检索结果-南通市图书馆

GTSE1在肝癌中的表达及其对预后和免疫浸润的影响

在线全文

学校读者我要写书评

暂无评论

医学研究杂志 2024年第2期53卷 29-35页

作者：谭程鹏刘晓红李锟武汉大学中南医院肝胆胰外科、湖北省肝胆胰疾病微创诊疗临床医学研究中心 430071

目的研究G_(2)/S期应答相关蛋白1(G_(2) and S phase-expressed protein 1,GTSE1)在肝细胞癌(hepatocellular carcinoma,HCC)中的表达、免疫学作用和预后分析,及其潜在作用机制。方法使用公共数据库癌症基因组图谱(The Cancer Genome Atlas,TCGA)提供的数据,用Kaplan-Meier、肿瘤免疫评估资源(Tumor Immune Estimation Resource,TIMER)数据库和基因表达谱交互分析(Gene Expression Profiling Interactive Analysis,GEPIA)数据库进行GTSE1基因表达、免疫学作用及预后分析,通过免疫组化实验验证GTSE1在临床样本中的表达,应用R软件对GTSE1相关差异基因进行基因本体(gene ontology,GO)和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)富集分析。结果GTSE1在人类癌组织中显著高表达,且与肝细胞癌预后不良显著相关(P<0.05);GTSE1基因表达与HCC中浸润性免疫细胞的丰度显著相关(P<0.001)。GTSE1相关的差异表达基因主要富集于核分裂、细胞器裂变、离子通道活性等基因模块;其参与的信号通路主要包括神经活性配体-受体的相互作用、细胞周期等。结论GTSE1在HCC中的表达显著上调并与患者预后不良显著相关,且在免疫细胞浸润中发挥重要作用,可作为HCC的预后标志物和免疫治疗靶点。

关键词： G_(2)/S期应答相关蛋白1 肝细胞癌预后免疫细胞

Evolution model of a modern delta fed by a seasonal river in Daihai Lake,North China:determined from groundpenetrating radar and trenches

在线全文

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2019年第2期13卷 262-276页

作者： Beibei LIU chengpeng tan Xinghe YU Xin SHAN Shunli LI College of Geosciences China University of PetroleumBeijing 102249China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China Key Laboratory of Marine Sedimentology and Environmental Geology First Institute of OceanographyState Oceanic AdministrationQingdao 266061China School of Energy Resources China University of Geosciences (Beijing)Beijing 100083China

While deltas fed by seasonal rivers are common in modem sedimentary environments,their characteristics remain unclear as compared to those fed by perennial *** study identifies a small delta discharged by a seasonal stream flowing into Daihai Lake,in northern China,which is driven by ephemeral and high-energy flood *** 3D facies architecture was analyzed using ground-penetrating radar (GPR) and sedimentary logs from outcrop and *** types of radar surfaces,including truncations of underlying inclined strata,weak reflections,and depositional surface of downlap and onlap,were *** radar facies (highangle obliquetangential,low-angle subparallel,gently plane parallel,plane-parallel,chaotic,and continuous strong reflection) were identified based on distinctive reflections,including amplitude,continuity,dip,and termination *** depositional units (Unit A to E) were documented from proximal to distal *** discharge signatures include significant grain-size decrease over short distance,abundant Froude supercritical flow sedimentary structures,poorly developed barforms,and small-scale scour and fill *** of lake-level and sediment budget were evaluated over the past 60 *** highstand stage (1960- 1980),amalgamated channel (Units A and B),and delta front (Unit C) were *** slope stage (1980-1996),the lower deposits (Units A,B,C) were eroded by Unit D with a distinct truncation *** lowstand stage,most eroded sediments bypassed the incised channel and accumulated in the distal part,in which a new depositional unit was formed (Unit E).The model demonstrates that deltas fed by seasonal rivers tend to accumulate large amounts of sediments carried by high magnitude floods within short periods.

关键词： delta evolution seasonal discharge ground-penetrating radar sedimentary architecture Daihai Lake

消融与手术切除治疗直径2~5 cm肝癌的疗效

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

武汉大学学报（医学版） 2024年第3期45卷 316-320页

作者：冯哲刘晓红谭程鹏李自强何跃明李锟武汉大学中南医院肝胆胰外科湖北武汉430071

目的:探讨超声引导下经皮肝射频消融与腹腔镜肝切除术治疗直径2~5 cm肝细胞癌(HCC)的临床疗效。方法:回顾性收集2016年1月至2020年12月43例行超声引导下经皮射频消融治疗的患者(射频组)及54例腹腔镜下肝切除术治疗的HCC患者(手术组)的... 详细信息

目的:探讨超声引导下经皮肝射频消融与腹腔镜肝切除术治疗直径2~5 cm肝细胞癌(HCC)的临床疗效。方法:回顾性收集2016年1月至2020年12月43例行超声引导下经皮射频消融治疗的患者(射频组)及54例腹腔镜下肝切除术治疗的HCC患者(手术组)的临床资料,比较两组患者术后指标、并发症及1年、3年、5年生存情况以及复发情况。结果:射频组与手术组比较,术后指标血清丙氨酸氨基转移酶(ALT)与天冬氨酸氨基转移酶(AST)以及总胆红素(TBIL)水平更低,术后并发症发生率更低,术后住院时间及总住院时间更短(P0.05)。多因素分析显示Child-Pugh分级(P<0.001)为影响HCC患者总生存率的独立危险因素。结论:对于直径2~5 cm肝癌,消融联合其他治疗方案能取得与腹腔镜肝切除术切除相当的治疗效果,并且具有手术时间短、创伤小、术后并发症少、住院时间短、恢复快的优点。

关键词：肝细胞癌射频消融腹腔镜肝切除术疗效

Interaction between Downslope and Alongslope Processes on the Margins of Daihai Lake,North China:Implication for Deltaic Sedimentation Models of Lacustrine Rift Basin

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2012年第4期86卷 932-948页

作者： YU Xinghe LI Shunli CHEN Bintao tan chengpeng XIE Jing HU Xiaonong China University of Geosciences Florida State University Department of EarthOcean and Atmospheric SciencesTallahasseeFL 32306USA

Daihai Lake, a modern lacustrine rift basin, located in Inner Mongolia, North China, serves as an important modern analog for understanding deltaic depositional processes in an active rift setting. Two of the deltas （Yuanzigou delta and Bulianghe delta） on the margins of Daihai Lake were surveyed to compare and contrast stacking patterns using aerial photographs, field trenching and sediment sampling. Shallow cores and trench data collected from the margins of Daihai Lake indicate that a variety of depositional processes have been active since Daihai Lake formed. Two 3-D sedimentation models which employ chronostratigraphic correlation technique were generated. The chronostratigraphic sedimentation models predict and represent the architectures and sand-body continuity of sediments. Stratigraphical coincidence of the broad sheeted drifts and channel erosion suggests a coupling between downslope and alongslope processes. Distributary mouth bars are prevalent in the front of deltas on steeper slopes due to the dominance of down-slope flows. On the contrary, the along-slope currents favor the development of distal bar deposits with sheeted sandbodies on gentle depositional slopes. This study provides an insight into the architecture of complex sedimentary facies associated with highlighting key differences between downslope flows and alongslope currents. The distribution of sand within these deltas is of particular interests, with applications in understanding the architecture of hydrocarbon reservoirs formed in lacustrine rift basin.

关键词： downslope flows alongslope currents architectural element spatial extension model Daihai Lake

Ground-penetrating radar study of beach-ridge deposits in Huangqihai Lake, North China： the imprint of washover processes

在线全文

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2016年第1期10卷 183-194页

作者： Xin SHAN Xinghe YU Peter D. CLIFT chengpeng tan Shunli LI Zhixing WANG Dongxu SU School of Energy Resources China University of Geosciences (Beijing) Beijing 100083 China Department of Geology and Geophysics Louisiana State University Baton Rouge LA 70803 USA

Determining the origin of beach ridges in lacustrine basins can often be problematic. The sedimen- tary processes responsible for formation of beach ridges on the north shore of Huangqihai Lake were investigated by using ground penetrating radar （GPR）. A 400 MHz GPR antenna was used to achieve a high vertical resolution of 0.044）.08 m. The radar stratigraphy was then determined using principles of seismic stratigraphy. The radar facies （RF） were determined by analyzing internal configuration and continuity of reflections, as well as reflection termination patterns. The identified RF fall into three groups （inclined, horizontal and irregular）. The inclined group consists of RF that display inclined reflections. The horizontal group consists of RF that exhibit predominantly horizontal reflections. In the irregular group, the reflections are typically weak. RF with reflections with gently landward dips in the shore-normal profile are interpreted as washover sheet deposits. RF with steeply landward-dipping and imbricated reflections are interpreted as washover lobes. Washover sheets develop when overwash fails to enter a significant body of water and sedimentation takes place entirely on the relatively flattened topography. Washover lobe development occurs when overwash enters a region in which topography dips steeply landward, and sedimentation takes place on the surface of washover sheets or previous washover lobes. The beach-ridge deposits are interpreted as being formed entirely from vertically and laterally stacked washover sheets and washover lobes. They were formed by wave-dominated processes and secondary overwash processes supplemented by longshore currents.

关键词： beach-ridge ground penetrating radar radar facies radar stratigraphy washover process

The response of deltaic systems to climatic and hydrological changes in Daihai Lake rift basin,Inner Mongolia,northern China

在线全文

学校读者我要写书评

暂无评论

Journal of Palaeogeography 2013年第1期2卷 41-55页

作者： Yu Xinghe Li Shunli tan chengpeng Xie Jing Chen Bintao Yang Fan School of Energy Resources China University of Geosciences(Beijing) Research Institute of Petroleum Exploration & Development PetroChina

Delta systems are ubiquitous around lacustrine rift basins. Its peripheral ge-ometry, progradation structures and sedimentary successions were controlled by both tec-tonic settings and climatic changes. Peripheral geometry of a delta was strongly influenced by depositional gradients which formed the fan-shape delta on the steep slopes and developed the lobe-shape delta on the gentle slopes. Due to the discharge feed rivers can change rapidly driven by climatic variations, and the nearshore area of deltas display considerable facies variability. The rise of annual rainfall, which suggests the rivers feeding deltas are continuous, and result in distributary mouth bars that are prevalent in the front of deltas since the down-slope flows are greater than the along-slope currents. On the contrary, when the annual rainfall decreases and evaporation increases, the rivers only can feed deltas ephemerally. If the along-slope currents were in a dominant position, the distal bars were deposited. Progra-dation structure and sedimentary successions of deltas were controlled by the gradients of slopes. On gentle depositional slopes, shingle foreset beds predominate with fine sediments and small-scale sedimentary structures or vice versa.

关键词： coarse/fine-grained deltas depositional gradients continuity of rivers annual evaporation progradation structure

Towards direct superlubricity and superlow wear via amino modification of polyhydroxy alcohol solutions

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第9期12卷 1980-1990页

作者： Qiang MA chengpeng YAN Rui YAN Xin XU Haifeng WANG State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi'an 710072China Chongqing Innovation Center Northwestern Polytechnical UniversityChongqing 401135China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China

Friction remains as the primary mode of energy dissipation and components wear,and achieving superlubricity shows high promise in energy conservation and lifetime wear *** results in this work demonstrate that direct superlubricity combined with superlow wear can be realized for steel/Si_(3)N_(4)contacts on engineering scale when polyhydroxy alcohol solution was selectively modified by amino *** direct superlubricity occurs because 3-amino-1,2-propanediol molecules at the friction interface could be induced to rotate and adsorb vertically on the friction surface,forming in-situ thick and dense molecular films to passivate the asperity ***,amino modification is also conducive to improving the lubrication state from boundary to mixed lubrication regime by strengthening the intermolecular hydrogen bonding interaction,presenting enhanced load-bearing capability and reduced direct solid asperity ***,direct superlow average friction of 0.01 combined with superlow wear are achieved *** design principle of direct superlubricity and superlow wear in this work indeed offers an effective strategy to fundamentally improve energy efficiency and provide lifetime wear protection for moving mechanical assemblies.

关键词： direct superlubricity amino modification molecular layer superlow wear

Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2819-2834页

作者： Jikai Deng Shimin Yang Yingjian Li Xue tan Jiejie Liu Yanying Yu Qiang Ding chengpeng Fan Hongyun Wang Xianyin Chen Qianyun Liu Xiao Guo Feiyu Gong Li Zhou Yu Chen State Key Laboratory of Virology RNA InstituteCollege of Life Sciences and Frontier Science Center for Immunology and MetabolismWuhan UniversityWuhanChina School of Medicine Tsinghua UniversityBeijingChina School of Basic Medical Sciences Wuhan UniversityWuhanChina Animal Bio-Safety Level Ⅲ Laboratory/Institute for Vaccine Research Wuhan University School of MedicineWuhanChina

Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune ***,the K-D-K-E catalytic motif of 2′-O-MTase is highly conserved across numerous viruses,including flaviviruses,vaccinia viruses,coronaviruses,and extends even to ***,we observed a stronger 2′-O-MTase activity in SARS-CoV-2 compared to SARS-CoV,despite the presence of a consistently active catalytic *** further identified critical residues(Leu-36,Asn-138 and Ile-153)which served as determinants of discrepancy in 2′-O-MTase activity between SARS-CoV-2 and *** residues significantly enhanced the RNA binding affinity of 2′-O-MTase and boosted its versatility toward RNA *** interest,a triple substitution(Leu^(36)→Ile^(36),Asn^(138)→His^(138),Ile^(153)→Leu^(153),from SARS-CoV-2 to SARS-CoV)within nsp16 resulted in a proportional reduction in viral 2′-O-methylation and impaired viral ***,it led to a significant upregulation of type I interferon(IFN-I)and proinflammatory cytokines both in vitro and vivo,relying on the cooperative sensing of melanoma differentiation-associated protein 5(MDA5)and laboratory of genetics and physiology 2(LGP2).In conclusion,our findings demonstrated that alterations in residues other than K-D-K-E of 2′-O-MTase may affect viral replication and subsequently influence *** changes in nsp16 residues is crucial as it may aid in identifying and assessing future alteration in viral pathogenicity resulting from natural mutations occurring in nsp16.

关键词： pathogenesis impaired alterations

Material-SAM:Adapting SAM for Material XCT

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第3期78卷 3703-3720页

作者： Xuelong Wu Junsheng Wang Zhongyao Li Yisheng Miao chengpeng Xue Yuling Lang Decai Kong Xiaoying Ma Haibao Qiao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China Senior Engineer at the Simulation Center Citic Dicastal Co.Ltd.Qinhuangdao066010China

X-ray Computed Tomography(XCT)enables non-destructive acquisition of the internal structure of materials,and image segmentation plays a crucial role in analyzing material XCT *** paper proposes an image segmentation method based on the Segment Anything model(SAM).We constructed a dataset of carbide in nickel-based single crystal superalloys XCT images and preprocessed the images using median filtering,histogram equalization,and gamma ***,SAM was fine-tuned to adapt to the task of material XCT image segmentation,resulting in *** compared the performance of threshold segmentation,SAM,U-Net model,and *** method achieved 88.45%Class Pixel Accuracy(CPA)and 88.77%Dice Similarity Coefficient(DSC)on the test set,outperforming SAM by 5.25%and 8.81%,respectively,and achieving the highest ***-SAM demonstrated lower input requirements compared to SAM,as it only required three reference points for completing the segmentation task,which is one-fifth of the requirement of ***-SAM exhibited promising results,highlighting its potential as a novel method for material XCT image segmentation.

关键词： Segment Anything model X-ray computed tomography U-Net Ni-based superalloys foundation models