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Caspase-11 mediated inflammasome activation in macrophages by systemic infection of *** exacerbates arthritis

International Journal of Oral Science 2024年第3期16卷 499-514页

作者： Tokuju Okano Hiroshi Ashida Noriko Komatsu Masayuki Tsukasaki Tamako Iida Marie Iwasawa Yuto Takahashi Yasuo Takeuchi Takanori Iwata Miwa Sasai Masahiro Yamamoto Hiroshi takayanagi Toshihiko Suzuki Department of Bacterial Pathogenesis Infection and Host ResponseGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Lifetime Oral Health Care Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunoparasitology Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan

Clinical studies have shown that Aggregatibacter actinomycetemcomitans(***)is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis(RA).However,the mechanism is poorly ***,we show that systemic infection with *** triggers the progression of arthritis in mice anti-collagen antibody-induced arthritis(CAIA)model following IL-1βsecretion and cell infiltration in paws in a manner that is dependent on caspase-11-mediated inflammasome activation in *** administration of polymyxin B(PMB),chloroquine,and anti-CD11b antibody suppressed inflammasome activation in macrophages and arthritis in mice,suggesting that the recognition of lipopolysaccharide(LPS)in the cytosol after bacterial degradation by lysosomes and invasion via CD11b are needed to trigger arthritis following inflammasome activation in *** data reveal that the inhibition of caspase-11-mediated inflammasome activation potentiates aggravation of RA induced by infection with *** work highlights how RA can be progressed by inflammasome activation as a result of periodontitis-associated bacterial infection and discusses the mechanism of inflammasome activation in response to infection with ***.

关键词： CD11b inflam infection

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The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

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International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira Yamaguchi Kazuyuki Ishihara Hiroshi takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

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Brief history of the Asian International Seminars on Atomic and Molecular Physics

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原子与分子物理学报 2006年第6期23卷 1162-1163页

作者： takayanagi Kazuo Institute of Space and Astronatucial Science Professor Emeritus University of Tokyo

中日原子与分子物理讨论会是由中国著名学者清泉教授与日本著名学者高柳和夫教授共同发起创办的。第一次会议于1985年8月在成都举行。第二次会议于1988年10月在日本富士山北面脚下会议中心举行。第三次会议于1990年10月在山东泰安举... 详细信息

中日原子与分子物理讨论会是由中国著名学者清泉教授与日本著名学者高柳和夫教授共同发起创办的。第一次会议于1985年8月在成都举行。第二次会议于1988年10月在日本富士山北面脚下会议中心举行。第三次会议于1990年10月在山东泰安举行。第四次会议于1992年10月在日本东京举行。此次会议又称为第一届亚洲国际原子与分子物理讨论会。从此以后,会议规模扩大了,改称为亚洲国际原子分子论坛。现将高柳和夫教授所写的会议发展简史发表在本学报。供大家参考。

关键词：亚洲国际原子与分子物理 Brief history of the Asian International Seminars on Atomic and Molecular Physics 会议

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SOME COLLISION PROCESSES IN PLASMAS WITH HIGHER TEMPERATURE AND DENSITY

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原子与分子物理学报 1990年第4期7卷 1561-1564页

作者： Kazuo takayanagi

Some collision processes important in hot and dense plasmas are *** calculation of secondary electron velocity distribution in ionizing collision between an electron and a multiply-charged ion is reported.

关键词：等离子体高温高密度碰撞过程

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Influence of oxygen exposure on instabilities of perfluoropentacene transistor characteristics with different gate insulators

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Progress in Natural Science:Materials International 2011年第1期21卷 12-16页

作者： Hideharu UEKI Hiroaki YANO Hirokuni OHUCHI Yutaro takayanagi Yasushiro NISHIOKA Department of Precision Machinery College of Science and TechnologyNihon UniversityChiba 274-8501Japan

Pentacene for p-channel organic field effect transistors（OTFTs） and perfluoropentacene for n-channel OTFTs have attracted strong attentions to be used as CMOS type organic semiconductor materials for flexible organic displays.n-channel OTFTs with different gate insulators of polyimide（PI） and SiO2and perfluoropentacene as a semiconductor layer were fabricated,and their instability of the transistor characteristics measured in air,vacuum and oxygen was *** results show that both of the transistors exhibit a significant increase of mobility when measured in ***,the mobility of the transistors is significantly reduced when measured in pure oxygen,and the threshold voltages continuously *** phenomena may be related to water diffusion into the perfluoropentacene/gate insulator interface in air and oxidation of perfluoropentacene in oxygen.

关键词： oxygen exposure OTFT perfluoropentacene gate insulator polyimide SiO2

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Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1αsignaling

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Bone Research 2022年第4期10卷 770-783页

作者： Takehito Ono Ryosuke Denda Yuta Tsukahara Takashi Nakamura Kazuo Okamoto Hiroshi takayanagi Tomoki Nakashima Department of Cell Signaling Graduate School of Medical and Dental SciencesTokyo Medical and Dental University(TMDU)Yushima 1-5-45Bunkyo-kuTokyo 113-8549Japan Department of Orthopaedic Surgery The Jikei University School of Medicine3-25-8 Nishi-ShimbashiMinato-kuTokyo 105-8461Japan School of Dentistry Tokyo Medical and Dental University(TMDU)Yushima 1-5-45Bunkyo-kuTokyo 113-8549Japan Department of Biochemistry Tokyo Dental CollegeKandamisakicho 2-9-18Chiyoda-kuTokyo 101-0061Japan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan

Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becoming *** exercise at times can be an effective remedy for frailty,but exercise therapy cannot be applied in all clinical *** is safer than exercise,but there are no drugs that reinforce both muscle and bone when administered *** medications increase the risk of adverse events;thus,there is a need for individual drugs targeting both *** this end,we established a novel sequential drug screening system and identified an aminoindazole derivative,locamidazole(LAMZ),which promotes both myogenesis and osteoblastogenesis while suppressing *** of this drug enhanced locomotor function,with muscle and bone significantly ***,LAMZ induced Mef2c and PGC-1αin a calcium signaling–dependent *** this signaling is activated upon physical exercise,LAMZ mimics physical ***,LAMZ is a promising therapeutic drug for locomotor diseases,including sarcopenia and osteoporosis.

关键词： drugs clinical diseases

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ATOMIC PROCESSES IN AURORAE

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原子与分子物理学报 1985年第4期 9-11页

作者： Kazuo takayanagi Institute of Space and Astronautical Science Komaba 4-3-1 Meguro-ku Tokyo 153 Japan

Aurorae are produced in the upper atmosphere by the precipitation ofelectrons and protons from outside the atmosphere,Excitation of the visibleauroral activities is caused mainly by electrons in the energy range below... 详细信息

关键词： ATOMIC PROCESSES IN AURORAE In down

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Identification of an intronic enhancer regulating RANKL expression in osteocytic cells

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骨研究:英文版 2023年第3期11卷 607-616页

作者： Minglu Yan Masayuki Tsukasaki Ryunosuke Muro Yutaro Ando Kazutaka Nakamura Noriko Komatsu Takeshi Nitta Tadashi Okamura Kazuo Okamoto Hiroshi takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Microbiology Tokyo Dental CollegeTokyoJapan Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The bony skeleton is continuously renewed throughout adult life by the bone remodeling process,in which old or damaged bone is removed by osteoclasts via largely unknown *** regulate bone remodeling by producing the osteoclast differentiation factor RANKL(encoded by the TNFSF11 gene).However,the precise mechanisms underlying RANKL expression in osteocytes are still ***,we explored the epigenomic landscape of osteocytic cells and identified a hitherto-undescribed osteocytic cell-specific intronic enhancer in the TNFSF11 gene *** analyses showed that transcription factors involved in cell death and senescence act on this intronic enhancer ***-cell transcriptomic data analysis demonstrated that cell death signaling increased RANKL expression in osteocytic *** deletion of the intronic enhancer led to a high-bone-mass phenotype with decreased levels of RANKL in osteocytic cells and osteoclastogenesis in the adult stage,while RANKL expression was not affected in osteoblasts or *** data suggest that osteocytes may utilize a specialized regulatory element to facilitate osteoclast formation at the bone surface to be resorbed by linking signals from cellular senescence/death and RANKL expression.

关键词： utilize removed linking

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LOW—ENERGY MOLECULAR COLLISI0NS

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原子与分子物理学报 1985年第4期 12-15页

作者： Kazuo takayanagi Institute of Space and Astronautical Science Komaba 4-6-1 Meguro-ku Tokyo 153 Japan

Ⅰ:Collision processes involved In this talk,emphasis will be put in the sub-eV energy *** of molecules with atoms,molecules,or their ions lead to elasticcollisions,rotational transitions,vibrational transitions,excit... 详细信息

关键词： In ENERGY MOLECULAR COLLISI0NS LOW PRS

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Differential cross sections and oscillator strengths in electron energy loss spectrum of b^1П_u electronic state of N_2

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Science China Mathematics 1995年第3期38卷 368-375页

作者：徐克尊钟志萍武淑兰凤任飞 S.Ohtani T.takayanagi A.Kimota Department of Modern Physics University of Science and Technology of China Hefei 230027 China Institute for Laser Science University of Electro-Communication Tokyo 182 Japan

The energy loss spectrum of the molecular nitrogen in the energy region 12 -14 eV has been measured at 300 eV impact energy and in the range of scattering angles of 2.75℃- 10.25℃. The differential cross sections and generalized oscillator strengths have been determined for individual vibronic excitation band (v’ = 1 - 4) of b1Пu from the ground state of N2 and the absolute optical oscillator strengths have also been obtained by taking the limit of K→ 0. Results have been compared with experimental data and theoretical calculations previously published.

关键词： optical oscillator strength differential cross sections generalized oscillator strength Frank-Condon factor.

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