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Observations on the Function of Mucous Cells in the Epidermis of the Cat-fish Clarias batrachus Exposed to Sodium Dodecyl Sulfate

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Biomedical and Environmental Sciences 1993年第2期6卷 119-133页

作者： tarun kumar garg AJAY kumar MITTAL Skin Skin Physiology LaboratoryDepartment of ZoologyBanaras Hindu UniversityVaranasi-221005IndiaPhysiology LaboratoryDepartment of ZoologyBanaras Hindu UniversityVaranasi-221005India

Response of mucous cells, in the epidermis of the catfish Clarias batrachus, to a sublethal concentration of sodium dodecyl sulfate was studied and correlated with the alteration in the status of their secretory activity after different durations of the treatment. At 4h, 8h, 24h,48h and 72h of the detergent treatment, most mucous cells attained voluminous dimensions and appeared closely approximating to or even overlapping the adjacent ones. At 12h, 36h, and 60h, in contrast, the mucous cells appeared small and slender, and seemed to be located at greater intervals. These changes in dimensions were responsible for the apparent increase or decrease in the density of mucous cells after different durations of detergent treatment. Statistically, however, no significant change was observed in the total number of the mucous cells throughout the experiment.The mucous cells appeared enlarged towards the end of the experiment signifying increased mucus production. This is considered as an adaptation, for protection, assisting the fish to adjust to the changed environment.A shift in the histochemical nature of the secretory contents at the middle and basal parts of the mucous cells, from a mixture of neutral and acid glycoproteins to neutral glycoproteins, during the early stages of the treatment suggests that acid moities could not simultaneously be synthesized as an immediate response to enhanced mucous secretion. The apical parts of the mucous cells, however, showed no histochemical change throughout the experiment.

关键词： Observations on the Function of Mucous Cells in the Epidermis of the Cat-fish Clarias batrachus Exposed to Sodium Dodecyl Sulfate

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Exploring the association between hypertension and cognitive impairment:Evidence-based insights

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Chronic Diseases and Translational Medicine 2024年第2期10卷 153-155页

作者： tarun kumar Suvvari Rangaraya Medical College KakinadaAndhra PradeshIndia Squad Medicine and Research VizagAndhra PradeshIndia

To the Editor,Hypertension,also known as high blood pressure(BP),affects millions of people *** its well-documented cardiovascular consequences,hypertension has been uncovered an association with cognitive impairment.1 This is a growing concern,as the number of people with hypertension is expected to increase in the coming years,particularly in developing countries.

关键词： hypertension impairment cardiovascular

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Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

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Genes & Diseases 2024年第1期11卷 34-37页

作者： Budhadev Baral Dharmendra Kashyap Nidhi Varshney tarun Prakash Verma Ajay kumar Jain Debi Chatterji Vinod kumar Amit Mishra Awanish kumar Hem Chandra Jha Infection Bioengineering Group Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Choithram Hospital and Research Center IndoreMadhya Pradesh452014India Department of Metallurgy Engineering and Materials Science Indian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Department of Bioscience&Bioengineering Indian Institute of Technology JodhpurNH 65 Nagaur RoadJodhpur DistrictKarwarRajasthan 342037India Department of Biotechnology National Institute of Technology RaipurGE RoadRaipurChhattisgarh 492010India

Persistent gastritis induced by Helicobacter pylori(***)is the strongest known risk factor for gastric cancer(GC).*** is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that *** infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

关键词： H.pylori pylori Helicobacter

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Overlap in oncogenic and pro-inflammatory pathways associated with areca nut and nicotine exposure

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Cancer Pathogenesis and Therapy 2024年第3期2卷 187-194页

作者： Krati garg Anuj kumar Vidisha Kizhakkethil Pramod kumar Shalini Singh Department of Biochemical Engineering and Biotechnology Indian Institute of Technology(IIT)DelhiDelhi 110016India Division of Molecular Biology ICMR-National Institute of Cancer Prevention and Research(ICMR-NICPR)Indian Council of Medical ResearchNoidaUttar Pradesh 201301India Department of Biotechnology Vellore Institute of Technology(VIT)VelloreTamil Nadu 632024India ICMR-National Institute of Cancer Prevention&Research(ICMR-NICPR) Indian Council of Medical ResearchNoidaUttar Pradesh 201301India

Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of *** other psychoactive substances,such as nicotine,the mechanisms underlying addiction to areca nuts and related oncogenesis remain *** reports suggest a possible overlap in the mechanisms of action of nicotine and areca nuts in the human ***,this study aimed to investigate the interactome of human proteins associated with areca nut exposure and the intricate similarities and differences in the effects of the two psychoactive substances on ***:A list of proteins associated with areca nut use was obtained from the available literature using terms from Medical Subject Headings(MeSH).Protein-protein interaction(PPI)networks and functional enrichment were *** results obtained for both psychoactive substances were ***:Given the limited number of common proteins(36/226,16%)in the two sets,a substantial overlap(612/1176 nodes,52%)was observed in the PPI networks,as well as in Gene *** nuts mainly affect signaling pathways through three hub proteins(alpha serine/threonine-protein kinase,tumor protein 53,and interleukin-6),which are common to both psychoactive substances,as well as two unique hub proteins(epidermal growth factor receptor and master regulator of cell cycle entry and proliferative metabolism).Areca nut-related proteins are associated with unique pathways,such as extracellular matrix organization,lipid storage,and metabolism,which are not found in nicotine-associated ***:Areca nuts affect regulatory mechanisms,leading to systemic toxicity and *** nuts also affect unique pathways that can be studied as potential markers of exposure,as well as targets for anticancer therapeutic agents.

关键词： Cancer Areca nut Nicotine Interactome Cell signaling

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Are case reports valuable?Exploring their role in evidence based medicine and patient care

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World Journal of Clinical Cases 2024年第24期12卷 5452-5455页

作者： tarun kumar Suvvari Department of Clinical Research Squad Medicine and Research(SMR)Amadalavalasa 532185Andhra PradeshIndia Department of Medicine Rangaraya Medical CollegeKakinada 533001Andhra PradeshIndia

Case reports,often overlooked in evidence-based medicine(EBM),play a pivotal role in healthcare *** provide unique insights into rare conditions,novel treatments,and adverse effects,serving as valuable educational tools and generating new *** their limitations in generalizability,case reports contribute significantly to evidence-based practice by offering detailed clinical information and fostering critical thinking among healthcare *** acknowledging their limitations and adhering to reporting guidelines,case reports can contribute significantly to medical knowledge and patient care within the evolving landscape of *** editorial explores the intrinsic value of case reports in EBM and patient care.

关键词： Clinical cases Case reports Evidence based medicine Editorial Healthcare research

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Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

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World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： Madhan Jeyaraman Naveen Jeyaraman tarun Jayakumar Swaminathan Ramasubramanian Rajni Ranjan Saurabh kumar Jha Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of Orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease *** regenerative medicine,current treatments have *** regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism *** To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee *** The study included 50 patients with Kellgren-Lawrence grades II and III *** were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)*** were followed up at 1,3,6,12,and 24 *** analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all *** safety of SVF in terms of adverse and severe adverse events was *** analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United *** Both groups had similar demographics and baseline clinical ***-up showed minor patient loss,resulting in 23 and 24 in groups A and B *** A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group *** difference in pain reduction in group A was statistically significant from the third month ***,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to *** improvement in Group A was statistically significant from 6 months and maintained through 24 *** Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in pa

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

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In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity:Insights from national inpatient sample 2020

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World Journal of Hepatology 2024年第6期16卷 912-919页

作者： Sashwath Srikanth Vibhor garg Lakshmi Subramanian Jyoti Verma Hansika Sharma Harroop Singh Klair Shrenil A Kavathia Jithin Kolli Teja Nikhil Sai Vasireddy kumar Anmol Dhanush Kolli Shruti Sanjay Bodhankar Sobya Hashmi Shaylika Chauhan Rupak Desai Department of Medicine ECU Health Medical CenterGreenvilleNC 27834United States Department of Medicine Jacobi Medical Center/Albert Einstein College of MedicineBronxNY 10461United States Department of Medicine North Alabama Medical CentreFlorenceAL 35630United States Department of General Medicine Gandhi Medical CollegeSecunderabad 500003TelanganaIndia Department of Medicine Government Medical CollegePatiala 147001PunjabIndia Department of Medicine B.J.Medical CollegeAhmedabad 380016GujaratIndia Department of Medicine JSS Medical CollegeMysore 570015KarnatakaIndia Department of Internal Medicine Gandhi Medical CollegeSecunderabad 500003TelanganaIndia Department of Medicine Kasturba Medical CollegeManipal 575001KarnatakaIndia Clinical Extern Department of Internal MedicineBeaumont HospitalDearbornMI 48124United States Department of Internal Medicine Geisinger Health SystemWilkes-BarrePA 18702United States Independent Researcher AtlantaGA 30079United States

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular diseases independently of other risk ***,data on its effect on cardiovascular outcomes in coronavirus disease 2019(COVID-19)hospitalizations with varied obesity levels is *** management and patient care depend on understanding COVID-19 admission results in NAFLD patients with varying obesity *** To study the in-hospital outcomes in COVID-19 patients with NAFLD by severity of *** COVID-19 hospitalizations with NAFLD were identified using International Classification of Disease-10 CM codes in the 2020 National Inpatient Sample *** and Obesity Classes Ⅰ,Ⅱ,and Ⅲ(body mass index 30-40)were *** adverse cardiac and cerebrovascular events(MACCE)(all-cause mortality,acute myocardial infarction,cardiac arrest,and stroke)were compared between *** regression analyses adjusted for sociodemographic,hospitalization features,and *** Our analysis comprised 13260 hospitalizations,7.3% of which were overweight,24.3% Class Ⅰ,24.1% Class Ⅱ,and 44.3% Class Ⅲ.Class Ⅲ obesity includes younger patients,blacks,females,diabetics,and hypertensive *** multivariable logistic analysis,Class Ⅲ obese patients had higher risks of MACCE,inpatient mortality,and respiratory failure than Class Ⅰ obese *** Ⅱ obesity showed increased risks of MACCE,inpatient mortality,and respiratory failure than Class I,but not *** obesity classes had non-significant risks of MACCE,inpatient mortality,and respiratory failure compared to the overweight *** Class Ⅲ obese NAFLD COVID-19 patients had a greater risk of adverse outcomes than class Ⅰ.Using the overweight group as the reference,unfavorable outcomes were not significantly *** obesity had a greater risk of MACCE regardless of the referent group(overweight or Class Ⅰ obese)compared to overweight NAFLD patients admitte

关键词： Non-alcoholic fatty liver disease Obesity Obese Body mass index Major adverse cardiac and cerebrovascular events Mortality Acute myocardial infarction Cardiac arrest Stroke

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Continuous Mixed p-norm Control Scheme with Reweighted L_(0) norm Variable Step Size for Mitigating Power Quality Problems of Grid Coupled Solar PV Systems

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CSEE Journal of Power and Energy Systems 2023年第4期9卷 1394-1404页

作者： Pallavi Verma Avdhesh kumar Rachana garg Priya Mahajan Delhi technological university DelhiDelhi 110085India.

In this paper,the performance of a two-stage three-phase grid coupled solar photovoltaic generating system(SPVGS)is analyzed by using a novel reweighted Lo norm variable step size continuous mixed p-norm(RLo-VSSCMPN)of a voltage source inverter(VSI)control *** efficacy of the system is determined by considering unbalanced grid voltage,DC offset,voltage sag and swell,unbalanced load and variations in solar ***-VSSCMPN is used for inverter control and it ex-tracts fundamental components of load current for generating the reference grid current with a faster convergence rate and lesser steady state *** the proposed control,harmonics in the grid current follows the IEEE-519 norm and the performance is also satisfactory under varying environmental/load *** power generated from SPvGS is transferred optimally using a DC-DC boost converter utilizing the incremental conductance(INC)maximum power point *** proposed system is simulated using MATLAB/Simulink 2018a and test results are verified experimentally using dSPACE1202 in the laboratory to ensure the validity of a novel proposed robust *** Terms-INC maximum power point tracker,power quality,reweighted LoVSSCMPN algorithm,solar PV generating system,total harmonic distortion,voltage source inverter.

关键词： INC maximum power point tracker power quality reweighted LoVSSCMPN algorithm solar PV generating system total harmonic distortion voltage source inverter.

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Mass balance and morphological evolution of the Dokriani Glacier,central Himalaya,India during 1999–2014

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Geoscience Frontiers 2022年第1期13卷 255-267页

作者： Purushottam kumar garg Jairam Singh Yadav Santosh kumar Rai Aparna Shukla Indian Institute of Technology Indore Khandwa RoadSimrolIndore 453552India Wadia Institute of Himalayan Geology 33GMS RoadDehradun 248001India Ministry of Earth Sciences Prithvi BhavanLodhi RoadNew Delhi 110003India

Glaciological mass balance(MB)is considered the most direct,undelayed and unfiltered response of the glaciers to climatic ***,it may inherit errors associated with stake underrepresentation,averaging over the entire glacier and human ***,proper validation of glaciological MB with geodetic MB is highly recommended by the World Glacier Monitoring Service(WGMS).The present study focuses on the Dokriani Glacier,central Himalaya which is one of the bench-mark glaciers in the region and has glaciological MB records from 1993 to 2013 with intermittent *** the present study,firstly the glaciological MB series is extended to 2014 i.e.,field-based MB for one more year is computed and,to compare with it,the geodetic MB is computed for the 1999–2014 period using high resolution Cartosat-1 digital elevation model(DEM)and SRTM ***,the study assesses the regional representation of the Dokriani Glacier in terms of MB and evaluates the influence of the MB regime on its morphological *** show that the average glaciological MB(-0.34±0.2 m water equivalent(w.e.)y-1)is more negative than the geodetic MB(-0.23±0.1 m w.e.y-1)for the 1999–2014 *** is likely because of the partial representation of glacier margins in the glaciological MB,where melting is strikingly low owing to thick debris cover(>30 cm).In contrast,geodetic MB considers all marginal pixels leading to a comparatively low MB.A comparative assessment shows that the MB of Dokriani Glacier is less negative(possibly due to its huge accumulation area)than most other glacier-specific and regional MBs,restricting it to be a representative glacier in the ***,continuous negative MB has brought a peculiar change in the epiglacial morphology in the lower tongue of the glacier as differential debris thickness-induced differential melting has turned the glacier surface into a concave *** concavity has led to development of a large(10–20 m deep)supraglacial ch

关键词： Glacier mass balance Debris cover Epiglacial morphology Supraglacial channel Dokriani Glacier Central Himalaya

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Bibliometric analysis of Blockchain in the healthcare domain

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Intelligent and Converged Networks 2023年第4期4卷 305-312页

作者： Shilpi garg Rajesh kumar Kaushal Naveen kumar Anshul Verma Chitkara Institute of Engineering and Technology Chitkara UniversityPunjab 140401India Institute of Science Banaras Hindu UniversityVaranasi 221005India

As an innovation,Blockchain has transformed numerous industries and sparked the interest of the research community due to its abundance of benefits,opening up diverse research routes in the healthcare sector in the last *** Health 4.0 becoming ubiquitous in the healthcare industry,end-user transactions are being carried out on a decentralized network,making Blockchain profitable to meet the demands of the modern healthcare ***,a detailed analysis of Blockchain is very *** study emphasizes the evolution of science and the preliminary research of Blockchain in healthcare through bibliometric *** the data are extracted from the Scopus database,and the VOSviewer tool is used for analysis.A total of 1152 Scopus articles published between 2018 and 2022 are *** reveal that in 2022,the field of Blockchain experienced a notable increment in the number of publications and a significant growth *** Access became well known in this field and had a large number of *** is observed that China and India are the leading countries in terms of publications on *** study offers a number of recommendations that amateur and professional researchers can use as a benchmark before commencing a Blockchain investigation in the future.

关键词： Blockchain bibliometric healthcare VOSviewer

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