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Mrakia psy.hrophila ***.,a new species isolated from Antarctic soil

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Journal of Zhejiang University.Science B(Biomedicine & Biotechnology. 2007年第4期8卷 260-265页

作者： XIN Ming-xiu ZHOU Pei-jin College of Life Sciences Beijing Normal University Beijing 100875 China Institute of Microbiology Academia Sinica Beijing 100080 China

the y.ast strain （y.8） was isolated from a soil sample collected from Fildes Peninsula, Antarctica. the strain is a psy.hrophilic y.ast with optimum and maximum growth temperatures of 10 ℃ and 18 ℃, respectively. teliospores were formed after 7 d on malt agar, when the germination of teliospores was observed. Both inositol and D-glucuronate were assimilated. Positive results of the DBB （diazonium blue B） color reaction, urease test, and starch formation were observed. the major CoQ is Qs. All results indicated that.y.8 belongs to the genes of Mrakia. the 18S rDNA sequence analy.es showed that.y.8 is closely.related to Mrakiafrigida. DNA-DNA relatedness study. and some biochemist.y.characteristics indicated that.y.8 represents a new species for which Mrakia psy.hrophila sp. nov. is proposed.

关键词： Mrakiapsy.hrophila Psy.hrophilic y.ast 18S rDNA sequence teliospores

Parasy.pathetic neurogenesis is strongly.associated with tumor budding and correlates with an adverse prognosis in pancreatic ductal adenocarcinoma

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Chinese Journal of Cancer Research 2016年第2期28卷 180-186页

作者： Lingfu Zhang Limei Guo Ming tao Wei Fu Dianrong xiu Department of General Surgery Peking University Third HospitalBeijing 100191China Department of Pathology Peking University Third HospitalBeijing 100191China

Objective： to investigate the frequency.of parasy.pathetic neurogenesis and determine its association with tumor budding and prognosis in pancreatic ductal adenocarcinoma （PDAC）. Methods： Parasy.pathetic neurogenesis was defined as the distribution of abnormal parasy.pathetic nerves in the stroma tissue. Staining of vesicular acety.choline transporter （VACht）, as a marker for parasy.pathetic neurogenesis, was performed on a representative specimen of the tumor for 59 PDAC patients with available clinical, pathologic, and follow-up information. three specimens containing normal pancreatic tissues were stained in parallel. the number of parasy.pathetic nerve fibers was counted in five high-power microscopic fields （5×0.785 mm2）. Cut-offvalues were calculated by.receiver operating characteristic curve analy.is. Results： VACht-positive parasy.pathetic nerve fibers were not seen in the stroma of 3 cases of normal pancreatic tissues. In 59 PDAC cases, the range of parasy.pathetic neurogenesis was 4-38 fibers/（5×0.785） mm2, with a median of 18 fibers/（5×0.785） mm2. Patients with parasy.pathetic neurogenesis 〉 15 fibers/（5×0.785） mm2 were defined as the high-density.group （39 patients, 66.1%）, and those with parasy.pathetic neurogenesis 〈15 fibers/（5×0.785） mm2 as the low-density.group （20 patients, 33.9%）. the high-density.group had a higher occurrence of tumor budding （P=0.001） and a higher rate of early.recurrence （P=0.035）. Parasy.pathetic neurogenesis appeared to be an independent adverse prognostic factor [hazard ratio （HR）=2.45, 95% confidence interval （95% CI）： 1.25-4.81, P=0.009], in addition to American Joint Committee on Cancer （AJCC） stage （P=0.010） and tumor budding （P=0.009）. Conclusions： Parasy.pathetic neurogenesis is strongly.associated with tumor budding and correlates with an adverse prognosis in PDAC.

关键词： Pancreatic ductal adenocarcinoma parasy.pathetic neurogenesis tumor budding recurrence prognosis

响应面法优化铁皮石斛多酚提取工艺及其体外抗氧化活性研究

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现代中药研究与实践 2024年第3期38卷 74-78页

作者：廖秀周美杨艳李齐激贵州省天然产物研究中心功能天然产物与产品研究所贵州贵阳550014

目的研究不同因素对超声波法提取铁皮石斛多酚得率的影响,优化提取工艺,并探究铁皮石斛多酚的抗氧化活性。方法考察因素包括乙醇体积分数、料液比、提取时间、提取温度,基于单因素实验,综合Box-Benhnken实验对石斛多酚的提取工艺进行... 详细信息

目的研究不同因素对超声波法提取铁皮石斛多酚得率的影响,优化提取工艺,并探究铁皮石斛多酚的抗氧化活性。方法考察因素包括乙醇体积分数、料液比、提取时间、提取温度,基于单因素实验,综合Box-Benhnken实验对石斛多酚的提取工艺进行优化,以不同自由基清除率的IC_(50)判定石斛多酚抗氧化效果。结果铁皮石斛多酚最佳提取工艺条件:乙醇体积分数为80%,料液比1∶35 g/mL,温度为50℃,提取时间1 h,该工艺条件下铁皮石斛多酚的得率高达25.04%。石斛多酚提取物对DPPH、超氧阴离子、ABtS自由基清除的IC_(50)值分别为:47.51μg/mL、26.05μg/mL、97.35μg/mL。结论铁皮石斛多酚具有较强的抗氧化活性,研究结果可为石斛资源在抗氧化方面的研究提供一定的理论支撑。

关键词：铁皮石斛多酚提取工艺响应面法抗氧化活性

辛开苦降法对多囊卵巢综合征胰岛素抵抗患者卵巢功能、子宫内膜容受性及磷脂酰肌醇3激酶/丝苏氨酸蛋白激酶通路的影响

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世界中西医结合杂志 2024年第5期19卷 987-992页

作者：罗献英杨清谢秀超四川中医药高等专科学校中医系中医妇科教研室四川绵阳621000 绵阳市中医医院妇产科四川绵阳621000

目的观察辛开苦降法对多囊卵巢综合征(Poly.y.tic ovarian sy.drome,PCOS)胰岛素抵抗(Insulin resistance,IR)患者卵巢功能、子宫内膜容受性及磷脂酰肌醇3激酶/丝苏氨酸蛋白激酶(Phosphatidy.inositol 3 kinase/serine threonine protein kinase,PI3K/AKt)通路的影响。方法选取2018年11月—2020年1月期间四川中医药高等专科学校附属绵阳市中医医院收治的PCOS-IR患者83例,按随机数字表法分为对照组41例和治疗组42例。对照组采用炔雌醇环丙孕酮联合二甲双胍治疗,治疗组采用中医辛开苦降法(中药),均连续治疗12周。观察比较两组患者治疗前后体质量指数(Body.mass index,BMI)、卵巢功能[卵泡刺激素(Follicle stimulating hormone,FSH)、黄体生成素(Luteinizing hormone,LH)、LH/FSH与抗缪勒管激素(Anti-mullerian hormone,AMH)]、血糖[空腹胰岛素(Fasting insulin,FIN)、空腹血糖(Fasting blood glucose,FPG)、餐后2 h血糖(2 hours postprandial blood glucose,2 h PBG)与胰岛素抵抗指数(Homeostasis model assessmentinsulin resistance,HOMA-IR)]、子宫内膜容受性[收缩期峰值流速(Vmax)、搏动指数(Pulse index,PI)、阻力指数(Resistance index,RI)、血流参数血管化指数(Vascularity.index,VI)、血流指数(Flow index,FI)与血管化血流指数(Vascularity.flow index,VFI)]、外周血PI3K/AKt通路(PI3K、AKt mNRA),治疗期间不良反应情况。结果治疗后两组患者BMI、FPG、FIN、2 h GLU、HOMA-IR水平均较治疗前明显降低,差异有统计学意义(P0.05);且治疗组AMH、LH、LH/FSH明显低于对照组,差异有统计学意义(PtmRN表达均较治疗前升高,差异有统计学意义(PtmRN表达均明显高于对照组,差异有统计学意义(Pt通路,安全性高。

关键词：辛开苦降法多囊卵巢综合征胰岛素抵抗卵巢功能子宫内膜容受性磷脂酰肌醇3激酶/丝苏氨酸蛋白激酶通路

theoretical optimization of complete forbidden bands in woodpile-ty.e photonic cry.tals

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Optoelectronics Letters 2008年第5期4卷 358-360页

作者： ZHAN y. ZHENG y. LI xiu-Xia College of Graphic Arts Qufu Normal University Rizhao 276826 China College of Science Beijing Jiaotong University Beijing 100044 China

Based on the plane-wave method, the optical properties of complete forbidden bands of woodpile structure photonic cry.tal with an entire Lattice rotation of 45° in the x-y.plane were theoretically.studied in terms of height-to-pitch ratios, filling factors, and rotation angles. the calculated results show that the gap to mid-gap ratio changes slight.y.with a filling fraction ranging from 0.25 to 0.30. the optimum height-to-pitch ratio is about 1.3. the gap to mid-gap ratio reaches more than 0.18 when the rotation angle increases from 40° to 50° and the maximum gap to mid-gap ratio of 0.2 remains unchanged for the rotation angle from 42°to 48° with a constant height-to-pitch ratio of 1.3. the gap to mid-gap ratio reaches the maximum value of 0.2 when the height-to-pitch ratio is 1.3. this woodpile-ty.e photonic cry.tal can provide large band gaps within a wider parameter range, which makes it convenient to manufacture three-dimensional photonic cry.tals in the laboratory.

关键词：晶体平面波方法禁用波段木料堆结构

Preparation of Crack-free 3y.tZP/Al_2O_3 Composite Ceramic Fiber by.Electroly.is-sol-gel Method

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Chemical Research in Chinese Universities 2007年第4期23卷 377-380页

作者： LI Jian-jun JIAO xiu-ling CHEN Dai-rong Department of Chemist.y. Shandong University Jinan 250100 P. R. China

Poly.ry.talline 3y.tZP/Al2O3 tetragonal zirconia fiber was obtained by.the py.oly.is of gel fibers using zirconium oxy.hloride octahy.rate（ZOC） as the raw material. the spinnable zirconia sol was prepared by.electroly.ing the zirco-nium oxy.hloride octahy.rate（ZOC） solution in the presence of acetic acid and sugar（ sucrose, glucrose or fructose） , in which the molar ratios of CH3 COOH/ZOC and sugar/ZOC were 1.0-4.0 and 0.2-0.4, respectively. the pre- pared tetragonal zireonia fibers sintered at different temperatures showed smooth and crack-free surfaces with diame, ters of 5-10 μm. the addition of Al2O3 enhanced the sintering process and prevented the cry.tals from growing. thermogravimetric analy.is（tG）, X-ray.diffraction （ XRD ）, Fourier transform infrared spectroscopy.FtIR）, and scanning electron microscope（SEM） techniques were used to characterize the prepared fibers.

关键词： Electroly.is Sol-gel Zirconia Ceramic fiber Al2O3

Ordered Charge Distribution in Superconductor tl-Ba-Ca-Cu-O

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Chemical Research in Chinese Universities 1999年第3期15卷 271-280页

作者： LI Ping XIAO Shen xiu WANG Rong shun Department of Chemistry Sichuan UniversityChengdu 610064P.R.China

the lay.red charges were calculated by.means of constructing the complete structure of tl Ba Ca Cu O superconductor. the weak link between Cu O and Ba O, or between Cu O and tl O or Ba O or tl O lay.rs is explained with the aid of the charge of limited lay.r unit calculated from the values of ions obtained, in addition to the possibility.of forming charges fluctuation, which depends on the π coordination covalent bond on Cu O plane and O tl O structure. the possible chemical tight bonding orbitals are in accordance with those of other superconductors obtained by.quantum theoretical method, which occur at Cu 3d (x 2-y. 2) and O 2p x,y. . the valence band composed of Cu 3d and O 2p orbital energy.levels is obviously.an energy.band of conduction. the ordered charge on lay.rs is the main reason that raises t c of superconductors. the difference of electronic structure of ab plane and c axis leads to the anisotropy.properties.

关键词： Superconductor Ordered charge Completing structure Exchange and correlation potential Lay.r

基于中药物料语义分类的临方水丸制剂处方预测模型优化

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中国中药杂志 2024年第3期49卷 596-606页

作者：李云琪田文秀薛爱乐李文杰赵立杰洪燕龙上海中医药大学上海中医健康服务协同创新中心上海201203 上海健康医学院附属周浦医院上海201318 上海中医药大学创新中药研究院上海201203 中药现代制剂技术教育部工程研究中心上海201203

为优化前期已建立的临方水丸制剂处方预测模型,该研究选择山药、益母草、党参、苦杏仁、煅牡蛎分别为粉性料、纤维性料、糖性料、油性料、脆性料的代表性中药,利用混料均匀设计得到模型处方,以羟丙甲纤维素(HPMC-E5)水溶液为黏合剂,采... 详细信息

为优化前期已建立的临方水丸制剂处方预测模型,该研究选择山药、益母草、党参、苦杏仁、煅牡蛎分别为粉性料、纤维性料、糖性料、油性料、脆性料的代表性中药,利用混料均匀设计得到模型处方,以羟丙甲纤维素(HPMC-E5)水溶液为黏合剂,采用挤出搓圆法制备临方水丸。结合丸剂制备过程中的评价指标和多个模型的统计分析,优化并验证临方水丸制剂处方预测模型。得到临方水丸黏合剂浓度预测方程y.(1)=-4.172+3.63XA+15.057X_(B)+1.838X_(C)-0.997XD(y.(1)y.(1)>0时黏合剂质量分数为20%),黏合剂浓度预测模型整体正确率为96.0%;黏合剂用量预测方程y.(2)=6.051+94.944 XA 1.5+161.977 X_(B)+70.078 X_(C)2+12.016 X_(D)^(0.3)+27.493 X_(E)^(0.3)-2.168 X_(F)^(-1)(R^(2)=0.954,P<0.001)。同时采用中药物料分类的语义预测模型对验证处方包含的中药物料进行分类,制备丸剂,验证临方水丸制剂处方预测模型,验证处方在制丸过程中均一次成型,且成型质量优于前期所建方法,实现了临方水丸制剂处方预测模型的优化。

关键词：临方水丸预测模型语义分析中药物料分类

3D pseudo-seismic imaging of transient electromagnetic data-a feasibility.study

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3D pseudo-seismic imaging of transient electromagnetic data-...