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Inbreeding and genetic load in a pair of sibling grouse species:Tetrastes sewersowi and ***

Avian Research 2024年第2期15卷 265-270页

作者： Kai Song Tom van der Valk Bin gao Peter Halvarsson Yun Fang Wendong Xie Siegfried Klaus Zhiming Han Yue-hua Sun Jacob Hoglund Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China Animal Ecology Department of Ecology and GeneticsUppsala UniversityNorbyvagen 18DUppsala75236Sweden Department of Cell and Molecular Biology Uppsala75273Sweden Unit of Parasitology Department of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesPO Box 7036Uppsala75007Sweden Lindenhohe 5 JenaD-07749Germany The State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China

Genetic load and inbreeding are recognized as important factors to be considered in conservation *** levels of both can increase the risk of population extinction by negatively impacting fitness-related characters in many species of plants and animals,including humans(inbreeding depression).Genomic tech-niques are increasingly used in measuring and understanding genetic load and inbreeding and their importance in evolution and *** used whole genome resequencing data from two sibling grouse species in subarctic Eurasia to quantify *** found a large range of inbreeding measured as FROH(fraction of runs of homozygosity)in individuals from different populations of Chinese Grouse(Tetrastes sewerzowi)and Hazel Grouse(***).FROH estimated from genome-wide runs of homozygosity(ROH)ranged from 0.02 to 0.24 among Chinese Grouse populations and from 0.01 to 0.44 in Hazel *** from a population of Chinese Grouse residing in the Qilian mountains and from the European populations of Hazel Grouse(including samples from Sweden,Germany and Northeast Poland)were the most inbred(FROH ranged from 0.10 to 0.23 and 0.11 to 0.44,respectively).These levels are comparable to other highly inbred populations of *** Grouse from northern China and Chinese Grouse residing in the Qinghai-Tibetan Plateau showed relatively lower inbreeding *** of the ratio between deleterious missense mutations and synonymous mutations revealed higher levels in Chinese Grouse as compared to Hazel *** results are possibly explained by higher fixation rates,mutational melt down,in the range-restricted Chinese Grouse compared to the wide-ranging Hazel ***,when we compared the relatively more severe class of loss-of-function muta-tions,Hazel Grouse had slightly higher levels than Chinese Grouse,a result which may indicate that purifying selection(purging)has been more efficient in Chinese Grouse on this class of mutations.

关键词： Genetic load Inbreeding Purifying selection Qinghai-Tibetan Plateau ROH Tetrastes

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Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 472-480页

作者： Jin-Yang Li Tian-Shuo Feng Ji gao Xin-Xiang Yang Xiang-Cheng Li Zhen-hua Deng Yong-Xiang Xia Zheng-Shan Wu Hepatobiliary Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of Liver Transplantation Chinese Academy of Medical SciencesNanjing 210029China NHC Key Laboratory of Living Donor Liver Transplantation Nanjing Medical UniversityNanjing 210029China

Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the target mRNA, and yet the relationship between Bregs and mi R-29a-3p has not yet been fully explored. This study aimed to investigate the impact of miR-29a-3p on the regulation of differentiation and immunosuppressive functions of memory Bregs(m Bregs) and ultimately provide potentially effective therapies in inducing immune tolerance after liver transplantation. Methods: Flow cytometry was employed to determine the levels of Bregs in peripheral blood mononuclear cells. TaqMan low-density array miRNA assays were used to identify the expression of different miRNAs, electroporation transfection was used to induce mi R-29a-3p overexpression and knockdown, and dual luciferase reporter assay was used to verify the target gene of miR-29a-3p. Results: In patients experiencing acute rejection after liver transplantation, the proportions and immunosuppressive function of m Bregs in the circulating blood were significantly impaired. mi R-29a-3p was found to be a regulator of m Bregs differentiation. Inhibition of miR-29a-3p, which targeted nuclear factor of activated T cells 5(NFAT5), resulted in a conspicuous boost in the differentiation and immunosuppressive function of m Bregs. The inhibition of mi R-29a-3p in CD19~+ B cells was capable of raising the expression levels of NFAT5, thereby promoting B cells to differentiate into m Bregs. In addition, the observed enhancement of differentiation and immunosuppressive function of m Bregs upon mi R-29a-3p inhibition was abolished by the knockdown of NFAT5 in B cells. Conclusions: mi R-29a-3p was found to be a crucial regulator for m Bregs differentiation and immunosuppressive function. Silencing mi R-29a-3p could be a potentially effective therapeutic strategy for inducing immune tolerance after liver transplantation.

关键词： Regulatory B cells miR-29a-3p NFAT5 Liver transplantation

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Lead-free hybrid two-dimensional double perovskite with switchable dielectric phase transition

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Chinese Chemical Letters 2024年第6期35卷 176-179页

作者： Tian Yang Yi Liu Lina hua Yaoyao Chen Wuqian Guo Haojie Xu Xi Zeng Changhao gao Wenjing Li Junhua Luo Zhihua Sun College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Molecular dielectric switches constitute a type of intelligent materials that are highly coveted for their distinctive advantages of switchable dielectric responses,lightweight,and mechanical ***(2D)hybrid perovskites have demonstrated excellent promise for assembling dielectric switches,in which the dynamic motions of organic moieties afford driving force to trigger switchable dielectric phase ***,we successfully assembled a new lead-free hybrid double perovskite,(CHA)4Cu Bi Br8(1,CHA=cyclohexylammonium),adopting a typical 2D structural motif,which shows dielectric anisotropy and bistable behaviors during the reversible phase transition near T_(c)=378 K(the Curie temperature).That is,its dielectric constants could be switched and tuned between high-dielectric and low-dielectric *** analyses reveal that the ordered-disordered transformation of the organic CHA+moiety and distortion of inorganic framework account for its phase *** result will stimulate further exploration of molecular dielectric switches in this 2D environmentally friendly family.

关键词： Dielectric switch Lead-free Double perovskite Phase transition Symmetry breaking

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Permeability Estimation of Shale Oil Reservoir with Laboratory-derived Data: A Case Study of the Chang 7 Member in Ordos Basin

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Applied Geophysics 2024年第3期21卷 440-455,616页

作者： Zhang Lin gao Li Ba Jing Zhang Meng-Bo JoséM.Carcione Liu Wei-hua School of Earth Sciences and Engineering Hohai UniversityNanjingJiangsu211000 Exploration and Development Research Institute of PetroChina Changqing Oilfield CompanyXi'an Shanxi710018 National Institute of Oceanography and Applied Geophysics(OGS) SgonicoTrieste 34010 Sinopec Geophysical Research Institute NanjingJiangsu211103

The shale oil reservoir within the Yanchang Formations of Ordos Basin harbors substantial oil and gas resources and has recently emerged as the primary focus of unconventional oil and gas exploration and *** to its complex pore and throat structure,pronounced heterogeneity,and tight reservoir characteristics,the techniques for conventional oil and gas exploration and production face challenges in comprehensive implementation,also indicating that as a vital parameter for evaluating the physical properties of a reservoir,permeability cannot be effectively *** study selects 21 tight sandstone samples from the Q area within the shale oil formations of Ordos *** systematically conduct the experiments to measure porosity,permeability,ultrasonic wave velocities,and resistivity at varying confining *** reveal that these measurements exhibit nonlinear changes in response to effective *** using these experimental data and effective medium model,empirical relationships between P-and S-wave velocities,permeability and resistivity and effective pressure are established at logging and seismic ***,relationships between P-wave impedance and permeability,and resistivity and permeability are determined.A comparison between the predicted permeability and logging data demonstrates that the impedance–permeability relationship yields better results in contrast to those of resistivity–permeability *** relationships are further applied to the seismic interpretation of shale oil reservoir in the target layer,enabling the permeability profile predictions based on inverse P-wave *** predicted results are evaluated with actual production data,revealing a better agreement between predicted results and logging data and productivity.

关键词： shale oil reservoir P-wave impedance resistivity permeability rock physics experiment

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YTE-17 inhibits colonic carcinogenesis by resetting antitumor immune response via Wnt5a/JNK mediated metabolic signaling

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Journal of Pharmaceutical Analysis 2024年第4期14卷 525-541页

作者： hua Sui Wanli Deng Qiong Chai Bing Han Yuli Zhang Zhenzhen Wei Zan Li Ting Wang Jiling Feng Man Yuan Qingfeng tang Hongxi Xu Medical Experiment Center Jiading Branch of Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai201803China Translational Medicine Research Center for Cancer Prevention and Treatment Shanghai General Hospital Jiading Branch-School of Pharmacy of Shanghai University of Traditional Chinese Medicine Joint LaboratoryShanghai201803China Department of Medical Oncology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai201203China The Second Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450000China Shanghai University of Traditional Chinese Medicine Shanghai201203China Precision Research Center for Refractory Diseases Institute for Clinical ResearchShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai201620China

The density and composition of lymphocytes infiltrating colon tumors serve as predictive factors for the clinical outcome of colon *** previous studies highlighted the potent anti-cancer properties of the principal compounds found in Garcinia yunnanensis(YTE-17),attributing these effects to the regu-lation of multiple signaling ***,knowledge regarding the mechanism and effect of YTE-17 in the prevention of colorectal cancer is *** this study,we conducted isobaric tags for relative and absolute quantification(iTRAQ)analysis on intestinal epithelial cells(IECs)exposed YTE-17,both in vitro and in vivo,revealing a significant inhibition of the Wnt family member 5a(Wnt5a)/c-Jun N-terminal kinase(JNK)signaling ***,we elucidated the influence and mechanism of YTE-17 on the tumor microenvironment(TME),specifically focusing on macrophage-mediated T helper 17(Th17)cell induction in a colitis-associated cancer(CAC)model with Wnt5a ***,we performed the single-cell RNA sequencing(scRNA-seq)on the colonic tissue from the Wnt5a-deleted CAC model to characterize the composition,lineage,and functional status of immune mesenchymal cells during different stages of colorectal cancer(CRC)***,our findings demon-strate a significant reduction in M2 macrophage polarization and Th17 cell phenotype upon treatment with YTE-17,leading to the restoration of regulatory T(Treg)/Th17 cell balance in azoxymethane(AOM)/dextran sodium sulfate(DSS)***,we also confirmed that YTE-17 effectively inhibited the glycolysis of Th17 cells in both direct and indirect co-culture systems with M2 ***,our study shed light on potential mechanisms linking the non-canonical Wnt5a/JNK signaling pathway and well-established canonical b-catenin oncogenic pathway in ***,we proposed that Wnt5a/JNK signaling activity in IECs promotes the development of cancer stem cells with b-catenin activity within

关键词： Tumor microenvironment Intestinal epithelial cells Treg/Th17 cells Metabolism Wnt5a/JNK signaling Tumorigenesis

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Impacts of high temperature,relative air humidity,and vapor pressure deficit on the seed set of contrasting maize genotypes during flowering

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Journal of Integrative Agriculture 2024年第9期23卷 2955-2969页

作者： Xin Dong Baole Li Zhenzhen Yan Ling Guan Shoubing huang Shujun Li Zhiyun Qi Ling tang Honglin Tian Zhongjun Fu hua Yang Chongqing Academy of Agricultural Sciences Chongqing 401329China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China

Heat stress is a major constraint to current and future maize production at the global *** and female reproductive organs both play major roles in increasing seed set under heat stress at flowering,but their relative contributions to seed set are *** this study,a 2-year field experiment including three sowing dates in each year and 20 inbred lines was *** set,kernel number per ear,and grain yield were all reduced by more than 80%in the third sowing dates compared to the first sowing *** viability,silk emergence ratio,and anthesis-silking interval were the key determinants of seed set under heat stress;and their correlation coefficients were 0.89^(***),0.65^(***),and-0.72^(***),*** pressure deficit(VPD)and relative air humidity(RH)both had significant correlations with pollen viability and the silk emergence *** RH can alleviate the impacts of heat on maize seed set by maintaining high pollen viability and a high silk emergence *** a warming climate from 2020 to 2050,VPD will decrease due to the increased *** on their pollen viability and silk emergence ratios,the 20 genotypes fell into four different *** group with high pollen viability and a high silk emergence ratio performed better under heat stress,and their performance can be further improved by combining the improved flowering pattern traits.

关键词： maize pollen viability silk emergence heat stress relative humidity

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中国特色高水平高职院校建设的逻辑、特质与路径

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武汉职业技术学院学报 2020年第5期19卷 10-14页

作者：唐高华深圳信息职业技术学院创新教育研究院广东深圳518172

中国特色高水平高职院校建设是当前我国高职教育发展的重心。随着“双高计划”建设单位的评选立项与实施推进,中国特色高水平高职院校建设在国家顶层设计与地方主动作为的相互配合中不断前行。为了快速有效地推进中国特色高水平高职院... 详细信息

中国特色高水平高职院校建设是当前我国高职教育发展的重心。随着“双高计划”建设单位的评选立项与实施推进,中国特色高水平高职院校建设在国家顶层设计与地方主动作为的相互配合中不断前行。为了快速有效地推进中国特色高水平高职院校建设,首先要了解其逻辑,逻辑能有助于我们高效清晰的思考。中国特色高水平高职院校建设有其发轫的逻辑起点,也具有整体性、长期性、时代性、自主性和开放性的逻辑条件。在中国特色社会主义宏大背景下,体现出时代契合性、价值导向性和实践引领性的内在特质。基于此,应遵从其逻辑机理,结合其内在特质,探寻其实践路径,推进中国特色高水平高职院校的科学有序发展。

关键词：中国特色高水平高职院校逻辑特质路径

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粤港澳大湾区职业教育合作的价值、基础与推进方略

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职业教育研究 2019年第11期 19-22页

作者：唐高华深圳信息职业技术学院

在国家层面全力推进粤港澳大湾区建设背景下,粤港澳职业教育也应在大湾区建设中有所作为。粤港澳大湾区职业教育合作对粤港澳大湾区建设内容的完善和对中国职业教育改革发展的引领与示范拥有重要价值。同时,粤港澳大湾区职业教育合作在... 详细信息

在国家层面全力推进粤港澳大湾区建设背景下,粤港澳职业教育也应在大湾区建设中有所作为。粤港澳大湾区职业教育合作对粤港澳大湾区建设内容的完善和对中国职业教育改革发展的引领与示范拥有重要价值。同时,粤港澳大湾区职业教育合作在社会、经济、文化、教育等方面具有较好的基础。为此,应抓住大湾区建设的时代契机,积极推进粤港澳大湾区职业教育合作,围绕意识层面、规划层面、制度层面、进程层面、运行层面进行探索,实现新时代三地职业教育的合作共赢。

关键词：粤港澳大湾区职业教育合作价值基础推进方略

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Effects of PEAR1 gene polymorphism on big endothelin-1 levels in Chinese patients with acute myocardial infarction after percutaneous coronary intervention

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World Journal of Emergency Medicine 2024年第3期15卷 229-231页

作者： Yi Yao Na Xu Xiaofang tang Ce Zhang Sida Jia Jingjing Xu Ying Song Xueyan Zhao Runlin gao Jinqing Yuan Center for Coronary Heart Disease National Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Acute myocardial infarction (AMI) has been associated with poor prognosis,even after revascularization with percutaneous coronary intervention (PCI),likely due to coronary endothelial cell dysfunction and injury.^([1,2])Endothelin-1 (ET-1),a peptide that serves as a vasoconstrictor of smooth muscle cell proliferation,can reflect endothelial cell functional *** to low circulation levels and short plasma half-life time,measuring plasma ET-1 levels is *** contrast,big ET-1.

关键词： coronary percutaneous endothelin

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现代化国际化创新型城市建设背景下的东进战略研究

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特区经济 2018年第2期 29-31页

作者：唐高华深圳信息职业技术学院

建设成为现代化国际化创新型城市是当前及未来几年深圳发展的目标定位,为促进这种目标的实现,东进战略被提上了深圳城市发展的议程。东进战略具有较强的时代价值,具备较好的发展环境,也具备一定的发展动力。在实施推进东进战略时,要在... 详细信息

建设成为现代化国际化创新型城市是当前及未来几年深圳发展的目标定位,为促进这种目标的实现,东进战略被提上了深圳城市发展的议程。东进战略具有较强的时代价值,具备较好的发展环境,也具备一定的发展动力。在实施推进东进战略时,要在政治、制度、资金、管理等方面提供相应的保障,应根据东进战略目标和使命,结合深圳的现实特点和未来发展诉求,探寻东进战略的策略和路径。

关键词：现代化国际化创新型城市东进战略

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