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Reduced Macular Vascular Density in Myopic Eyes

Chinese Medical Journal 2017年第4期130卷 445-451页

作者： hua Fan Hao-Yu Chen Hong-Jie Ma Zheng Chang Hai-Quan Yin Danny Siu-Chun Ng Carol Y Cheung Shan Hu Xiang Xiang Shi-Bo tang Shuang-Nong Li Aier School of Ophthalmology Central South University Changsha Hunan 410015 China Joint Shantou International Eye Center Shantou Guangdong 515000 China Shenzhen Aier Eye Hospital Shenzhen Guangdong 518000 China Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong 999077 China

Background： Morphological changes of the vasculature system in patients with myopia have been observed by Doppler ultrasound and fundus fluorescein angiography （FFA）; however, these studies have limitations. Doppler ultrasound provides low-resolution images which are mainly obtained from visualized large vessels, and FFA is an invasive examination. Optic coherence tomography （OCT） angiography is a noninvasive, high-resolution measurement for vascular density. The purpose of this study was to investigate the change of vascular density in myopic eyes using OCT angiography. Methods： This cross-sectional study includes a total of 91 eyes ~Yom 47 participants including control, moderate, and high myopia that were evaluated by OCT angiography. Patients with myopia were recruited from the Refractive Department, Shenzhen Aier Eye Hospital, from August 5, 2015 to April 1, 2016. Emmetropic eyes were from healthy volunteers. The vascular density at macula and optic disc regions, ganglion cell complex （GCC） thickness, and retinal nerve fiber layer （RNFL） thickness were measured. Their relationships with axial length （AL） and refractive error were analyzed. One-way analysis of variance （ANOVA）, Pearson＇s correlation, and generalized estimating equation were used for statistical analysis, Results： Both superficial and deep macular vascular density were highest in control （25.64% ± 3.76% and 37.12% ± 3.66%, respectively）, then in moderate myopia （21.15% ± 5.33% and 35.35% ± 5.50%, respectively）, and lowest in high myopia group （ 19.64% ± 3.87% and 32.81% ± 6.29%, respectively）（F =13.74 and 4.57, respectively; both P 〈 0.001）. Both superficial （β = -0.850 and 0.460, respectively） and deep （β = -0.766 and 0.396, respectively） macular vascular density were associated with AL and spherical equivalent （all P 〈 0.001 ）. Superficial macular vascular density was associated with GCC thickness （β = 0.244, P = 0.040）, independent of spherical equivalent. The vascular density in optic disc r

关键词： Myopia Optic Coherence Tomography Angiography Vascular Density

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一种HAP型高效缓蚀阻垢剂的研制及应用

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表面技术 2018年第1期47卷 149-153页

作者：高庆华陕西延长石油(集团)有限责任公司研究院西安710075 延长油田股份有限公司勘探开发技术研究中心陕西延安716000

目的通过对延长油田JX区块腐蚀结垢情况分析,针对性地研制并筛选缓蚀阻垢剂配方,获得阻垢、缓蚀效果最佳的HAP缓蚀阻垢剂。方法采用EDTA滴定法、称重法和腐蚀挂片分析技术,在温度为90℃时,对缓蚀阻垢剂的缓蚀效果和阻垢性能进行评价,通... 详细信息

目的通过对延长油田JX区块腐蚀结垢情况分析,针对性地研制并筛选缓蚀阻垢剂配方,获得阻垢、缓蚀效果最佳的HAP缓蚀阻垢剂。方法采用EDTA滴定法、称重法和腐蚀挂片分析技术,在温度为90℃时,对缓蚀阻垢剂的缓蚀效果和阻垢性能进行评价,通过反复对比分析,筛选配方,并进行了现场试验。结果与未添加缓蚀阻垢剂时相比,油井产出液分离水的腐蚀速率由0.125~0.161 mm/a下降到0.023~0.034 mm/a,缓蚀率达到了80%以上;混合结垢量由130~290 mg/L下降到7~15 mg/L,阻垢率达到了91%以上。结论应用EDTA滴定法、称重法和腐蚀挂片分析技术优选了缓蚀阻垢剂配方,在高温环境下,缓蚀阻垢剂综合性能优良,现场试验中的缓蚀阻垢效果显著。

关键词：油井腐蚀结垢碳酸钙缓蚀阻垢剂

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Comparison of transperitoneal and retroperitoneal laparoscopic living donor nephrectomy

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Chinese Medical Journal 2007年第24期120卷 2314-2316页

作者： gao Zhen-li WU Ji-tao LIU Yu-jie LIN Chun-hua WANG Lin SHI Lei MEN Chang-ping ZHANG Peng YANG Dian-dong WANG Ke Department of Urology Yantai Yuhuangding Hospital Yantai 264000 China

Since its introduction in 1995, laparoscopic living donor nephrectomy （LDN） has been shown to alleviate postoperative pain, shorten hospital stay, reduce loss and improve cosmesis while hastening the recovery of normal activities of donors. However, there has been much controversy over minimally invasive surgery with transperitoneal or retroperitoneal approach for nephrectomy. In this non-randomized retrospective study, we analyzed some parameters of the donors who had undergone transperitoneal LDN compared with those who had had retroperitoneoscopic nephrectomy.

关键词： kidney transplantation laparoscopy nephrectomy living donors

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***-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death

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Protein & Cell 2018年第12期9卷 1013-1026页

作者： Yang Li Yu Zhang Qiwen Gan Meng Xu Xiao Ding Guihua tang Jingjing Liang Kai Liu Xuezhao Liu Xin Wang Lingli Guo Zhiyang gao Xiaojiang Hao Chonglin Yang Department of Pharmacology Key Laboratory of Metabolism and Molecular Medicine (The Ministry of Education)School of Basic Medical ScienceFudan UniversityShanghai 200032China State Key Laboratory of Phytochemistry and Plant Resources in Western China Kunming Institute of BotanyChinese Academy of SciencesKunming 650021China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China The Key Laboratory of Chemistry for Natural Product of Guizhou Province Chinese Academy of ScienceGuiyang 550002China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Center for Life SciencesSchool of Life SciencesYunnan UniversityKunming 650091China

Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal abnormality using Caenorhabditis elegans (C. elegans) as a model system. A group of vobasinyl-ibogan type bisindole alkaloids (ervachinines A-D) were identified that caused lysosome enlargement in C. elegans macrophage-like cells. Intriguingly, these compounds triggered cell death in the germ line independently of the canonical apoptosis pathway. In mammalian cells, ervachinines A-D induced lysosomal enlargement and damage, leading to leakage of cathepsin proteases, inhibition of autophagosome degradation and necrotic cell death. Further analysis revealed that this ervachinine-induced lysosome damage and lysosomal cell death depended on STAT3 signaling, but not RIP1 or RIP3 signaling. These findings suggest that lysosome-damaging compounds are promising reagents for dissecting signaling mechanisms underlying lysosome homeostasis and lysosome-related human disorders.

关键词： Caenorhabditis elegans STAT3 alkaloids lysosomal cell death lysosome

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住宅市场博弈分析

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华中师范大学学报（人文社会科学版） 2008年第5期47卷 50-56页

作者：高炳华华中师范大学经济学院湖北武汉430079

本文运用博弈论分析方法研究了住宅市场中政府与开发商、开发商与经纪机构、开发商与购房者之间的关系,认为住宅市场是一个多主体参与者相互作用的过程,在这一过程中,任何参与者都会影响其他参与者的决策和行为,且又受到其他参与者决策... 详细信息

本文运用博弈论分析方法研究了住宅市场中政府与开发商、开发商与经纪机构、开发商与购房者之间的关系,认为住宅市场是一个多主体参与者相互作用的过程,在这一过程中,任何参与者都会影响其他参与者的决策和行为,且又受到其他参与者决策和行为的影响。因此,要使我国住宅市场健康有序发展,政府要规范住宅市场参与者行为,加大违规经营处罚力度;开发商要注重住宅质量,实施规模化和专业化战略;经纪机构要实施诚信经营,失信经营者必须承担高成本;购房者要广泛收集住宅市场交易信息,对住宅市场价格进行理性预期。

关键词：住宅市场参与者博弈分析

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为什么合声波成为了弥散极光形成的主因

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Science Bulletin 2024年第5期69卷 597-600页

作者：高新亮马玖琦邵同陈瑞柯阳光陆全明 Deep Space Exploration Laboratory School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Hefei 230026China

Earth’s diffuse aurora(structureless auroras,5-15 s pulsations and microbursts)occurs over a broad latitude range,which arises from the collision of energetic charged particles with atoms in the upper atmosphere[1].Diffuse aurora exists for most of the time,and intensifies during geo magnetically active periods[2].Although generally not visible to the naked eyes,it is the major source of energy input into the Earth’s nightside upper atmosphere[3].During magnetospheric substorms,~100 eV to 1 keV plasmasheet particles are injected into the midnight sector *** to the conservation of the particles’first two adiabatic invariants,the particles are energized to~10-100 keV energies.A mechanism that violates the first adiabatic invariant of electrons is required to scatter them to enter the atmospheric loss cone(a small cone of angle~3°wide at the equator)[4].

关键词： Earth latitude storm

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无创产前检测在胎儿性染色体异常筛查中的应用

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浙江医学 2024年第11期46卷 1147-1150页

作者：黄萍华唐萍周赤燕高丹苑黄轶敏王建国祝建军嘉兴市妇幼保健院胎儿医学中心 314000 嘉兴市妇幼保健院中心实验室 314000

目的探讨无创产前检测(NIPT)在胎儿性染色体异常筛查中的应用。方法回顾性选取2019年1月至2022年12月在嘉兴市妇幼保健院行NIPT提示性染色体异常且行介入性产前诊断的73例孕妇为研究对象,分析并比对NIPT与介入性产前诊断结果,同时分析N... 详细信息

目的探讨无创产前检测(NIPT)在胎儿性染色体异常筛查中的应用。方法回顾性选取2019年1月至2022年12月在嘉兴市妇幼保健院行NIPT提示性染色体异常且行介入性产前诊断的73例孕妇为研究对象,分析并比对NIPT与介入性产前诊断结果,同时分析NIPT与介入性产前诊断结果不一致情况。结果73例孕妇中,NIPT诊断性染色体增多34例,性染色体减少39例。71例行染色体核型分析的孕妇中,33例核型异常。65例行染色体微阵列分析的孕妇中,37例芯片结果异常。在NIPT提示性染色体增多的孕妇中,染色体核型分析与NIPT结果阳性符合率为69.70%;染色体微阵列分析与NIPT结果阳性符合率为70.00%。在NIPT提示性染色体减少的孕妇中,染色体核型分析与NIPT结果阳性符合率为23.68%,染色体微阵列分析与NIPT结果阳性符合率为20.00%。在NIPT提示性染色体异常的孕妇中,有1例染色体核型分析异常但与NIPT结果不一致,9例染色体微阵列分析异常但与NIPT结果不一致。在63例同时行染色体核型分析和染色体微阵列分析的孕妇中,26例与NIPT结果一致,37例与NIPT结果不一致(包括染色体核型分析和染色体微阵列分析均为阴性23例、染色体核型分析阴性但染色体微阵列分析阳性8例、染色体微阵列分析阴性但染色体核型分析阳性4例、染色体核型分析和染色体微阵列分析为染色体异常但结果不一致2例)。结论NIPT可作为胎儿性染色体异常的筛查方法,对于NIPT检出阳性者建议进一步行介入性产前诊断。

关键词：无创产前检测性染色体异常染色体核型分析染色体微阵列分析

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Novel human H7N9 influenza virus in China

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Integrative Zoology 2014年第3期9卷 372-375页

作者： Chengmin WANG Jing LUO Jing WANG Wen SU Shanshan gao Min ZHANG Li XIE hua DING Shelan LIU Xiaodong LIU Yu CHEN Yaxiong JIA Hongxuan HE National Research Center for Wildlife Borne Diseases Institute of ZoologyChinese Academy of SciencesBeijingChina Department of Infectious Diseases Hangzhou Center for Disease Control and PreventionHangzhouChina Department of Infectious Diseases Zhejiang Center for Disease Control and PreventionHangzhouChina Beijing Animal Husbandry and Veterinary Station BeijingChina

Outbreaks of H7N9 avian influenza in humans in 5 provinces and 2 municipalities of China have reawakened concern that avian influenza viruses may again cross species barriers to infect the human population and thereby initiate a new influenza *** analysis shows that human H7N9 influenza viruses originated from the H9N2,H7N3 and H11N9 avian viruses,and that it is as a novel reassortment influenza *** article reviews current knowledge on 11 subtypes of influenza A virus from human which can cause human infections.

关键词： China H7N9 human influenza virus

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Self-Adjusting Characterization for Steady-State, Direct Current Cathode-Dominated Glow Discharge Plasmas at High Pressures

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Chinese Physics Letters 2013年第8期30卷 107-109页

作者： DING Fang ZHENG Shi-Jian KE Bo tang Zhong-Liang ZHANG Yi-Chuan YANG Kuan XIE Xin-hua ZHU Xiao-Dong CAS Key Laboratory of Basic Plasma Physics Department of Modern PhysicsUniversity of Science and Technology of ChinaHefei 230026 Institute of Plasma Physics Chinese Academy of SciencesHefei 230031

A steady-state,direct-current high-pressure CH_(4)-H_(2) glow discharge in a cup-shaped cathode parallel to anode configuration is investigated by using their V–I characteristics and CCD *** discharges display an abnormal glow feature,and an expansion of a negative glow is observed on the cathode sidewall with the increasing discharge *** exists a dependence of voltage on gas pressure for different fixed *** voltage decreases with gas pressure initially,and then increases conversely,which is correlated with the glow states of the cathode *** study exhibits a self-adjusting characterization for plasmas in cathode fall,which is important for maintaining steady-state,abnormal glow discharge in a relatively high pressure range.

关键词： initially shaped Cathode

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Overview of point-of-care ultrasound in diagnosing intestinal obstruction

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World Journal of Emergency Medicine 2022年第2期13卷 135-140页

作者： Rui-ting Li Yue Zhao Xiao-jing Zou hua-qing Shu Ting Zhou Shang-wen Pan Xue-hui gao Hai-yan huang Hong Liu You Shang Department of Critical Care Medicine Institute of Anesthesia and Critical Care MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Critical Care Medicine Jin Yin-tan HospitalWuhan 430048China

Intestinal obstruction(IO),which refers to a partial or complete blockage of the intestine,is an emergency gastrointestinal disorder commonly seen in the intensive care unit(ICU)and emergency department and associated with high morbidity and mortality.[1,2]Common etiologies of IO include adhesions,hernias,intussusception,foreign bodies,ischemia,tumors,*** in the diagnosis and management of IO is associated with higher mortality due to complications such as bowel necrosis,perforation,sepsis,and septic shock.[3]IO can be divided into small bowel obstruction(SBO)and colonic obstruction(CO).In SBO,74%of cases are caused by adhesions,which may respond to conservative *** is critical to identify which of those cases may progress and require emergent surgical intervention with the help of the diagnostic and assessment *** contrast to SBO,most cases of CO demand *** this instance,appropriate assessment tools are required to define the location of the obstruction,which will assist in the proper surgical procedure.[4]

关键词： intestine diagnosis ischemia

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