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Sparse-Grid Implementation of Fixed-Point Fast Sweeping WENO Schemes for Eikonal Equations

Communications on Applied Mathematics and Computation 2024年第1期6卷 3-29页

作者： Zachary M.Miksis yong-tao Zhang Department of Applied and Computational Mathematics and Statistics University of Notre DameNotre DameIN46556USA

Fixed-point fast sweeping methods are a class of explicit iterative methods developed in the literature to efficiently solve steady-state solutions of hyperbolic partial differential equations(PDEs).As other types of fast sweeping schemes,fixed-point fast sweeping methods use the Gauss-Seidel iterations and alternating sweeping strategy to cover characteristics of hyperbolic PDEs in a certain direction simultaneously in each sweeping *** resulting iterative schemes have a fast convergence rate to steady-state ***,an advantage of fixed-point fast sweeping methods over other types of fast sweeping methods is that they are explicit and do not involve the inverse operation of any nonlinear local ***,they are robust and flexible,and have been combined with high-order accurate weighted essentially non-oscillatory(WENO)schemes to solve various hyperbolic PDEs in the *** multidimensional nonlinear problems,high-order fixed-point fast sweeping WENO methods still require quite a large amount of computational *** this technical note,we apply sparse-grid techniques,an effective approximation tool for multidimensional problems,to fixed-point fast sweeping WENO methods for reducing their computational ***,we focus on fixed-point fast sweeping WENO schemes with third-order accuracy(Zhang et al.2006[41]),for solving Eikonal equations,an important class of static Hamilton-Jacobi(H-J)*** experiments on solving multidimensional Eikonal equations and a more general static H-J equation are performed to show that the sparse-grid computations of the fixed-point fast sweeping WENO schemes achieve large savings of CPU times on refined meshes,and at the same time maintain comparable accuracy and resolution with those on corresponding regular single grids.

关键词： Fixed-point fast sweeping methods Weighted essentially non-oscillatory(WENO)schemes Sparse grids Static Hamilton-Jacobi(H-J)equations Eikonal equations

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Heuristic Expanding Disconnected Graph:A Rapid Path Planning Method for Mobile Robots

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 68-82页

作者： yong tao Lian Duan He Gao Yufan Zhang Yian Song Tianmiao Wang School of Mechanical Engineering&Automation Beihang UniversityBeijing 100191China Aero-Engine Research Institute Beihang UniversityBeijing 102206China School of Large Aircraft Engineering Beihang UniversityBeijing 100191China

Existing mobile robots mostly use graph search algorithms for path planning,which suffer from relatively low planning efficiency owing to high redundancy and large computational *** to the limitations of the neighborhood search strategy,the robots could hardly obtain the most optimal global path.A global path planning algorithm,denoted as EDG*,is proposed by expanding nodes using a well-designed expanding disconnected graph operator(EDG)in this ***,all obstacles are marked and their corners are located through the map ***,the EDG operator is designed to find points in non-obstruction areas to complete the rapid expansion of disconnected ***,the EDG*heuristic iterative algorithm is *** selects the candidate node through a specific valuation function and realizes the node expansion while avoiding collision with a minimum *** planning experiments were conducted in a typical indoor environment and on the public dataset *** result shows that the proposed EDG*reduced the planning time by more than 90%and total length of paths reduced by more than 4.6%.Compared to A*,Dijkstra and JPS,EDG*does not show an exponential explosion effect in map *** EDG*showed better performance in terms of path smoothness,and collision *** shows that the EDG*algorithm proposed in this paper can improve the efficiency of path planning and enhance path quality.

关键词： Global path planning Mobile robot Expanding disconnected graph Edge node Offset

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Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer’s Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice

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Neuroscience Bulletin 2024年第2期40卷 182-200页

作者： Yang Zhu Hao Huang Zhi Chen yong tao Ling-Yi Liao Shi-Hao Gao Yan-Jiang Wang Chang-Yue Gao Department of Rehabilitation Medicine Daping HospitalArmy Medical UniversityChongqing 400042China Department of Neurology and Center for Clinical Neuroscience Daping HospitalArmy Medical UniversityChongqing 400042China Department of Special Medicine Daping HospitalArmy Medical UniversityChongqing 400042China

Intermittent theta burst stimulation(iTBS),a time-saving and cost-effective repetitive transcranial magnetic stimulation regime,has been shown to improve cognition in patients with Alzheimer’s disease(AD).However,the specific mechanism underlying iTBS-induced cognitive enhancement remains *** studies suggested that mitochondrial functions are modulated by magnetic ***,we showed that iTBS upregulates the expression of iron-sulfur cluster assembly 1(ISCA1,an essential regulatory factor for mitochondrial respiration)in the brain of APP/PS1 *** vivo and in vitro studies revealed that iTBS modulates mitochondrial iron-sulfur cluster assembly to facilitate mitochondrial respiration and function,which is required for ***,iTBS rescues cognitive decline and attenuates AD-type pathologies in APP/PS1 *** present study uncovers a novel mechanism by which iTBS modulates mitochondrial respiration and function via ISCA1-mediated iron-sulfur cluster assembly to alleviate cognitive impairments and pathologies in *** provide the mechanistic target of iTBS that warrants its therapeutic potential for AD patients.

关键词： Intermittent theta burst stimulation Alzheimer’s disease Iron-sulfur cluster assembly 1 Mitochondrial dysfunction Neurodegeneration

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泛素化在调控铁死亡中的作用

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生物化学与生物物理进展 2024年第6期51卷 1269-1283页

作者：曹灿陶永光石颖中南大学肿瘤研究所长沙410078

铁死亡是一种由脂质过氧化驱动的铁依赖性的新的细胞死亡方式,越来越多的证据表明,铁死亡与各种病理状态有关,如神经退行性疾病、糖尿病肾病、癌症等,脂质过氧化驱动的铁死亡可能促进或抑制这些疾病的发生发展,细胞中抗氧化系统通过抑... 详细信息

铁死亡是一种由脂质过氧化驱动的铁依赖性的新的细胞死亡方式,越来越多的证据表明,铁死亡与各种病理状态有关,如神经退行性疾病、糖尿病肾病、癌症等,脂质过氧化驱动的铁死亡可能促进或抑制这些疾病的发生发展,细胞中抗氧化系统通过抑制脂质过氧化在抵抗铁死亡过程中发挥着重要作用。铁死亡的关键通路有以SLC7A11-GPX4为关键分子的氨基酸代谢通路、以铁蛋白或转铁蛋白为主的铁代谢通路,以及脂质代谢通路。铁死亡的发生受到细胞内蛋白质的调节,这些蛋白质会发生各种翻译后修饰,包括泛素化修饰。泛素-蛋白酶体系统(ubiquitin-proteasome system,UPS)是细胞内主要降解系统之一,通过酶促级联反应催化泛素分子标记待降解蛋白,随后由蛋白酶体识别并降解目标蛋白质。UPS根据其降解底物的不同在调节铁死亡的反应中发挥双重作用。UPS通过促进铁死亡关键分子(如SLC7A11、GPX4、GSH)以及抗氧化系统成分(如NRF2)的泛素化降解从而促进铁死亡,也可以通过促进脂质代谢通路中相关分子(如ACSL4、ALOX15)的泛素化降解从而抑制铁死亡。本综述介绍泛素化修饰在调控铁死亡进程中作用的最新研究进展,总结了已发表的关于E3泛素连接酶和去泛素酶调控铁死亡的研究,归纳了泛素连接酶、去泛素酶调控铁死亡的作用靶点,有助于确定人类疾病中新的预后指标,为这些疾病提供潜在的治疗策略。

关键词：铁死亡泛素化去泛素化脂质过氧化

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Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe WANG Rui Chen LI Yan ZHANG Jun Feng LIU Sheng Hui HU Dan He XU Chong Xiao YIN Jia Yu YIN Qi Kai HE Ying LI Fan FU Shi Hong NIE Kai LIANG Guo Dong tao yong XU Song tao MA Chao Feng WANG Huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

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基于D-S证据理论的岩爆预测方法研究

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东北大学学报（自然科学版） 2024年第2期45卷 244-251页

作者：高永涛朱强吴顺川王勇兵北京科技大学土木与资源工程学院北京100083 昆明理工大学国土资源工程学院云南昆明650093 云南驰宏锌锗股份有限公司云南曲靖655000

为了有效预测岩爆,提出基于D-S证据理论的岩爆预测方法.首先,选取与岩爆发生相关的6个指标因素作为证据体,并通过模糊物元框架和正态型隶属度函数构建证据体的基本概率分配.然后,利用K均值将证据体分类,并提出簇内证据用传统方式融合而... 详细信息

为了有效预测岩爆,提出基于D-S证据理论的岩爆预测方法.首先,选取与岩爆发生相关的6个指标因素作为证据体,并通过模糊物元框架和正态型隶属度函数构建证据体的基本概率分配.然后,利用K均值将证据体分类,并提出簇内证据用传统方式融合而簇间证据用权重方式融合的组合融合规则,以减轻高冲突证据融合的不利影响.最后,将模型应用在秦岭终南山公路隧道2号竖井工程,且与经验方法对比.为了分析预测过程的不确定性和估计岩爆发生概率,采用蒙特卡洛模拟进行抽样仿真,并通过Spearman秩相关系数衡量输入指标的全局敏感性.研究结果表明:输入指标在不同的岩爆案例的影响程度差异较大且方向不同;5个岩爆案例的发生概率在40.8%~70.1%之间.该模型表现出优异的预测分类性能,可为深埋地下工程岩爆预测提供参考.

关键词：岩石力学岩爆预测 D-S证据理论模糊物元 K均值

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Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms

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Neuroprotection 2024年第1期2卷 16-32页

作者： Yang Zhu Lingyi Liao Shihao Gao yong tao Hao Huang Xiangqin Fang Changyan Yuan Changyue Gao Department of Rehabilitation Medicine Daping HospitalArmy Medical UniversityChongqingChina Department of Rehabilitation Medicine General Hospitalof SouthernTheatre Command of PLAGuangzhouChina

Alzheimer's disease(AD)is a prevalent neurodegenerative disorder characterized by gradual deterioration of cognitive functions,for which an effective treatment is currently *** transcranial magnetic stimulation(rTMS),a well-established noninvasive brain stimulation method,is utilized in clinical settings to address various neuropsychiatric conditions,such as depression,neuropathic pain,and poststroke *** evidence suggests that rTMs may enhance cognitive abilities in individuals with ***,its optimal therapeutic protocols and precise mechanisms are currently unknown,impeding its clinical *** the present review,we aimed to summarize and discuss the efficacy-related parameters in rTMs treatment,encompassing stimulus frequency,stimulus pattern,stimulus intensity,and the configuration of the stimulus ***,we reviewed promising rTMS therapeutic protocols involving various combinations of these factors,that were examined in clinical *** on our analysis,we propose that a multisite high-frequency rTMS(HF-rTMS)regimen has value in AD therapy,and that promising single-site protocols,such as HF-rTMS,applied over the left dorsolateral prefrontal cortex,precuneus,or cerebellum are required to be validated in larger clinical ***,we provide a comprehensive review of the potential mechanisms underlying the neuroprotective effects of rTMS on cognition in AD in terms of brain network modulation as well as cellular and molecular *** conclusion,the interaction of diverse mechanisms may be responsible for the total therapeutic effect of rTMS on *** review provides theoretical and practical evidence for the future clinical application and scientific research of rTMS in AD.

关键词： Alzheimer's disease cognitive improvement molecular mechanism neuroprotection repetitive transcranial magnetic stimulation synaptic plasticity

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A survey of composite robot for aviation intelligent manufacturing application

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High Technology Letters 2024年第1期30卷 85-98页

作者：陶永 XUE Jiao WEI Hongxing LIU Haitao GAO He WANG Tianmiao School of Mechanical Engineering&Automation Beihang UniversityBeijing 100191P.R.China Research Institute of Aero Engine Beihang UniversityBeijing 100191P.R.China

With the rapid development of the aviation industry,the development of intelligent manufacturing equipment represented by composite robots has been paid close attention by the aviation *** on the analysis of the background and main structure function of composite robots,this paper focuses on the analysis of key technologies such as composite robot hardware design,visual sensing and planning system,integrated control of‘hands,feet,and eyes',multi-robot collaborative operation,and *** typical applications of composite robots in aviation intelligent manufacturing such as automatic drilling and connection of aircraft,aircraft surface spraying and finishing,parts handling,aircraft measurement,and inspection are *** development trends such as standardization of composite robots,integration of‘5G+cloud computing+AI',and fusion of intelligent sensors are proposed.

关键词： aviation manufacturing composite robot key technology development trend safety

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教师“变革恐惧”的表征、生成与化解

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教学与管理 2024年第12期 5-9页

作者：李永涛华东师范大学教育学系上海200062

“变革恐惧”是教师面对变革而产生的焦虑和不安的情绪体验,这种情绪体验往往是消极的,会直接影响学校变革的成效。教师“变革恐惧”在实践中表现为恐惧被校长问责、恐惧自身能力不足、恐惧变革的不确定性和恐惧人际关系中的沟通。从归... 详细信息

“变革恐惧”是教师面对变革而产生的焦虑和不安的情绪体验,这种情绪体验往往是消极的,会直接影响学校变革的成效。教师“变革恐惧”在实践中表现为恐惧被校长问责、恐惧自身能力不足、恐惧变革的不确定性和恐惧人际关系中的沟通。从归因视角分析教师“变革恐惧”的形成机理,发现教师对自身能力的怀疑是其内因,变革的不确定性、新技术的介入和“理论文化”对“实践文化”的漠视是其外因。可以从学校、学校与教师的互动、教师个体三个层面化解教师“变革恐惧”,进而使学校变革得以实现。加强变革主体间的沟通,从“问责”到“能力建设”;营造校园“学习文化”,形成“变革合力”;在行动中学习,将变革视为“学习经历”。

关键词：教师变革恐惧学校变革变革文化变革合力

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习近平文化思想的辩证逻辑

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中南民族大学学报（人文社会科学版） 2024年第6期44卷 1-10,181页

作者：高晓林梁永涛复旦大学马克思主义学院上海200433

作为习近平新时代中国特色社会主义思想的文化篇,习近平文化思想蕴含着极富哲学特质的辩证逻辑:在发展立场层面,它坚持党对宣传思想文化工作的全面领导,文化为民、文化靠民、文化惠民、文化利民,凝聚文化强国建设与民族伟大复兴的精神伟... 详细信息

作为习近平新时代中国特色社会主义思想的文化篇,习近平文化思想蕴含着极富哲学特质的辩证逻辑:在发展立场层面,它坚持党对宣传思想文化工作的全面领导,文化为民、文化靠民、文化惠民、文化利民,凝聚文化强国建设与民族伟大复兴的精神伟力,体现了党性与人民性的辩证统一;在发展要素层面,它全盘思考“总”与“分”,统筹兼顾“一”与“多”,科学把握“主”与“次”,体现了全面性与重点性的辩证统一;在发展过程层面,它遵循批判继承与创新发展有机结合的主线基调、问题导向与体用贯通并驾齐驱的脉络演进、长期建设与曲折发展相互依存的趋势表征,体现了守正性与创新性的辩证统一;在发展语境层面,它注重走自己的路与融入世界全面联通,在深化交流互鉴中开创全球文明发展新格局,体现了民族性与世界性的辩证统一。深刻领会习近平文化思想蕴含的辩证逻辑,对于深入推动文化繁荣发展,铸就社会主义文化新辉煌具有重要意义。

关键词：习近平文化思想 “两个结合” 中华民族现代文明辩证逻辑

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