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Science China Earth Sciences 2020年第5期63卷 649-661页

作者： Wei LI Yun CHEN Ping tan Xiaohui yuan State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China Institute of Disaster Prevention Sanhe 065201China Deutsches GeoForschungsZentrum GFZ Telegrafenberg14473 PotsdamGermany

The Pamir plateau,located north of the western syntaxis of the India-Eurasia collision system,is regarded as one of the most possible places of the ongoing continental deep *** on a N-S trending linear seismic array across the Pamir plateau,we use the methods of the harmonic analysis of receiver functions and the cubic spline interpolation of surface wave dispersions to coordinate their resolutions,and perform a joint inversion of these datasets to construct a 2-D S-wave velocity model of the crust and uppermost mantle there.A spatial configuration among the intermediate-depth seismicity,Moho topography,and low-velocity anomalies within the crust and upper mantle is revealed,which provides new seismological constraints on the geodynamic processes of the continental *** results not only further confirm the deep subduction of the Asian continental lower crust beneath the Pamir plateau,but also indicate the importance of the metamorphic dehydration of the subducting continental crustal material in the genesis of the intermediate-depth seismicity and the crustal deformation.

关键词： Pamir plateau Continental deep subduction Intermediate-depth seismicity Low-velocity zone Receiver function Ambient noise Joint inversion

nfluence of immune inflammation on androgen receptor expression in benign prostatic hyperplasia tissue

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Asian Journal of Andrology 2012年第2期14卷 316-319页

作者： zong-Lin Wu Ya yuan Shu-Jie Xia Department of Urology Putuo District People's HospitalShanghai 200060China Department of Pathology Putuo District People's HospitalShanghai 200060China Department of Urology Shanghai First People's HospitalShanghai Jiao Tong UniversityShanghai 200080China

This study was designed to investigate the association between immune inflammation and androgen receptor （AR） expression in benign prostatic hyperplasia （BPH）. We retrospectively analyzed 105 prostatectomy specimens. An immune inflammation score for each specimen was defined by combining three immunohistochemical markers （CD4, CD8 and CD20）. The immunohistochemical markers were CD4 and CD8 for T lymphocytes, CD20 for B lymphocytes and AR antibody for the AR in BPH samples. Rates of CD4, CD8, CD20 and AR expression in BPH were 20 （19.0%）, 21 （20.0%）, 101 （96.2%） and 48 （45.7%）, respectively. Total prostate volume （TPV） was higher in the immune inflammation group than in the non-immune inflammation group （62.7 ml vs. 49.2 ml, t=-2.482, P〈0.05）. Patients in the immune inflammation group had a higher serum prostate-specific antigen （PSA） than those in the non-inflammation group （7.5 ng m1-1 vs. 5.4 ng m1-1, t=-2.771, P〈0.05）. Specifically, the immune inflammation group showed a higher rate of AR expression than the non-inflammation group （56.1% vs. 28.2%, χ2=7.665, P〈0.05）. Our study revealed a strong association between immune inflammation and TPV, serum PSA and AR expression in BPH tissue. Prostate hyperplasia caused by an immune inflammatory process may contribute to BPH progression over time. Therefore, the inflammatory response involved in BPH may be a prime therapeutic target.

关键词： androgen androgen receptor benign prostatic hyperplasia immunohistochemistry inflammation

Optimized Degenerate Bose-Fermi Mixture in Microgravity： DSMC Simulation of Sympathetic Cooling

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Chinese Physics Letters 2014年第4期31卷 41-45页

作者： LUAN Tian JIA Tao CHEN Xu-zong MA Zhao-yuan School of Electronics Engineering and Computer Science Peking University Beijing 100871 Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800

Applying the direct simulation Monte Carlo （DSMC） method developed for the cold atom system, we explore the possibility of a high-efflciency sympathetic cooling process between 87Rb and 40K without gravitational force in an optical trap. The relation between the pre-cooling of Bosons and the sympathetic cooling efficiency is also studied. We find that the absence of gravitational force is beneficial to the process of sympathetic cooling. fhrthermore, an inefficient pre-cooling process will in fact hamper the creation of Fermi degenerate gases. This suggests the advantages of sympathetic cooling in microgravity.

关键词： Cooling Optimized direct

Endogenous/exogenous dual stimulation“ROS engineering”amplification combined with autophagy-augmented for efficient ferroptosis therapy

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Nano Research 2025年第1期18卷 597-606页

作者： Pengye Du Pengpeng Lei yuan Liang Ran An Yi Wei Shuyu Liu Jianhao Zheng Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Chemistry Tsinghua UniversityBeijing 100084China

“Reactive oxygen species(ROS)engineering”is one of the most promising anti-tumor treatments developed in recent *** explosion of ROS will cause oxidative stress,thereby inducing tumor cell ***,ROS accumulation in tumor cells is eliminated by endogenous cellular self-regulation *** this work,a kind of endogenous/exogenous dual stimulation nanoagent noted as UMZC is *** reaction occurs between NH_(2)-MIL-88B(Fe)contained in UMZC and the overexpression of endogenous H_(2)O_(2)to generate ROS,amplified by endogenous H_(2)S of colon tumor *** addition,NH_(2)-MIL-88B(Fe)also functions to deplete glutathione(GSH)for stopping it from consuming *** nanoparticles at the core of UMZC convert near-infrared into visible light,which excites zinc phthalocyanine to initiate the photochemical reaction that generates more ROS,thus alleviating the lack of tissue penetration depth for visible *** agonist chitosan oligosaccharides induce enhancement of cellular autophagy for disrupting cellular metabolic stress and the resistance to oxidative stress of tumor cells,allowing“ROS engineering”to fully exert anti-tumor *** of ROS generation,GSH depletion,and induced cellular autophagy caused by nanoagents have promoting effects on the occurrence of ***,the nanoagents show the ability to effectively treat colon tumors.

关键词： reactive oxygen species(ROS)engineering upconversion nanoparticles cellular autophagy ferroptosis tumor therapy

Two-Stage Mathematical Programming Approach for Steelmaking Process Scheduling Under Variable Electricity Price

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Journal of Iron and Steel Research International 2013年第7期20卷 1-8页

作者： tan yuan-yuan HUANG Ying-lei LIU Shi-xin College of Information Science and Engineering Northeastern University State Key Laboratory of Synthetical Automation for Process Industries Enterprise Solution Business Group Shanghai Baosight Software Limited Company

The steelmaking process scheduling problem by considering variable electricity price （SMSPVEP） was in- vestigated. A decomposition approach was proposed for the SMSPVEP. At the first stage, mathematical program-ming was utilized to minimize the maximum completion time for each cast without considering variable electricity price. At the second stage, based on obtained relative schedules of all casts, a mathematical model was formulated with an objective of minimizing the energy cost for all casts scheduling problem. The two-stage models were tested on randomly generated instances based on the practical process in a Chinese steelmaking plant. Computational results demonstrate the effectiveness of the proposed approach.

关键词： steelmaking process scheduling variable electricity price mathematical programming

Spectral and Energy Efficiency of Downlink MU-MIMO Systems with MRT

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China Communications 2017年第5期14卷 105-111页

作者： Weiqiang tan Shi Jin Jide yuan National Communications Research Laboratory Southeast UniversityNanjing 210096China

This paper studies the achievable spectral efficiency(SE)of downlink multiuser multiple-input-multiple-output(MIMO)system,where the base station(BS)is deployed an arbitrary finite antenna number and communicates simultaneously with many users. We assume that the BS has accurate channel state information(CSI)and adopt maximum ratio transmission(MRT)precoding. An accurate analytical result for the achievable SE is obtained. Based on the analytical result on the achievable SE,we further study the achievable energy efficiency(EE)of multiuser MIMO system by considering an energy consumption model. Results indicate that the increasing number of BS antennas can boost the achievable SE of system,whilst the achievable SE tends to a saturated rate in the high signal-tonoise ratios(SNR)regime. Furthermore,an important conclusion is that the increasing number of users is beneficial for the achievable EE and there is an optimal antenna number to maximize the EE of system.

关键词： energy efficiency multiuser MIMO maximum ration transmission spectral efficiency

Recovery of iron and calcium aluminate slag from high-ferrous bauxite by high-temperature reduction and smelting process

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International Journal of Minerals,Metallurgy and Materials 2016年第8期23卷 881-890页

作者： Ying-yi Zhang Wei Lü yuan-hong Qi zong-shu Zou College of Materials Science and Engineering Chongqing University State Key Laboratory of Advance Steel Processes and Products Central Iron and Steel Research Institute School of Material and Metallurgy Northeastern University

A high-temperature reduction and smelting process was used to recover iron and calcium aluminate slag from high-ferrous bauxite. The effects of w（CaO）/w（SiO_2） ratio, anthracite ratio, and reduction temperature and time on the recovery and size of iron nuggets and on the Al_2O_3 grade of the calcium aluminate slag were investigated through thermodynamic calculations and experiments. The optimized process conditions were the bauxite/anthracite/slaked lime weight ratio of 100：16.17：59.37, reduction temperature of 1450°C and reduction time of 20 min. Under these conditions, high-quality iron nuggets and calcium aluminate slag were obtained. The largest size and the highest recovery rate of iron nuggets were 11.42 mm and 92.79wt%, respectively. The calcium aluminate slag mainly comprised Ca_2 SiO_4 and Ca_（12）Al_（14）O_（33）, with small amounts of Fe Al_2O_4, CaAl_2O_4, and Ca_2Al_2SiO_7.

关键词： bauxite reduction smelting recovery rate calcium aluminate slag

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冷却风扇气动性能及噪声模拟与试验验证

太原学院学报（自然科学版） 2025年第1期43卷 55-62页

作者：谭礼斌袁越锦陕西科技大学机电工程学院陕西西安710021

为评估冷却风扇气动性能及噪声,以某摩托车用轴流式冷却风扇为研究对象,应用计算流体力学和计算声学方法,采用流体分析软件STAR-CCM+和噪声分析软件Virtual Lab对风扇性能及噪声开展研究,并与风扇性能和噪声试验数据对比验证计算模型的... 详细信息

为评估冷却风扇气动性能及噪声,以某摩托车用轴流式冷却风扇为研究对象,应用计算流体力学和计算声学方法,采用流体分析软件STAR-CCM+和噪声分析软件Virtual Lab对风扇性能及噪声开展研究,并与风扇性能和噪声试验数据对比验证计算模型的可靠性。结果表明:轴流式冷却风扇风量仿真值与实测值变化趋势一致,最大误差约为4.9%,总体平均误差约为2.94%。轴流式风扇转速4213 r/min及风压0 Pa时,噪声仿真值与试验值的误差为9.7%,误差低于10%,可满足工程需求。类似研究方法应用于发电机组用离心式风扇风量及噪声预测研究中,经分析得出离心式风扇入口风速试验值与仿真值间最大误差为9.17%,最小误差为5%;1 m远场噪声监测点的噪声声压级仿真值为66 dB(A),实测声压级为75 dB(A),两者差异为9 dB(A),误差约为13.6%,原因是实测噪声值中含有电机驱动系统运转的噪声。研究结果可为轴流式及离心式风扇的气动性能及噪声评估提供方法参考。

关键词：冷却风扇气动性能噪声轴流式风扇离心式风扇风量

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor