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Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3457-3475页

作者： Manqing tang Zhijie Zhang Ping Wang Feng Zhao Lin Miao Yuming Wang Yingpeng Li Yunfei Li Zhonggao gao College of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Tumor metastasis,the apex of cancer progression,poses a formidable challenge in therapeutic *** tumor cells(CTCs),resilient entities originating from primary tumors or their metastases,significantly contribute to this process by demonstrating remarkable *** survive shear stress,resist anoikis,evade immune surveillance,and thwart *** comprehensive review aims to elucidate the intricate landscape of CTC formation,metastatic mechanisms,and the myriad factors influencing their *** signaling pathways,such as integrin-related signaling,cellular autophagy,epithelial-mesenchymal transition,and interactions with platelets,are examined in ***,we explore the realm of precision nanomedicine design,with a specific emphasis on the anoikis‒platelet *** innovative approach strategically targets CTC survival mechanisms,offering promising avenues for combatting metastatic cancer with unprecedented precision and *** review underscores the indispensable role of the rational design of platelet-based nanomedicine in the pursuit of restraining CTC-driven metastasis.

关键词： CTCs Anoikis Platelet Cancer stem cell Metastasis Platelet‒CTC interaction Platelet targeting Nanomedicines

Metal-free two-dimensional phosphorene-based electrocatalyst with covalent P-N heterointerfacial reconstruction for electrolyte-lean lithium-sulfur batteries

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Carbon Energy 2024年第5期6卷 175-185页

作者： Jiangqi Zhou Chengyong Shu Jiawu Cui Chengxin Peng Yong Liu Weibo hua Laura Simonelli Yuping Wu Shi Xue Dou Wei tang School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'anChina School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power-SourcesShanghaiChina CELLS-ALBA Synchrotron BarcelonaSpain School of Energy and Environment Southeast UniversityNanjingChina

The use of lithium-sulfur batteries under high sulfur loading and low electrolyte concentrations is severely restricted by the detrimental shuttling behavior of polysulfides and the sluggish kinetics in redox ***-dimensional(2D)few layered black phosphorus with fully exposed atoms and high sulfur affinity can be potential lithium-sulfur battery electrocatalysts,which,however,have limitations of restricted catalytic activity and poor electrochemical/chemical *** resolve these issues,we developed a multifunctional metal-free catalyst by covalently bonding few layered black phosphorus nanosheets with nitrogen-doped carbon-coated multiwalled carbon nanotubes(denoted c-FBP-NC).The experimental characterizations and theoretical calculations show that the formed polarized P-N covalent bonds in c-FBP-NC can efficiently regulate electron transfer from NC to FBP and significantly promote the capture and catalysis of lithium polysulfides,thus alleviating the shuttle ***,the robust 1D-2D interwoven structure with large surface area and high porosity allows strong physical confinement and fast mass ***,with c-FBP-NC as the sulfur host,the battery shows a high areal capacity of 7.69 mAh cm^(−2) under high sulfur loading of 8.74 mg cm^(−2) and a low electrolyte/sulfur ratio of 5.7μL mg^(−1).Moreover,the assembled pouch cell with sulfur loading of 4 mg cm^(−2) and an electrolyte/sulfur ratio of 3.5μL mg^(−1) shows good rate capability and outstanding *** work proposes an interfacial and electronic structure engineering strategy for fast and durable sulfur electrochemistry,demonstrating great potential in lithium-sulfur batteries.

关键词： black phosphorus electronic structure high sulfur loading interfacial covalent bonds lean electrolyte

Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu Jun-Xiu Shi Yi-Ming Ou hua-Jie Jiang Yi-Jun Fang Qi-Ming Wang Quan gao Jie Yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

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Opening Wider with

China Report ASEAN 2024年第4期9卷 18-19页

作者： tang hua 不详

The March weather in Beijing has been naggingly chilly,but the annual sessions of the National People’s Congress(NPC)and the Chinese People’s Political Consultative Conference(CPPCC)National Committee(Two Sessions)have been sending signals of further opening-up,kindling some warmth for a world economy troubled by unilateralism and regional conflicts.

关键词： weather trouble session

Recent advances in artificial intelligence generated content

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 1-5页

作者： Junping ZHANG Lingyun SUN Cong JIN Junbin gao Xiaobing LI Jiebo LUO Zhigeng PAN Ying tang Jingdong WANG School of Computer Science Fudan UniversityShanghai 200433China International Design Institute Zhejiang UniversityHangzhou 310058China School of Information and Communication Engineering Communication University of ChinaBeijing 100024China The University of Sydney Business School The University of SydneyNSW 2006Australia Department of AI Music and Music Information Technology Central Conservatory of MusicBeijing 100032China Department of Computer Science University of RochesterNY 14627USA School of Artificial Intelligence Nanjing University of Information Science and TechnologyNanjing 210044China Electrical and Computer Engineering Department Rowan UniversityGlassboroNJ 08028USA Baidu Beijing 100085China

Artificial intelligence generated content(AIGC)has been a research hotspot in the field of artificial intelligence in recent *** is expected to replace humans in performing some of the work of content generation at a low cost and a high volume,such as music,painting,multimodal content generation,news articles,summary reports,stock commentary summaries,and even content and digital people generated in the *** provides a new technical path for the development and implementation of AI in the future.

关键词： artificial replace content

Design and test of a wheel-belt type cotton stalk puller

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 102-108页

作者： Jialin Cai Jiaxi Zhang Zebin gao Xiaoxuan Wang Gang Guo Yasenjiang Baikeli Xuepeng tang Yichao Wang College of Mechanical and Electrical Engineering Xinjiang Agricultural UniversityUrumqi 830052China Key Laboratory of Xinjiang Intelligent Agricultural Equipment Urumqi 830052China

During the harvesting process,rigid materials are prone to causing damage to the cotton stalks,which will increase the risk of stalk breakage.A cotton stalk pulling component that blends stiff and flexible materials was devised to lower the breaking *** cotton stalk pulling component was made up of rollers and flexible belts that pull the stalks using clamping force and the forward speed of the *** influence of various factors in the equipment on the harvesting effect of cotton stalks were analyzed through response surface experiments,and a multiple quadratic regression response surface model with missing pulling rate and breakage rate as response values was *** significant of influencing factors on the breaking rate of cotton stalks are in a descending order as:the angle of cotton stalk pulling,tractor’s forward speed,and the clamping speed of the cotton stalk *** working parameters of the wheel-belt type cotton stalk pulling machine have been optimized using the response surface combination experimental method,and the optimal parameter combination was obtained as:tractor forward speed of 4.5 km/h,cotton stalk pulling angle of 60°,and clamping speed of the cotton stalk pulling component of 349 r/*** results of validation experiments showed that the missing pulling rate of cotton stalks was 5.06%and the breakage rate was 13.12%,indicating a good harvesting effect of the cotton *** model was reasonable and the performance parameters could meet the relevant inspection *** results can provide a reference for further research on the technology of flexible cotton stalk pulling.

关键词： cotton stalk puller wheeled belt flexible cotton stalks pulling verification testing

LSM6 promotes cell proliferation and migration regulated by HMGB1 in laryngeal squamous cell carcinoma

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Engineered Regeneration 2024年第2期5卷 247-254页

作者： Dengbin Ma Jiayi Li Hui Li Yao tang Xia gao Hong Chen Xiaoyun Qian Xiaohui Shen Department of Otolaryngology Head and Neck Surgery Research Institute of OtolaryngologyNanjing Drum Tower HospitalJiangsu Provincial Key Medical DisciplineAffiliated Hospital of medical SchoolNanjing UniversityNanjing210008China Department of Otorhinolaryngology Minda Hospital of Hubei Minzu UniversityEnshi445000China Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University 321 Zhongshan RoadNanjing210008China

Elevated levels of high mobility group protein B1(HMGB1)play a significant role in the pathogenesis of many diseases,but is particularly important for the formation of malignant ***,the function of HMGB1 and the underlying mechanism of laryngeal squamous cell carcinoma(LSCC)remain incompletely understood,causing *** we found immunohistochemistry from 97 LSCC tissues showed HMGB1 was upreg-ulated,which was associated with poor ***1 knockdown could significantly inhibit wound closure and colony *** full-genome gene expression microarray was performed to investigate the *** knockdown of HMGB1 by siRNA,among the expressed differential genes,10 genes were ran-domly selected for ***,shRNA lentivirus targeting these genes were constructed to explore their role in LSCC by cell proliferation ***6 downregulation was dramatically promoted by HMGB1 knockdown,resulting in higher expression in LSCC ***,downregulation of LSM6 could significantly suppress cell proliferation,migration and colony *** study indicated that HMGB1 promoted LSCC cell malig-nant phenotypes through regulation of *** anticipate that HMGB1-LSM6 could be a putative therapeutic target for LSCC.

关键词： HMGB1 LSM6 Laryngeal squamous cell carcinoma Cell proliferation Migration

Underwater RGB-D imaging system with millimetric precision

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Science China(Information Sciences) 2024年

作者： Yajun gao Yang CONG Xu tang Mingxue LI State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences University of Chinese Academy of Sciences College of Automation Science and Engineering South China University of Technology

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Applications of gastric peroral endoscopic myotomy in the treatment of upper gastrointestinal tract disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 658-669页

作者： Shi-Yu Chang Guo-hua Jin Hai-Bo Sun Dong Yang Tong-Yu tang Department of Gastroenterology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Gastric peroral endoscopic myotomy(G-POME)is an emerging minimally invasive endoscopic technique involving the establishment of a submucosal tun-nel around the pyloric *** 2013,Khashab et al used G-POME for the first time in the treatment of gastroparesis with enhanced therapeutic efficacy,prov-iding a new direction for the treatment of *** the recent and rapid development of G-POME therapy technology,progress has been made in the treatment of gastroparesis and other upper digestive tract diseases,such as congenital hypertrophic pyloric stenosis and gastric sleeve stricture,with *** article reviews the research progress and future prospects of G-POME for the treatment of upper digestive tract gastrointestinal diseases.

关键词： Gastric peroral endoscopic myotomy Upper digestive tract diseases Gastroparesis Congenital hypertrophic pyloric stenosis Gastric sleeve stricture