检索结果-南通市图书馆

Imaging HNCO Photodissociation at 201 nm:State-to-State Correlations between CO(X^1∑^+) and NH(a^1△)

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2018年第6期31卷 735-740,733页

作者： Zhi-guo Zhang Min Xin yan-ning Wu Shu-tao Zhao Yi-jia Tang yang Chen School of Physics and Electronic Engineering Fuyang Normal University Fuyang 236041 China Department of Chemical Physics and Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei 230026 China

The NH(a^1Δ)+CO(X^1Σ+) product channel for the photodissociation of isocyanic acid(HNCO) on the first excited singlet state S1 has been investigated by means of time-sliced ionvelocity map imaging technique at photolysis wavelengths around 201 nm. The CO productwas detected through (2+1) resonance enhanced multiphoton ionization (REMPI). Imageswere obtained for CO products formed in the ground and vibrational excited state (v=0 and v=1). The energy distributions and product angular distributions were obtained from the CO velocity imaging. The correlated NH(a^1Δ) rovibrational state distributions were *** vibrational branching ratio of 1NH (v=1/v=0) increases as the rotational state of CO(v=0) increases initially and decreases afterwards, which indicates a special state-tostate correlation between the 1NH and CO products. About half of the available energy was partitioned into the translational degree of freedom. The negative anisotropy parameter indicates that it is a vertical direct dissociation process.

关键词： HNCO Ion velocity map imaging Energy distributions

ER-alpha promoter methylation is a biomarker for outcome prediction of cisplatin resistant in triple-negative breast cancer

在线全文

学校读者我要写书评

暂无评论

ER-alpha promoter methylation is a biomarker for outcome pre...

Initial support distance of a non-circular tunnel based on convergence constraint method and integral failure criteria of rock

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青...

作者： Junnan Xu tao Sun Xiangyu Guo yan Wang Mingxi Jing Department of Medical Oncology Liaoning Cancer Hospital & Institute

An increasing number of studies have suggested that the link between ERα methylation and triplenegative breast cancer(TNBC). However, the association of ERα methylation and drug resistant during the therapy in TNBC remains unclear. Methylation-specific polymerase chain reaction was used to investigate the methylation of ERα in genomic DNA of 35 patients with TNBC, who were analyzed cisplatin-based chemotherapy resistant status by chemosensitivity testing. Survival probabilities by covariates were assessed by Kaplan-Meier curve and Cox proportional hazards models adjusting for age, menotpausal status, tumor size, lymph node metastasis and ERα promoter DNA methylation were estimated. Of the 35 TNBC analysed, eight cases showed ERα promoter DNA methylation. Cisplatin resistant was confirmed in univariate and multivariate analysis to be overwhelmingly associated with ERα methylation. Even in a limited analysis in the patients with ERα methylation, the results generated from methylated tumor tissue and unmethylated tumor tissue revealed that BRCA expression were higher in breast tumor tissue with ERα methylation than that in unmethylated tissue. ERα methylation group had tended to have a significantly shorter PFS(P=0.010) and shorter OS(P=0.023) than unmethylation group. Similar survival results were showed in cisplatin resistant group and non-resistant group. ERα methylation predicts a poor clinical outcome for patients with triple negative breast cancer. This suggested that ERα methylation could be a candidate surrogate biomarker for outcome prediction and cisplatin-based resistant in TNBC. Further investigation will be necessary to identify the biomarker with a larger cohort in a prospective study.

关键词： triple negative breast cancer estrogen receptor α methylation BRCA1 drug resistant cisplatin

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Central South University 2022年第11期29卷 3732-3744页

作者： AN Xue-xu HU Zhi-ping SU yan CAO Shuang-li tao Lei ZHANG Yong-hui School of Civil Engineering Chang’an UniversityXi’an 710061China Institute of Underground Structure and Engineering Chang’an UniversityXi’an 710061China Hanjiang to Weihe River Valley Water Diversion Project Construction Co. Ltd.Xi’an 710024China

For deep tunnel projects,selecting an appropriate initial support distance is critical to improving the self-supporting capacity of surrounding *** this work,an intuitive method for determining the tunnel’s initial support distance was ***,based on the convergence-confinement method,a three-dimensional analytical model was constructed by combining an analytical solution of a non-circular tunnel with the Tecplot ***,according to the integral failure criteria of rock,the failure tendency coefficients of hard surrounding rock were computed and the spatial distribution plots of that were *** this basis,the tunnel’s key failure positions were identified,and the relationship between the failure tendency coefficient at key failure positions and their distances from the working face was ***,the distance from the working face that corresponds to the critical failure tendency coefficient was taken as the optimal support distance.A practical project was used as an example,and a reasonable initial support distance was successfully determined by applying the developed ***,it is found that the stability of hard surrounding rock decreases rapidly within the range of 1.0D(D is the tunnel diameter)from the working face,and tends to be stable outside the range of 1.0D.

关键词： tunnel engineering convergence confinement method integral failure criteria of rock non-circular tunnel initial supporting distance

COVID-19 or treatment associated immunosuppression may trigger hepatitis B virus reactivation: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第19期9卷 5266-5269页

作者： Yi-Feng Wu Wan-Jun Yu Yu-Hua Jiang Yin Chen Bo Zhang Rui-Bing Zhen Jun-tao Zhang Yi-Ping Wang Qiang Li Feng Xu yan-Jun Shi Xian-Peng Li Department of Hepatobiliary and Pancreas Surgery The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Respiratory Disease and Critical Care Medicine The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Infectious Diseases The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Ophthalmology The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Laboratory Medicine The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Radiology The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Gastroenterology The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Hepatobiliary and Pancreas Surgery The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 315009Zhejiang ProvinceChina

BACKGROUND Since the initial recognition of coronavirus disease 2019(COVID-19)in Wuhan,this infectious disease has spread to most areas of the *** pathogenesis of COVID-19 is yet *** B virus(HBV)reactivation occurring in COVID-19 patients has not yet been *** SUMMARY A 45-year-old hepatitis B man with long-term use of adefovir dipivoxil and entecavir for antiviral therapy had HBV reactivation after being treated with methylprednisolone for COVID-19 for 6 *** COVID-19 or treatment associated immunosuppression may trigger HBV reactivation.

关键词： COVID-19 Hepatitis B virus Reactivation Diagnose Therapy Case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

纳秒脉冲下温度、频率对尼龙6电老化的影响

高电压技术 2015年第4期41卷 1334-1341页

作者：王涛王珏严萍冉慧娟中国科学院电工研究所北京100190 中国科学院电力电子与电气驱动重点实验室北京100190 中国科学院大学北京100190

尼龙6作为绝缘材料经过长时间运行后,绝缘性能会受老化的影响而劣化。目前对此类绝缘材料的研究多集中在常温和工频下,在ns脉冲条件下的研究较少。为了研究温度、频率对尼龙6中电树枝引发的影响,实验采用了固态ns脉冲发生器MPC50D为激励... 详细信息

尼龙6作为绝缘材料经过长时间运行后,绝缘性能会受老化的影响而劣化。目前对此类绝缘材料的研究多集中在常温和工频下,在ns脉冲条件下的研究较少。为了研究温度、频率对尼龙6中电树枝引发的影响,实验采用了固态ns脉冲发生器MPC50D为激励源,其具有30 ns的下降沿和70 ns的脉冲宽度;使用温度循环实验箱SP-80U控制实验温度。实验的温度设定为-40-60℃,频率设定为20-1 500 Hz。实验结果表明：温度对尼龙6中的电树枝引发电压有明显的影响,随温度的升高电树枝引发电压下降明显;频率对电树枝的影响并不明显,只在200 Hz以下出现了较明显的趋势;尼龙6、聚四氟乙烯（PTFE）和有机玻璃（PMMA）中的电树枝形态差异巨大,尼龙6中为丛林形,PTFE中为树枝形,PMMA中为层裂形;ns脉冲下击穿通道出现了放电引发的扇形结构。实验数据为尼龙6在ns脉冲下的绝缘应用提供了参考。

关键词：尼龙6 电树枝 ns脉冲电老化 PTFE PMMA

基于随机模型预测控制的能源局域网优化调度研究

在线全文

学校读者我要写书评

暂无评论

中国电机工程学报 2016年第13期36卷 3451-3462,3364页

作者：张彦张涛刘亚杰郭波国防科技大学信息系统与管理学院湖南省长沙市410073

针对高可再生能源渗透率的能源局域网中可再生能源输出不确定性、负载需求波动性和实时电价随机性对能源局域网优化调度的影响,提出了基于随机模型预测控制的能源局域网优化调度方法。通过分析能源局域网系统架构及其各类设备的特性,构... 详细信息

针对高可再生能源渗透率的能源局域网中可再生能源输出不确定性、负载需求波动性和实时电价随机性对能源局域网优化调度的影响,提出了基于随机模型预测控制的能源局域网优化调度方法。通过分析能源局域网系统架构及其各类设备的特性,构建了混合整数二次规划模型的能源局域网能量优化调度目标函数,并运用模型预测控制框架实现该能源局域网的在线优化调度。提出了能够快速实现场景缩减,选出典型场景的两阶段场景缩减方法。通过与传统开环调度方法以及标准模型预测控制调度方法的比较,证明文中所提方法的可行性与鲁棒性。

关键词：能源互联网能源局域网随机模型预测控制混合整数二次规划可再生能源

Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第4期24卷 475-483页

作者： yan-Shen Kuang Yi Wang Li-Dan Ding Liu yang Ying Wang Si-Han Liu Bing-tao Zhu Xu-Ning Wang Hong-Yi Liu Jun Li Zhi-Jie Chang Yin-Yin Wang Bao-Qing Jia General SurgeryⅡDepartment Chinese PLA General HospitalBeijing 100853China State Key Laboratory of Membrane Biology Department of Basic Medical SciencesSchool of MedicineTsinghua UniversityBeijing 100084China Institute of Immunology PLAThe Third Military Medical UniversityChongqing 400038China

AIM To investigate expression of cell cycle-related and expression-elevated protein in tumor(CREPT) in colorectal cancer(CRC) and determine its prognostic value in response to 5-fluorouracil(5-FU).METHODS The relative expression of CREPT in CRC tumor samples was determined using immunohistochemistry. The protein content in cell lines was analyzed by immunoblotting. Cell viability was measured with the CCK-8 assay. Cell cycle and apoptosis analyses were performed with flow *** CREPT was overexpressed in CRC tissues and correlated with histological grade. Clinicopathological analysis indicated that CREPT was positively related to tumor progression. Exogenous expression of CREPT stimulated cell proliferation and accelerated the cell cycle. More importantly, high expression of CREPT sensitized CRC cells to 5-FU treatment. Furthermore, we demonstrated that 5-FU elicited significant apoptosis in CREPT-positive *** Aberrant overexpression of CREPT contributes to tumorigenesis of CRC by promoting cell proliferation and accelerating the cell cycle, and confers sensitivity to 5-FU. CREPT is a potential prognostic biomarker for 5-FU in CRC.

关键词： CREPT Colorectal cancer 5-Fluorouracil Apoptosis Cell proliferation

金纳米微粒共振光散射光谱探针测定维生素B4-水溶性腺嘌呤的研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

分析试验室 2009年第1期28卷 48-52页

作者：郭艳丽阎宏涛西北大学合成与天然功能分子化学教育重点实验室西北大学化学系西安710069

建立了一种以金纳米微粒为探针共振光散射(RLS)法测定维生素B_4的新方法。在弱酸性介质中(pH 4.2),金纳米微粒在635 nm有一最大共振散射峰。加入微量维生素B_4后,金纳米微粒与维生素B_4通过静电引力结合,形成了粒径较大的聚集体,导致RL... 详细信息

建立了一种以金纳米微粒为探针共振光散射(RLS)法测定维生素B_4的新方法。在弱酸性介质中(pH 4.2),金纳米微粒在635 nm有一最大共振散射峰。加入微量维生素B_4后,金纳米微粒与维生素B_4通过静电引力结合,形成了粒径较大的聚集体,导致RLS强度显著增强。研究了体系的共振光散射光谱特征和反应适宜条件,探讨了共振光散射增强的机理。结果表明,维生素B_4质量浓度在0.1～5.0μg/mL时与散射强度(ΔI)呈线性关系,检出限(3σ)为12.0 ng/mL,相对标准偏差(RSD)为2.2%。该方法已用于片剂中维生素B_4的测定。

关键词：金纳米微粒共振光散射光谱维生素B4

穿支位置与穿支穿深筋膜后走行方式对股前外侧皮瓣发生部分坏死的影响初探

在线全文

学校读者我要写书评

暂无评论

中华损伤与修复杂志（电子版） 2024年第2期19卷 141-146页

作者：高钦锋杨林黄永涛杨成鹏孙丰文曹阳刘禹城张岩程俊楠张韬巨积辉苏州瑞华骨科医院手外科 215104 苏州大学苏州医学院 215123

目的探讨穿支位置与穿支穿深筋膜后走行方式对股前外侧皮瓣发生部分坏死的影响。方法回顾性研究苏州瑞华骨科医院手外科2018年10月至2021年6月采用游离股前外侧皮瓣修复四肢创面术后皮瓣发生部分坏死的25例患者资料,同时在同一时期内随... 详细信息

目的探讨穿支位置与穿支穿深筋膜后走行方式对股前外侧皮瓣发生部分坏死的影响。方法回顾性研究苏州瑞华骨科医院手外科2018年10月至2021年6月采用游离股前外侧皮瓣修复四肢创面术后皮瓣发生部分坏死的25例患者资料,同时在同一时期内随机选择25例采用股前外侧皮瓣修复创面皮瓣完全成活患者。对比分析两组年龄、性别、穿支类型、穿支距皮缘距离、穿支位置设计与穿支穿深筋膜后走行方式的一致性、皮瓣切取时间、皮瓣大小的差异,探索股前外侧皮瓣发生部分坏死的原因。结果皮瓣部分坏死组和皮瓣完全成活组年龄、性别、穿支类型、穿支距皮缘距离、皮瓣切取时间、皮瓣大小差异无统计学意义(P>0.05),两组穿支位置设计是否与穿支深筋膜后走行一致的例数差异有统计学意义(P=0.001)。将其进行logistic回归分析显示,穿支位置设计与穿支穿深筋膜后走行方式是否一致为皮瓣部分坏死的影响因素(OR=38.812,P<0.001)。结论穿支位置设计与穿支穿深筋膜后走行方式是否一致是影响皮瓣发生部分坏死的原因。根据穿支穿深筋膜后走行方式及穿支位置设计皮瓣,可降低皮瓣发生部分坏死的概率。

关键词：穿支皮瓣股前外侧皮瓣部分坏死入皮方式皮瓣设计