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Alterations in the gut microbiota and the faecal metabolomes are potentially associated with gestational diabetes mellitus through inflammatory response

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Food Science and Human Wellness 2024年

作者： Ruili Pan Xiaopeng Xu Ying Chen Haojue Wang Linlin Wang Peijun tian xing Jin Jianxin zhao Wei Chen Gang Wang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University The Department of Clinical Laboratory， Wuxi Xishan People's Hospital The Department of Obstetrics and Gynecology， Wuxi Xishan People's Hospital National Engineering Research Center for Functional Food， Jiangnan University (Yangzhou) Institute of Food Biotechnology， Jiangnan University

Gestational diabetes mellitus (GDM) is a disease of glucose intolerance that first occurs during pregnancy. Accumulating evidence underlined a link between gut microbiota dysbiosis and GDM， and microbial metabolites represent a unique way to explore microbiota–host interactions. However， the associations between changes in the gut microbiota and microbial metabolites and immune homeostasis in the GDM pathogenesis remain largely unclear. In this prospective study， the characteristics of gut microbiota in both first trimester (T1) and second trimester (T2 ) were investigated in 46 GDM patients and 44 matched controls. We comprehensively profiled the microbial metabolites using non-targeted metabolomics and quantitatively targeted metabolomics， measurements of inflammatory cytokines and biomarkers of intestinal barrier function， and combined with correlation analysis in T2. Gut microbiota dybiosis was observed in GDM patients in both T1 and T2， and was characterised by the enrichment of multiple potentially harmful bacteria， such as UBA1819 and Erysipelatoclostridium. Besides， alterations in the microbiota were accompanied by a disturbance in tryptophan metabolism， mainly manifested as a shift towards the production of more kynurenine and less indole derivatives. Most importantly， correlation network analysis indicated that overgrowth of potential pathogens and tryptophan metabolism disorder were associated with inflammatory imbalance and disrupted epithelial barrier in GDM patients. Theses findings provide a greater understanding of the pathogenesis and new targets for microecological interventions by mediating tryptophan metabolism in GDM.

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Experimental Investigation on Heat Transfer and Combustion of a Stirling Engine Combustor Fueled by Reformed Gas and Diesel Fuel

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Journal of Thermal Science 2024年第5期33卷 1907-1919页

作者： LAN Jian zhao Yanchun LIN Guangtao LI Yelin REN Zhe LYU tian SHEN Mengmeng GU Genxiang HAN Dong Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China Shanghai Marine Diesel Engine Research Institute Shanghai 201108China

Thermochemical recuperation heat recovery is an advanced waste heat utilization technology that can effectively recover exhaust waste heat from oxy-fuel Stirling *** novel combustor of a Stirling engine with thermochemical recuperation heat recovery system is expected to utilize both reformed gas and diesel fuels as sources of *** this research,the effects of various factors,including the H_(2)O addition,fuel distribution ratio(FDR),excess oxygen coefficient,and cyclone structure on the temperature distribution in the combustor,combustion emissions,and external combustion system efficiency of the Stirling engine were experimentally *** the increase of steam-to-carbon ratio(S/C),the temperature difference between the upper and lower heating tubes reduces and the circumferential temperature fluctuation decreases,and the combustion of diesel and reformed gas remains close to complete *** S/C=2,the external combustion efficiency is 80.6%,indicating a 1.6%decrease compared to conventional *** the increase of FDR,the temperature uniformity of the heater tube is improved,and the CO and HC emissions ***,the impact of the FDR on the maximum temperature difference and temperature fluctuation across the heater is *** the FDR rises from 21%to 38%,the external combustion efficiency increases from 87.4%to92.3%.The excess oxygen coefficient plays a secondary role in influencing temperature uniformity and temperature difference,and the reformed gas and diesel fuel can be burned efficiently at a low excess oxygen coefficient of *** an increase in the cyclone angle,the heater tube temperature increases,while the maximum temperature difference at the lower part decreases,and the temperature fluctuation ***,the CO and HC emissions increase,and the external combustion efficiency experiences a decrease.A cyclone angle of 30°is found to be an appropriate value for achieving optimal

关键词： Stirling engine fuel reforming synthetic gas oxy-combustion external combustion efficiency

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Highly efficient recognition of similar objects based on ionic robotic tactile sensors

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Science Bulletin 2024年第13期69卷 2089-2098页

作者： Yongkang Kong Guanyin Cheng Mengqin Zhang Yongting zhao Wujun Meng Xin tian Bihao Sun Fuping Yang Dapeng Wei Chongqing Key Laboratory of Generic Technology and System of Service Robots Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China School of Computer Science and Technology Chongqing University of Posts and TelecommunicationsChongqing 400065China

Tactile sensing provides robots the ability of object recognition,fine operation,natural interaction,***,in the actual scenario,robotic tactile recognition of similar objects still faces difficulties such as low efficiency and accuracy,resulting from a lack of high-performance sensors and intelligent recognition *** this paper,a flexible sensor combining a pyramidal microstructure with a gradient conformal ionic gel coating was demonstrated,exhibiting excellent signal-to-noise ratio(48 dB),low detection limit(1 Pa),high sensitivity(92.96 kPa^(-1)),fast response time(55 ms),and outstanding stability over 15,000 compression-release ***,a Pressure-Slip Dual-Branch Convolutional Neural Network(PSNet)architecture was proposed to separately extract hardness and texture features and perform feature *** tactile experiments on different kinds of leaves,a recognition rate of 97.16%was achieved,and surpassed that of human hands recognition(72.5%).These researches showed the great potential in a broad application in bionic robots,intelligent prostheses,and precise human–computer interaction.

关键词： Tactile recognition Conformal ionic gel coating Flexible sensors Dual-branch convolutional neural network

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Method for detector description conversion from DD4hep to Filmbox

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Nuclear Science and Techniques 2024年第9期35卷 115-126页

作者： zhao-Yang Yuan tian-Zi Song Yu-Jie Zeng Kai-Xuan Huang Yu-Mei Zhang Zheng-Yun You School of Physics Sun Yat-sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

DD4hep serves as a generic detector description toolkit recommended for offline software development in next-generation high-energy physics(HEP)***,Filmbox(FBX)stands out as a widely used 3D modeling file format within the 3D software *** this paper,we introduce a novel method that can automatically convert complex HEP detector geometries from DD4hep description into 3D models in the FBX *** feasibility of this method was dem-onstrated by its application to the DD4hep description of the Compact Linear Collider detector and several sub-detectors of the super Tau-Charm facility and circular electron-positron collider *** automatic DD4hep–FBX detector conversion interface provides convenience for further development of applications,such as detector design,simulation,visualization,data monitoring,and outreach,in HEP experiments.

关键词： Detector description DD4hep FBX Geometry Offline software

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Synthesis,Structure and Chemical Bonding of Polyantimony Clusters Containing Coinage Metals[M_(2)Sb_(14)]^(4-)(M=Cu,Ag)

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Chinese Journal of Chemistry 2024年第6期42卷 617-622页

作者： Wei-xing Chen Yu-He Xu Cui-Cui Wang Lei Qiao Zi-Yan Guo Wen-Juan tian Zhong-Ming Sun State Key Laboratory of Element-Organic Chemistry Tianjin Key Lab for Rare Earth Materials and ApplicationsSchool of Materials Science and EngineeringNankai UniversityTianjin300350 China Institute of Molecular Science Shanxi UniversityTaiyuanShanxi030006 China

Binary polyantimony clusters,namely[Cu_(2)Sb_(14)]^(4–) and [Ag_(2)Sb_(14)]^(4–),containing coinage metals,were successfully synthesized and characterized,in which two homoatomic Sb73–subunits are bridged by two coinage metals in η^(4):η^(1) and η^(1):η^(1) coordination modes,***[M_(2)Sb_(14)]^(4-),two bridging Cu ions and two Sb atoms form a planar rhombic unit,which was revealed to have antiaromatic properties by theoretical *** electron structure and bonding analysis confirmed the presence of delocalized bonds in the rhombic unit and the metallophilic interaction between two formal M^(+) ions.

关键词： Polyantimony cluster Copper Silver Antiaromaticity Metallophilic interaction Quantum chemical calculations

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中医药防治肿瘤放化疗后骨髓抑制的应用及研究进展

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中国医院药学杂志 2017年第2期37卷 190-193页

作者：田兆兴杨倩日照市中医医院山东日照276800

介绍目前中医药防治肿瘤放化疗后骨髓抑制的治法和经验,对其临床疗效进行分析,为临床有效防治放化疗导致的骨髓抑制提供选方依据和思路。通过检索中医药防治肿瘤放化疗后骨髓抑制的相关临床和实验研究文献,对中医药防治骨髓抑制的方药... 详细信息

介绍目前中医药防治肿瘤放化疗后骨髓抑制的治法和经验,对其临床疗效进行分析,为临床有效防治放化疗导致的骨髓抑制提供选方依据和思路。通过检索中医药防治肿瘤放化疗后骨髓抑制的相关临床和实验研究文献,对中医药防治骨髓抑制的方药和治法及其临床疗效进行综述。结果显示,中医药防治肿瘤放化疗后骨髓抑制的治法主要有内治法和外治法,内治法包括经方验方治疗、自拟方辩证施治及中成药治疗,灸法是最常用的外治法,内治法和外治法均取得了较好的临床疗效,其作用机制也得到了初步阐释。中医药防治肿瘤放化疗后骨髓抑制效果显著,值得推广,但其有效物质基础、作用机制、作用靶点等尚不明确,仍需进行进一步研究。

关键词：中医药肿瘤放化疗骨髓抑制

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Multi-distortion suppression for neutron radiographic images based on generative adversarial network

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Nuclear Science and Techniques 2024年第4期35卷 176-188页

作者： Cheng-Bo Meng Wang-Wei Zhu Zhen Zhang Zi-Tong Wang Chen-Yi zhao Shuang Qiao tian Zhang School of Physics Northeast Normal UniversityChangchun 130024China

Neutron radiography is a crucial nondestructive testing technology widely used in the aerospace,military,and nuclear ***,because of the physical limitations of neutron sources and collimators,the resulting neutron radiographic images inevitably exhibit multiple distortions,including noise,geometric unsharpness,and white ***,these distortions are particularly significant in compact neutron radiography systems with low neutron ***,in this study,we devised a multi-distortion suppression network that employs a modified generative adversarial network to improve the quality of degraded neutron radiographic *** neutron radiographic image datasets with various types and levels of distortion were built for the first time as multi-distortion suppression ***,the coordinate attention mechanism was incorporated into the backbone network to augment the capability of the proposed network to learn the abstract relationship between ideally clear and degraded *** experiments were performed;the results show that the proposed method can effectively suppress multiple distortions in real neutron radiographic images and achieve state-of-theart perceptual visual quality,thus demonstrating its application potential in neutron radiography.

关键词： Neutron radiography Multi-distortion suppression Generative adversarial network Coordinate attention mechanism

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Designing High-Porosity Porous Structures with Complex Geometries for Enhanced Thermal Conductivity Using Selective Laser Melting and Heat Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 808-824页

作者： Hulin Tang Xiang Zhang Chenping Zhang tian Zhou Shiyue Guo Gaopeng Xu Rusheng zhao Boyoung Hur Xuezheng Yue School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai 200082China National Center for Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyDepartment of Oral Maxillofacial-Head and Neck OncologyShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityShanghai 200011China Longzhong Lab Wuhan of Science and TechnologyYancheng 224000China Tokyo Metropolitan University TokyoJapan Gyeongsang National University JinjuKorea

Rapid advancements in the aerospace industry necessitate the development of unified,lightweight and thermally conductive *** complex geometries,including bionic and porous structures,is paramount in thermally conductive structures to attain improved thermal *** design of two high-porosity porous lattice structures was inspired by pomelo peel structure,using Voronoi parametric *** combining characteristic elements of two high-porostructuressity porous lattice structures designed,a novel high-porosity porous gradient structure is *** structure is based on gradient *** selective laser melting(SLM),fabrication comprises ***-state thermal characteristics are evaluated via finite element analysis(FEA).The experimental thermal conductivity measurements correlate well with simulation results,validating the sequence of K_L as the highest,followed by D_K_L and then D_*** treatment significantly improves thermal conductivity,enhancing the base material by about 45.6%and porous structured samples by approximately 43.7%.

关键词： Selective laser melting Porous lattice structure Thermal conductivity Heat treatment

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Heterogeneous integration of 2D materials on Si charge-coupled devices as optical memory

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Science China(Information Sciences) 2024年第6期67卷 190-197页

作者： Zheng BIAN Feng tian Zongwen LI Xiangwei SU tianjiao ZHANG Jialei MIAO Bin YU Yang XU Yuda zhao College of Integrated Circuits Hangzhou Global Scientific and Technological Innovation CentreZhejiang University

Optical memory integrates the function of optical sensing in memory devices, remarkably promoting the interconnection between sensory and memory terminals. Silicon charge-coupled photodetectors and floating gate memory have been widely used in imaging and storage technologies, respectively. However,the heterogeneous integration of the two devices requires technological innovation and complex electrical connections. In this work, we adopt a three-dimensional layer stacking method to design a novel optical memory device. On the top of Si charge-coupled photodetectors, we successively deposit two-dimensional graphene,hexagonal boron nitride, and molybdenum disulfide as a floating gate layer, a tunneling layer, and a readout layer, respectively. By applying a gate bias on lightly doped Si, a deep depletion layer is formed with a high voltage potential drop. Under dark conditions, the depletion layer cannot be filled, and the electric field across the h-BN tunnel barrier is relatively small. Under light irradiation, the deep depletion layer is gradually filled, and the h-BN tunneling layer withstands the increasing electric field, resulting in charge storage in the floating gate layer. Based on this mechanism, the device exhibits a gate voltage-dependent operation mode, including an integrated optical sensing-memory mode and an electrically driven storage mode. Under moderate gate voltage, the device can effectively detect the optical information with varied intensity and store the optical information in the floating gate, displaying optically controlled memory characteristics. Our work demonstrates a compact device structure for optical memory and displays excellent optically controlled memory performance, which can be applied in artificial vision systems.

关键词： heterogeneous integration charge-coupled device floating gate optical memory molybdenum disulfide lightly doped silicon

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Immunological Exploration of Helicobacter pylori Serotype O_(2) O-Antigen by Using a Synthetic Glycan Library

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Chinese Journal of Chemistry 2024年第3期42卷 243-251页

作者： Ming zhao Guangzong tian Chunjun Qin Xiaopeng Zou Peter H. Seeberger Jing Hu Jian Yin Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China Biomolecular Systems Department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany Wuxi School of Medicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

Helicobacter pylori(***)infection is a threat to human *** lipopolysaccharide(LPS)O-antigen holds promise for developing *** is meaningful to explore the immunological activity of oligosaccharides with different lengths and frameshifts for antigen ***,a glycan library of *** O2 O-antigen containing eight fragments is *** screening with *** O2 LPS sera and patients’sera by glycan microarray,the disaccharide HPO2G-2b and trisaccharide HPO2G-3a show strong antigenicity and then are separately conjugated with carrier protein *** glycoconjugates elicit a robust immunoglobulin G(IgG)immune response in *** anti-HPO2G-3a IgG antibodies possess a much stronger binding affinity with the LPS and bacteria of *** O2 than the anti-HPO2G-2b IgG *** is no cross-reaction between both sera IgG antibodies with LPS and bacteria of *** O1,O6,and *** results demonstrate the trisaccharide HPO2G-3a is a promising candidate for *** vaccine development.

关键词： Glycoconjugates Helicobacter pylori Immunology Microarrays O-antigen Oligosaccharides

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