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Nanoimprint lithography for high-throughput fabrication of metasurfaces

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Frontiers of Optoelectronics 2021年第2期14卷 229-251页

作者： Dong Kyo OH taejun lee Byoungsu KO Trevon BADLOE Jong G.OK Junsuk RHO Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673.Republic of Korea Department of Mechanical and Automotive Engineering Seoul National University of Science and Technology(SEOULTECH)Seoul 01811Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Metasurfaces are composed of periodic subwavelength nanostructures and exhibit optical properties that are not found in *** have been widely investigated for optical applications such as holograms,wavefront shaping,and structural color printing,however,electron-beam lithography is not suitable to produce large-area metasurfaces because of the high fabrication cost and low *** alternative optical technologies,such as holographic lithography and plasmonic lithography,can overcome these drawbacks,such methods are still constrained by the optical diffraction *** break through this fundamental problem,mechanical nanopatteming processes have been actively studied in many fields,with nanoimprint lithography(NIL)coming to the *** NIL replicates the nanopattem of the mold regardless of the diffraction limit,NIL can achieve sufficiently high productivity and patterning resolution,giving rise to an explosive development in the fabrication of *** this review,we focus on various NIL technologies for the manufacturing of ***,we briefly describe conventional NIL and then present various NIL methods for the scalable fabrication of *** also discuss recent applications of NIL in the realization of ***,we conclude with an outlook on each method and suggest perspectives for future research on the high-throughput fabrication of active metasurfaces.

关键词： nanoimprint scalable fabrication large-area metasurface tailored nanostructure hierarchical nanostructures

Giant chiro-optical responses in multipolar-resonances-based single-layer dielectric metasurfaces

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Photonics Research 2021年第9期9卷 1667-1674页

作者： HAFIZ SAAD KHALIQ INKI KIM AIMA ZAHID JOOHOON KIM taejun lee TREVON BADLOE YESEUL KIM MUHAMMAD ZUBAIR KASHIF RIAZ MUHAMMAD QASIM MEHMOOD JUNSUK RHO NanoTech Lab Department of Electrical EngineeringInformation Technology University(ITU)of the PunjabLahore 54600Pakistan Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea National Institute of Nanomaterials Technology(NINT) Pohang 37673Republic of Korea

Chiro-optical effects offer a wide range of potential applications in nanophotonics,such as advanced imaging and molecular sensing and *** single-layer metasurfaces composed of subwavelength meta-atoms have gained significant attention due to their exceptional characteristics in light–matter *** metasurface-based devices have manipulated electromagnetic waves,the compact on-chip realization of giant chiro-optical effects remains a challenge at optical *** this work,we experimentally and numerically demonstrate an all-dielectric metasurface to realize large chiro-optical effects in the visible ***,the proposed strategy of utilizing achiral nanofins instead of conventional chiral structures provides an extra degree of design *** mutual coupling between carefully engineered nanofins produces constructive and destructive interference,leading to the asymmetric transmission of 70%and average circular dichroism exceeding 60%.We investigate the underlying mechanism behind the chiro-optical effects using the theory of multipolar *** proposed design mechanism maximizes the chiro-optical response through a single-layer metasurface with potential applications in high-efficiency integrated ultrathin polarization rotators and shapers,chiral polarizers for optical displays,chiral beam splitters,and chiral sensors.

关键词： chiral dielectric polar

Association between follistatin-related protein 1 and the functional status of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

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Chinese Medical Journal 2021年第10期134卷 1168-1174页

作者： taejun Yoon Sung Soo Ahn Jung Yoon Pyo Jason Jungsik Song Yong-Beom Park Sang-Won lee Department of Medical Science BK21 Plus ProjectYonsei UniversityCollege of MedicineSeoulRepublic of Korea Division of Rheumatology Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea Institute for Immunology and Immunological Diseases Yonsei University College of MedicineSeoulRepublic of Korea

Background:Follistatin-like 1(FSTL1)plays both pro-inflammatory and anti-inflammatory roles in the inflammatory *** investigated whether serum FSTL1 could predict the current anti-neutrophil cytoplasmic antibody-associated vasculitis(AAV)-specific ***:We randomly selected 74 patients with AAV from a prospective and observational cohort of Korean patients with *** and laboratory data and AAV-specific indices were ***1 concentration was determined using the stored *** lowest tertile of the short-form 36-item health survey(SF-36)was defined as the current low *** cutoffs of serum FSTL1 for the current low SF-36 physical component summary(PCS)and SF-36 mental component summary(MCS)were extrapolated by the receiver operator characteristic ***:The median age was 62.5 years(55.4%were women).Serum FSTL1 was significantly correlated with SF-36 PCS(r=-0.374),SF-36 MCS(r=-0.377),and C-reactive protein(CRP)(r=0.307),but not with Birmingham vasculitis activity score(BVAS).In the multivariable linear regression analyses,BVAS,CRP,and serum FSTL1 were independently associated with the current SF-36 PCS(β=-0.255,β=-0.430,andβ=-0.266,respectively)and the current SF-36 MCS(β=-0.234,β=-0.229,andβ=-0.296,respectively).Patients with serum FSTL1≥779.8 pg/mL and those with serum FSTL1≥841.6 pg/mL exhibited a significantly higher risk of having the current low SF-36 PCS and SF-36 MCS than those without(relative risk 7.583 and 6.200,respectively).Conclusion:Serum FSTL1 could predict the current functional status in AAV patients.

关键词： Anti-neutrophil cytoplasmic antibody Follistatin-like 1 Functional status Vasculitis

Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems

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Asian Journal of Pharmaceutical Sciences 2020年第3期15卷 336-346页

作者： Kanghee Jo Hyeongmin Kim Prakash Khadka taejun Jang Soo Jin Kim Seong-Ha Hwang Jaehwi lee College of Pharmacy Chung-Ang UniversitySeoul 06974Republic of Korea

The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated selfmicroemulsifying drug delivery system(S-SMEDDS) that can maintain a high concentration of saquinavir in gastro-intestinal fluid thorugh inhibiting the drug precipitation to enhance the lymphatic transport of saquinavir and to increase the bioavailability of saquinavir considerably. Solubilizing capacity of different oils, surfactants, and cosurfactants for saquinavir was evaluated to select optimal ingredients for preparation of *** the construction of pseudo-ternary phase diagram, SMEDDS formulations were established. A polymer as a precipitation inhibitor was selected based on its viscosity and drug precipitation inhibiting capacity. The S-SMEDDS and SMEDDS designed were administered at an equal dose to rats. At predetermined time points, levels of saquinavir in lymph collected from the rats were assessed. SMEDDS prepared presented a proper selfmicroemulsification efficiency and dispersion stability. The S-SMEDDS fabricated using the SMEDDS and hydroxypropyl methyl cellulose 2910 as a precipitation inhibitor exhibited a signficantly enhanced solubilizing capacity for saquinavir. The drug concentration in a simulated intestinal fluid evaluated with the S-SMEDDS was also maintained at higher levels for prolonged time than that examined with the SMEDDS. The S-SMEDDS showed a considerably enhanced lymphatic absoprtion of saquinavir in rats compared to the ***, the S-SMEDDS would be usefully exploited to enhance the lymphatic absorption of hydrophobic drugs that need to be targeted to the lymphatic system.

关键词： Lymphatic drug delivery Self-microemulsifying drug delivery system Saquinavir Precipitation inhibitor Supersaturation Lipid-based formulation

Comparative Paraquat Sensitivity of Newly Germinated and Mature Fronds of the Aquatic Macrophyte <i>Spirodela polyrhiza</i>

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American Journal of Plant Sciences 2020年第7期11卷 1008-1024页

作者： Jihae Park Hojun lee taejun Han Lab of Plant Growth Analysis Ghent University Global Campus Incheon Republic of Korea Department of Marine Science Incheon National University Incheon Republic of Korea

Here, we compared the intrinsic characteristics of 3-day-(newly germinated;“young”) and 8-week-old (“mature”) fronds of the aquatic plant Spirodela polyrhiza and their sensitivity to paraquat, a toxic herbicide. Endpoints measured were frond area and fresh weight, root length, chlorophyll a and b contents, and chlorophyll a fluorescence. Significant differences were detected in the intrinsic physiological traits between young and mature fronds. Young fronds showed higher root length, chlorophyll contents, maximum quantum yield (Fv/Fm), maximal relative electron transport rate (rETRmax) and saturating photon flux density (PFD), whereas mature fronds exhibited greater frond area and fresh weight. After a 72 h exposure to paraquat, root length and rETRmax were identified as the most sensitive endpoints of paraquat toxicity for both frond types, with EC50 values of 0.66 and 0.76 μg·

关键词： Spirodela polyrhiza Paraquat Herbicide Chlorophyll Contents Chlorophyll a Fluorescence Root Length

Anionic Synthesis of Primary and Secondary Amine-Functionalized Polymers Using Imine Chemistry

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应用化学 2001年第5期18卷 289-295页

作者： Roderic P.QUIRK, taejun YOO, Tae-Hee.CHEONG, Youngjoon lee (Maurice Morton Institute of Polymer Science,The University of Akron, Akron,Ohio,44325-3909,U.S.A.) Dedicated to the Occasion of the 80th Birthday of Prof.HUANG Bao-Tong and Prof.Feng Zhi-Li The University of Akron 美国 44325-3909

A review of methods for the anionic synthesis of well-defined, amine-functionalized polymers using imines as functionalizing agents is provided. The disparate results in the literature regarding functionalizations with N -(benzylidene)trimethylsilylamine to form primary amine functionalized polymers are discussed; the efficiency of functionalization depends on the molecular weight of the polymeric organolithium(PLi). Efficient functionalizations are observed for PLi with n>10 000 g/mol. The poor functionalization yields using ketimines with enolizable hydrogens is explained. The use of N -trimethylsilyldiphenylcarbimide as a quantitative primary amine functionalizing reagent is described. Recent results on the anionic synthesis of secondary amine-functionalized polymers using N -(benzylidene)methylamine as the functionalization agent are presented.

关键词：胺功能团聚合物亚胺衍生物阴离子聚合

Electrolyte changes after bowel preparation for colonoscopy:A randomized controlled multicenter trial

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World Journal of Gastroenterology 2015年第10期21卷 3041-3048页

作者： Kyong Joo lee Hong Jun Park Hyun-Soo Kim Kwang Ho Baik Yeon Soo Kim Sung Chul Park Hyun Il Seo Division of Gastroenterology and Hepatology Department of Internal Medicine Yonsei University Wonju College of Medicine Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Department of Internal Medicine Kangwon National University Hospital Department of Internal Medicine Ulsan Medical University Gangneung Asan Hospital

AIM:To investigate the electrolyte changes between 2-L polyethylene glycol with ascorbic acid 20 g(PEGAsc) and 4-L PEG ***:From August 2012 to February 2013,a total of 226 patients were enrolled at four tertiary *** patients were randomly allocated to a PEG-Asc group or a 4-L *** colonoscopy,patients completed a questionnaire to assess bowel preparation-related symptoms,satisfaction,and *** assessed the bowel preparation using the Boston Bowel Preparation Scale(BBPS).In addition,blood tests,including serum electrolytes,serum osmolarity,and urine osmolarity were evaluated both before and after the ***:A total of 226 patients were *** scores were similar and the adequate bowel preparation rate(BBPS≥6)was not different between the two groups(PEG-Asc vs 4-L PEG,73.2%vs 76.3%,P=0.760).Bowel preparation-related symptoms also were not different between the two *** taste of PEG-Asc was better(41.1%vs 16.7%,P<0.001),and the willingness to undergo repeated bowel preparation was higher in the PEG-Asc group(73.2%vs 59.3%,P=0.027)than in 4-L *** were no significant changes in serum electrolytes in either ***:In this multicenter trial,bowel preparation with PEG-Asc was better than 4-L PEG in terms of patient satisfaction,with similar degrees of bowel preparation and electrolyte changes.

关键词： Colonoscopy Bowel preparation Ascorbic acid Polyet