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Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： wen YANG BIN tang DAN XU wenXIU YANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

Modified Da-Cheng-Qi Decoction reduces intra-abdominal hypertension in severe acute pancreatitis： a pilot study

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Chinese Medical Journal 2012年第11期125卷 1941-1944页

作者： WAN Mei-hua LI Juan HUANG Wei Rajarshi Mukherjee GONG Han-lin XIA Qing ZHU Lin CHENG Gui-lan tang wen-fu Pancreatic Diseases Research Group Department of Integrated Traditional and Western Medicine West China Hospital Sichuan University Chendu Sichuan 610064 China Liverpool NIHR Pancreas Biomedical Research Unit Royal Liverpool University Hospital University of Liverpool Liverpool L69 3BX UK

Background Intra-abdominal hypertension （IAH） is a recognized prognostic marker for severity of severe acute pancreatitis （SAP） and has a strong impact on the clinical course of SAP. Previous studies indicate that a Da-Cheng-Qi Decoction （DCQD） is beneficial in the treatment of SAP. The purpose of this study was to evaluate the effect of modified DCQD on IAH in patients with SAP. Methods Between January 2008 and December 2008, 42 patients from the West China Hospital were randomized into either the DCQD or control group （n=21 in each group）. Mortality, intra-abdominal pressure （lAP）, Acute Physiology and Chronic Health Evaluation II （APACHE II） score, C-reactive protein （CRP）, oxygenation index, Balthazar CT score, rate of renal failure, decompression rate, intensive care unit （ICU） transfer rate, and length of hospital stay （LOS） were compared between the two groups. Results Compared to the control group, the modified DCQD treatment significantly decreased lAP （P 〈0.05） and APACHE II （P 〈0.05） scores on days 4-8, CRP on day 8 （P 〈0.01）, renal failure rate （P 〈0.05）, and LOS （P 〈0.05）. The oxygenation index was significantly improved in the DCQD group compared with the control group （P 〈0.05）. No significant differences in the Balthazar CT score, shock rate, ICU transfer rate, or mortality occurred between the two groups. Conclusions The modified DCQD can effectively relieve IAH and decrease LOS for patients with SAP. Larger clinical trials are needed to confirm these findings.

关键词： severe acute pancreatitis randomized, controlled trial, Da-Cheng-Qi Decoction, intra-abdominal hypertension

基于自组织临界理论的岩石声发射能量与时间的统计分析

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岩土力学 2022年第9期43卷 2525-2538页

作者：孙冰唐文福曾晟侯珊珊方耀楚南华大学土木工程学院湖南衡阳421001 南华大学资源环境与安全工程学院湖南衡阳421001 中国矿业大学深部岩石力学与地下工程国家重点实验室江苏徐州221000

自组织临界理论为无序和非线性复杂系统的行为特征和演化模式提供了新的解释,基于该理论探讨岩石破裂演化的规律。考虑到体型对其破坏特征的影响,制作了立方体和圆柱体两种体型岩石试件,开展单轴压缩和声发射试验,分析岩石破裂演化过程... 详细信息

自组织临界理论为无序和非线性复杂系统的行为特征和演化模式提供了新的解释,基于该理论探讨岩石破裂演化的规律。考虑到体型对其破坏特征的影响,制作了立方体和圆柱体两种体型岩石试件,开展单轴压缩和声发射试验,分析岩石破裂演化过程中自组织临界点前后的声发射信息,根据声发射能量概率密度、声发射空间定位及等候时间的分布,对临界指数k、余震分布指数α和等候时间分布指数δ等参数进行统计。结果表明:不论是立方体还是圆柱体试样,其破坏过程均是一个由低能值的无序稳定态向高能值的有序非稳定态发展的自组织过程,体型对其破坏的自组织过程影响较小,立方体试件相对圆柱体试件,前者从受压到自组织第一临界点(体积膨胀起始点)的持续时间相对较久,且由第一到第二临界点(峰值强度点)的自组织演化过程更迅速,其破坏更具规律性,破坏预测优于后者;立方体试件在受压过程中趋于多向应力状态,对岩石内部裂缝的发展具有一定的限制作用,破裂全过程的临界指数较大,圆柱体试件的局部屈服弱化特征较明显,在受压作用下更容易导致裂隙的发展,破裂全过程的临界指数较小;对于岩石的Omori定律分布统计指数α,立方体试件破裂自组织演化过程中第二阶段声发射余震分布的α值大于1,而圆柱体试件的α值小于1,表明立方体试件在第二临界点出现前已进入了临界失稳状态;在大的等候时间差范围内(>0.1s),试件破裂自组织演化过程第二阶段的临界指数相对第一阶段较大,意味着新裂纹出现的频率随着破裂的自组织演化而加剧,声发射能量的临界特征可以较好反映岩石破裂过程中的内部响应。

关键词：岩石破裂过程自组织临界性声发射能量幂律分布临界指数

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo Li fu tang Jingkai Zhang Yuetong Kang Hean Zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

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荒漠孑遗植物裸果木的花部特征及繁育系统

生态学杂志 2016年第10期35卷 2592-2598页

作者：李新蓉唐欣付文洁新疆农业大学草业与环境学科学学院新疆土壤与植物生态过程重点实验室乌鲁木齐830052

裸果木是亚洲中部荒漠区少有的第三纪孑遗物种,也是构成石质荒漠植被群落的重要建群种之一,由于人为干扰,其自然种群处于不断衰退中。本文通过野外观察和人工授粉实验等方法,对裸果木的花部特征及繁育系统进行研究,对于揭示该物种生活... 详细信息

裸果木是亚洲中部荒漠区少有的第三纪孑遗物种,也是构成石质荒漠植被群落的重要建群种之一,由于人为干扰,其自然种群处于不断衰退中。本文通过野外观察和人工授粉实验等方法,对裸果木的花部特征及繁育系统进行研究,对于揭示该物种生活史特征并探讨影响其生殖成功的因素及制定相应的保护和管理策略具有重要意义。结果表明:裸果木为两性花,花小,无花瓣,雄蕊10枚,外轮5枚雄蕊败育,胚珠1枚,开花盛期有少量花蜜并散发浓烈难闻气味,花粉活力和柱头可授性之间存在46 h的重叠期,且不完全雌性先熟,柱头和花药在多数花的单花花期结束时并未接触,因此,裸果木花主要表现为适应异花传粉的雌雄异位特征;花粉/胚珠比(P/O)为1371.67±236.21,异交系数(OCI)为3;不同花粉来源(自然授粉、自花授粉、同株异花和异株异花授粉)的花粉在柱头上均能萌发,但花粉管生长速度存在差异,同株异花授粉和异株异花授粉的花粉管生长速度较快,自花授粉的花粉管生长速度最慢且部分花粉管(43%)在到达子房时停止生长,并未到达胚珠;人工套袋实验的结果表明,裸果木不存在无融合生殖,自然结种子数低,自然授粉花的种子数远远低于人工异株异花授粉花,说明存在由于异花传粉者不足造成的传粉限制。裸果木部分雌性先熟和雌雄异位是两性花为避免雌雄功能重叠,促进异交而采取的一种花部机制,其繁育系统为兼性异交类型且需要传粉者,部分自交不亲和和传粉限制是影响该物种有性生殖成功的主要因素。

关键词：裸果木花粉胚珠比异交系数花粉活力花粉管生长

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu wen-Qiang Xu Ying-Tong Di Man-Cheng tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai fu Zhiyi Wei Ai-Hui tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang tang Daochen wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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下穿铁路框构桥顶进施工技术

建材世界 2019年第2期40卷 27-30页

作者：唐文夫中交第二航务工程局有限公司第五工程分公司武汉430000

结合唐廊高速公路唐山段桥顶施工工程实例,介绍了框架桥顶进施工技术。鉴于该框架结构的施工难度和技术的复杂性,论文反复研究和优化了施工方案,并制定了一系列有效措施。采用了多项新技术,顶进施工工作顺利完成。

关键词：大跨度框构桥施工技术