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2005年全国疟疾形势

中国寄生虫学与寄生虫病杂志 2006年第6期24卷 401-403页

作者：周水森王漪汤林华中国疾病预防控制中心寄生虫病预防控制所世界卫生组织血吸虫病疟疾和丝虫病合作中心上海200025

Totally,42 319 malaria cases and 57 787 suspected cases with 48 deaths were reported by the Annual Case Repor-ting System in 1186 counties of 21 Provinces/Municipality/Autonomous Region(P/M/A) in 2005,and the annual incidence was 0.59/10 000,an increase of 55.3% than that of the last *** the Case Reporting Information System,an internet reporting process started in 2004,40 371 malaria cases were reported from 1 075 counties of 31 P/M/*** number of malaria cases and the rank of P/M/A were basically in concordance by the two *** the 1186 counties with reported malaria cases,27 counties had an incidence of more than 10/10 000 distributed in Yunnan(15 counties),Hainan(7 counties) and Anhui(5 counties).There were 80 counties in which the malaria incidence was between 1/10 000 and 10/10 *** number of Plasmodium falciparum malaria cases was 4 146,accounting for 9.8% of the total cases,of which 63.5%(2 632) were imported cases in 178 counties/cities of 18 P/M/*** falciparum malaria was found in 47 counties/cities of Yunnan and Hainan Provinces,of which 31 counties/cities were in Yunnan,increased by 29,16 counties/cities were in Hainan,same with that of *** and Hainan Provinces are still relatively high transmission *** ranked No.2 in the country in terms of the number of cases while Hainan ranked No.1 by malaria incidence in 2005.19 588 malaria cases were reported from the two provinces in 2005,accounting for 46.3% of the total reported cases in the *** were 15 072 cases with 38 deaths reported from Yunnan,the incidence was 4.95/10 000,an increase of 60.2% than that in the last *** the reported cases,3 497 were falciparum malaria with 69.0% imported from the bordering *** number of reported cases in Hainan was 4 516,with an incidence of 5.46/10 000,53.1% decrease than the last *** central China,the resurgence of malaria was considerable in provinces along the huai River,especially in Anhui Provi

关键词：中国疟疾病例报告

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Deciphering the role of mtH_(2)O_(2) in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding PanPan Li Bo Peng hua Bai lin Li Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China

Hepatic ischemia-reperfusion injury(HIRI)is characterized by mitochondrial dysfunction and oxidative *** mitochondrial hydrogen peroxide(mtH_(2)O_(2))levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during ***,low-background fluorogenic probes have been overlooked in the context of super-resolution *** this study,we developed a low-background fluorogenic probe(MitoWG)with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH_(2)O_(2)in *** of the desirable fluorescence properties of the probe by mtH_(2)O_(2)was confirmed using structural illumination microscopy(SIM),enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH_(2)O_(2)levels were successfully observed in both cellular and rat models of ***,we associated the decline in mitochondrial redox homeostasis with accelerated mtH_(2)O_(2)production during HIRI,which triggered mitophagy deficiency and led to cell *** conclusion,Mito-WG possesses excellent photophysical and low-background properties for SIM imaging,making it a promising tool for mtH_(2)O_(2)tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH_(2)O_(2)-activatable super-resolution imaging fluorogenic probe

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Isothermal reduction kinetics and reduction prediction for iron ore pellets

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Journal of Iron and Steel Research International 2025年第1期32卷 64-72页

作者： Fei Meng Hao Liu Yue-lin Qin huang-jie hua Yin Deng Ze-zheng Sun Long-hai Liu School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing401331China CISDI Group Co. Ltd.Chongqing401122China College of Materials Science and Engineering Chongqing UniversityChongqing400044China Sichuan Desheng Group Vanadium&Titanium Co. Ltd.Leshan614000SichuanChina

Iron ore pellets,as one of the main charges of blast furnaces,have a greater impact on the CO_(2)emission reduction and stable operation of blast *** isothermal reduction behavior of the pellets obtained from a Chinese steel plant was studied in the gas mixtures of CO and N_(2).The results showed the reduction process is divided into two *** reduction in the initial stage(time t≤40 min)is cooperatively controlled by internal diffusion and interface chemical reactions with the activation energy of 30.19 and 16.67 kJ/mol,*** controlling step of the reduction in the final stage(t>40 min)is internal diffusion with the activation energy of 34.60 kJ/*** reduction process can be described by two equations obtained from kinetic *** reduction degree can be predicted under different temperatures and time,and the predicted results showed an excellent correlation with the experimental *** reduction mechanisms were confirmed by the analysis of the scanning electron microscope equipped with an energy dispersive spectrometer and optical microscope.

关键词： Pellet Reduction behavior Kinetics Mechanism Reduction prediction

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二轴低周疲劳载荷下船体裂纹板累积塑性与断裂性能分析

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船舶力学 2022年第1期26卷 113-124页

作者：熊康邓军林裴志勇汤华林涂雯羚武汉理工大学交通学院武汉430063 北部湾大学机械与船舶海洋工程学院广西钦州535011

恶劣海况中在多轴高应力、低循环交变载荷作用下,船体结构不仅会出现多轴低周疲劳破坏,而且还存在着明显的累积塑性破坏。应变强度因子ΔK_(ε)、J积分是评估船体结构二轴低周疲劳裂纹扩展断裂失效的重要控制参数。本文重点研究了二轴... 详细信息

恶劣海况中在多轴高应力、低循环交变载荷作用下,船体结构不仅会出现多轴低周疲劳破坏,而且还存在着明显的累积塑性破坏。应变强度因子ΔK_(ε)、J积分是评估船体结构二轴低周疲劳裂纹扩展断裂失效的重要控制参数。本文重点研究了二轴低周疲劳载荷作用下船体裂纹板的累积塑性规律以及二轴低周疲劳裂纹断裂参数。利用有限元数值模拟分析了二轴低周疲劳载荷下不同平均应力、应力幅和二轴应力比等相关因素对应变强度因子、J积分的影响,为正确评估船体裂纹板二轴低周疲劳裂纹扩展断裂行为提供了基础。

关键词：船体结构二轴低周疲劳累积塑性应变强度因子 J积分

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恶性疟原虫药物抗性相关的分子标记及其在药物抗性监测中的应用

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中国寄生虫学与寄生虫病杂志 2005年第2期23卷 117-120页

作者：官亚宜(综述) 汤林华(审校) 中国疾病预防控制中心寄生虫病预防控制所世界卫生组织疟疾血吸虫病和丝虫病合作中心上海200025

疟疾仍是全球的一个重要公共卫生问题.在很多地区,由于恶性疟原虫对常用的抗疟药物产生了抗性,使得恶性疟治疗和预防措施的有效性受到限制.抗性问题已对疟疾流行国家的疟疾控制产生重要的影响.50多年前,在泰缅边境和哥伦比亚出现了氯喹... 详细信息

疟疾仍是全球的一个重要公共卫生问题.在很多地区,由于恶性疟原虫对常用的抗疟药物产生了抗性,使得恶性疟治疗和预防措施的有效性受到限制.抗性问题已对疟疾流行国家的疟疾控制产生重要的影响.50多年前,在泰缅边境和哥伦比亚出现了氯喹抗性.目前,氯喹的抗性几乎遍布恶性疟流行区.恶性疟原虫虫株几乎对所有常用的抗疟药都产生了抗性[1].药物抗性的出现促进了确定恶性疟原虫对药物的敏感性/抗性方法的发展.过去仅有体内和体外测试方法.分子生物学技术的迅猛发展为确定疟原虫药物抗性的遗传学基础提供了新的、方便、快捷的研究工具.近年,不少学者研究了与恶性疟原虫对药物抗性相关的分子标记,描述了其生物学特性及在流行病学、抗性监测上的意义.……

关键词：恶性疟原虫抗性监测分子标记药物抗性相关公共卫生问题预防措施氯喹抗性哥伦比亚疟疾药物产性问题流行区抗疟药

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B2-CuZr reinforced amorphous alloy matrix composites:A review

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China Foundry 2025年第1期22卷 1-11页

作者： Wei Guo Run-hua huang Zhen Zhang Mi Zhao Jin-cheng Wang Yan-qiang Qiao Shu-lin Lü Shu-sen Wu State Key Lab of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China School of Aerospace Engineering Huazhong University of Science and TechnologyWuhan 430074China Research Institute of huazhong University of Science and Technology in Shenzhen Shenzhen 518057GuangdongChina

B2-CuZr phase reinforced amorphous alloy matrix composites has become one of the research hotspots in the field of materials science due to the“transformation-induced plasticity”phenomenon,which makes the composites show better macroscopic plastic deformability and obvious work-hardening behavior compared to the conventional amorphous alloy matrix composites reinforced with ductile ***,the in-situ metastable B2-CuZr phase tends to undergo eutectoid decomposition during solidification,and the volume fraction,size,and distribution of B2-CuZr phase are difficult to control,which limits the development and application of these *** date,much efforts have been made to solve the above problems through composition optimization,casting parameter tailoring,and post-processing *** this study,a review was given based on relevant studies,focusing on the predictive approach,reinforcing mechanism,and microstructure tailoring methods of B2-CuZr phase reinforced amorphous alloy matrix *** research focus and future prospects were also given for the future development of the present composite system.

关键词： amorphous alloy matrix composite B2-CuZr phase plasticity microstructure tailoring

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中华按蚊对3种细菌的产卵反应

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中国媒介生物学及控制杂志 2010年第2期21卷 102-104页

作者：李美汤林华中国疾病预防控制中心寄生虫病预防控制所卫生部寄生虫病原与媒介生物学重点实验室世界卫生组织疟疾血吸虫病和丝虫病合作中心上海200025

目的具吸引作用的细菌或其挥发物能提高按蚊与杀虫或抗疟工程细菌接触的机会,为此,拟测定中华按蚊对A4细菌(未鉴定)、气单胞菌和肠杆菌的产卵反应特性,以明确3种细菌对中华按蚊是否具有吸引特性,为应用这3种细菌开展阻断疟疾传播研究提... 详细信息

目的具吸引作用的细菌或其挥发物能提高按蚊与杀虫或抗疟工程细菌接触的机会,为此,拟测定中华按蚊对A4细菌(未鉴定)、气单胞菌和肠杆菌的产卵反应特性,以明确3种细菌对中华按蚊是否具有吸引特性,为应用这3种细菌开展阻断疟疾传播研究提供理论和实验依据。方法已交配雌按蚊吸饱血48～60h后,将含不同细菌的滤纸产卵器放入蚊笼中供按蚊产卵。保持黑暗12h,待按蚊产卵后计数产卵器中按蚊卵的数量,应用成对t检验法比较中华按蚊在不同处理的产卵器中产卵量的差异。结果中华按蚊在含肠杆菌产卵器中的产卵量最多,在含A4菌和气单胞菌的产卵器中的产卵量明显低于对照和含肠杆菌的产卵器中的产卵量,P值分别为0.026、0.012、0.048和0.016;含肠杆菌的产卵器中的按蚊卵数量略高于对照,但差异无统计学意义(P>0.05)。结论中华按蚊产卵时对A4菌和气单胞菌具有明显的负趋性,而对肠杆菌仅具有微弱的趋向性,推测这3种细菌可能不是中华按蚊食物的优先选择,但具有在蚊中肠内较为稳定存活的可能性,因此更适合于作为蚊幼生物杀虫基因的寄主细胞和仿转基因按蚊抗疟基因的寄主细胞被应用。

关键词：中华按蚊产卵反应产卵器负趋性寄主细胞成对t测验

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检测4种人体疟原虫多重PCR体系的建立和应用

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中国寄生虫学与寄生虫病杂志 2015年第2期33卷 91-95页

作者：李美夏志贵汤林华中国疾病预防控制中心寄生虫病预防控制所卫生部寄生虫病原与媒介生物学重点实验室世界卫生组织疟疾血吸虫病和丝虫病合作中心上海200025

目的应用新建的多重PCR体系检测4种人体疟原虫。方法应用DNAman软件比较分析4种人体疟原虫的18S rDNA基因序列，采用Oligo 6.0软件，在其第5和第6保守区间的变异区设计4条下游引物序列，并以含4种疟原虫18S rDNA部分序列的质粒DNA为... 详细信息

目的应用新建的多重PCR体系检测4种人体疟原虫。方法应用DNAman软件比较分析4种人体疟原虫的18S rDNA基因序列，采用Oligo 6.0软件，在其第5和第6保守区间的变异区设计4条下游引物序列，并以含4种疟原虫18S rDNA部分序列的质粒DNA为模板，检测多重PCR体系的特异性和敏感性。此外，将新建的多重PCR体系与NP-1993体系的第1轮属特异引物组合，形成新的巢式PCR扩增体系（M-Nest体系），并用该体系和新建的多重PCR体系对不同稀释倍数的恶性疟和间日疟患者血样DNA进行扩增，检测这两种体系的敏感性。应用M-Nest体系和NP-1993体系检测广西2013年自加纳疟疾高流行区返乡人员的307份血样，比较两者的检测结果是否一致。最后，应用M-Nest和NP-2002体系对广西2014年1～5月份报告的66份镜检以卵形疟原虫感染为主的血样进行复核，比较两者的检测结果是否一致。结果应用新建的多重PCR体系得到的恶性疟原虫、三日疟原虫、卵形疟原虫和间日疟原虫的扩增片段大小分别为268、446、394和323 bp，且不同原虫的扩增条带恰好位于50 bp DNA标志物条带之间，更易于区分，但不同疟原虫的Tm值较为接近，不易区分和鉴别虫种。新建体系对4种疟原虫18S rDNA基因的最低检出浓度分别为：恶性疟原虫5.58×102 拷贝/μl，三日疟原虫1.56×103 拷贝/μl，卵形疟原虫1.66×103 拷贝/μl，间日疟原虫1.80×102 拷贝/μl。新建体系对恶性疟原虫血样的最低检测浓度为1.43×102～8.84×103 拷贝/μl或5.10×10～4.92×102个原虫/μl，高于间日疟原虫的17.4～69.1 拷贝/μl和13.5～83.2个原虫/μl。与单独的多重PCR体系相比，应用M-Nest检测体系将对疟原虫的最低检测浓度降低了10～100倍。M-Nest体系和NP-1993体系对从加纳返乡的307份血样的检测结果不一致，并且M-Nest体系还检测到2例卵形疟原虫感染，而NP-1993体系则未能检测到该感染。此外，M-Nest体系和NP-2002体系对66份镜检以卵形疟原虫感染为主的血样的复核结果一致。结论新建的多重PCR检测体系可同时检测4种人体疟原虫，具有良好的现场适用性。

关键词：多重PCR 巢式PCR 卵形疟原虫wallikeri亚种

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2006年全国疟疾形势

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中国寄生虫学与寄生虫病杂志 2007年第6期25卷 439-441页

作者：周水森王漪汤林华中国疾病预防控制中心寄生虫病预防控制所世界卫生组织疟疾血吸虫病和丝虫病合作中心上海200025

本文根据2006年全国有疟疾发病的23个省（市、区）专业单位上报的年度疟疾防治工作总结和有关疫情报表（年报系统）汇总整理，除特别注明“网络直报系统”外，所有疫情数据均来自年报系统。

关键词：中国疟疾报告病例

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2003年全国疟疾形势

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中国寄生虫学与寄生虫病杂志 2005年第6期23卷 385-387页

作者：周水森汤林华盛慧锋中国疾病预防控制中心寄生虫病预防控制所上海200025

Total 40 681 malaria cases and 129 147 suspected cases with 52 deaths were reported by the case reporting system in 910 counties of 21 Provinces/Municipality/Autonomous Region(P/M/A) in 2003,and the annual incidence was 0.39/10 000,an increase of 15.3% than that of the last year,which is the third year that malaria incidence consecutively increased since *** on a baseline survey in the project funded by the Global Fund to Fight AIDS,Tuberculosis and Malaria(GFATM),the estimated number of malaria cases was about 740 000 in 2003,18 times more than reported. Among the 910 counties with reported malaria cases,29 counties with an incidence more than 10/10 000 distributed in Yunnan(17 counties),Hainan(9),Anhui(1),Hubei(1) and Henan(1).There were 69 counties in which the malaria incidence was between 1/10 000 and 10/10 000. The number of Plasmodium falciparum malaria cases was 4 727,accounting for 11.6% of the total cases,of which 13.1%(621) were imported cases reported in 107 counties/cities of 16 P/M/*** falciparum malaria was found in 78 counties/cities of Yunnan and Hainan Provinces,of which 64 counties/cities were in Yunnan,increased by 22,14 counties/cities were in Hainan,decreased by 2 compared to that of 2002. Yunnan and Hainan are still the relatively high transmission *** has ranked No.1 in the country in terms of the number of cases while Hainan ranked No.1 by malaria incidence in recent years.21 788 malaria cases were reported from the two provinces in 2003,accounting for 53.6% of the total reported cases in the *** were 15 431 cases with 43 deaths reported from Yunnan,the incidence was 4.24/10 000,with an increase of 26.3% than that in the last *** the reported cases,3 529 were falciparum malaria,increased by 22.9% in comparison to *** number of reported cases in Hainan was 6 357,with an incidence of 7.94/10 000,19.6% increase than the last year. In central China,the re,emergence of malaria was considerable in pro

关键词：疟疾病例报告局部爆发发病数不同程度出现上升安徽云南湖北

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