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Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

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Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： Luo-Xi XIAO Zi-Yu WANG Jiang-Tao LI Hai-mei WANG Yi-Ming HAO Pan ZHOU Yu-Lin HUANG qiu-Ju DENG Yong-Chen HAO Na YANG Li-Zhen HAN Zhao YANG Ping-Ping JIA Yue qi Jing LIU Center for Clinical and Epidemiologic Research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(HR=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity

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Effects of three-dimensional quality assessment nursing intervention on efficacy and disease management of patients undergoing esophageal cancer surgery

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2979-2985页

作者： Hai-Yan Wu Jie Jin Chen Chen Jing-Jing Xu qi Jiang Dong-mei Lu Department of Cardiothoracic Surgery Huai'an First People's HospitalHuai'an 223300Jiangsu ProvinceChina

BACKGROUND Esophageal cancer is one of the most common malignant *** three-dimensional quality structure model is a quality assessment theory that includes three dimensions:Structure,process,and *** To investigate the effects of nursing interventions with three-dimensional quality assessment on the efficacy and disease management ability of patients undergoing esophageal cancer *** In this prospective study,the control group received routine nursing,and the intervention group additionally received a three-dimensional quality assessment intervention based on the above routine ***-efficacy and patient disease management abilities were evaluated using the General Self-Efficacy Scale(GSES)and Exercise of Self-Care Agency scale,*** SPSS Statistics for Windows,version 17.0,was used for the data *** This study recruited 112 patients who were assigned to the control and experi-mental groups(n=56 per group).Before the intervention,there was no significant difference in GSES scores between the two groups(P>0.05).After the inter-vention,the GSES scores of both groups increased,with the experimental group showing higher values(P<0.05).At the time of discharge and three months after discharge,the scores for positive attitudes,self-stress reduction,and total score of health promotion in the experimental group were higher than those in the control group(P<0.05).CONCLUSION The implementation of a three-dimensional quality structure model for postoperative patients with esophageal cancer can effectively improve their self-management ability and self-efficacy of postoperative patients.

关键词： Esophageal cancer Three-dimensional quality structure model Self-efficacy Disease management ability

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Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN qi CHENG Niang-mei LIU Wen-han YANG Ye CHEN Wei ZHANG Xiang-zhi ZHENG Xiao-yuan CHEN Ming-sheng ZHUANG qiu-yu ZHAO Bi-xing LIU Cong-sheng LIU Xiao-long LI qin WANG Ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of Biological Science and Engineering and Mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular ***:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMC-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into B-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(P<0.01).Transcriptome analysis indicated that Hippo signaling pathway was associated with anti-metastasis function of *** study showed PZH significantly inhibited the expressions of platelet derived growth factor receptor beta(PDGFRB),YAP,connective tissue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein

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Nomogram for predicting short-term response to anti-vascular endothelial growth factor treatment in neovascular age-related macular degeneration:An observational study

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World Journal of Radiology 2024年第9期16卷 418-428页

作者： Zhen-Huan Huang Xue-Zhao Tu qi Lin mei Tu Guo-Cai Lin Kai-Ping Zhang Department of Radiology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000Fujian ProvinceChina Department of Orthopedics Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000Fujian ProvinceChina Department of Endocrinology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000Fujian ProvinceChina Department of Ophthalmology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000Fujian ProvinceChina

BACKGROUND Anti-vascular endothelial growth factor(anti-VEGF)therapy is critical for managing neovascular age-related macular degeneration(nAMD),but understanding factors influencing treatment efficacy is essential for optimizing patient *** To identify the risk factors affecting anti-VEGF treatment efficacy in nAMD and develop a predictive model for short-term *** In this study,65 eyes of exudative AMD patients after anti-VEGF treatment for≥1 mo were observed using optical coherence tomography *** were classified into non-responders(n=22)and responders(n=43).Logistic regression was used to determine independent risk factors for treatment response.A predictive model was created using the Akaike Information Criterion,and its performance was assessed with the area under the receiver operating characteristic curve,calibration curves,and decision curve analysis(DCA)with 500 bootstrap *** Multivariable logistic regression analysis identified the number of junction voxels[odds ratio=0.997,95%confidence interval(CI):0.993-0.999,P=0.010]as an independent predictor of positive anti-VEGF treatment *** predictive model incorporating the fractal dimension,number of junction voxels,and longest shortest path,achieved an area under the curve of 0.753(95%CI:0.622-0.873).Calibration curves confirmed a high agreement between predicted and actual outcomes,and DCA validated the model's clinical *** The predictive model effectively forecasts 1-mo therapeutic outcomes for nAMD patients undergoing anti-VEGF therapy,enhancing personalized treatment planning.

关键词： Vascular endothelial growth factor Macular degeneration Neovascularization Age-related macular degeneration Choroidal neovascularization Optical coherence tomography angiography Nomogram

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科技期刊青年编辑双向奔赴的招募和全面培养

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编辑学报 2024年第4期36卷 464-467页

作者：祁丽娟方梅中国科学院软件研究所期刊联合编辑部北京100190

优秀的青年编辑是科技期刊的主力军。如何遴选和培养青年编辑,是各期刊出版单位共同的课题。本文分享了中国科学院软件研究所期刊联合编辑部青年编辑招募和培养的实践经验。在招募阶段,借助微信考察应聘者的价值观,通过初试题目考察应... 详细信息

优秀的青年编辑是科技期刊的主力军。如何遴选和培养青年编辑,是各期刊出版单位共同的课题。本文分享了中国科学院软件研究所期刊联合编辑部青年编辑招募和培养的实践经验。在招募阶段,借助微信考察应聘者的价值观,通过初试题目考察应聘者对岗位的渴求度、岗位胜任力和专业素质等,招募对象和编辑岗位的关系一定是双向奔赴的;在培养阶段,通过传帮带、编辑学研究、“夸夸卡”和“从错误中学习”等方式提升青年编辑的编辑业务能力和个人自身素质,引导青年编辑修炼职业情怀,充分激发青年编辑的优势特长和潜能,共同组成一支可持续发展的高水平编辑队伍。

关键词：科技期刊青年编辑选才育才人才培养

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Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study

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Journal of Geriatric Cardiology 2024年第5期21卷 506-522页

作者： Yi XU Tian XU Jia-Cong NONG Xiao-Han KONG Meng-Yao ZHAO Zhi-Jing GAO Yi-Fei WANG Wei YOU Pei-Na MENG Yu-He ZHOU Xiang-qi WU Zhi-Ming WU mei-En ZHAN Yan-qing WANG De-Feng PAN Fei YE Department of Cardiology Nanjing First HospitalNanjing Hospital Affiliated to Nanjing Medical UniversityNanjing Medical UniversityNanjingChina Department of Cardiology Clinical Medicine School of Nanjing UniversityNanjingChina Department of Cardiology Tianchang People’s HospitalTianchangChina Department of Cardiology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina

OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent *** A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCI) treatment guided by IVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete IVUS detection pre-and post-PCI and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NIH at SBO at the 1-year follow-up. If the correlation was confirmed, the cutoff value of the remodeling index(RI) for predicting NIH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of *** In phase I: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the RI cutoff value predicting percent NIH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. In phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P < 0.0001)was significantly higher in the several NR(s NR, defined as RI ≤ 0.85) group than in the non-s NR *** The NR of LCx O is associated with more in-stent NIH post-PCI for distal LMb lesions with a 2-stent strategy,and NR with RI ≤ 0.85 is linked to percent NIH area ≥ 50% at the 1-year follow-up and more TLF at the 5-year follow-up.

关键词： lesions remodeling intravascular

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Fine mapping and characterization of stripe rust resistance gene YrAYH in near-isogenic lines derived from a cross involving wheat landrace Anyuehong

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The Crop Journal 2024年第3期12卷 826-835页

作者： Li Long Jue Li Linyu Huang Huiling Jin Fangnian Guan Haipeng Zhang Sasa Zhao Hao Li Zhien Pu Wei Li qiantao Jiang Yuming Wei Jian Ma Houyang Kang Shoufen Dai Pengfei qi qiang Xu mei Deng Youliang Zheng Yunfeng Jiang Matthew James Moscou Guoyue Chen State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina College of Resources Sichuan Agricultural UniversityChengdu 611130SichuanChina The Sainsbury Laboratory Norwich Research ParkNorwich NR47UHEnglandUK United States Department of Agriculture-Agricultural Research Service Cereal Disease LaboratorySt.PaulMN 55108USA

Stripe rust,caused by Puccinia striiformis ***(Pst),is a devastating disease in wheat *** and characterizing new resistance genes/QTL is crucial for wheat breeding *** this study,we fine-mapped and characterized a stripe rust resistance gene,YRAYH,on chromosome arm 5BL in the Chinese wheat landrace Anyuehong(AYH).Evaluations of stripe rust response to prevalent Chinese Pst races in near-isogenic lines derived from a cross of Anyuehong and Taichung 29 showed that YrAYH conferred a high level of resistance at all growth *** mapping using a large segregating population of 9748 plants,narrowed the YRAYH locus to a 3.7 Mb interval on chromosome arm 5BL that included 61 annotated *** analysis of two NIL pairs identified 64 upregulated differentially expressed genes(DEGs)in the resistant NILs(NILs-R).Annotations indicated that many of these genes have roles in plant disease resistance *** a combined approach of fine-mapping and transcriptome sequencing,we identified a serine/threonine-protein kinase SRPK as a candidate gene underlying YrAYH.A unique 25 bp insertion was identified in the NILs-R compared to the NILs-S and previously published wheat *** InDel marker was developed and co-segregated with *** trait evaluation of the NILs suggested that YrAYH not only reduces the impact of stripe rust but was also associated with a gene that increases plant height and spike length.

关键词： Candidate gene analysis Crop protection Puccinia striiformis Transcriptome analyses

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论史志目录编纂中的神话历史化——以《隋书·经籍志》为考察中心

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贵州工程应用技术学院学报 2024年第1期42卷 86-95页

作者：谭梅湖南工商大学数字传媒与人文学院湖南长沙410205

《隋书·经籍志》是唐初官修史志目录,《隋志》在对“史部”“子部”书籍的分类与认识中表现出明显的神话历史化倾向。《隋志》《隋书》的编修中存在明显的神话历史化与历史神话化互动,而且这是唐初史书编纂中所表现出的一种共同思想倾... 详细信息

《隋书·经籍志》是唐初官修史志目录,《隋志》在对“史部”“子部”书籍的分类与认识中表现出明显的神话历史化倾向。《隋志》《隋书》的编修中存在明显的神话历史化与历史神话化互动,而且这是唐初史书编纂中所表现出的一种共同思想倾向。《隋志》在其书籍分类方式中所表现出的神话历史化倾向渊源有自,与其对《七录》等目录分类方式的承继、唐初史书编纂的共同选择以及史官传统有密切的关系。

关键词：《隋书·经籍志》史部分类历史神话

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Brain development in newborns and infants after ECMO

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World Journal of Pediatrics 2024年第6期20卷 556-568页

作者： Kai Yan Lu-Kun tang Fei-Fan Xiao Peng Zhang Guo-qiang Cheng Lai-Shuan Wang Chun-mei Lu Meng-Meng Ge Li-Yuan Hu Yuan-Feng Zhou Tian-Tian Xiao Yan Xu Zhao-qing Yin Gang-Feng Yan Guo-Ping Lu qi Li Wen-Hao Zhou Department of Neonatology Children Hospital of Fudan UniversityShanghai 201102China Kunming Medical University Affiliated Dehong Hospital DehongYunnanChina Graduate School Kunming Medical UniversityKunmingYunnanChina Department of Neurology Children's Hospital of Fudan UniversityShanghaiChina School of Medicine Chengdu Women's and Children's Central HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Department of Intensive Care Medicine Children's Hospital of Fudan UniversityShanghaiChina Department of Intensive Care Medicine The Sixth Medical Center of PLA General HospitalBeijingChina Key Laboratory of Neonatology National Health Care CommissionShanghaiChina

Background Extracorporeal membrane oxygenation(ECMO)not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental *** systematically review the available literature on the neurodevelopmental outcomes of neonates and infants who have undergone ECMO treatment,with a focus on motor deficits,cognitive impairments,sensory impairments,and developmental *** review aims to understand the incidence,prevalence,and risk factors for these problems and to explore current nursing care and management *** sources A comprehensive literature search was performed across PubMed,EMBASE,and Web of Science using a wide array of keywords and phrases pertaining to ECMO,neonates,infants,and various facets of *** initial screening involved reviewing titles and abstracts to exclude irrelevant articles,followed by a full-text assessment of potentially relevant *** quality of each study was evaluated based on its research methodology and statistical ***,citation searches were conducted to identify potentially overlooked *** the focus was primarily on neonatal ECMO,studies involving children and adults were also included due to the limited availability of neonate-specific *** About 50%of neonates post-ECMO treatment exhibit varying degrees of brain injury,particularly in the frontal and temporoparietal white matter regions,often accompanied by neurological *** occur in 18%–23%of neonates within the first 24 hours,and bleeding events occur in 27%–60%of ECMO procedures,with up to 33%potentially experiencing ischemic *** some studies suggest that ECMO may negatively impact hearing and visual development,other studies have found no significant differences;hence,the influence of ECMO remains *** terms of cognitive,language,and intellectual development,ECMO treatment may be associated with potential deve

关键词： Brain development Extracorporeal membrane oxygenation Infants Neonates Neurological outcomes

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Exogenous electric field to accelerate wound healing

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Biomedical Engineering Communications 2024年第3期3卷 1-2页

作者： Kai-qi Yang Jia Chen Xiao-mei Li Si-Yuan Chang Yan-Jun Yang Yan-Ling Hu College of Material Engineering Fujian Agriculture and Forestry UniversityFuzhou 350108 China.2Medical Science and Technology Innovation Center School of RadiologyShandong First Medical University&Shandong Academy of Medical SciencesTai’an 271016 China.3School of Basic Medicine Medical College of Putian UniversityPutian 351100 China.4College of Life and Health Nanjing Polytechnic InstituteNanjing 210048 China.5School of Electrical and Computer Engineering College of EngineeringThe University of GeorgiaAthens 30602USA.

Wound healing is a critical physiological process in living organisms that includes repair cell proliferation and migration,etc.[1,2].While effective wound-healing treatment strategies have been developed in the past,few have actively controlled the behavior of skin cells to accelerate wound healing[3,4].The importance of accelerated wound healing lies in its ability to shorten treatment time,reduce the risk of infection,and lower the cost of *** stimulation can modulate cell behavior during wound healing by simulating endogenous electric fields,boosting cell migration,fibroblast proliferation,and granulation tissue growth more significantly than traditional methods[5-7].However,electrical stimulation devices’size,space limitations,and unsustainability make them challenging to use in clinical surgery,hindering real-time and convenient *** is therefore crucial to explore the miniaturization of electrical stimulation devices to advance the healing of skin wounds in clinical ***,Chen et *** a flexible micro-Zn-MnO2(mZMB)battery-based woundplast for wound management,which shows a promising path in biomedical applications(Figure 1)[8].

关键词： healing wound stimulation

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