Modified Da-Cheng-Qi Decoction reduces intra-abdominal hypertension in severe acute pancreatitis： a pilot study

作     者：WAN Mei-hua LI Juan HUANG Wei Rajarshi Mukherjee GONG Han-lin XIA Qing ZHU Lin CHENG Gui-lan TANG Wen-fu 

作者机构：Pancreatic Diseases Research Group Department of Integrated Traditional and Western Medicine West China Hospital Sichuan University Chendu Sichuan 610064 China Liverpool NIHR Pancreas Biomedical Research Unit Royal Liverpool University Hospital University of Liverpool Liverpool L69 3BX UK 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2012年第125卷第11期

页      面：1941-1944页

核心收录：

学科分类：090603[农学-临床兽医学] 12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 08[工学] 09[农学] 0906[农学-兽医学] 081201[工学-计算机系统结构] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：This study was supported by a grant from the National Natural Science Foundation of China (No. 30801457) 

主　　题：severe acute pancreatitis randomized, controlled trial, Da-Cheng-Qi Decoction, intra-abdominal hypertension 

摘      要：Background Intra-abdominal hypertension （IAH） is a recognized prognostic marker for severity of severe acute pancreatitis （SAP） and has a strong impact on the clinical course of SAP. Previous studies indicate that a Da-Cheng-Qi Decoction （DCQD） is beneficial in the treatment of SAP. The purpose of this study was to evaluate the effect of modified DCQD on IAH in patients with SAP. Methods Between January 2008 and December 2008, 42 patients from the West China Hospital were randomized into either the DCQD or control group （n=21 in each group）. Mortality, intra-abdominal pressure （lAP）, Acute Physiology and Chronic Health Evaluation II （APACHE II） score, C-reactive protein （CRP）, oxygenation index, Balthazar CT score, rate of renal failure, decompression rate, intensive care unit （ICU） transfer rate, and length of hospital stay （LOS） were compared between the two groups. Results Compared to the control group, the modified DCQD treatment significantly decreased lAP （P 〈0.05） and APACHE II （P 〈0.05） scores on days 4-8, CRP on day 8 （P 〈0.01）, renal failure rate （P 〈0.05）, and LOS （P 〈0.05）. The oxygenation index was significantly improved in the DCQD group compared with the control group （P 〈0.05）. No significant differences in the Balthazar CT score, shock rate, ICU transfer rate, or mortality occurred between the two groups. Conclusions The modified DCQD can effectively relieve IAH and decrease LOS for patients with SAP. Larger clinical trials are needed to confirm these findings.