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Emergence of H5N1 highly pathogenic avian influenza in Democratic People's Republic of Korea

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Journal of Integrative Agriculture 2022年第5期21卷 1534-1538页

作者： LIU Li-ling YANG Huan-liang guo Fu-sheng WANG Xiu-rong DENG guo-hua SHI Jian-zhong tian guo-bin ZENG Xian-ying State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China China Animal Health and Epidemiology Center Qingdao 266032P.R.China

In the past decade,there has been extensive global surveillance for highly pathogenic avian influenza(HPAI)infection in both animals and humans,however,few studies on epidemiology of avian influenza in Democratic People’s Republic of Korea(DPRK)were *** the period 2013–2014,HPAI H5N1 viruses were detected with outbreaks in domestic poultry in *** analysis revealed that the hemagglutinin gene of all samples belonged to clade 2.***.2.1c with high *** HPAI H5N1 virus found in ducks at the Tudan Duck Farm in 2013 was might introduced by migratory birds and then led to the outbreaks on neighboring chicken farms in *** data provide direct evidence for the transmission of avian influenza viruses from wild birds to waterfowl to terrestrial ***,the monitoring and control of influenza virus in ducks must be given top priority,which are essential components to prevent and control HPAI.

关键词： avian influenza H5N1 Democratic People’s Republic of Korea clade 2.3.2.1c

Effect of heat treatment on corrosion behaviors of Mg-6Gd-3Y-0.5Zr alloy

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China Foundry 2024年第5期21卷 599-612页

作者： Fei Wang bin-guo Fu Yu-feng Wang tian-shun Dong guo-lu Li Jin-hai Liu Hebei Key Laboratory of New Functional Materials School of Materials Science and EngineeringHebei University of TechnologyTianjin 300401China tianjin Institute of Aerospace Mechanical and Electrical Equipment Tianjin 300301China tianjin Aerospace Long March Technology and Equipment Co. Ltd.Tianjin 300462China

The microstructures and corrosion behaviors of as-cast,T4-treated,and T6-treated Mg-6Gd-3Y-0.5Zr alloys were systematically investigated by SEM,TEM,immersion test,and electrochemical corrosion *** results show that the microstructure of the as-cast alloy is composed ofα-Mg and Mg_(24)(Gd,Y)_(5)eutectic phase,and in T4-treated alloy,Mg_(24)(Gd,Y)_(5)phase dissolves into theα-Mg matrix,leading to an increase in the(Y,Gd)H_(2)*** T6 treatment,nanoscale Mg_(24)(Gd,Y)_(5)phase dispersedly precipitates from theα-Mg matrix,and exhibits a specific orientation relationship with theα-Mg:(332)Mg_((24)(Gd,Y)_(5))//(1011)_(α-Mg),[136]Mg_((24)(Gd,Y)_(5))//[1210]_(α-Mg).The corrosion resistance of the Mg-6Gd-3Y-0.5Zr alloys can be ranked in the following order:T6-treated alloy exhibits the highest corrosion resistance,followed by the T4-treated alloy,and finally,the as-cast *** corrosion products of the alloys are all composed of MgO,Mg(OH)_(2),Gd_(2)O_(3),Y_(2)O_(3),and MgCl_(2).The corrosion behavior of Mg-6Gd-3Y-0.5Zr alloy is closely related to the precipitated *** establishing the relationship between corrosion rate,hydrogen evolution rate,and corrosion potential,it is further demonstrated that during the micro galvanic corrosion process,the coarse Mg_(24)(Gd,Y)_(5)phase in the as-cast alloy undergoes extensive dissolution,and(Y,Gd)H_(2)phase promotes the dissolution of theα-Mg matrix in the T4-treated alloy,intensifying the hydrogen evolution *** T6-treated alloy,with dispersive precipitation of nanoscale Mg_(24)(Gd,Y)_(5)phase,exhibits better corrosion resistance performance.

关键词： Mg-6Gd-3Y-0.5Zr alloy heat treatment microstructure precipitated phase corrosion resistance

Feasibility of medical radioisotope production based on the proton beams at China Spallation Neutron Source

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Nuclear Science and Techniques 2024年第6期35卷 26-39页

作者： bing Jiang bin-bin tian Han-Tao Jing Qi-Fan Dong Spallation Neutron Source Science Center Dongguan 523803China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high *** medical isotope production based on the proton beam at the CSNS is significant for the development of future radiopharmaceuticals,particularly for theα-emitting *** production yield and activity of typical medical isotopes were estimated using the FLUKA *** results indicate that the 300-MeV proton beam with a power of 100 kW at CSNS-II is highly suitable for proof-of-principle studies of most medical *** particular,this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes,such as 225Ac,whose theoretical production yield can reach approximately 57 Ci/*** on these results,we provide perspectives on the use of CSNS proton beams to produce radioisotopes for medical applications.

关键词： CSNS proton beam Medical isotope production α-Emitting radionuclides Nuclidic purity analysis

Generating ^(1)O_(2) and Co^(IV)=O through efficient peroxymonosulfate activation by ZnCo_(2)O_(4)nanosheets for pollutant control

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Nano Research 2024年第9期17卷 8025-8035页

作者： Xiaoke Zhang Yangyang Zhang Jiaqi tian Yadan guo Zhongkui Zhou Zhongyi Liu Zaiwang Zhao bin Liu Jun Li College of Chemistry Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450052China State Key Laboratory of Coking Coal Resources Green Exploitation Zhengzhou UniversityZhengzhou 450001China School of Water Resources and Environmental Engineering East China University of TechnologyNanchang 330013China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China College of Energy Materials and Chemistry College of Chemistry and Chemical EngineeringInnerMongolia UniversityHohhot 010070China

Heterogeneous advanced oxidation processes(AOPs)based on non-radical reactive species are considered as a powerful technology for wastewater purification due to their long half-lives and high adaptation in a wide pH ***,we fabricate surface Co defect-rich spinel ZnCo_(2)O_(4)porous nanosheets,which can generate≡CoIV=O and ^(1)O_(2) over a wide pH range of 3.81-10.96 by the formation of amphoteric≡Zn(OH)2 in peroxymonosulfate(PMS)activation *** functional theory(DFT)calculations show Co defect-rich ZnCo_(2)O_(4)possesses much stronger adsorption ability and more electron transfer to ***,the adsorption mode changes from terminal oxygen Co-O-Co to Co-O,accelerating the polarization of adjacent oxygen,which is beneficial to the generation of≡CoIV=O and Generating ^(1)O_(2) .Co defect-rich ZnCo_(2)O_(4)porous nanosheets exhibit highly active PMS activation activity and stability in p-nitrophenol(PNP)degradation,whose toxicity of degradation intermediates is significant *** Co defect-rich ZnCo_(2)O_(4)nanosheet catalyst sponge/PMS system achieved stable and efficient removal of PNP with a removal efficiency higher than 93%over 10 *** work highlights the development of functional catalyst and provides an atomic-level understanding into non-radical PMS activation process in wastewater treatment.

关键词： advanced oxidation processes ZnCo_(2)O_(4)nanosheets peroxymonosulfate activation CoIV=O,wastewater treatment

Protective efficacy of an H5/H7 trivalent inactivated vaccine(H5-Re13,H5-Re14, and H7-Re4 strains) in chickens, ducks, and geese against newly detected H5N1, H5N6, H5N8, and H7N9 viruses

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Journal of Integrative Agriculture 2022年第7期21卷 2086-2094页

作者： ZENG Xian-ying HE Xin-wen MENG Fei MA Qi WANG Yan BAO Hong-mei LIU Yan-jing DENG guo-hua SHI Jian-zhong LI Yan-bing tian guo-bin CHEN Hua-lan State Key Laboratory of Veterinary Biotechnology National Poultry Laboratory Animal Resource CenterHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China

Some H5 viruses isolated in poultry or wild birds between 2020 and 2021 were found to be antigenically different from the vaccine strains(H5-Re11 and H5-Re12) used in China. In this study, we generated three new recombinant vaccine seed viruses by using reverse genetics and used them for vaccine production. The vaccine strain H5-Re13 contains the hemagglutinin(HA) and neuraminidase(NA) genes of an H5 N6 virus that bears the clade 2.***.4.4 h HA gene, H5-Re14 contains the HA and NA genes of an H5 N8 virus that bears the clade 2.***.4.4 b HA gene, and H7-Re4 contains the HA and NA genes of H7 N9 virus detected in 2021. We evaluated the protective efficacy of the novel H5/H7 trivalent inactivated vaccine in chickens, ducks, and geese. The inactivated vaccine was immunogenic and induced substantial antibody responses in the birds tested. Three weeks after vaccination, chickens were challenged with five different viruses detected in 2020 and 2021: three viruses(an H5 N1 virus, an H5 N6 virus, and an H5 N8 virus) bearing the clade 2.***.4.4 b HA gene, an H5 N6 virus bearing the clade 2.***.4.4 h HA gene, and an H7 N9 virus. All of the control birds shed high titers of virus and died within 4 days post-challenge, whereas the vaccinated chickens were completely protected from these viruses. Similar protective efficacy against H5 viruses bearing the clade 2.***.4.4 h or 2.***.4.4 b HA gene was observed in ducks and geese. Our study indicates that the newly updated H5/H7 vaccine can provide solid protection against the H5 and H7 N9 viruses that are currently circulating in nature.

关键词： avian influenza H5/H7 trivalent vaccine H5-Re13 H5-Re14 H7-Re4 strains protective efficacy chickens ducks and geese

Development of a reverse-transcription loop-mediated isothermal amplification assay to detect avian influenza viruses in clinical specimens

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Journal of Integrative Agriculture 2019年第7期18卷 1428-1435页

作者： SHI Lin YU Xue-wu YAO Wei YU Ben-liang HE Li-kun GAO Yuan ZHANG Yun-xian tian guo-bin PING Ji-hui WANG Xiu-rong State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China College of Veterinary Medicine Nanjing Agricultural UniversityNanjing 210095P.R.China VICA Group Shenyang Animal Husbandry Technology Co.Ltd.Shenyang 110027P.R.China Animal Epidemic Diseases Prevention and Control Center of Liaoning Province Shenyang 110164P.R. China Qilu Animal Health Products Co. Ltd.Jinan 250110P.R.China

In recent years,the avian influenza has brought not only serious economic loss to the poultry industry in China but also a serious threat to human health because of the avian influenza virus(AIV) gene recombination and *** now,traditional RT-PCR,fluorescence RT-PCR and virus isolation identification have been developed and utilized to detect AIV,but these methods require high-level instruments and experimental conditions,not suitable for the rapid detection in field and *** order to develop a rapid,sensitive and practical method to detect and identify AIV subtypes,4 specific primers to the conserved region of AIV M gene were designed and a loop-mediated isothermal amplification(RT-LAMP) method was *** this method,the M gene of H1–H16 subtypes of AIV were amplified in 30 min with a water bath and all 16 H subtypes of AIV were able to be visually identified in presence of fluorescein,without cross reaction with other susceptible avian *** addition,the detection limit of the common H1,H5,H7,and H9 AIV subtypes with the RT-LAMP method was 0.1 PFU(plaque-forming unit),which was 10 times more sensitive than that using the routine *** comparative tests found that the positivity rate of RT-LAMP on detecting clinical samples was 4.18%(14/335) comparing with 3.58%(12/335) from real-time *** these results suggested that the RT-LAMP method can specifically detect and identify AIV with high sensitivity and can be considered as a fast,convenient and practical method for the clinic test and epidemiological investigation of AIV.

关键词： avian influenza virus(AIV) RT-LAMP diagnostic method clinical specimens

A thermodynamics-based three-scale constitutive model for partially saturated granular materials

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1813-1831页

作者： Jianqiu tian Enlong Liu Yuancheng guo State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China School of Geoscience and Technology Southwest Petroleum UniversityChengdu610500China College of Civil Engineering Zhengzhou UniversityZhengzhou450001China

A three-scale constitutive model for unsaturated granular materials based on thermodynamic theory is *** three-scale yield locus,derived from the explicit yield criterion for solid matrix,is developed from a series of discrete interparticle contact *** three-scale yield locus is sensitive to porosity changes;therefore,it is reinterpreted as a corresponding constitutive model without phenomenological ***,a water retention curve is proposed based on special pore morphology and experimental *** features of the partially saturated granular materials are well captured by the *** wetting and isotropic compression,volumetric compaction occurs,and the degree of saturation ***,the higher the matric suction,the greater the strength,and the smaller the volumetric *** with the phenomenological Barcelona basic model,the proposed three-scale constitutive model has fewer parameters;virtually all parameters have clear physical meanings.

关键词： Unsaturated granular material Unsaturated porous material Geomaterials Multi-scale constitutive model Water retention curve Plasticity

A Fractional-Order Ultra-Local Model-Based Adaptive Neural Network Sliding Mode Control of n-DOF Upper-Limb Exoskeleton With Input Deadzone

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 760-781页

作者： Dingxin He HaoPing Wang Yang tian Yida guo the School of Automation Nanjing University of Science and TechnologyNanjing 210094China IEEE Norinco Group Institute of Navigation and Control Technology Beijing 100089China

This paper proposes an adaptive neural network sliding mode control based on fractional-order ultra-local model for n-DOF upper-limb exoskeleton in presence of uncertainties,external disturbances and input *** the model complexity and input deadzone,a fractional-order ultra-local model is proposed to formulate the original dynamic system for simple controller ***,the control gain of ultra-local model is considered as a *** fractional-order sliding mode technique is designed to stabilize the closed-loop system,while fractional-order time-delay estimation is combined with neural network to estimate the lumped ***,a fractional-order ultra-local model-based neural network sliding mode controller(FO-NNSMC) is ***,to avoid disadvantageous effect of improper gain selection on the control performance,the control gain of ultra-local model is considered as an unknown ***,the Nussbaum technique is introduced into the FO-NNSMC to deal with the stability problem with unknown ***,a fractional-order ultra-local model-based adaptive neural network sliding mode controller(FO-ANNSMC) is ***,the stability analysis of the closed-loop system with the proposed method is presented by using the Lyapunov ***,with the co-simulations on virtual prototype of 7-DOF iReHave upper-limb exoskeleton and experiments on 2-DOF upper-limb exoskeleton,the obtained compared results illustrate the effectiveness and superiority of the proposed method.

关键词： Adaptive control input deadzone model-free control n-DOF upper-limb exoskeleton neural network

Accelerating Asteroidal Period and Pole Inversion from Multiple Lightcurves Using Parallel Differential Evolution and Cellinoid Shape Model

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Research in Astronomy and Astrophysics 2024年第4期24卷 271-286页

作者： Yong-Xiong Zhang Wen-Xiu guo Xiao-Ping Lu Hua Zheng Hai-bin Zhao Jun tian Wei-Lin Wang School of Engineering Guangzhou College of Technology and BusinessGuangzhou 510850China School of Computer Science and Engineering Macao University of Science and TechnologyTaipaMacao 999078China School of Mathematics and Statistics Shaoguan UniversityShaoguan 512099China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China Key Laboratory of Planetary Sciences Purple Mountain ObservatoryCASNanjing 210023China

Determining asteroid properties provides valuable physical insights but inverting them from photometric lightcurves remains computationally *** paper presents a new approach that combines a simplified Cellinoid shape model with the Parallel Differential Evolution(PDE)algorithm to accelerate *** PDE algorithm is more efficient than the Differential Evolution algorithm,achieving an extraordinary speedup of 37.983 with 64 workers on multicore *** PDE algorithm accurately derives period and pole values from simulated *** analysis of real asteroid lightcurves validates the method’s reliability:in comparison with results published elsewhere,the PDE algorithm accurately recovers the rotational periods and,given adequate viewing geometries,closely matches the pole *** PDE approach converges to solutions within 20,000 iterations and under one hour,demonstrating its potential for large-scale data *** work provides a promising new tool for unveiling asteroid physical properties by overcoming key computational bottlenecks.

关键词： methods:numerical minor planets asteroids:general techniques:photometric astrom