour and 2 hours after *** PMN respiratory burst was assessed by the nitroblue tetrazolium *** was found that there were three types of RLED PBM on the respiratory burst of 3 types of PMNs,respectively,inducing for the subactivated PMNs,inhibiting for the overactivated PMNs and none for the PMNs in *** was then concluded that there may be RLED PBM on dysfunctional human PMNs while none on those in homeostasis,and RLED at 300 J/m^(2)for 100 seconds may have bi-direction modulation on PMN respiratory burst.

关键词： Polymorphonuclear neutrophils photobiomodulation homeostasis

Longevity Photobiomodulation

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Longevity Photobiomodulation

Advances in Laser Sports Medicine

中国遗传学会第十届全国激光生物学学术会议

作者： timon cheng-yi liu South China Normal University Laboratory of Laser Sports Medicine

Background and Objective:Longevity factors such as SIR2/Hst/sirtuins(SIRTs),heat-shock factor 1(HSFI),SKN-1,DAF-16/FOXO,PHA-4/FOXa and so on mediate lifespan extension in calorie *** mediation of longevity factors in ...

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Advances in Laser Sports Medicine